The relative resistance of children to sepsis mortality: from pathways to drug candidates by Rose B Joachim, Gabriel M Altschuler, John N Hutchinson, Hector R Wong, Winston A Hide, Lester Kobzik

“…Using public datasets, we identified key differences in pathway activity (Pathprint) in blood transcriptome profiles of septic adults and children. …”
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Polystyrene microplastics induce potential toxicity through the gut-mammary axis by Zhanhang Wang, Shiyu Wang, Shujuan Liu, Zhewei Wang, Fu Li, Qiqi Bu, Xiaopeng An

“…Moreover, they can accumulate in mammary tissue and cause inflammatory damage. Transcriptome data suggested that PS-MPs cause maternal mammary lipid metabolism disorders and ferroptosis. …”
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Transcriptional regulation of male-sterility in 7B-1 male-sterile tomato mutant. by Vahid Omidvar, Irina Mohorianu, Tamas Dalmay, Yi Zheng, Zhangjun Fei, Anna Pucci, Andrea Mazzucato, Vendula Večeřová, Michaela Sedlářova, Martin Fellner

“…TUNEL assay showed a defect in programmed cell death (PCD) of tapetal cells in 7B-1 anthers. The present study provides insights into the transcriptome of the 7B-1 mutant. …”
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Between Two Extremes: Tripsacum dactyloides Root Anatomical Responses to Drought and Waterlogging by Joel F. Swift, Desi Thimesch, Lucas Bengfort, Shahzaib Asif, Maggie R. Wagner

“…These findings highlight spatial variation in root anatomical responses to water stress and provide a framework that can inform sampling protocols for various other data types where sampling effort is limiting (e.g., microbiome, transcriptome, proteome).…”
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Genome-wide identification and expression analysis of the ferritin family in sweetpotato and its two diploid relatives by Jia-Li Peng, Hui-Ni Xu, Wan-Lin Yang, Xu Li

“…Our results provide a theoretical basis for future genetic research, development of breeding strategies against abiotic stresses and food enrichment with iron in sweetpotato.…”
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Acanthamoeba castellanii as a model for unveiling Campylobacter jejuni host–pathogen dynamics by Fauzy Nasher, Burhan Lehri, Richard A. Stabler, Brendan W. Wren

“…We analyzed the whole transcriptome of A. castellanii infected with C. jejuni 11168H. …”
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Two-sample bi-directional causality between two traits with some invalid IVs in both directions using GWAS summary statistics by Siyi Chen

“…We also provide simulations to compare our approach with existing transcriptome-wide association study (TWAS) to show its effectiveness. …”
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Tumor-colonizing Lachnoclostridium-mediated chemokine expression enhances the immune infiltration of bladder urothelial carcinoma by Liang Chen, Qingquan Xu, Weinan Chen, Jun Liu, Tao Xu, Jialiang Yang, Lei Ji

“…Collectively, our study provides new insights into the regulation of TIME by intratumoral microbiota and provides guidance for improving immunotherapy against BUC.…”
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Post-transcriptional regulation of Dufour’s gland reproductive signals in bumble bees by Nathan Derstine, Tatiana Laremore, Etya Amsalem

“…However, a previous transcriptome analysis revealed no gene expression differences in the Dufour’s gland of workers despite differences in both ester production and ovarian activation, suggesting that ester production may be regulated lower down. …”
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Genome-wide identification of the AAAP gene family and expression analysis under tissue-specific expression in five legumes by Naiyu Chen, Shulei Wang, Yajie Yin, Guoling Ren, Yiting Zhang, Lina Qu, Lei Ling

“…In addition, by analysing the transcriptome data, we determined that the expression levels of AAAP differed in each tissue. …”
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Innate Immune Response Against Batai Virus, Bunyamwera Virus, and Their Reassortants by David D. J. A. Zöller, Josefin Säurich, Julia Metzger, Klaus Jung, Bernd Lepenies, Stefanie C. Becker

“…Our results provide the first evidence that BATV elicits a strong innate immune response compared to BUNV, which largely evades early detection. …”
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Multifaceted Role of Specialized Neuropeptide-Intensive Neurons on the Selective Vulnerability to Alzheimer’s Disease in the Human Brain by Manci Li, Nicole Flack, Peter A. Larsen

“…To test this hypothesis, multiscale and spatiotemporal transcriptome data from ~1900 human brain samples were analyzed using publicly available datasets. …”
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Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens by Relu Cocoș, Bogdan Ovidiu Popescu

“…To contextualize these genetic discoveries, we provide a comprehensive critical overview of genetic architecture concepts, from Mendelian inheritance to the latest insights from oligogenic and omnigenic models. …”
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Combining 'omics and microscopy to visualize interactions between the Asian citrus psyllid vector and the Huanglongbing pathogen Candidatus Liberibacter asiaticus in the insect gut... by Angela Kruse, Somayeh Fattah-Hosseini, Surya Saha, Richard Johnson, EricaRose Warwick, Kasie Sturgeon, Lukas Mueller, Michael J MacCoss, Robert G Shatters, Michelle Cilia Heck

“…To investigate the effects of CLas exposure at the gut-pathogen interface, we performed RNAseq and mass spectrometry-based proteomics to analyze the transcriptome and proteome, respectively, of ACP gut tissue. …”
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Hesperetin Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Downregulating the P38/JUN/FOS Pathway In Vitro by Ruiheng Gu, Feike Zhao, Quanying Li, Limin Hou, Guochang Liu, Xueyan Sun, Junyuan Du, Binghu Fang

“…Porcine reproductive and respiratory syndrome virus (PRRSV) is a persistent pathogen that causes significant economic losses to the global swine industry. Commercial vaccines provide only partial protection, and no effective therapeutic treatments are currently available. …”
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Genome Microscale Heterogeneity among Wild Potatoes Revealed by Diversity Arrays Technology Marker Sequences by Alessandra Traini, Massimo Iorizzo, Harpartap Mann, James M. Bradeen, Domenico Carputo, Luigi Frusciante, Maria Luisa Chiusano

“…Our analytical approach provides knowledge of genome structural and sequence variability that could not be detected by transcriptome and proteome approaches.…”
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Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice by Yuan Zhuang, Xixian Liao, Fei Niu, Ming Li, Yu Yan, Chuanhang He, Xiang Wu, Runfa Tian, Guoyi Gao

“…Here, we performed single-nucleus RNA sequencing with spatial transcriptome sequencing in both normal and mTBI brainstems in male mice, revealing thirty-five neuron and non-neuron clusters. …”
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The SWEET14 sugar transporter mediates mycorrhizal symbiosis and carbon allocation in Dendrobium officinale by Liumin Li, Xueying Wang, Hua Li, Muhammad Moaaz Ali, Xiaobo Hu, Ralf Oelmuller, Ahmed Fathy Yousef, Abdulwahed Fahad Alrefaei, Jianfu Liu, Faxing Chen

“…Transcriptome sequencing revealed significant changes in gene expression in mycorrhizal roots, particularly the upregulation of DoSWEET14. …”
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Age-dependent glial heterogeneity and traumatic injury responses in a vertebrate brain structure by Huiwen Qin, Shuguang Yu, Ruyi Han, Jie He

“…Overall, our findings provide the molecular and cellular framework of TBI-induced age-related glial dynamics in vertebrate brains.…”
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Microbial Synthesis of <i>Neo-Allo</i>-Ocimene by Celery-Derived <i>Neo-Allo</i>-Ocimene Synthase by Zheng Liu, Ting Gao, Shaoheng Bao, Penggang Han, Ge Yao, Tianyu Song, Longbao Zhu, Chang Chen, Hui Jiang

“…In this study, we mined a terpene synthase, AgTPS40, from the transcriptome of celery leaf tissues. Through sequence and phylogenetic analysis, AgTPS40 was characterized as a monoterpene synthase. …”
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