Metagenomic analysis reveals Bacillus cereus OTU8977 as a potential probiotic in promoting walnut growth by Changxi Wang, Weichen Song, Chunyu Li, Yiran Cao, Xichen Li, Jing Zhao, Fei Yang, Haiyi Yu, Qiang Liang, Ke Qiang Yang, Jian Ning Liu, Hongcheng Fang

“…Moreover, the study further elucidated the mechanisms underlying its growth-promoting effects, providing a theoretical foundation for the development of walnut-specific microbial fertilizers.…”
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Cell-cell communication-mediated cell-type-specific parent-of-origin effects in mammals by Jia-Jin Wu, Enqin Zheng, Langqing Liu, Jianping Quan, Donglin Ruan, Zekai Yao, Jifei Yang, Xuehua Li, Shiyuan Wang, Ming Yang, Zebin Zhang, Meng Lin, Zheng Xu, Zicong Li, Gengyuan Cai, Jie Yang, Zhenfang Wu

“…Here we generate a single-nucleus transcriptomic landscape of mammalian placental development, identifying 5 major cell types and 14 trophoblast subtypes. …”
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Multi-dimensional annotation of porcine variants using genomic and epigenomic features in pigs by Hongwei Yin, Liu Yang, Qianyi Zhao, Wenye Yao, Jinyan Teng, Yahui Gao, Zhiting Xu, Qing Lin, Shuqi Diao, Xiaohong Liu, Fuping Zhao, Zhongyin Zhou, Qishan Wang, Jiaqi Li, Zhe Zhang, Huaijun Zhou, Martien A. M. Groenen, Ole Madsen, Lijing Bai, Dailu Guan, Lingzhao Fang, Kui Li

“…Conclusions In summary, our study provides a comprehensive catalog of genomic variants in both protein-coding and non-coding regions, and elucidated their functional consequences on epigenome, transcriptome, and complex traits in pigs.…”
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Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer by Xiaojun Wang, Qiqiao Du, Qiuwen Mai, Qiaojian Zou, Shuyi Wang, Xiaoying Lin, Qianrun Chen, Mengxun Wei, Chudan Chi, Zhangqing Peng, Karima Abdugheni, Liu Du, Yili Chen, Shuzhong Yao, Junxiu Liu

“…Our study aims to clarify the mechanisms underlying cisplatin resistance in CC and provide a novel treatment strategy to overcome the cisplatin resistance of CC patients. …”
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A meta-analysis approach for annotation and identification of lncRNAs controlling perirenal fat deposition in suckling lambs by María Alonso-García, Beatriz Gutiérrez-Gil, Rocío Pelayo, Pablo A. S. Fonseca, Héctor Marina, Juan José Arranz, Aroa Suárez-Vega

“…Based on the analysis of perirenal fat transcriptomes, this research explored the relevance of these regulatory elements to fat deposition in suckling lambs. …”
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A 23-gene multi-omics signature predicts prognosis and treatment response in non-small cell lung cancer by Yinxu Zhang, Siwang Wang, Xiaoyang Chen, Guangyu Zhang, Yuxi Wang, Xiaomei Liu

“…Conducted MR analysis to explore causal links between signature genes and NSCLC incidence, providing biological insights. (3) Results: A prognostic signature was developed, including 23 prognostic genes related to 19 PCD patterns and three organelle functions. …”
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Single-cell sequencing reveals dysregulated cell type perturbations and critical mediator communication remodelling in colorectal cancer by Chengyuan Xu, Chengyuan Xu, Siqi Zhang, Zhouyu Zhang, Luoqiu Zhang, Bin Sun, Zicheng Yu, Hailong Liu

“…Understanding the cellular composition and dynamic changes is essential for uncovering mechanisms of tumour progression.MethodsTo investigate the cellular heterogeneity and immune microenvironment of CRC, identifying critical subpopulations, functional pathways, and prognostic biomarkers, single-cell transcriptomic data from 41 CRC samples across four datasets were integrated. …”
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A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade therapy for hepatocellular carcinoma by Xingyang Zhao, Feichao Xuan, Zirong Li, Xiangyi Yin, Xiaojun Zeng, Jiali Chen, Chihua Fang

“…This study confirmed KIF20A as a promising immunogenic antigen through transcriptomic mRNA sequencing analysis in the context of HCC. …”
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Riluzole Reverses Blood–Testis Barrier Loss to Rescue Chemotherapy–Induced Male Infertility by Binding to TRPC by Rufei Huang, Huan Xia, Wanqing Lin, Zhaoyang Wang, Lu Li, Jingxian Deng, Tao Ye, Ziyi Li, Yan Yang, Yadong Huang

“…Moreover, repurposing riluzole could streamline the drug development process, providing a cost-effective approach with reduced risk compared to developing entirely new drugs.…”
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Enhancing abscisic acid production in Botrytis cinerea through metabolic engineering based on a constitutive promoter library by Ling-Ru Wang, Ji-Zi-Hao Tang, Shu-Ting Zhu, Na Wu, Zhi-Kui Nie, Tian-Qiong Shi

“…To our best knowledge, this is the first constitutive promoter library suitable for B. cinerea, providing important tools for the industrial production of ABA.…”
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Single-cell sequencing on PBMCs from patients with HA and HB with inhibitors reveals different immune responses to FVIII and FIX by Enhao Li, Zekun Li, Jinzeng Wang, Haoyang Wu, Yilun Xue, Can Lou, Zhenping Chen, Feng Liu, Wenman Wu, Qiulan Ding, Runhui Wu, Xuefeng Wang, Jing Dai

“…After quality control, a total of 75 051 cells were clustered into 19 subsets. Transcriptome analysis revealed differences in the composition of lymphocyte subsets and the functional status of immune cells between the HA and HB groups. …”
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Montbretia flowers as a source of bioactive crocins: Biotechnology tools and delivery systems by Lucía Morote, Cristian Martínez Martínez Fajardo, María Mondéjar López, Elena Moreno-Gimenez, Ángela Rubio-Moraga, Olivia Costantina Demurtas, Gianfranco Diretto, Enrique Niza, Verónica Aragonés, Alberto López Jiménez, José-Antonio Daròs, Oussama Ahrazem, Lourdes Gómez-Gómez

“…Our findings highlight the specialization of CCD subfamilies in monocots and dicots for crocin biosynthesis and provide evidence of the anti-inflammatory activity of exosome-transported crocins. …”
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Clock gene NR1D1 mediated inflammatory response after Streptococcus agalactiae challenge in Nile Tilapia (Oreochromis niloticus) brain by Zhang Wang, Zhigang Liu, Weijuan Zhu, Meiyan Zhang, Shaowei Huang, Jianmeng Cao, Miao Wang, Mengmeng Yi, Fengying Gao, Maixin Lu, Xiaoli Ke

“…Altogether, this study provide new insights into the pathogenic mechanism of NR1D1 in tilapia brain following S. agalactiae infection.…”
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Unraveling the genetic basis of resistance traits for fungal diseases in sorghum by Vinoth Kumar Govintharaj, M. Arumugam Pillai, V. Sumithra, Andrew Peter Leon, Ephrem Habyarimana, Jeshima Khan Yasin

“…Through quantitative trait loci mapping studies, numerous genomic regions linked to fungal disease resistance have been reported, providing crucial insights for targeted breeding strategies. …”
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Uridine diphosphate glucose confers oxidative stress tolerance in microalgae by Ruihao Zhang, Tengfei Xiao, Baohua Zhu, Chengxiang Kan, Xing Chen, Zihao Cao, Yan Zhao, Yun Li, Guanpin Yang, Kehou Pan

“…Conclusions Our findings unveil that UDPG is involved in the regulation of oxidative stress response in P. tricornutum, providing a worthy target for improving stress tolerance in microalgae.…”
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Identifying molecular signatures of post-traumatic stress disorder vulnerability and progression in a longitudinal study: a study protocol by Federico Suprani, Federico Suprani, Pasquale Paribello, Pasquale Paribello, Giulia Federica Mancini, Giulia Federica Mancini, Maria Morena, Maria Morena, Marco Pinna, Marco Pinna, Federica Pinna, Federica Pinna, Martina Contu, Martina Contu, Caterina Visioli, Fabio Medas, Gian Luigi Canu, Federico Cappellacci, Pietro Giorgio Calò, Gabriele Finco, Salvatore Sardo, Monica Maria Francesca Puligheddu, Monica Maria Francesca Puligheddu, Ernesto D’Aloja, Claudia Pisanu, Alessio Squassina, Donatella Congiu, Gian Marco Leggio, Mirko Manchia, Mirko Manchia, Mirko Manchia, Patrizia Campolongo, Patrizia Campolongo

“…The molecular signature will be based on the analysis of the endocannabinoid (eCB) system, as well as miRNome and transcriptome profiles. The study will recruit 60 participants hospitalized in the Intensive Care Unity of the University Hospital Agency of Cagliari. …”
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Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis by Tingting Zhu, Qixia Shen, Lingling Shen, Yucheng Wang, Bochen Zhu, Lifeng Ma, Shi Feng, Cuili Wang, Sijing Yan, Jingyi Li, Zhimin Chen, Jingyi Zhou, Hongfeng Huang, Bingjue Li, Zhouji Shen, Qian Wang, Jianwei Wang, Wilfried Gwinner, Irina Scheffner, Song Rong, Bing Yang, Junwen Wang, Hermann Haller, Xiaoping Han, Guoji Guo, Zhinan Yin, Jin Jin, Hui-Yao Lan, Jianghua Chen, Hong Jiang

“…To study the mechanism, we performed kidney transplantation on mice and observed attenuated allograft rejection in senescent recipients. Single-cell transcriptome analysis of allograft kidneys indicated a protective role of p21high macrophages in aged mice. …”
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The regulatory variant rs1950834 confers the risk of depressive disorder by reducing LRFN5 expression by Di Luan, Yifan Li, Aini Zhang, Qingqing Bai, Te Zhao, Xi Chen, Xinglun Dang, Junyang Wang, Shaolei Jiang, Yun Sun, Yingjie Zhu, Yan Kong, Xiong-Jian Luo, Zhijun Zhang

“…Meta-analysis of multiple transcriptomic datasets was performed to clarify the brain region responsible for LRFN5 downregulation in MDD patients. …”
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Reduced circulating regulatory T cells in primary Sjögren’s syndrome: the contribution of enhanced apoptosis and impaired survival by Yanlin Wang, Yanlin Wang, Yanlin Wang, Yuhan Jia, Hui Guo, Hui Guo, Min Feng, Min Feng, Min Feng, Yan Qin, Yan Qin, Yan Qin, Zhaojun Liang, Zhaojun Liang, Zhaojun Liang, Xiangcong Zhao, Xiangcong Zhao, Xiangcong Zhao, Chong Gao, Jing Luo, Jing Luo, Jing Luo

“…Therefore, approaches for increasing Treg numbers in vivo could provide precise pSS therapy.…”
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From Genomic Exploration to Personalized Treatment: Next-Generation Sequencing in Oncology by Vishakha Vashisht, Ashutosh Vashisht, Ashis K. Mondal, Jana Woodall, Ravindra Kolhe

“…Next-generation sequencing (NGS) has revolutionized personalized oncology care by providing exceptional insights into the complex genomic landscape. …”
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