Expression of COA6 in breast cancer and its correlation with tumor immune cell infiltration by JIN Xiaoxia, LIU Yushan, HU Jiping, ZHU Xinghua

“…Methods Differential genes were screened by the whole transcriptome sequencing and the expression of COA6 was explored with TCGA(The Cancer Genome Atlas Program) database. …”
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Detection, molecular function and mechanisms of m5C in cancer by Linhui Zhang, Yuelong Li, Liqing Li, Fei Yao, Maoping Cai, Dingwei Ye, Yuanyuan Qu

“…Moreover, strides in methodologies for discerning m5C have facilitated intricate transcriptome cartography of RNA methylation at the solitary nucleotide echelon. …”
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Metabolic Response of <i>Sanghuangporus baumii</i> to Zn²⁺ Induction and Biosynthesis of a Key Pharmacological Component: Triterpenoid by Xinyu Tong, Ying Yu, Jin Huang, Ying Xu, Anxin Wang, Zengcai Liu, Li Zou

“…Furthermore, 5 mM Zn²⁺ induced upregulation of genes in the mevalonate (MVA) pathway, thereby promoting triterpenoid accumulation by 167.86% compared with the Zn0 group. Transcriptome analysis identified <i>SbHMGS</i> as the key gene involved in triterpenoid biosynthesis under Zn²⁺ induction. …”
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RSL3 induces ferroptosis by activating the NF-κB signalling pathway to enhance the chemosensitivity of triple-negative breast cancer cells to paclitaxel by Jialin Yuan, Cong Liu, Chengwei Jiang, Ning Liu, Zhaoying Yang, Hua Xing

“…Our research validated the synergistic effects of PTX and RSL3 both in vivo and in vitro, with RSL3 inducing ferroptosis by activating the NF-κB signalling pathway, thereby increasing the chemosensitivity of TNBC to PTX. This study provides new insights for improving the therapeutic efficacy of treatment strategies.…”
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ACSS2 mediates an epigenetic pathway to regulate β-cell adaptation during gestation in mice by Yu Zhang, Shuang He, Xi Wang, Xin Wang, Mao-Yang He, Xin-Xin Yu, Cheng-Ran Xu

“…Using single-cell transcriptome combined with genetic analyses, we identified a precise process of β-cell adaptation in mice, characterized by progressive metabolic stress-related β-cell dysfunction, increased acetyl-CoA biosynthesis, and gene element-specific histone acetylation. …”
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Comprehensive analysis of mRNA and lncRNA expression for predicting lymph node metastasis in cervical cancer: a novel seven-gene signature approach by Jiahui Wei, Ming Wang, Yumei Wu

“…Our work bridges molecular insights with clinical practice and provides a foundation for further research into the management of CC.…”
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Silencing SMAD4 inhibits inflammation and ferroptosis in asthma by blocking the IL-17A signaling pathway by Xingyu Rao, Hong Luo, Kaiyuan Luo, Chaohua Hu

“…Conclusion Silencing SMAD4 prevents inflammation and ferroptosis in asthma by inhibiting the IL-17 pathway, which provides a novel potential approach for asthma therapy.…”
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The TOR kinase pathway is relevant for nitrogen signaling and antagonism of the mycoparasite Trichoderma atroviride. by Rossana Segreto, Hoda Bazafkan, Julia Millinger, Martina Schenk, Lea Atanasova, Maria Doppler, Christoph Büschl, Mélanie Boeckstaens, Silvia Soto Diaz, Ulrike Schreiner, Fabiano Sillo, Raffaella Balestrini, Rainer Schuhmacher, Susanne Zeilinger

“…The latter also applied to mutants missing the npr1-1 gene that encodes a fungus-specific kinase known as TOR target in yeast. Genome-wide transcriptome analysis confirmed TOR1 as a regulatory hub that governs T. atroviride metabolism and processes associated to ribosome biogenesis, gene expression and translation. …”
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Effect of Low Nighttime Temperature on Oil Accumulation of Rapeseed Seeds (<i>Brassica napus</i> L.) Based on RNA-Seq of Silique Wall Tissue by Chao Mi, Yanning Zhao, Xuetao Yang, Liangbin Lin, Jinxiong Wang

“…Field experiments across different altitudes and controlled low nighttime temperature (LNT) treatments (20/18 °C and 20/13 °C) were conducted. Transcriptome analysis of the silique walls was performed to explore gene expression changes. …”
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Regulatory Networks of lncRNAs, miRNAs, and mRNAs in Response to Heat Stress in Wheat (Triticum Aestivum L.): An Integrated Analysis by Dwijesh Chandra Mishra, Sayanti Guha Majumdar, Anuj Kumar, Jyotika Bhati, K. K. Chaturvedi, Ranjeet Ranjan Kumar, Suneha Goswami, Anil Rai, Neeraj Budhlakoti

“…In the present study, an attempt has been made to identify differentially expressed heat stress-responsive long non-coding RNAs (lncRNAs) in the wheat genome using publicly available wheat transcriptome data (24 SRAs) representing two conditions, namely, control and heat-stressed. …”
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Transcriptional and cytokine signatures of Mycobacterium abscessus complex pulmonary disease during disease progression and treatment. by Ayesa Syenina, Yi Hern Tan, Danny Jian Hang Tng, Sandy Xue Qi Sim, Valerie Shyn Yun Chew, Jia Xin Yee, Eugenia Ziying Ong, Eng Eong Ooi, Jenny Guek Hong Low, Dorothy Hui Lin Ng

“…<h4>Methodology/principal findings</h4>To address the gaps in clinically relevant indicators, we profiled whole blood transcriptome and 45 plasma proteins of MABC-PD patients across different disease and treatment phases. …”
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Rap1 overexpression boosts triterpenoid saponin production in yeast by enhancing precursor supply and heterologous gene expression by Ji-Young Byun, Thi Thuy Nguyen, Byung-Kwan Cho, Soo-Hoon Park, Sun-Chang Kim

“…Additionally, this approach provides a versatile framework for enhancing both precursor supply and heterologous gene expression.…”
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Phosphorus Alleviates Cadmium Damage by Reducing Cadmium Accumulation and Enhancing Antioxidant Enzymes at the Vegetative Phase in Soybean by Sen Jia, Xiang Zhao, Junxia Huang, Xingdong Yao, Futi Xie

“…This study aimed to explore the interactive effects of Cd and phosphate on soybeans at the physiological, transcriptomic, and metabolic levels using a multi-omics approach. …”
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CCDC110 promotes the progression of hepatocellular carcinoma by activating the TGF-β/SMAD signaling pathway through targeted regulation of TGFBR1 by Hao Shen, Haifeng Li, Haodong Tang

“…In the course of studying the transcriptome of HCC tissues, the protein coiled-coil domain-containing 110 (CCDC110) was identified. …”
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Lettuce immune responses and apoplastic metabolite profile contribute to reduced internal leaf colonization by human bacterial pathogens by Cristián Jacob, Maeli Melotto

“…Results We characterized whole-leaf transcriptome and apoplast metabolome profiles of three lettuce cultivars upon exposure to the human pathogenic bacteria S. enterica ser. …”
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Comprehensive analysis of alternative splicing in Rosa roxburghii Tratt reveals its role in flavonoid synthesis by Yanlin An, Jiahua Wu, Yani Chen, Shize Li, Shize Li

“…However, the role of AS in its metabolite synthesis is rarely reported.MethodsThe transcriptome data of eight tissues of Rosa roxburghii were analyzed by using Trimmomatic, Hisat2 and StringTie software. …”
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High-Throughput Sequencing Reveals CXCR4 and IGF1 Behave Different Roles in Weightlessness Osteoporosis by Dong Wang, Weihang Li, Ziyi Ding, Quan Shi, Shilei Zhang, Zhuoru Zhang, Zhibin Liu, Xiaocheng Wang, Ming Yan

“…In addition, the results of this study provide a theoretical basis and novel ideas for the subsequent research of the pathogenesis and clinical treatment of weightlessness osteoporosis.…”
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Engineered extracellular vesicles promote the repair of acute kidney injury by modulating regulatory T cells and the immune microenvironment by Lulu Xie, Kaiyue Zhang, Kai Pan, Xiaomin Su, Xiaotong Zhao, Rui Li, Yixin Wang, Haotian Pang, Enze Fu, Zongjin Li

“…Methods and results In this study, P-selectin binding peptide-extracellular vesicles (PBP-EVs) that target and repair ECs are engineered. Transcriptome sequencing reveals that PBP-EVs reduce the expression of inflammatory genes in AKI mice. …”
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Genome-wide analysis of phytochrome-interacting factor (PIF) families and their potential roles in light and gibberellin signaling in Chinese pine by Yingtian Guo, Chengyan Deng, Guizhi Feng, Dan Liu

“…Overall, this research provides a foundation for future studies investigating the functions of PIFs in conifer growth and development.…”
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Genome-wide characterization and expression analysis of WRKY family genes in the biosynthesis of triptolide in Tripterygium wilfordii by Limei Tang, Xinyu Qi, Jiayu Chen, Yujun Zhao, Junhao Gu, Shanshan Zhu, Wei Gao, Lichan Tu

“…Conclusion Our study provides a valuable resource for further research on TwWRKY in T. wilfordii. …”
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