Characterization of the aroma and flavor profiles of guava fruit (Psidium guajava) during developing by HS-SPME-GC/MS and RNA sequencing by Jie Zhang, Yi Zhang, Shuaiyu Zou, Endian Yang, Ziyi Lei, Tingting Xu, Chen Feng

“…This is the first study to describe the expression patterns of these genes throughout guava development, providing new insights into guava flavor development.…”
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HOX gene expression in the developing human spine by John E. G. Lawrence, Kenny Roberts, Elizabeth Tuck, Tong Li, Lira Mamanova, Petra Balogh, Inga Usher, Alice Piapi, Pavel Mazin, Nathaniel D. Anderson, Liam Bolt, Laura Richardson, Elena Prigmore, Xiaoling He, Roger A. Barker, Adrienne Flanagan, Matthew D. Young, Sarah A. Teichmann, Omer Bayraktar, Sam Behjati

“…Here, we use single-cell and spatial-transcriptomics, along with in-situ sequencing, to create a developmental atlas of the human fetal spine. …”
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Genome-wide identification and functional analysis of R2R3-MYB genes in Acer pseudosieboldianum: insights into low temperature stress response and anthocyanin biosynthesis by Shikai Zhang, Dong Zeng, Heng Zhang, Luwei Ding, Dongyuan Guo, Peilin Sun, Zhiming Han, Guanzheng Qu, Tuya Siqin, Xiangling You

“…Using a combination of bioinformatic approaches and transcriptomic profiling, we identified 95 ApseMYB genes, classified into 12 subfamilies with conserved motif architectures and structural features. …”
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Exploring omics strategies for drug discovery from Actinomycetota isolated from the marine ecosystem by Manik Prabhu Narsing Rao, Syed Raziuddin Quadri, Manda Sathish, Ngoc Tung Quach, Wen-Jun Li, Wen-Jun Li, Arinthip Thamchaipenet, Arinthip Thamchaipenet

“…The emergence of omics technologies such as genomics, metagenomics, transcriptomics, and metabolomics has dramatically enhanced the ability to investigate microorganisms by providing detailed insights into their biosynthetic gene clusters, metabolic pathways, and regulatory mechanisms. …”
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Lactate links exercise to synaptic protection and cognitive enhancement in Alzheimer’s disease models by Hao Han, Yi Wu, Ru Mi, Cijia Zhang, Fengying Guan, Xiaoyan Lu, Guangwei Zhang, Zhaojie Meng, Li Chen, Ming Zhang

“…Serum lactate levels were assessed, and sodium L-lactate (NaLA) was administered to determine its neuroprotective effects. Transcriptomic analysis was performed on hippocampal tissue to explore lactate-regulated pathways. …”
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Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization by Gang Wang, Tianchen Peng, Liang Chen, Kangping Xiong, Lingao Ju, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang

“…In summary, our findings underscore the role of the MVA pathway in BLCA metastasis, providing insights into potential therapeutic targets of this malignancy.…”
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Application of Artificial Intelligence Algorithms in the Field of Antimicrobial Peptide Prediction by QIAN Yuchen, NIE Ting, HUA Yanming, XU Shiying, GUO Sheng, ZHANG Xin, LUO Xiaohu, LIU Yanan

“…Currently, several specialized databases have been established, providing rich resources for algorithmic model training. …”
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Current cutting-edge omics techniques on musculoskeletal tissues and diseases by Xiaofei Li, Liang Fang, Renpeng Zhou, Lutian Yao, Sade W. Clayton, Samantha Muscat, Dakota R. Kamm, Cuicui Wang, Chuan-Ju Liu, Ling Qin, Robert J. Tower, Courtney M. Karner, Farshid Guilak, Simon Y. Tang, Alayna E. Loiselle, Gretchen A. Meyer, Jie Shen

“…Traditional bulk transcriptomics, genomics, proteomics, and metabolomics have played a pivotal role in uncovering disease-associated alterations at the population level. …”
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Application of Omics in Donkey Meat Research: A Review by Qifei Zhu, Yongdong Peng, Xiaotong Liu, Wenting Chen, Mingyang Geng, Jincheng Na, Muhammad Zahoor Khan, Changfa Wang

“…Advanced genomic and transcriptomic analyses have revealed numerous candidate genes, such as <i>ACTN3</i>, <i>BMP7</i>, <i>NR6A1</i>, <i>Wnt7a</i>, <i>HOXC8</i>, <i>LCORL</i>, <i>TPM2</i>, and <i>TPM3</i>, associated with growth traits and meat quality characteristics, providing valuable insights for genetic improvement programs. …”
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Shared and distinct peripheral blood immune cell landscape in MCTD, SLE, and pSS by Yanling Cui, Huina Zhang, Yaxuan Deng, Orion Fan, Junbang Wang, Zhonggang Xing, Jianping Tang, Wenmin Zhu, Bangdong Gong, Yi Eve Sun

“…Results We first resolved transcriptomic changes in peripheral blood immune cells of MCTD, and then revealed the shared and unique features among MCTD, SLE, and pSS. …”
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Expression characteristics, molecular mechanisms, and clinical significance of DICER1 in breast cancer by Xi Zhang, Long Yu, Cuizhi Geng

“…ObjectiveThis study aims to investigate the expression patterns, molecular mechanisms, and clinical significance of DICER1 in breast cancer (BRCA), providing new biomarkers and therapeutic targets for prognosis assessment and personalized treatment of breast cancer.MethodsBy integrating RNA-seq data, clinical data, and tumor mutation burden (TMB) data from The Cancer Genome Atlas (TCGA) database, as well as single-cell transcriptomic data from the Gene Expression Omnibus (GEO) database, we analyzed the expression characteristics of DICER1 in breast cancer. …”
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Identification and experimental validation of biomarkers associated with mitochondrial and programmed cell death in major depressive disorder by Shengjie Xiong, Lixin Liao, Meng Chen, Qing Gan

“…This study aimed to investigate the molecular pathways involved in MDD using a transcriptomic analysis approach.MethodsTranscriptomic data related to MDD were obtained from public databases. …”
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Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells by Sophia Varriano, Amy Yu, Yu Qing Xu, Devorah M. Natelson, Anthony Ramadei, Frida E. Kleiman

“…Here, we reveal a novel biological role of ER alpha (ERα) in mRNA 3’ end processing in breast cancer cells, providing an alternative mechanism in regulating gene expression at the post-transcriptional level. …”
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Unveiling the hidden dance: SPP1 + macrophages identified in ulcerative colitis reveal crosstalk with CHI3L1 + fibroblasts by Peiwen Zhou, Tongyu Tang, Pingwei Zhao, Quan Wang, Xintong Hu, Junzhuo Si, Tianshi Yang, Shuai Zhou, Wenyan An, Yanfang Jiang

“…Bulk RNA sequencing and spatial transcriptomic data from the Gene Expression Omnibus (GEO) database and flow cytometry and multiplex immunohistochemistry (mIHC) data were used for validation. …”
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The inhibitory receptor LAG3 affects NK cell IFN-γ production through glycolysis and the PSAT1/STAT1/IFNG pathway by Hongchi Ge, Nan Guo, Yufei Liu, Bin Lang, Xiaowan Yin, Xiaowen Yu, Zining Zhang, Yajing Fu, Haibo Ding, Qinghai Hu, Xiaoxu Han, Wenqing Geng, Hong Shang, Yongjun Jiang

“…Overall, these results provide new insights and identify potential targets for immunotherapy of HIV infection.IMPORTANCEWe demonstrate that lymphocyte activation gene 3 (LAG3) expression is upregulated on natural killer (NK) cells during HIV infection. …”
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Identification of yield-related QTLs and their applications using DH population in maize by Yifei Wang, Dongxu Yao, Junfeng Song, Xiaochun Zhang, Yanbin Zhu, Zhichun Luo, Jinsheng Lai, Weibin Song, Tianxia Yang

“…By integrating genome-wide association studies (GWAS), transcriptomic and gene sequence analysis, we identified 3 candidate genes in the new consensus QTLs. …”
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Propionic acid/FBP1 is involved in polystyrene nanoplastic-induced cardiac injury via the gut-heart axis by Huiwen Kang, Danyang Huang, Wei Zhang, JingYu Wang, Ziyan Liu, Ziyan Wang, Guangyu Jiang, Ai Gao

“…Conclusions In summary, our study systematically demonstrated the role of gut-heart axis in NPs-induced cardiac injury, and the specific process was that NPs exposure reduced propionate level, which in turn inhibited FBP1 expression to impair cardiac function. These findings provide new insights into NPs-induced cardiotoxicity and identifie potential therapeutic targets, providing clues for the prevention and treatment of NPs-induced cardiac injury in the future. …”
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Comprehensive multi-omics integration uncovers mitochondrial gene signatures for prognosis and personalized therapy in lung adenocarcinoma by Wenjia Zhang, Lei Zhao, Tiansheng Zheng, Lihong Fan, Kai Wang, Guoshu Li

“…Furthermore, we conducted comprehensive analyses of tumor mutation burden (TMB), immune microenvironment characteristics, and genome-wide association study (GWAS) data, providing additional insights into the mechanistic roles of mitochondrial-related genes in LUAD pathogenesis. …”
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Association of RDoC dimensions with post mortem brain transcriptional profiles in Alzheimer's disease by Weiqian Jiang, Jonathan Vogelgsang, Shu Dan, Peter Durning, Thomas H. McCoy, Sabina Berretta, Torsten Klengel

“…DISCUSSION Our findings provide evidence for distinct transcriptional profiles associated with RDoC domains suggesting that each dimension is characterized by sets of genes providing insight into the underlying mechanisms. …”
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Multi-omics analysis reveals cancer stemness function and establishes a predictive model for thyroid cancer prognosis and immunotherapy by Zhanrong Feng, Yue Xu, Ying Ding, Xiaoxiao Sun, Qian Zhao, Jingjing Zhu, Qiang Chen, Yang Zhang, Yilai Zhang

“…In this study, 26 mRNAs linked to cancer stemness were identified through an analysis of 13 publicly available THCA transcriptomic datasets alongside a CRISPR dataset for thyroid cancer cell lines. …”
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