Ubiquitin‐specific protease 25 improves myocardial ischemia–reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes by Bozhi Ye, Diyun Xu, Lingfeng Zhong, Yi Wang, Wei Wang, Haowen Xu, Xue Han, Julian Min, Gaojun Wu, Wenhai Huang, Guang Liang

“…This finding extends the protective role of USP25 in cardiovascular disease and provides an experimental basis for future USP25‐based drug development for the treatment of MI/RI. …”
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Functions of thyroid hormone signaling in regulating melanophore, iridophore, erythrophore, and pigment pattern formation in spotted scat (Scatophagus argus) by Yongguan Liao, Tong Han, Dongneng Jiang, Chunhua Zhu, Gang Shi, GuangLi Li, Hongjuan Shi

“…However, the formation of iridophore differentiation and guanine synthesis genes expression were stimulated by thyroid hormones. These findings provide new insights for exploring the formation of body color patterns in fish, and help to elucidate the molecular mechanism of thyroid hormone in regulating pigment cell development and body coloration, and may also contribute to selective breeding of ornamental fish.…”
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Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors by Yan Zhang, Di Chen, Qiqi Lu, Yu Yao, Gaopeng Li, Chunxia Ji, Ying Qi, Chao Tang, Ji Xiong, Jian Hu, Fatma Betul Aksoy Yasar, Dave S B Hoon, Liangfu Zhou

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The VDAC3/DHODH Axis Ameliorates Sepsis-induced Myocardial Injury by Regulating Ferroptosis by Jiali Wang, Fan Zhang, Chaoqing Tan, Nana Wang, Xuexia Xia, Yun Ye, Yue Cao, Xin Huang, Zhenjiang Bai, He Zhao, Ling Sun, Qiuqin Xu, Huiting Zhou, Jie Huang

“…Conclusion: Collectively, this research provides insights into the molecular mechanism behind the VDAC3/DHODH axis in SIMI. …”
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C1QBP promotes apoptosis of goat fetal turbinate cells via inhibiting the expression of TRIM5 or TNFSF10 by Qiuyun Li, Zhengding Tang, Hua Xiang, Yixin Dan, Yupeng Ren, Huanrong Zhang, Falong Yang, Jiangjiang Zhu

“…In particular, the apoptosis rate was significantly increased in the TRIM5-siRNA2 or TNFSF10-siRNA2 and C1QBP-siRNA2 group compared to the only C1QBP-siRNA2 group.ConclusionThese findings provide a deeper understanding of the role of C1QBP in apoptosis and could pave the way for further study investigating the role and mechanism of C1QBP protein in mediating the regulation of cell apoptosis by ORFV.…”
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Identification of potential susceptibility loci for non-small cell lung cancer through whole genome sequencing in circadian rhythm genes by Xiaohang Xu, Luopiao Xu, Zeyong Lang, Gege Sun, Junlong Pan, Xue Li, Zilong Bian, Xifeng Wu

“…RNA sequencing data were utilized for transcriptomic verification. Our study identified eight candidate SNPs associated with NSCLC susceptibility within the circadian rhythm pathway that met the requirement with P < 0.05 in both the discovery and validation populations. …”
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Bioinformatics identification and validation of m6A/m1A/m5C/m7G/ac4 C-modified genes in oral squamous cell carcinoma by Cheng-Hui Lu, Xue-Lai Yin, Zhuo-Deng Huang, Si-Ang Lv, Jun Wu, Jie Wei

“…The present study aimed to evaluate the effects and mechanisms of RRGs on OSCC development progression. Methods RNA-seq transcriptome data, along with clinical and prognostic information, were extracted for 328 patients with OSCC from the TCGA database. …”
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<i>CdGLK1</i> Transcription Factor Confers Low-Light Tolerance in Bermudagrass via Coordinated Upregulation of Photosynthetic Genes and Enhanced Antioxidant Enzyme Activity by Peng Han, Jun Liu, Jingjin Yu, Zhongpeng Liu, Fahui He, Zhimin Yang

“…These findings establish <i>CdGLK1</i> as a master integrator of photoprotection and metabolic adaptation under light-limiting conditions, providing both mechanistic insights and practical strategies for developing shade-resilient turfgrass cultivars.…”
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Fungus-mediated plant-pollinator mutualism in Monoon laui (Annonaceae): functional differentiation of stigmatic exudate and petal nectar by Yanwen Chen, Bine Xue, Juan Diego Gaitán-Espitia, Richard M. K. Saunders

“…Abstract Background Floral nectar typically functions as a pollinator reward in mutualistic flower-pollinator interactions, with this mutualism sometimes strengthened when plants provide the pollinators with brood sites and larval food as rewards. …”
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Interpretable and integrative analysis of single-cell multiomics with scMKL by Samuel D. Kupp, Ian A. VanGordon, Mehmet Gönen, Sadık Esener, Sebnem Ece Eksi, Çiğdem Ak

“…It outperforms existing methods while delivering interpretable results that identify key transcriptomic and epigenetic features, as well as multimodal pathways– that existing methods have failed to achieve, in breast, lymphatic, prostate, and lung cancers. …”
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Northern Norway Sporophytes of Saccharina latissima Display Distinct Gene Expression Profiles in Response to Temperature and Photoperiod by Martin Bua Rønhovde, Catia Monteiro, David Dolan, Kjersti Sjøtun, Håkon Dahle

“…In addition, genes related to growth, metabolism, protein synthesis, and translation were upregulated in the NN genotype, providing evidence that the NN genotype is better adapted to low temperatures than the SN and MN genotypes. …”
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Epigenetic profiling for prognostic stratification and personalized therapy in breast cancer by Xiao Guo, Chuanbo Feng, Jiaying Xing, Yuyan Cao, Tengda Liu, Wenchuang Yang, Runhong Mu, Tao Wang

“…Using multi-cohort transcriptomic datasets, MLEM was constructed with rigorous machine learning techniques and validated across independent datasets. …”
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Human iPSC-derived spinal neural progenitors enhance sensorimotor recovery in spinal cord-injured NOD-SCID mice via differentiation and microenvironment regulation by Xuanbao Yao, Kehua Zhang, Tao Na, Yuchun Wang, Yuhan Guo, Jiajie Xi, Xiang Li, Shufang Meng, Miao Xu

“…Our findings highlight the therapeutic potential of human iPSC-spNPGs in reconstructing neural networks and mitigating secondary damage, providing compelling preclinical evidence for advancing stem cell-based SCI therapies.…”
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Brain connectivity and transcriptional changes induced by rTMS in first-episode major depressive disorder by Muzhen Guan, Yuanjun Xie, Zhongheng Wang, Ye Miao, Xiaosa Li, Shoufen Yu, Hua-ning Wang

“…In this study, we investigated the voxel-wise degree centrality (DC) induced by 10 Hz rTMS targeting the left dorsolateral prefrontal cortex, as well as their associations with transcriptomic data from the Allen Human Brain Atlas. …”
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Machine learning based anoikis signature predicts personalized treatment strategy of breast cancer by Xiao Guo, Jiaying Xing, Yuyan Cao, Wenchuang Yang, Xinlin Shi, Runhong Mu, Tao Wang

“…AIDAS was developed using multi-cohort transcriptomic data and validated through immunohistochemistry assays on clinical samples to ensure robustness and broad applicability.ResultsAIDAS outperformed existing prognostic models in accurately predicting breast cancer outcomes, providing a reliable tool for personalized treatment. …”
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Exploring the role of epigenetic regulation in cancer prognosis with epigenetic score by Ruiguang Zhang, Shimin Jin, Qi Xu, Rongxiao Dai

“…To explore the relationship between epigenetic regulation and cancer progression, we utilized transcriptomic data from The Cancer Genome Atlas (TCGA) datasets to investigate the association.MethodsWe obtained transcriptomic data of epigenetic gene dataset from the TCGA database and calculated an epigenetic score using the Least Absolute Shrinkage and Selection Operator (LASSO) Cox model. …”
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The gut-liver axis plays a limited role in mediating the liver’s heat susceptibility of Chinese giant salamander by Runliang Zhai, Chunlin Zhao, Liming Chang, Jiongyu Liu, Tian Zhao, Jianping Jiang, Wei Zhu

“…Histological and transcriptomic data revealed metabolic exhaustion and liver fibrosis in heat-stressed salamanders, underscoring the liver’s critical role in heat sensitivity. …”
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Therapeutic potential and mechanistic insights of silibinin targeting cancer-associated fibroblasts in colorectal cancer by Shenglan He, Jianmei Ji, Kaisi Zhu, Youlan Chen, Xiaowen Xu

“…CAFs were isolated post-treatment for transcriptomic analysis to identify differentially expressed genes, with molecular docking providing in silico evidence of SB’s binding to target proteins. …”
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Decoding the Genes Orchestrating Egg and Sperm Fusion Reactions and Their Roles in Fertility by Ranjha Khan, Muhammad Azhar, Muhammad Umair

“…Together, these tools enable the discovery of novel genes, pathways, and molecular mechanisms involved in fertility, providing insights that were previously unattainable. …”
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YTHDC1 Promotes Stemness Maintenance and Malignant Progression in Head and Neck Squamous Cell Carcinoma by Junquan Weng, Haidong Fan, Huijuan Liu, Su Tang, Yuyan Zheng

“…These findings suggest that YTHDC1 may serve as a biomarker for stem maintenance and malignant progression in HNSCC, providing new insights into the treatment of cancer.…”
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