The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5 by Marina Reichlmeir, Ruth Pia Duecker, Hanna Röhrich, Jana Key, Ralf Schubert, Kathryn Abell, Anthony P. Possemato, Matthew P. Stokes, Georg Auburger

“…The impact of ATM on secretory granules confirms previous ATM-null cerebellar transcriptome findings. This study provides the first link of A-T neural atrophy to growth cone collapse and aberrant microtubule dynamics.…”
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Xyloglucan endotransglucosylase/hydrolase 25 positively regulates the lead tolerance in Raphanus sativus by Tong Han, Yongmei Cui, Yang Jing, Meiying Liu, Xuanchao Chen, Yinghui Song, Xinping Gu, Jiahao Wang, Long Wang, Long Wang

“…Overall, this study provides insights into the XTH gene family in R. sativus and highlights their critical roles in Pb stress response.…”
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Potential cardiac-derived exosomal miRNAs involved in cardiac healing and remodeling after myocardial ischemia–reperfusion injury by Yu Liu, Jiao Chen, Jian Xiong, Jin-Qun Hu, Li-Yuan Yang, Yu-Xin Sun, Ying Wei, Yi Zhao, Xiao Li, Qian-Hua Zheng, Wen-Chuan Qi, Fan-Rong Liang

“…In conclusion, we elucidated the potential mechanism of MIRI in cardiac remodeling from the perspective of cell migration, and inhibition of cellular overmigration based on this network may provide new therapeutic targets for MIRI and to prevent MIRI from developing into other diseases.…”
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The transcription factor PbeNAC83 positively regulates the Valsa canker resistance in apple and pear by DOU Zhiqi, CAI Minrui, DU Chenglong, HU Huanhuan, ZUO Cunwu

“…[Methods] Based on transcriptome data, we screened PbeNAC83(Chr9.g47397) and performed bioinformatics analysis on it. …”
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EGR1 mRNA expression levels and polymorphisms are associated with slaughter performance in chickens by Mao Ye, Xiaohuan Chao, Chutian Ye, Lijin Guo, Zhexia Fan, Xuerong Ma, Aijun Liu, Weiming Liang, Shuya Chen, Cheng Fang, Xiquan Zhang, Qingbin Luo

“…In addition, polymorphisms in EGR1 were associated with slaughter performance, providing a potential basis for further utilization of EGR1 as a breeding marker.…”
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Epigenetic dynamics in meniscus cell migration and its zonal dependency in response to inflammatory conditions by Yize Zhang, Ellen Y. Zhang, Catherine Cheung, Yuna Heo, Bat-Ider Tumenbayar, Se-Hwan Lee, Yongho Bae, Su Chin Heo

“…Interestingly, TNF-α differentially alters histone modifications, particularly H3K27me3, between the cell types. Transcriptome analysis showed significant gene expression changes with inner cells more affected than outer cells. …”
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Genome-Wide Identification of DNA Methyltransferase and Demethylase in <i>Populus</i> sect. Turanga and Their Potential Roles in Heteromorphic Leaf Development in <i>Populus euphra... by Chen Qiu, Jianhao Sun, Mingyu Jia, Xiaoli Han, Jia Song, Zhongshuai Gai, Zhijun Li

“…Overall, this study provides significant insights for exploring the functions and expression regulation of plant DMTs and DMLs and will contribute to future research unraveling the molecular mechanisms of epigenetic regulation in <i>P. euphratica</i>.…”
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Hub biomarkers and their clinical relevance in glycometabolic disorders: A comprehensive bioinformatics and machine learning approach by Liping Xiang, Bing Zhou, Yunchen Luo, Hanqi Bi, Yan Lu, Jian Zhou, Jinjiao Li

“…This study aimed to identify hub biomarkers of these disorders to provide a theoretical foundation for enhancing diagnosis and treatment. …”
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UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia by Yan Huang, Luting Luo, Yangqi Xu, Jiazheng Li, Zhengjun Wu, Chenxing Zhao, Jingjing Wen, Peifang Jiang, Haojie Zhu, Lingyan Wang, Yanxin Chen, Ting Yang, Jianda Hu

“…In this investigation, utilizing single-cell transcriptome sequencing technology, we discerned a correlation between Ubiquitin-like containing PHD and RING finger domain 1 (UHRF1) and the progression of B-cell acute lymphoblastic leukemia. …”
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Role of Maternal Obesity in Offspring Cardiovascular Development and Congenital Heart Defects by Ashleigh McMullan, James B. Zwierzynski, Nina Jain, Laura S. Haneline, Weinian Shou, Kok Lim Kua, Swetansu K. Hota, Matthew D. Durbin

“…Embryos were generated and their developing hearts analyzed. Transcriptome analysis was performed using single‐nucleus and bulk RNA sequencing. …”
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New insights into the cold tolerance of upland switchgrass by integrating a haplotype-resolved genome and multi-omics analysis by Bingchao Wu, Dan Luo, Yuesen Yue, Haidong Yan, Min He, Xixi Ma, Bingyu Zhao, Bin Xu, Jie Zhu, Jing Wang, Jiyuan Jia, Min Sun, Zheni Xie, Xiaoshan Wang, Linkai Huang

“…This study advances our understanding of plant cold tolerance, which provides crop breeding for improved cold tolerance.…”
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CHML regulates migration and invasion in hepatocellular carcinoma via transcriptional and metabolic reprogramming by Huanqian Cao, Siyu Wang, Li Zhang, Li Zhang, Heying Xie, Yiqiong Liu, Ruijiao Kong, Yin Jia, Ling Lu, Junfeng Jiang, Junfeng Jiang, Shanrong Liu

“…Notably, the integration of transcriptomics and untargeted metabolomics identified choline metabolism as a pivotal pathway in CHML-regulated migration and invasion. …”
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Reveal the mechanism of hepatic oxidative stress in mice induced by photo-oxidation milk using multi-omics analysis techniques by Sijia Tan, Qiangqiang Li, Can Guo, Sumeng Chen, Afaf Kamal-Eldin, Gang Chen

“…In addition, comprehensive metabolome, lipidome, and transcriptome analyses were conducted to elucidate the underlying molecular mechanisms of hepatic damage caused by photo-oxidized milk. …”
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Genomewide analysis of the Class III peroxidase gene family in apple (Malus domestica) by Yao Lu, Rongqun Ma, Kunhao Wu, Jilu Sun, Yutong Li, Jiawei Zhao, Zhenbao Qi, Guangli Sha, Hongjuan Ge, Yanjing Shi

“…This systematic analysis provides a foundation for the further functional characterization of MdPRX genes, with the aim of improving apple rootstock dwarfing ability and branching characteristics.…”
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Rice transcription factors OsNIGT2/3 regulate nitrogen acquisition by repressing OsNRTs and OsAMTs under high-nitrogen conditions by Hongyang Du, Xihan Cong, Xinmin Ruan, Yang Yang, Fuzhi Shi, Yanchang Luo, Zhixiang Luo

“…Additionally, field tests shown that OsNIGT2 and OsNIGT3 knockout promotes both grain yield and NUE. This study provides potential genetic targets for improving yield and NUE in rice and other crops, laying a significant foundation for future crop improvement.…”
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Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. by Maxime Rotival, Tanja Zeller, Philipp S Wild, Seraya Maouche, Silke Szymczak, Arne Schillert, Raphaele Castagné, Arne Deiseroth, Carole Proust, Jessy Brocheton, Tiphaine Godefroy, Claire Perret, Marine Germain, Medea Eleftheriadis, Christoph R Sinning, Renate B Schnabel, Edith Lubos, Karl J Lackner, Heidi Rossmann, Thomas Münzel, Augusto Rendon, Cardiogenics Consortium, Jeanette Erdmann, Panos Deloukas, Christian Hengstenberg, Patrick Diemert, Gilles Montalescot, Willem H Ouwehand, Nilesh J Samani, Heribert Schunkert, David-Alexandre Tregouet, Andreas Ziegler, Alison H Goodall, François Cambien, Laurence Tiret, Stefan Blankenberg

“…One major expectation from the transcriptome in humans is to characterize the biological basis of associations identified by genome-wide association studies. …”
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Alternative Splicing of BnABF4L Mediates Response to Abiotic Stresses in Rapeseed (Brassica napus L.) by Ruijia Zhu, Chu Yue, Shifan Wu, Mingting Wu, Ziyue Xu, Xiaoqun Liu, Rui Wang, Maolin Wang

“…Utilizing bioinformatics techniques, we analyzed their motifs, conserved domains, and cis-acting elements of their promoters. Through transcriptome data from the stress-tolerant dwarf strain ndf2 and its parental line 3529, we uncovered a significantly differentially expressed ABF4 gene, which we named BnABF4L. …”
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Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells by Tang J, Hu Y, Fang J, Zhu W, Xu W, Yu D, Zheng Z, Zhou Q, Fu H, Zhang W

“…RT-PCR and Western blot took advantage of detecting transcription factors, inflammatory factors, and tight junction proteins. Transcriptome sequencing was performed on colon tissue and 16S rRNA gene sequencing was enforced on intestinal contents.Results: The administration of HED enhanced the survival rate of colitis mice, significantly restored body weight, DAI score, colon weight and index, spleen weight and index. …”
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Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis by Xiu-Ya Chan, Kai-Ping Chang, Chia-Yu Yang, Chiao-Rou Liu, Chu-Mi Hung, Chun-Chueh Huang, Hao-Ping Liu, Chih-Ching Wu

“…Methods To identify OSCC progression-related proteins, we conducted integrated proteome and transcriptome analyses on cancer tissues from patients and patient-derived xenograft (PDX) model mice. …”
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SSR42 is a novel regulator of cytolytic activity in Staphylococcus aureus by Mary-Elizabeth Jobson, Brooke R. Tomlinson, Emilee M. Mustor, Emily A. Felton, Andy Weiss, Clayton C. Caswell, Lindsey N. Shaw

“…Herein, we used transcriptomic and proteomic approaches to probe the role of SSR42, revealing that it is a powerful, novel activator of the primary leukocidin LukAB. …”
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