GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy by Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li

“…This work finds that C5‐PE38‐induced cell death stimulates STING‐dependent cytosolic DNA release to promote antitumor immunity, a mechanism not previously reported for PE38, providing valuable insights for its clinical use.…”
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Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation o... by Lin Zheng, Lin Zheng, Lin Zheng, Chengyun Pan, Chengyun Pan, Dan Ma, Dan Ma, Dan Ma, Qin Shang, Qin Shang, Tianzhen Hu, Tianzhen Hu, Tianzhuo Zhang, Tianzhuo Zhang, Qian Kang, Qian Kang, Xiuying Hu, Xiuying Hu, Shuyun Cao, Shuyun Cao, Li Wang, Li Wang, Li Wang, Hong Luo, Hong Luo, Hong Luo, Jishi Wang, Jishi Wang, Jishi Wang

“…We previously identified a novel mechanism by which Nrf2 promotes leukemia resistance, providing a potential therapeutic target for the treatment of drug-resistant/refractory leukemias. …”
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Preliminary exploration of mRNA, lncRNA, and miRNA expressions in the bovine jejunum unveils novel aspects of Mycobacterium avium subspecies paratuberculosis infections by Yahui Gao, Jie Cao, Bo Han, Dongxiao Sun

“…Conclusion The present study provided a global view of the dynamics in transcriptomes of the bovine jejunum tissues in terms of JD status. …”
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The systematic analysis of genes related to butyrate metabolism suggests that CDKN3 could serve as a promising therapeutic target for lung adenocarcinoma treatment by Yanchao Luan, Chao Liang, Qingsong Han, Xueqin Zhou, Na Yang, li Zhao

“…Conclusion We identify and validate a novel BMR-related prognostic signature comprising 5 DEGs for LUAD patients. Our data might provide a new molecular target for LUAD treatment.…”
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Analytical validation of the Percepta Nasal Swab classifier; an RNA next-generation sequencing assay for the assessment of lung cancer risk in pulmonary nodules by Shuyang Wu, Ruochen Jiang, Grazyna Fedorowicz, Mei Wong, Janna S. Chamberlin, Lori Lofaro, P. Sean Walsh, Giulia C. Kennedy, Yangyang Hao, Jing Huang, Bill Bulman

“…The PNS classifier leverages this concept using whole transcriptome sequencing (RNASeq) of cells collected from the nasal epithelium and provides “high”, “intermediate” and “low risk” classification calls to help guide clinical management decisions. …”
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Tau mediates the reshaping of the transcriptional landscape toward intermediate Alzheimer’s disease stages by Giacomo Siano, Giacomo Siano, Martina Varisco, Marco Terrigno, Congwei Wang, Arianna Scarlatti, Vincenzo Iannone, Marco Groth, Marie-Christine Galas, Jeroen J. M. Hoozemans, Alessandro Cellerino, Alessandro Cellerino, Antonino Cattaneo, Cristina Di Primio

“…Our findings indicate that Tau is able to globally affect the neuronal transcriptome and that its subcellular unbalance changes gene expression in the intermediate stages of AD development. …”
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MoMkt1, a member of XPG/RAD2 nuclease family, regulates development and pathogenicity in Magnaporthe oryzae by Na Li, Junlian Xiao, Long Yan, Xiaoru Kang, Wenjuan Wang, Shen Chen, Weihuai Wu, Shulin Zhang

“…Our study provides insights into MoMkt1-mediated development and pathogenicity in M. oryzae.…”
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Cepharanthine Inhibits <i>Fusarium solani</i> via Oxidative Stress and CFEM Domain-Containing Protein Targeting by Yuqing Wang, Zenghui Yang, Jingwen Xue, Yitong Wang, Haibo Li, Zhihong Wu, Yizhou Gao

“…These results suggest that CEP is a potential bio-based antifungal agent and provide novel insights into its mechanism against <i>Fusarium solani</i>.…”
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Flavones enrich rhizosphere Pseudomonas to enhance nitrogen utilization and secondary root growth in Populus by Jiadong Wu, Sijia Liu, Haoyu Zhang, Sisi Chen, Jingna Si, Lin Liu, Yue Wang, Shuxian Tan, Yuxin Du, Zhelun Jin, Jianbo Xie, Deqiang Zhang

“…This study reveals that plant-metabolite-microbe regulation patterns contribute to the poplar fitness and thoroughly decodes the key regulatory mechanisms of tricin, and provides insights into the interactions of the plant’s key metabolites with its transcriptome and rhizosphere microbes.…”
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Integrated multi-omics reveals contrasting epigenetic patterns in leaf and root morphogenesis in Aegilops speltoides by Lingfeng Miao, Zhe Chen, Lifeng Gao, Jizeng Jia, Weilong Guo, Guangyao Zhao

“…Here, we present a comprehensive multi-omics atlas of leaves and roots in Ae. speltoides, encompassing transcriptome, DNA methylation, histone modifications, and small RNA profiling. …”
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Pronounced expression of extracellular matrix proteoglycans regulated by Wnt pathway underlies the parallel evolution of lip hypertrophy in East African cichlids by Nagatoshi Machii, Ryo Hatashima, Tatsuya Niwa, Hideki Taguchi, Ismael A Kimirei, Hillary DJ Mrosso, Mitsuto Aibara, Tatsuki Nagasawa, Masato Nikaido

“…Our comprehensive analyses showed that hypertrophied lips of the three different phylogenetic origins can be explained by similar proteomic and transcriptomic profiles, which may provide important clues into the molecular mechanisms underlying phenotypic parallelisms in East African cichlids.…”
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Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum by Qian Xiu, Xiaoru Yin, Yuanyuan Chen, Ziyang Zhang, Yushuai Mao, Tianshi Wang, Jie Zhang, Mingguo Zhou, Yabing Duan

“…Collectively, these findings provide compelling evidence for the involvement of de novo uracil biosynthesis as a mechanism of action for quinofumelin while identifying FgDHODHII as its specific target.…”
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Multi-omics analysis of the mechanism of alfalfa and wheat-induced rumen flatulence in Xizang sheep by Jing Wu, Xiaoming Zhang, Khan Ayesha, Shahzad Khuram, Jianzhao Cui, Gaofu Wang, Zhaxi Yangzong, Mingyan Shi, Xunping Jiang, Long Li, Guiqiong Liu, Wangsheng Zhao, Tianzeng Song

“…Microbial analysis indicated that the alpha- and beta-diversity of HRF and MRF groups were lower than LRF’s, with different microbial compositions. Transcriptome analysis revealed many differentially expressed genes (DEGs). …”
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The fasciclin-like arabinogalactan protein FLA3 of Jasminum sambac causes defects in pollen wall development by Xiangyu Qi, Huadi Wang, Xinru Li, Muhammad Zulfiqar Ahmad, Shuangshuang Chen, Jing Feng, Huijie Chen, Yanming Deng

“…Taken together, these findings suggested that JsFLA3 plays a significant role in cellulose biosynthesis, thereby affecting the development of the pollen wall. This study provides valuable insights into the role of FLAs in plant pollen development.…”
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Identification and Characterization of SWEET Gene Family in Peanuts and the Role of AhSWEET50 in Sugar Accumulation by Tiecheng Cai, Yijing Pan, Chong Zhang, Lang Chen, Biaojun Ji, Qiang Yang, Faqian Xiong, Weijian Zhuang

“…These results validate the functional role of <i>AhSWEET50</i> in sugar transport and provide a foundation for understanding the mechanisms of sugar allocation in peanuts, which has implications for improving seed quality through metabolic engineering.…”
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TACSTD2 in gelatinous drop-like corneal dystrophy: variant functional analysis and expression in the cornea after limbal stem cell transplantation by Liubov O. Skorodumova, Ekaterina N. Grafskaia, Daria D. Kharlampieva, Dmitry I. Maltsev, Tatiana V. Petrova, Alexandra V. Kanygina, Elena V. Fedoseeva, Pavel V. Makarov, Boris E. Malyugin

“…Our study provides experimental evidence that amyloid deposition can recur after LSCT despite complete restoration of wild-type TACSTD2 expression.…”
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B cell maturation antigen (BCMA) is dispensable for the survival of long-lived plasma cells by Shannon R. Menzel, Edith Roth, Jens Wittner, Stefanie Brey, Leonie Weckwerth, Jana Thomas, Thomas H. Winkler, Wolfgang Schuh, Hans-Martin Jäck, Katharina Pracht, Sebastian R. Schulz

“…Contrary to previous reports, both BCMA-deficient mouse lines have comparable numbers of antigen-specific long-lived plasma cells following both protein and mRNA immunizations. Transcriptome analysis reveals no reduction in survival signaling upon BCMA deletion. …”
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A gene expression atlas of Nicotiana tabacum across various tissues at transcript resolution by Shizhou Yu, Jufen Wan, Jufen Wan, Tenghang Xu, Tenghang Xu, Jie Zhang, Linggai Cao, Jie Liu, Hongfeng Liu, Xueliang Ren, Zhixiao Yang

“…Alternative splicing (AS) expands the transcriptome diversity by selectively splicing exons and introns from pre-mRNAs to generate different protein isoforms. …”
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Role of LncRNA MRPS28 in Secondary Hair Follicle Development of Cashmere Goats by Youjun Rong, Rong Ma, Qing Ma, Bingjie Ma, Xuxu Bao, Yiming Zhang, Le Wang, Fangzheng Shang, Ruijun Wang, Rui Su, Yu Wang, Yanjun Zhang

“…Based on a previously established transcriptome database of embryonic skin tissue from cashmere goats, this study ultimately identified lncRNA MRPS28, which exhibits significant differential expression during the morphogenesis of secondary hair follicles. …”
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Molecular insights into heterosis for Vibrio alginolyticus resistance in crosses between two geographically distinct wild populations of Ruditapes philippinarum by Hongda Li, Hongtao Nie, Bin Wang, Zhongming Huo, Xiwu Yan

“…To explore the molecular mechanism of this heterosis, we then performed transcriptome sequencing on the hybrid and inbred progeny challenged with V. alginolyticus for 48 h and those that were not stressed. …”
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