Enhanced antioxidant activity improves deep-sowing tolerance in maize by Mingfei Sun, Menglin Pu, Guangming Zheng, Ziang Tian, Mingyue Zhang, Xiaofei He, Yajie Zhao, Xiangyu Zhao, Xiansheng Zhang, Xuerong Yang, Hongjun Liu, Chao Zhou

“…Our study has contributed to a deeper understanding of the complex tolerance mechanisms in maize and provided new insights for the development of new maize varieties under deep sowing conditions.…”
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Transcription factor BnaA1.WRKY53 is involved in regulation of auxin-induced leaf curling under boron deficiency in Brassica napus by Jinliang Yao, Rui Cui, Beibei Fang, Sheliang Wang, Xiangsheng Ye, Zhaojun Liu, Fangsen Xu

“…Overall, these findings demonstrate that auxin and the transcription factor BnaA1.WRKY53 synergistically regulate leaf curling to maintain an optimal leaf area under B deficiency, and provide novel insights into the resistance mechanisms against B-deficiency-induced leaf curling in oilseed rape.…”
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Pilot Study on the Profiling and Functional Analysis of mRNA, miRNA, and lncRNA in the Skeletal Muscle of Mongolian Horses, Xilingol Horses, and Grassland-Thoroughbreds by Wenqi Ding, Wendian Gong, Tugeqin Bou, Lin Shi, Yanan Lin, Huize Wu, Manglai Dugarjaviin, Dongyi Bai

“…Immunofluorescence analysis revealed that Grassland-Thoroughbreds had the highest proportion of fast-twitch muscle fibers at 78.63%, while Mongolian horses had the lowest proportion at 57.54%. Whole-transcriptome analysis identified 105 differentially expressed genes (DEGs) in the CY vs. …”
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Genome-Wide Identification and Abiotic Stress Response Analysis of C2H2 Zinc Finger Protein Genes in Foxtail Millet (<i>Setaria italica</i>) by Qian Zhao, Yingxin Zhang, Xiangyu Xing, Shuyao Li, Ruidong Sun, Weilong Zhang, Jun Zhang, Liangyu Jiang, Zhenyuan Zang, Ming Gao, Jian Zhang

“…This study provides some valuable insights into the <i>C2H2-ZFP</i> family in foxtail millet and highlights potential genetic markers for improving stress resilience through molecular breeding approaches.…”
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SOX7: Autism associated gene identified by analysis of multi-Omics data. by Samantha Gonzales, Jane Zizhen Zhao, Na Young Choi, Prabha Acharya, Sehoon Jeong, Xuexia Wang, Moo-Yeal Lee

“…The transcriptome captures molecular genomic complexity that the DNA sequence solely does not. …”
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<i>Polygonatum sibiricum</i> Polysaccharides Alleviate LPS-Induced Liver Injury in Chicks by Suppressing Inflammation and Oxidative Stress Through the PPAR Signaling Pathway by Yang Li, Jian Li, Xiaowang Liu, Zhili Cheng, Nana Gao, Jungang Kang, Xiaodan Wang

“…In conclusion, PSP may alleviate LPS-induced liver injury in chicks by modulating the PPAR signaling pathway. These findings provide valuable insights for promoting healthy chick rearing and ensuring the safe supply of poultry products.…”
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Combined analysis of embryonic gonadal development differences of mulard duck and muscovy duck using long non-coding RNAs and mRNAs by LI Li, ZHANG Linli, XIN Qingwu, MIAO Zhongwei, ZHU Zhiming, QIU Junzhi, HAO Xiaona, HUANG Qinlou, ZHENG Nenzhu

“…The qRT-PCR results showed that the expression levels of differential genes and lncRNAs were consistent with the expression trends in transcriptome sequencing, indicating that the data obtained by high-throughput sequencing are relatively reliable. …”
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Identification and validation of CKAP2 as a novel biomarker in the development and progression of rheumatoid arthritis by Qiongbing Zheng, Qiongbing Zheng, Youmian Lan, Jiexin Chen, Ling Lin, Ling Lin

“…This gene holds potential as a novel biomarker for RA and provides valuable insights into its molecular diagnosis and targeted therapies.…”
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Embryonic temperature has long-term effects on muscle circRNA expression and somatic growth in Nile tilapia by Golam Rbbani, Riaz Murshed, Prabhugouda Siriyappagouder, Fedor Sharko, Fedor Sharko, Artem Nedoluzhko, Rajesh Joshi, Jorge Galindo-Villegas, Joost A. M. Raeymaekers, Jorge M. O. Fernandes, Jorge M. O. Fernandes

“…Circular RNAs (circRNAs) are a class of regulatory RNAs that play important roles in various biological processes, but the effect of variable thermal conditions on the circRNA transcriptome and its long-term impact on muscle growth plasticity remains largely unexplored. …”
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Proteome‐Wide and Immune Cell Phenotype Mendelian Randomization Highlights Immune Involvement in Genetic Generalized Epilepsy by Jianxiong Gui, Hongyuan Chu, Junjiao Zhang, Xiao Li, Wenwei Liu, Renqiuguo Li, Fan Zhang, Meiyu Dong, Kai Gao, Huaxia Luo, Yuwu Jiang

“…Colocalization analysis assessed whether plasma proteins and GGE share a common causal variant. Transcriptome‐wide association studies (TWAS) from GTEx v8 brain tissue and whole blood were conducted for validation. …”
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Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning by Tao Zhou, Can Zhu, Wei Zhang, Qiongfang Wu, Mingqiang Deng, Zhiwei Jiang, Longfei Peng, Hao Geng, Zhouting Tuo, Zhouting Tuo, Ci Zou

“…Among them, PLAC8 is a promising diagnostic biomarker that modulates the immune response in patients with IC/BPS, which provides new insights into the future diagnosis of IC/BPS.…”
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Understanding glioblastoma at the single-cell level: Recent advances and future challenges. by Yahaya A Yabo, Dieter Henrik Heiland

“…Over the past decade, single-cell transcriptomics has enabled the molecular characterization of individual cells within glioblastomas, providing previously unattainable insights into the genetic and molecular features that drive tumorigenesis, disease progression, and therapy resistance. …”
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EIF4A3 Promotes Muscle Atrophy and Aging by Inhibiting the FAK Pathway Through NEDD9 mRNA Destabilization by Qian Li, Xiaohang Yin, Wensi Wan, Yi Zhou, Siqi Wang, Yuwei Yan, Jingying Chen, Xinyi Ren, Junli Gao, Yuying Chen, Yanan Zhang, Caiyue Cui, Emeli Chatterjee, Guoping Li, Ming Wu, Yan Zhang, Dongchao Lu, Tingting Yang, Yongjun Zheng, Jin Li

“…Methods Single‐cell transcriptome analysis and western blot were employed to analyse EJC expression in muscle atrophy. …”
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An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation by Sebastian Benjamin, GW McElfresh, Maanasa Kaza, Gregory J. Boggy, Benjamin Varco-Merth, Benjamin Varco-Merth, Sohita Ojha, Shana Feltham, William Goodwin, William Goodwin, Candice Nkoy, Candice Nkoy, Derick Duell, Derick Duell, Andrea Selseth, Tyler Bennett, Aaron Barber-Axthelm, Nicole N. Haese, Nicole N. Haese, Helen Wu, Courtney Waytashek, Carla Boyle, Jeremy V. Smedley, Jeremy V. Smedley, Caralyn S. Labriola, Caralyn S. Labriola, Michael K. Axthelm, Michael K. Axthelm, R. Keith Reeves, R. Keith Reeves, Daniel N. Streblow, Daniel N. Streblow, Jonah B. Sacha, Jonah B. Sacha, Afam A. Okoye, Afam A. Okoye, Scott G. Hansen, Scott G. Hansen, Louis J. Picker, Louis J. Picker, Benjamin N. Bimber, Benjamin N. Bimber

“…IntroductionRNA sequencing (RNA-seq) can measure whole transcriptome gene expression from tissues or even individual cells, providing a powerful tool to study the immune response. …”
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New hopes and challenges in targeted therapy and immunotherapy for primary central nervous system lymphoma by Chuanwei Yang, Chuanwei Yang, Xiaohui Ren, Xiaohui Ren, Yong Cui, Yong Cui, Haihui Jiang, Ming Li, Ming Li, Kefu Yu, Shaoping Shen, Shaoping Shen, Mingxiao Li, Xiaokang Zhang, Xiaokang Zhang, Xuzhe Zhao, Xuzhe Zhao, Qinghui Zhu, Qinghui Zhu, Xingyao Bu, Song Lin, Song Lin, Song Lin

“…Recently, gene sequencing, transcriptome sequencing, and single-cell sequencing platforms have provided a large amount of data revealing the mechanisms underlying the pathogenesis and drug resistance in PCNSL, including the activation of the NF-κB signaling pathway in tumor cells, tumor heterogeneity, and the immunosuppressive tumor microenvironment. …”
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A chromosome-level reference genome for the critically endangered Southern Corroboree frog (Pseudophryne corroboree) [version 1; peer review: 2 approved] by Lee Berger, Tiffany A. Kosch, Deon Gilbert, Andrew J. Crawford, David Hunter, Damian Goodall, Linelle Abueg, Michael McFadden, Giulio Formenti, Joanna Collins, Nivesh Jain, Tatiana Tilley, Conor Whelan, Brian O'Toole, Matthieu Muffato, Ira Cooke, Olivier Fedrigo, Bethan Yates, Erich D. Jarvis, Jennifer Balacco, Lee F. Skerratt

“…The resulting genome spans 8.87 Gb across 12 chromosomes, with a contig N50 of 6.8 Mb. This research provides a phased, annotated genome assembly along with transcriptomic resources to facilitate future conservation genomic studies of P. corroboree. …”
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GhWRKY75 positively regulates GhPR6-5b via binding to a W-box TTGAC (C/T) to orchestrate cotton resistance to Verticillium dahliae by Qichao Chai, Meina Zheng, Yanli Li, Mingwei Gao, Yongcui Wang, Xiuli Wang, Chao Zhang, Hui Jiang, Ying Chen, Jiabao Wang, Junsheng Zhao

“…Based on the analysis of pathogen-induced and Ghlmm transcriptome data, GhPR6-5b was identified as the key gene for V. dahliae resistance. …”
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Gene expression atlas of the Colorado potato beetle (Leptinotarsa decemlineata) by Léonore Wilhelm, Yangzi Wang, Shuqing Xu

“…However, research progress on CPB has been hindered by the lack of comprehensive genomic and transcriptomic resources. Here, leveraging a recently established chromosome-level genome assembly, we constructed a gene expression atlas of CPB using transcriptomic data from 61 samples representing major organs and developmental stages. …”
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Identification of potential crucial genes and mechanisms associated with metabolically unhealthy obesity based on the gene expression profile by Qingqing Wang, Silu Wang, Zhanyu Zhuang, Zhanyu Zhuang, Xueting Wu, Xueting Wu, Hongkun Gao, Tianyi Zhang, Tianyi Zhang, Guorong Zou, Guorong Zou, Xing Ge, Xing Ge, Yapeng Liu

“…This study aimed to understand the transcriptomic characteristics of the blood of metabolically unhealthy obesity (MUO) and provide insight into the target genes of differently expressed microRNAs in the occurrence and development of MUO.MethodsThe GSE146869, GSE145412, GSE23561, and GSE169290 datasets were analyzed to understand the transcriptome characteristics of the blood of MUO and provide insights into the target genes of differently expressed microRNAs (DEMs) in MUO. …”
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RNA multi-omics in single cells reveal rhythmical RNA reshaping during human and mouse oocyte maturation by Huan Yao, Danru Zhang, Haixia Jin, Yanjie Guo, Yan Liu, Shengnan Wang, Tong Li, Shenli Yuan, Gang Lu, Yingpu Sun

“…Conclusions Our results provided a valuable tool for RNAomics research and data resources provided novel insights into human oocyte maturation, which is helpful for IVM and oocyte selection for ART.…”
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