Cryptic divergence in and evolutionary dynamics of endangered hybrid Picea brachytyla sensu stricto in the Qinghai-Tibet Plateau by Shengming Lu, Lian Liu, Weixiao Lei, Donglei Wang, Hui Zhu, Qing Lai, Liru Ma, Dafu Ru

“…Results In this study, we conducted transcriptome analysis of 81 individuals from 18 natural populations of a northern lineage of Picea brachytyla sensu stricto that is endemic to the Qinghai-Tibet Plateau. …”
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Exploring the Molecular Mechanisms of Autophagy-related Genes in Hepatic Ischemia/Reperfusion Injury Using Bioinformatics by Qi Xiao, PhD, Xiaoxiao Hu, MD, Qiong Chen, MD, WenYu Wang, MD, JianSheng Xiao, PhD, Biqi Fu, PhD

“…Therefore, we conducted a comprehensive transcriptomics analysis to investigate the biomolecular mechanisms underlying autophagy in HIRI. …”
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Overproduction of endusamycin in Streptomyces endus subsp. aureus by Yingying Chang, Zhen Liu, Zixin Deng, Tiangang Liu

“…It establishes a superior chassis strain for exploring endusamycin derivatives and provides valuable insights into improving the production of polyether compounds.…”
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Gestational exposure to polystyrene microplastics incurred placental damage in mice: Insights into metabolic and gene expression disorders by Zhe Wang, Runyan Shi, Ruimin Wang, Zhenzhu Ma, Shuo Jiang, Fengquan Zhang, Weidong Wu

“…Overall, our results confirmed that maternal PSMP exposure led to placental damages associated with metabolic and gene expression disorders. This study would provide new insights into the developmental impacts of microplastic consumption during gestation.…”
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Overexpression of SiICE2 gene reduces plant height and increases yield in cotton (Gossypium hirsutum) by Zexing Zhang, Ping He, Tianqi Jiao, Hongliang Xin, Saisai Wang, Xiaoyan Wu, Qianqin Li, Zhihui Yang, Jianbo Zhu, Ruina Liu

“…In conclusion, the reduction in plant height observed in the ICE2 lines can be ascribed to the integration of the SiICE2 gene influencing the BR signaling pathway and the expression of the CBF1 gene in cotton, which inhibits cell elongation and results in shorter cotton plants. To provide a reference for the optimization of agricultural cotton production.…”
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Naked mole-rat macrophage polarization by E. A. Gorshkova, S. K. Purtova, E. M. Dvorianinova, M. Yu. Vyssokikh, S. A. Nedospasov

“…However, it was shown that myelopoiesis predominates in NMR, therefore it can be assumed that the innate immune cells in the naked mole rat contribute to the successful control of the cancer incidence and tumor growth. This brief provides an overview of ongoing research into the properties of naked mole rat macrophages. …”
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Pan-cancer drivers of metastasis by Ryan Lusby, Engin Demirdizen, Mohammed Inayatullah, Paramita Kundu, Oscar Maiques, Ziyi Zhang, Mikkel Green Terp, Victoria Sanz-Moreno, Vijay K. Tiwari

“…We investigate this through single-cell transcriptome analysis encompassing over two hundred patients with metastatic and non-metastatic tumours across six cancer types. …”
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Isoform‐resolved correlation analysis between mRNA abundance regulation and protein level degradation by Barbora Salovska, Hongwen Zhu, Tejas Gandhi, Max Frank, Wenxue Li, George Rosenberger, Chongde Wu, Pierre‐Luc Germain, Hu Zhou, Zdenek Hodny, Lukas Reiter, Yansheng Liu

“…Our findings support the tight association between transcriptome variability and proteostasis and provide a methodological foundation for studying functional protein degradation.…”
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Impact of Oxygen Availability on the Organelle‐Specific Redox Potentials and Stress in Recombinant Protein Producing Komagataella phaffii by Aliki Kostopoulou, Corinna Rebnegger, Borja Ferrero‐Bordera, Matthias Mattanovich, Sandra Maaß, Dörte Becher, Brigitte Gasser, Diethard Mattanovich

“…Also, as reported previously, hypoxic conditions led to increased recombinant protein secretion. Finally, transcriptome and proteome analyses provided novel insights into the short‐term response of the cells from normoxic to hypoxic conditions.…”
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A Novel Ferroptosis-Related Gene Prognosis Signature and Identifying Atorvastatin as a Potential Therapeutic Agent for Hepatocellular Carcinoma by Ling Wang, Xiaoqin He, Yang Shen, Jiayu Chen, Yukai Chen, Zhuolin Zhou, Ximing Xu

“…In conclusion, this research targets ferroptosis therapy and provides new insights for improving the prediction and prevention of HCC.…”
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Exposure to polyethylene terephthalate microplastics induces reprogramming of flavonoids metabolism and gene regulatory networks in Capsicum annuum by Rongchao Yang, Yilan Cui, Long Cheng, Mangu Hu, Mingzhu Guan, Youyang Fu, Yueqin Zhang

“…These findings enhance our comprehension of MPs pollution and provide valuable insights for the development of sustainable agro-ecosystems and food security in the future.…”
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Enhanced hierarchical attention networks for predictive interactome analysis of LncRNA and CircRNA in oral herpes virus by Pradeep Kumar Yadalam, Carlos M. Ardila

“…Background: Non-coding RNAs, including lncRNAs, circRNAs, and microRNAs, constitute 98 % of the human transcriptome and are vital regulators of gene expression, cellular processes, and host-pathogen interactions, particularly in viral infections. …”
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Bojungikki-Tang Augments Pembrolizumab Efficacy in Human PBMC-Injected H460 Tumor-Bearing Mice by Se Won Na, Jin-Mu Yi, Heerim Yeo, Sang-Min Park, Mibae Jeong, Jaemoo Chun, Mi-Kyung Jeong

“…Additionally, RNA sequencing, transcriptome analysis, and quantitative PCR analysis were performed on tumor tissues to investigate the molecular mechanisms underlying the observed effects. …”
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Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis by Özge Karayel, Peng Xu, Isabell Bludau, Senthil Velan Bhoopalan, Yu Yao, Freitas Colaco Ana Rita, Alberto Santos, Brenda A Schulman, Arno F Alpi, Mitchell J Weiss, Matthias Mann

“…Abstract Human erythropoiesis is an exquisitely controlled multistep developmental process, and its dysregulation leads to numerous human diseases. Transcriptome and epigenome studies provided insights into system‐wide regulation, but we currently lack a global mechanistic view on the dynamics of proteome and post‐translational regulation coordinating erythroid maturation. …”
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Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets. by Zhidong Tu, Mark P Keller, Chunsheng Zhang, Mary E Rabaglia, Danielle M Greenawalt, Xia Yang, I-Ming Wang, Hongyue Dai, Matthew D Bruss, Pek Y Lum, Yun-Ping Zhou, Daniel M Kemp, Christina Kendziorski, Brian S Yandell, Alan D Attie, Eric E Schadt, Jun Zhu

“…High-density genotypes, diabetes-related clinical traits, and whole-transcriptome expression profiling in five tissues (white adipose, liver, pancreatic islets, hypothalamus, and gastrocnemius muscle) were determined for all mice. …”
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Decellularised amniotic membrane-TDSCs composite promotes Achilles tendon healing by Xufeng Mao, Yulong Wang, Xiqian Zhang, Zheyu Yao, Zheyang Yuan, Liwei Yao, Leining Wang, Haijiao Mao

“…The dAM-TDSCs composite biomimetic peritendinous membrane material can effectively promote the healing of Achilles tendon. It provides a new direction for the development of biomimetic peritendinous membrane materials.…”
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An Isoflavone Synthase Gene in <i>Arachis hypogea</i> Responds to <i>Phoma arachidicola</i> Infection Causing Web Blotch by Xinying Song, Ying Li, Xia Zhang, Tom Hsiang, Manlin Xu, Zhiqing Guo, Kang He, Jing Yu

“…This study improves our understanding of the molecular mechanisms behind resistance of peanut infection by <i>P. arachidicola</i>, and provides important information that could be used to undertake greater detailed characterization of web blotch resistance genes in peanut.…”
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Proteogenomic characterisation of primary oral cancer unveils extracellular matrix remodelling and immunosuppressive microenvironment linked to lymph node metastasis by Yu Liu, Zhenyu Yang, Jingya Jane Pu, Jie Zhong, Ui‐Soon Khoo, Yu‐Xiong Su, Gao Zhang

“…Our integrated multi‐omics analysis provides a detailed understanding of molecular mechanisms driving lymph node metastasis of OSCC. …”
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Analysis of thaumatin-like protein (TLP) gene family in tea plant revealed that CsTLP8 contributes to tea blister blight resistance by Xiaozeng Mi, Mengsha Tang, Chun Yang, Sihui Liang, Yao Chen, Dahe Qiao, Zhengwu Chen

“…The combination of transcriptome analysis and qRT-PCR demonstrated that the expression of CsTLP8, CsTLP23, CsTLP28 and CsTLP34 were significantly up-regulated after tea blister blight infection. …”
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Overexpression of HmWOX8 promotes callus proliferation and shoot regeneration by regulating hormone signaling and shoot development-related genes by Xueying Zhao, Along Chen, Zhicong Gao, Fazhan Hou, Yajun Chen, Yingzhu Liu

“…The present research improves the understanding of molecular mechanisms for HmWOX8-mediated regeneration and provides valuable gene resources for breeding programs to promote plant regeneration.…”
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