Redefining the spliceosomal introns of the sexually transmitted parasite Trichomonas vaginalis and its close relative in columbid birds. by Francisco Callejas-Hernández, Mari Shiratori, Steven A Sullivan, Frances Blow, Jane M Carlton

“…In this study, we exploited our new T. vaginalis G3 chromosome-scale assembly and annotation and high-coverage transcriptome datasets to provide an up-to-date repertoire of spliceosomal introns in the species. …”
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Genome-Wide Analysis of Oxidosqualene Cyclase Genes in <i>Artemisia annua</i>: Evolution, Expression, and Potential Roles in Triterpenoid Biosynthesis by Changfeng Guo, Si Xu, Xiaoyun Guo

“…This genome-wide characterization provides insights into the evolution and functional diversification of the OSC gene family in <i>A. annua</i>. …”
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Decision level scheme for fusing multiomics and histology slide images using deep neural network for tumor prognosis prediction by Tingting Zhao, Yongyong Ren, Hui Lu, Yan Kong

“…The proposed decision level multimodal data fusion framework is expected to provide insights and technical methodologies for the follow-up studies.…”
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Phenotypic tolerance for rDNA copy number variation within the natural range of C. elegans. by Ashley N Hall, Elizabeth A Morton, Rebecca Walters, Josh T Cuperus, Christine Queitsch

“…Our study provides strain resources for future investigations into the boundaries of this tolerance.…”
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Vitamin B6 resensitizes mcr-carrying Gram-negative bacteria to colistin by Tianqi Xu, Dan Fang, Fulei Li, Zhiqiang Wang, Yuan Liu

“…Altogether, our study provides a novel metabolic-driven antibiotic sensitization strategy to tackle antibiotic resistance and identifies a potentially safe antibiotic synergist.…”
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Epigenetic regulation of organ-specific functions in Mikania micrantha and Mikania cordata: insights from DNA methylation and siRNA integration by Yatong Sang, Yitong Ma, Ruonan Wang, Zhen Wang, Ting Wang, Yingjuan Su

“…Conclusion This study provides insights into the complex regulatory role of DNA methylation and siRNAs in organ-specific functions and offers valuable information for exploring the invasive characteristics of M. micrantha from an epigenetic perspective.…”
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The heme-regulated inhibitor kinase Hri1 is activated in response to aminolevulinic acid deficiency in Schizosaccharomyces pombe. by Samuel Plante, Ariane Brault, Mariano Avino, Hajer Sakouhi, Florie Lo Ying Ping, Tobias Vahsen, Simon Labbé

“…Taken together, these findings provide the first report of a fungal eIF2α kinase being activated in response to stress directly linked to a defect in heme homeostasis.…”
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Diagnosis of Taenia solium infections based on "mail order" RNA-sequencing of single tapeworm egg isolates from stool samples. by Henrik Sadlowski, Veronika Schmidt, Jonathan Hiss, Johannes A Kuehn, Christian G Schneider, Gideon Zulu, Alex Hachangu, Chummy S Sikasunge, Kabemba E Mwape, Andrea S Winkler, Markus Schuelke

“…Here we present "mail order" single egg RNA-sequencing, a new method allowing the identification of the exact Taenia ssp. based on a few eggs found in routine diagnostic stool samples. We provide first T. solium transcriptome data, which show extremely high mitochondrial DNA (mtDNA) transcript counts that can be used for subspecies classification. …”
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Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2. by Michiel Smits, Shahryar E Mir, R Jonas A Nilsson, Petra M van der Stoop, Johanna M Niers, Victor E Marquez, Jacqueline Cloos, Xandra O Breakefield, Anna M Krichevsky, David P Noske, Bakhos A Tannous, Thomas Würdinger

“…Altogether, by identifying a pro-angiogenic VEGF/miR-101/EZH2 axis in endothelial cells we provide evidence for a functional link between growth factor-mediated signaling, post-transcriptional silencing, and histone-methylation in the angiogenesis process. …”
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RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications by Shanhe Huang, Zonglin Li, Weilong Lin, Ruihui Xie, Hai Huang

“…Together, our synthesis provides a comprehensive framework for understanding RNA epigenetics in tumor biology and lays the groundwork for precision oncology guided by transcriptome plasticity.…”
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Cerebrovascular gene expression in spontaneously hypertensive rats. by Anne-Sofie Grell, Simona Denise Frederiksen, Lars Edvinsson, Saema Ansar

“…Hypertension-susceptible genes may provide a novel insight into potential molecular mechanisms of hypertension and secondary complications associated with hypertension. …”
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Integrative Analysis of Diphasiastrum digitatum Holub: Unveiling Genetic Variation and Ecological Adaptations for Sustainable Ecosystem Management by Marcin Nowicki, Logan C. Houston, Sarah L. Boggess, Matthew L. Huff, Margaret E. Staton, Robert N. Trigiano

“…Based on the available transcriptome assembly, we generated numerous markers and utilized 13 robust microsatellite markers to genotype a collection of 402 specimens from the Eastern US (VT; VA; NC; TN). …”
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Genome-wide analysis of the AarPDR gene family in Artemisia argyi and its potential role in regulating terpenoids transport by Xiaoyu Han, Min Cui, Shuangxin Ma, Xuemei Gao, Liping Tang, Bin Li

“…Conclusions The AarPDRs were characterized by integrating genome analysis, transcriptome, and metabolite profiling. The results can provide useful clues for future studies aimed at the functional characterization of AarPDR genes.…”
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ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing. by Seungjae Lee, Lu Wei, Binglong Zhang, Raeann Goering, Sonali Majumdar, Jiayu Wen, J Matthew Taliaferro, Eric C Lai

“…Nevertheless, little was known about its impacts on the transcriptome, and potential functional overlap with its paralogs. …”
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Hrk1 plays both Hog1-dependent and -independent roles in controlling stress response and antifungal drug resistance in Cryptococcus neoformans. by Seo-Young Kim, Young-Joon Ko, Kwang-Woo Jung, Anna Strain, Kirsten Nielsen, Yong-Sun Bahn

“…Particularly, the finding that inhibition of Hrk1 substantially increases azole drug susceptibility provides a novel strategy for combination antifungal therapy.…”
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Identification of transcription factor-lipid droplet-related gene biomarkers for the prognosis of post-acute myocardial infarction-induced heart failure by Jianqiao Zhao, Can Guo, Mengyuan Cheng, Jie Li, Yangyang Liu, Huahua Wang, Jianping Shen

“…The TF-LDRG pair, ABHD5-ARID3a, was demonstrated good predictive accuracy.DiscussionOur findings suggest that ABHD5-ARID3a have significant potential as predictive biomarkers for heart failure post-AMI which also provides a foundation for further exploration into the molecular mechanisms underlying the progression from AMI to HF.…”
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Plant growth-promoting endophytic bacteria: a sustainable solution for climate change and environmental stresses in agriculture by Zabihullah Sherzad, Noor Agha Nawakht, Faridullah Sherzad

“…Plant growth-promoting endophytic bacteria (PGPEBs), which are shielded by the plant tissues from external environmental stressors, provide a stable solution to enhance plant resistance and productivity and could be used as eco-friendly tools in response to the future scenarios of environmental stresses. …”
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The organization of the transcriptional network in specific neuronal classes by Kellen D Winden, Michael C Oldham, Karoly Mirnics, Philip J Ebert, Christo H Swan, Pat Levitt, John L Rubenstein, Steve Horvath, Daniel H Geschwind

“…Here, we perform the first systems‐level analysis of microarray data from single neuronal populations using weighted gene co‐expression network analysis to examine how neuronal transcriptome organization relates to neuronal function and diversity. …”
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Cocaine-induced gene regulation in D1 and D2 neuronal ensembles of the nucleus accumbens by Philipp Mews, Autumn VA Mason, Emily G. Kirchner, Molly Estill, Eric J. Nestler

“…Notably, we identified a discrete D1 MSN population characterized by the upregulation of immediate early genes, as well as another group of D1 MSNs linked to prolonged withdrawal, uncovering novel regulators of withdrawal-related transcriptome dynamics. Our findings provide a high-resolution transcriptomic map of D1 and D2 MSNs, illustrating the dynamic changes induced by cocaine exposure and withdrawal. …”
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Genome-wide identification and expression analysis of TCP transcription factors in Chrysanthemum indicum reveals their critical role in the response to various abiotic stresses by Shengyan Chen, Bin Chen, Xingnong Xu

“…The results of our studies could provide comprehensive insights into the TCP family genes of C. indicum for further functional investigations.…”
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