lncRNA Ubr5 promotes BMSCs apoptosis and inhibits their proliferation and osteogenic differentiation in weightless bone loss by Dong Wang, Yuan Gao, Yingjun Tan, Na Li, Xi Li, Jiaxiang Li, Yikai Pan, Xingcheng Zhao, Ming Yan, Yongchun Wang

“…The aim of this study was to systematically investigate the differential expression profiles of mRNAs and long noncoding RNAs (lncRNAs) to explore the molecular pathogenesis underlying weightless bone loss.MethodsTranscriptome sequencing was performed on bone marrow mesenchymal stem cell (BMSCs) samples from the Ground control group and simulated microgravity (SMG) group using Illumina technology. …”
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Whole-genome resequencing to investigate the genetic diversity and mechanisms of plateau adaptation in Tibetan sheep by Xue Li, Buying Han, Dehui Liu, Song Wang, Lei Wang, Quanbang Pei, Zian Zhang, Jincai Zhao, Bin Huang, Fuqiang Zhang, Kai Zhao, Dehong Tian

“…Additionally, we analyzed the domestication traits and investigated the unique adaptation mechanisms residing varying altitudes in the plateau region of Tibetan sheep. This study provides valuable insights into the evolutionary processes of Tibetan sheep in extreme environments. …”
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The association between lutein and zeaxanthin intake and multi-level biological aging by Meiyi Tao, Lin Zhang, Lin Zhang, Caidi Jiang, Jia Xiang, Jia Xiang, Shipeng Chen, Shipeng Chen, Songwen Tan, Songwen Tan, Songwen Tan, Shengli Sun

“…These findings highlight lutein's translatable potential for aging interventions and provide insights for dietary strategies in aging health management.…”
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Genome-wide identification and expression profiles of NAC transcription factors in Poncirus trifoliata reveal their potential roles in cold tolerance by Tian Fang, Yue Wang, Haowei Chen, Jing Qu, Peng Xiao, Yilei Wang, Xin Jiang, Chunlong Li, Ji-Hong Liu

“…The identification of PtrNAC2, a negative regulator of cold tolerance in P. trifoliata, provides valuable insights into unravelling potential candidates for engineering cold tolerance in citrus.…”
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Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma by Yi Bai, Xiyue Deng, Dapeng Chen, Shuangqing Han, Zijie Lin, Zhongmin Li, Wen Tong, Jinming Li, Tianze Wang, Xiangyu Liu, Zirong Liu, Zilin Cui, Yamin Zhang

“…Conclusion This study provides a comprehensive analysis of the epigenetic landscape in HCC, encompassing both chromatin accessibility and the transcriptome. …”
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Analysis of abscisic acid-insensitive gene (ABI) sequence and phylogenetic relationship in genus Fagopyrum by WANG Yan, LIANG Chenggang, CHEN Qingqing, SHI Taoxiong, CHEN Qijiao, MENG Ziye, DENG Jiao, HUANG Juan, CHEN Qingfu

“…The ABI UniGene sequence of buckwheat was isolated from the previously performed transcriptome sequencing data (accession number: SRS1350375). …”
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First Indonesian Nasopharyngeal Cancer Whole Epigenome Sequencing Identify Tumour Suppressor CpG Methylation by Handoko, Adham M, Rachmadi L, Tobing DL, Asmarinah A, Fadilah F, Dai W, Lee AWM, Gondhowiardjo SA

“…The presence of EBV DNA was confirmed in all samples, implicating its role in influencing methylation patterns.Discussion: This study provides comprehensive insights into the epigenetic landscape of NPC, underscoring the role of CpG methylation in tumour suppressor gene silencing. …”
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The role of molecular biomarkers in the diagnosis, prognosis, and treatment stratification of oral squamous cell carcinoma: A comprehensive review by Saravanan Ravindran, Srinivasan Ranganathan, Karthikeyan R, Nandini J, Shanmugarathinam A, Senthil Kumar Kannan, Durga Prasad K, Jalaiah Marri, Rajaganapathi K

“…It is expected that the incorporation of multi-omics techniques, which integrate transcriptome, proteome, and genomic data, will improve these tactics and increase accuracy in OSCC treatment. …”
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Dynamic changes in DNA methylation play a regulatory role in gene expression during the formation of callus from immature barley embryos by Xinguo Huang, Jing Zhan, Haonan Wei, Siying Lou, Hongwu Bian, Junhui Wang, Ning Han

“…Conclusions This study provides insights into the intricate relationship between DNA methylation and gene expression during barley callus formation. …”
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LMOD2 interaction with ACTC1 regulates myogenic differentiation by Kaiming Wang, Caihong Liu, Lei Yi, Sui Liufu, Wenwu Chen, Xiaolin Liu, Bohe Chen, Xin Xu, Jingwen Liu, Xibing Liu, Yulong Yin, Haiming Ma

“…Moreover, LMOD2 and ACTC1 interact to regulate myogenic differentiation. Our study provides a new target for skeletal muscle development.…”
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Identification of WRKY transcription factors in Ipomoea pes-caprae and functional role of IpWRKY16 in sweet potato salt stress response by Jiaying Wu, Yiren Su, Zhiyuan Pan, Yiming Wang, Yongjing Zhang, Ludan Li, Jihong Jiang, Xiaoying Cao

“…Transcriptome data of I. pes-caprae under salt stress conditions identified 17 highly expressed WRKY genes, whose promoter regions contain cis-acting elements associated with plant growth, stress responses, and hormone signaling. …”
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Activation of store-operated calcium entry and mitochondrial respiration by enterovirus 71 is essential for efficient virus replication by Bang-Yan Hsu, Ya-Hui Tsai, Ta-Chou Weng, Szu-Hao Kung

“…Pharmacological inhibition of the STIM1–Orai1 interaction and knockdown of either STIM1 or Orai1 significantly reduced virus-induced cytosolic Ca2+ levels and viral replication. Global transcriptome analysis revealed that differentially expressed genes are primarily associated with the mitochondrial electron transport chain (ETC) upon SOCE activation, contributing to enhanced ATP generation and oxygen consumption. …”
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Characterizing hub biomarkers for metabolic-induced endothelial dysfunction and unveiling their regulatory roles in EndMT through RNA sequencing and machine learning approaches by Qi Sun, Longchuan Xie, He An, Wei Chen, Qirong Yang, Peng Wang, Yijun Tang, Chunyan Peng, Chunyan Peng

“…The ceRNA networks associated with EndMT are constructed and related lncRNAs including LINC002381, VIM-AS1, and ELF-AS1 were significantly upregulated in peripheral blood samples.ConclusionsThis study identified novel biomarkers for ED. These findings may provide both a potential biomarker and therapeutic target for the prevention and treatment of atherosclerosis and CAD.…”
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The Molecular Mechanism by Which miR-211-5p Regulates the Proliferation and Differentiation of Preadipocytes in Meat Rabbits by Targeting TPK1 by Xiaoxiao Zhang, Meigui Wang, Tao Tang, Jing Zhou, Wenqiang Sun, Xianbo Jia, Jie Wang, Hengwei Yu, Songjia Lai

“…To address this knowledge gap, this study utilized rabbit preadipocytes as experimental models to investigate the molecular mechanisms by which miR-211-5p regulates preadipocyte proliferation and differentiation. The findings aim to provide a theoretical basis for improving rabbit meat quality. …”
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Sjögren’s syndrome is associated with a reduction in the surface area of the right caudal anterior cingulate gyrus by Ping Wang, Yunpeng Tai, Xiaofang Zhu, Xinyi Wan, An Sun, Jiajia Wang, Hui Cheng, Jingwei Hong, Yi Zhang, Xiaobing Wang

“…The identified genes and cell types provide insights into the mechanisms underlying the effects of SS on brain structure.…”
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Identification and characterization of long non-coding RNA (lncRNA) in wild and semi-wild cucumbers by Shi-Wei Xia, Chang-Jiang Song, Xiao-Fang Zheng, Yuan Zhang, Wajid Anwar, Dissanayakalage D.N.V. Dissanayaka, Ping-Zhi Zhu, Jun-Li Liu, Yun-Song Lai

“…LncRNAs are less conserved among plant species and comparative genomic study of lncRNA in cucumbers can provide new insight about the evolution and function of cucumber lncRNAs. …”
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Self-assembled co-delivery nanoplatform for increasing the broad-spectrum susceptibility of fall armyworm toward insecticides by Shuo Yan, Mingjian Li, Qinhong Jiang, Mingshan Li, Mengfan Hu, Xueyan Shi, Pei Liang, Meizhen Yin, Xiwu Gao, Jie Shen, Lei Zhang

“…Method: Regulatory function of nuclear factor erythroid 2-related factor 2 (Nrf2) in detoxification was confirmed using transcriptome sequencing, quantitative real-time PCR and enzyme activity measurement. …”
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Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer by Kun Fang, Aigbe G. Ohihoin, Tianxiang Liu, Lavanya Choppavarapu, Bakhtiyor Nosirov, Qianben Wang, Xue-Zhong Yu, Sailaja Kamaraju, Gustavo Leone, Victor X. Jin

“…However, such integrated single-cell analysis has not yet been demonstrated to characterize the transcriptome and chromatin accessibility in breast cancer endocrine resistance. …”
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Application of Spatial Omics in the Cardiovascular System by Yuhong Hu, Hao Jia, Hao Cui, Jiangping Song

“…This review explores the application of spatial omics, including spatial transcriptomics, spatial proteomics, spatial metabolomics, spatial genomics, and spatial epigenomics, providing more insight into the molecular and cellular foundations of cardiovascular disease and highlighting the critical contributions of spatial omics to cardiovascular science, and discusses future prospects, including technological advancements, integration of multi-omics, and clinical applications. …”
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Characterizing transcripts of HIV-1 different substrains using direct RNA sequencing by Weizhen Li, Yong Huang, Haowen Yuan, Jingwan Han, Zhengyang Li, Aiping Tong, Yating Li, Hanping Li, Yongjian Liu, Lei Jia, Xiaolin Wang, Jingyun Li, Bohan Zhang, Lin Li

“…In this study, using Oxford Nanopore Technology (ONT) direct RNA sequencing (DRS), we provided a comprehensive analysis of the transcriptome and epitranscriptome features of the HIV-1 B (NL4-3) subtype strain and, for the first time, characterized these features in the CRF01_AE (GX2005002) subtype strain. …”
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