HEP14-activated PKC-ERK1/2 pathway boosts HEP14-empowered hADSCs for ovarian regeneration and functional restoration by Jiajia Sun, Qin Zhong, Kan Liu, Qili Sun, Chunan Lu, Yingtong Di, Lin Bai, Helen Picton, Bin Tang, Xiaojiang Hao, Liming Gui

“…Our findings highlight the pivotal role of h-hADSCs and the HEP14-activated PKC-ERK1/2 pathway in ovarian regeneration and provide a promising advancement in treating ovarian insufficiency.…”
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Brain-specific expression of cytomegalovirus immediate early protein 1 disrupts neurodevelopment in mice by inducing neuroinflammation and altering astrocytic metabolism by Meng Yu, Xianjuan Zhang, Zhifei Wang, Shan Wang, Jun Li, Huan Huang, Xu Li, Chen Wang, Wen Shen, Weiwei Sun, Jie Yu, Wanming Zhang, Yunyang Wang, Bin Wang

“…These transgenic mice exhibited impaired spatial working memory, hippocampal neurodegeneration, and proinflammatory activation of brain microglia and astrocytes. Transcriptome sequencing revealed that IE1 protein upregulated genes linked to metabolism and downregulated genes implicated in nervous system development. …”
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Cargo Analysis and MRI‐Based Therapeutic Assessment of Iron Oxide Labelled Extracellular Vesicles of Hypoxia Human Stem Cells in Ischemic Stroke by Shannon Helsper, Li Sun, Richard Jeske, Chang Liu, Jacob Athey, Xuegang Yuan, Samuel C. Grant, Yan Li

“…Magnetic resonance imaging following in vivo administration of iron oxide‐labelled hMSCs and EVs provided assessment of biodistribution and therapeutic efficacy. …”
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Biomimetic RBC-membrane-cloaked Prussian blue nanoparticles for synergistic photothermal-antibacterial therapy and accelerated wound healing by Xiaoyuan Ding, Haohao Wang, Fan Liu, Yan Wang, Leilei Gao, Fang Yang, Dong Liu

“…This resulted in excellent antibacterial efficacy in a MRSA wound infection model.In conclusion, the multifunctional photothermally activated antimicrobial nanoplatform RBC@PB-E provides a promising approach for combating bacterial infections and promoting wound healing.…”
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The role of the 5’ sensing function of ribonuclease E in cyanobacteria by Ute A. Hoffmann, Elisabeth Lichtenberg, Said N. Rogh, Raphael Bilger, Viktoria Reimann, Florian Heyl, Rolf Backofen, Claudia Steglich, Wolfgang R. Hess, Annegret Wilde

“…Here, we constructed a Synechocystis strain lacking the 5’ sensing function of RNase E and mapped on a transcriptome-wide level 283 5’-sensing-dependent cleavage sites. …”
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<i>GSTD1</i> Mediates the Tolerance to Abamectin and Beta-Cypermethrin in the Fall Armyworm <i>Spodoptera frugiperda</i> by Qian Ding, Yangyang Liu, Baoxiang Dai, Yujie Han, Yan Zhang, Zhongyuan Deng, Lixiang Wang, Xianchun Li

“…In this study, based on the transcriptome sequences of <i>S. frugiperda</i>, the full-length cDNA of <i>SfGSTD1</i> was cloned and characterized. …”
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Genome‑wide identification of the cotton FAR gene family reveals GhFAR3 as a positive regulator of Verticillium dahliae resistance by Wenhan Cheng, Siqi Gao, Zhaojie He, Nurimanguli Aini, Zengqiang Zhao, Xianpeng Xiong, Ning Wang, Rui Chen, Keyun Feng

“…Promoter cis-element analysis and transcriptome profiling revealed that while most FAR genes were downregulated under abiotic stress, many were notably upregulated in response to hormone treatments and Verticillium dahliae infection. …”
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The combination of polystyrene microplastics and di (2-ethylhexyl) phthalate promotes the conjugative transfer of antibiotic resistance genes between bacteria by Yu Li, Xiaomei Liu, Saisai Guo, Lan Wang, Jingchun Tang

“…This study may provide new insights for explaining the combined effects of various pollutants in the environment on the spread of ARGs.…”
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Enhanced early innate immunity and phagocytosis in grass carp (Ctenopharyngodon idella) induced by Aeromonas hydrophila fermentation broth during initial vaccine response by Xiaobo Yu, Qinglin Yang, Yanhong Jiang, Yanhong Li, Zhengli Wu

“…In this study, we observed that CIK cells exhibited typical phagocytic activity in response to immunostimulation by A. hydrophila. Transcriptome analysis suggested that exposure to inactivated A. hydrophila rapidly activated the host's innate immune defense system, as evidenced by the stimulation of 12 higher-order network correlations among immune-related differentially expressed genes. …”
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Differential Effects of Two Herbivore-Induced Plant Volatiles on the Oviposition of <i>Chilo suppressalis</i> by Xiaowei Yang, Chang Liu, Xixi Jia, Chen Zhang, Lanzhi Han, Wanlun Cai, Yunhe Li

“…To examine these effects, we conducted oviposition assays, preoviposition and longevity tests, combined with qPCR and transcriptome analyses to explore underlying molecular responses. …”
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Abnormal proportions and functions of myeloid-derived suppressor cells in peripheral blood of patients with diffuse large B-cell lymphoma by Jingru Liu, Shucheng Chen, Yanrong Huang, Kaiming Xu, Maoqing Tan, Wei Dai, Xiaoting Wang, Diyu Hou, Shuxia Zhang, Jiadi Chen, Huifang Huang

“…Using flow cytometry detected MDSCs and T cells proliferation, apoptosis, T cells activation and function in the co-culture groups. RNA transcriptome sequencing analysis was conducted on DLBCL-MDSCs and HDs-MDSCs. …”
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LAMC3 interference reduces drug resistance of carboplatin-resistant ovarian cancer cells by Xia Liu, Jun Zhang, Lianping Xia, Yuting Su, Xiaoying Chen, Cong Wang, Yiqiang Ouyang, Fuqiang Yin

“…This study indicated LAMC3 interference reduced drug resistance of carboplatin-resistant ovarian cancer cells principal by affecting cell cycle, autophagy, ferroptosis, and lysosome. The present study provides a potential target for clinical treatment of drug resistance in ovarian cancer.…”
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Generation of vascularized pancreatic progenitors through co-differentiation of endoderm and mesoderm from human pluripotent stem cells by Xiaopu Sang, Junming Xu, Yihang Wang, Jingyi Li, Jiasen Xu, Xiaoni Chen, Xianjie Shi, Fenfang Wu

“…Conclusion Our findings provide a robust method for generating vPPs, which holds significant promise for regenerative medicine applications, particularly in diabetes treatment.…”
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The response to desiccation in Acinetobacter baumannii by Massimiliano Lucidi, Giulia Capecchi, Cinzia Spagnoli, Arianna Basile, Irene Artuso, Luca Persichetti, Elisa Fardelli, Giovanni Capellini, Daniela Visaggio, Francesco Imperi, Giordano Rampioni, Livia Leoni, Paolo Visca

“…VBNC cell formation and extensive metabolic reprogramming provide a biological basis for the response of A. baumannii to desiccation, with implications on environmental control measures aimed at preventing the transmission of A. baumannii infection in hospitals.…”
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Integrated analysis of M2 macrophage-related gene prognostic model and single-cell sequence to predict immunotherapy response in lung adenocarcinoma by Meifang Li, Zhiping Wang, Bin Huang, Yanyun Lai, Meng Zhang, Cheng Lin

“…Moreover, the signature was an independent prognostic factor for LUAD and a potential biomarker for patients receiving immunotherapy. Single-cell transcriptome analysis may provide important information on molecular subtypes and heterogeneity.ConclusionRisk signature based on M2 macrophage-related genes is a valuable tool for predicting prognosis and immunotherapy response in patients with LUAD.…”
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Role of Calprotectin as a Modulator of the IL27-Mediated Proinflammatory Effect on Endothelial Cells by Susann A. Dorosz, Aurélien Ginolhac, Thilo Kähne, Michael Naumann, Thomas Sauter, Alexandre Salsmann, Jean-Luc Bueb

“…Therefore, we examined the inflammatory impact of IL27 on primary endothelial cells and the potentially modulatory effect of calprotectin on both transcriptome and proteome levels. A qPCR-based screening demonstrated high IL27-mediated gene expression of IL7, IL15, CXCL10, and CXCL11. …”
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Metabolomics analysis of extracellular vesicles derived from bovine colostrum and mature milk by Sitong Zhang, Xipeng Sun, Yameng Zhang, Rong Huang, Wenyou Situ, Huaxi Yi, Lingjun Tong

“…However, most research on mEVs has focused on their proteomics, lipidomics, and transcriptome, while metabolome analysis are still lacking. …”
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Oligo-dT anchored cDNA-SRAP and cDNA-SCoT aided identification of transcripts differentially expressed during the early stages of recovery of resurrection plant Haberlea rhodopensi... by Elena Kumanova, Gergana Mihailova, Elena Georgieva Todorovska, Katya Georgieva, Stefan Tsonev, Nikolai Kirilov Christov

“…Although extensive transcriptome data, including two RNAseq experiments, are available for drought induced desiccation and recovery, the gene expression during recovery after freezing-induced desiccation (RAF) remains largely unexplored. …”
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Study of the Function and Expression of the AhRUVBL2 Promoter in Arabidopsis by Penghui Miao, Xuanlin Li, Yongshan Wan, Kun Zhang, Haiyang Yu, Yuying Li, Huadong Li, Hui Yang, Lu Luo, Fengzhen Liu

“…Moreover, characterization of the AhRUVBL2 promoter provides a valuable genetic resource for enhancing peanut yield.…”
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Identification of chalcone isomerase gene family in Astragalus mongholicus revealed genes regulating isoflavone synthesis by Zhen Wang, Zhen Wang, Panpan Wang, Xinxin Wang, Lingyang Kong, Jianhao Wu, Weichao Ren, Xiubo Liu, Wei Ma

“…The evolutionary relationships, conserved motifs, gene structures, and cis-elements of AmCHIs are discussed. The transcriptome revealed the expression profiles of the AmCHI genes in roots, stems and leaves. …”
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