Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors by Chenhui Zhao, Xueyan Hu, Xiudong Guan, Xiaojun Fu, Tingting Wang, Mengyuan Li, Xinze Liu, Jiarui Zhao, Di Wu, Fan Zhang, Jiaying Fu, Jiang Li, Tieqiang Zhang, Xiaochun Jiang, Changxiang Yan, Wang Jia, Ence Yang, Jian Chen

“…Here, we perform a comprehensive multi-omics analysis of 189 cases of CNS SFTs integrating 94 whole genome sequencing, 88 transcriptomics, 7 single-nucleus RNA sequencing and 3 spatial transcriptome sequencing. …”
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Root hair developmental regulators orchestrate drought triggered microbiome changes and the interaction with beneficial Rhizobiaceae by Zhenghong Wang, Zewen Li, Yujie Zhang, Jingye Liao, Kaixiang Guan, Jingxuan Zhai, Pengfei Meng, Xianli Tang, Tao Dong, Yi Song

“…We isolated and sequenced 1479 root associated microbes, and confirmed that several Rhizobium strains presented stress-alleviating activities. Metagenome, root transcriptome and root metabolome studies further reveal the multi-omic changes upon drought stress. …”
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New mouse models for exploring renal tumor extension into the inferior vena cava by Xiubin Li, Huaikang Li, Xupeng Zhao, Jichen Wang, Di Li, Qiuyang Li, Qingjiang Xu, Shengpan Wu, Qiyang Liang, Shangwei Li, Qilong Jiao, Kan Liu, Songliang Du, Cheng Peng, Baojun Wang, Liangyou Gu, Xu Zhang, Qingbo Huang, Xin Ma

“…The proposed in vivo models mimic the progression of renal tumors with IVCTT, clarify that the immune system can inhibit tumor thrombus progression, and provide tools for subsequent mechanistic research and translational preclinical studies.…”
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Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro by Anna Podleśny-Drabiniok, Carmen Romero-Molina, Tulsi Patel, Wen Yi See, Yiyuan Liu, Edoardo Marcora, Alison M. Goate

“…Transcriptome profiling reveals gene expression changes related to oxidative phosphorylation, lysosome function, and lipid metabolism. …”
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Potential radiosensitive germline biomarkers in the testes of wild mice after the Fukushima accident by Syun Tokita, Ryo Nakayama, Yohei Fujishima, Valerie Swee Ting Goh, Donovan Anderson, Ippei Uemura, Hikari Ikema, Jin Shibata, Yoh Kinoshita, Yoshinaka Shimizu, Hisashi Shinoda, Jun Goto, Maria Grazia Palmerini, Abdulla Mohamed Hatha, Takashi Satoh, Akifumi Nakata, Manabu Fukumoto, Tomisato Miura, Hideaki Yamashiro

“…Conversely, in the non‐breeding season, Fmo2 and Fmo2 (highly similar) were significantly upregulated in radiation‐exposed Fukushima mice. qPCR analysis results were consistent with transcriptome sequencing, detecting Lsp1 and Ptprk regulation in the testes of Fukushima mice. …”
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The FOXO pathway mediates a conserved mechanism of antioxidant defense against microplastic-induced toxicity in Aurelia coerulea polyps and mouse liver by Xiaoxiao Chen, Yina Zhu, Feng Wu, Liangzhi Li, Yi Wang, Blessing Danso, Zhixiao Yang, Xiao Peng, Marina. pozzolini, Qinglong Tang, Liang Xiao, Xiaojie Dai

“…The similarities and differences in the defence mechanisms of the two species after exposure to microplastics were analysed by means of phenotypic observations, transcriptome sequencing, pathological sections, oxidative stress indicators, explosions and molecular docking. …”
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Dynamic interplay between RNA N 6-methyladenosine modification and porcine reproductive and respiratory syndrome virus infection by Zi-Han Wang, Jing Li, Sai-Ya Ma, Meng-Xuan Liu, Yu-Fei Zhan, Feng Jin, Bing-Xin Liu, Wenjing Wang, Mei He, Yu-Chuan Yang, Yandong Tang, Peng Wang, Wuchao Zhang, Jie Tong

“…Furthermore, m6A-seq was also used to determine the m6A landscape of the transcriptome in PAMs infected with pandemic or highly pathogenic PRRSV strains. …”
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Effects of intermittent theta burst stimulation on the inflammatory response and cerebral blood flow in promoting neurovascular repair after ischemic stroke by Jingjun Zhang, Siyue Li, Dan Huang, Jiale Fu, Shuying Chen, Na Ren, Pengkun Yang, Di Song, Xiaochen Bai, Hongyu Xie, Gang Liu, Kewei Yu, Shamay S. M. Ng, Junfa Wu, Xiao Xiao, Yi Wu

“…The impact of iTBS on neuronal damage and apoptosis in the peri-infarct area was evaluated via Nissl staining and a TUNEL assay. RNA transcriptome sequencing and immunofluorescence staining were performed to investigate the effects of iTBS on microglial and astrocyte activation and the associated inflammatory response. …”
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Machine learning driven multi-omics analysis of the genetic mechanisms behind the double-coat fleece formation in Hetian sheep by Yanwei Zhang, Wenrong Li, Xinming Xu, Mengwan Xie, Liping Tang, Peiyu Zheng, Nannan Song, Lijuan Yu, Jiang Di

“…IntroductionThe double-coated fleece is crucial for the adaptability and economic value of Hetian sheep, yet its underlying molecular mechanisms remain largely unexplored.MethodsWe integrated genome and transcriptome data from double-coated Hetian sheep and single-coated Chinese Merino sheep. …”
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Genome-wide identification, characterization and expression pattern analysis of the VDAC gene family reveals likely roles in rapid shoot growth and abiotic stress in Moso bamboo ((... by Zhen Yu, Sijia Cai, Xueyun Xuan, Shiying Su, Jiaqi Tan, Zhijun Zhang

“…Additionally, we predicted the transcription factors that regulate VDAC-related transcripts, performed protein interaction analysis and initially constructed a VDAC-related regulatory and interaction network. This study provides a theoretical basis for exploring the functions of VDACs in bamboo plants and screening candidate genes related to rapid growth and stress tolerance.…”
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Proteome and Metabolome Alterations in Radish (<i>Raphanus sativus</i> L.) Seedlings Induced by Inoculation with <i>Agrobacterium tumefaciens</i> by Nadezhda Frolova, Daria Gorbach, Christian Ihling, Tatiana Bilova, Anastasia Orlova, Elena Lukasheva, Ksenia Fedoseeva, Irina Dodueva, Lyudmila A. Lutova, Andrej Frolov

“…Because of this, infection of plant tissues with <i>A. tumefaciens</i> provides a convenient model to address the dynamics of cell metabolism accompanying plant development. …”
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Identification and Analysis of Endoplasmic-Reticulum-Stress- and Salt-Stress-Related Genes in <i>Solanum tuberosum</i> Genome: <i>StbZIP60</i> Undergoes Splicing in Response to Sal... by Peiyan Guan, Dongbo Zhao, Chenxi Zhang, Zhennan Qiu, Qingshuai Chen, Inna P. Solyanikova, Peinan Sun, Peipei Cui, Ru Yu, Xia Zhang, Yanmei Li, Linshuang Hu

“…We identified 29 genes involved in ER stress response in the potato genome. Transcriptome data analysis showed that the expression levels of related genes were significantly different in different tissues. …”
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Functional characterization of COMT genes in Chinese white pear (Pyrus bretschneideri) and their role in lignin synthesis by Xiaofeng Feng, Xiaofeng Feng, Xianang Wu, Xianang Wu, Jiayi Hong, Jiayi Hong, Zihui Guo, Zihui Guo, Yasmin Khan, Yasmin Khan, Dongyi Wei, Dongyi Wei, Honghong Fan, Honghong Fan, Yongping Cai, Yongping Cai

“…These genes exhibit five conserved motifs, and promoter analysis indicates potential hormonal regulation. Transcriptome data showed that PbrCOMT1 is the predominant COMT gene in ‘Dangshan Su’ fruit and is likely crucial for lignin synthesis. …”
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Dietary effects of astaxanthin on gonadal development in female broodstock of Macrobrachium rosenbergii by Mingwei Tao, Jie Wei, Clement de Cruz, Junyi Wang, Houkuan Du, Hangxian Zhou, Qiyou Xu

“…Optimal astaxanthin levels (114.30–165.14 mg/kg) enhanced gonadal development, antioxidant capacity, and sex hormone regulation. This study provides insights into the molecular pathways through which astaxanthin supports reproductive health in broodstock M. rosenbergii.…”
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PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma by Binfeng Liu, Wei Li, Wenchao Zhang, Chengyao Feng, Lu Wan, Shasha He, Ruiling Xu, Zheng Fu, Zhongyue Liu, Haodong Xu, Xin Jin, Chao Tu, Zhihong Li

“…Here, we conducted a kinome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen, coupled with transcriptome sequencing, to identify regulators of DDP sensitivity. …”
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Identification and expression analysis of the cysteine synthase (CSase) gene family in Brassica napus L. under abiotic stress by Tianyuan Xue, Yuqing He, Yudi Gao, Zhiheng Lei, Jingdong Chen, Shuai Yin, Xigang Dai, Changli Zeng, Heping Wan

“…These members were analyzed for their physicochemical properties, phylogenetic relationships, covariance relationships, protein-protein interaction (PPI) networks, associated miRNAs, and SNP variations. Based on transcriptome data, the expression patterns of BnCSase genes under different abiotic stress treatments were investigated. …”
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IGF2BP2 orchestrates global expression and alternative splicing profiles associated with glioblastoma development in U251 cells by Wenqing Liu, Yan Liu, Haoyuan Li, Shixiong Wang, Pengfei Chen, Zhongtao Liu, Xianhao Huo, Jihui Tian

“…The study provides a foundation for further investigation into the molecular mechanisms of IGF2BP2 in GBM and its implications for cancer treatment.…”
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Differential epigenetic regulation by blue and UV-A light reveals the key role of CsSDG36-mediated H3K4 methylation in leaf development and secondary metabolism in Camellia sinensi... by Pu Wang, Hong Zhang, Yongli Yin, Yue Ge, Binrui Chen, Jing Hu, Yu Wang, Dejiang Ni, Fei Guo

“…Conclusion Our results not only reveal the landscape of histone modifications, transcripts, leaf development, and metabolites from different lights in tea plants, but also provide insight into the roles of photoreceptors and epigenetic mechanisms involved in leaf development and secondary metabolism.…”
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Mesorhizobium huakuii 7653 R regulates the endophytic bacterial communities and disease resistance pathways to promote clubroot resistance in Brassica napus by Chao Li, Zhen Zhang, Feng Rao, Zanzan Xu, Jiasen Cheng, Jiatao Xie, Yang Lin, Tom Hsiang, Yanping Fu, Daohong Jiang, Tao Chen

“…Our findings provide a theoretical basis for the widespread application of M. huakuii 7653 R in clubroot biocontrol.…”
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MiR-204-5p overexpression abrogates Dacarbazine-induced senescence in melanoma cells in vivo by Ekaterina Lapkina, Ivan Zinchenko, Viktoriya Kutcenko, Eugeniya Bondar, Andrey Kirichenko, Irina Yamskikh, Nadezhda Palkina, Tatiana Ruksha

“…In the present study we performed NGS-based transcriptomic profiling of B16 melanoma tumors after Dacarbazine treatment in vivo. …”
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