FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction by Clarissa Tacto, Meghan Tahbaz, Andrew Salib, Shudi Wang, Fritz Cayabyab, Jinhyuk Choi, Kiyoka Kim, Yu Hamba, Harvey Perez, Paul D. Gershon, Robert Damoiseaux, Tae Gyu Oh, Eiji Yoshihara

“…Human pluripotent stem cells (hPSCs) provide a potential alternative source to cadaveric human pancreatic islets for replacement therapy in diabetes. …”
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Sucrose Promotes Strawberry Fruit Ripening and Affects Ripening-Related Processes by Ya Luo, Yuanxiu Lin, Fan Mo, Cong Ge, Leiyu Jiang, Yong Zhang, Qing Chen, Bo Sun, Yan Wang, Xiaorong Wang, Haoru Tang

“…While in the effects of sucrose application timing and concentration on ripening, fruit qualities remain unclear, as well as the transcriptome-wide details about the effects of sucrose on the gene expression involved in ripening-related processes. …”
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FB5P-seq-mAbs: monoclonal antibody production from FB5P-seq libraries for integrative single-cell analysis of B cells by Sakina Ado, Chuang Dong, Noudjoud Attaf, Myriam Moussa, Agathe Carrier, Agathe Carrier, Pierre Milpied, Jean-Marc Navarro

“…Parallel analysis of phenotype, transcriptome and antigen receptor sequence in single B cells is a useful method for tracking B cell activation and maturation during immune responses. …”
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Genetic and functional characterization of inherited complex chromosomal rearrangements in a family with multisystem anomalies by He Fang, Stephen M. Eacker, Yu Wu, Whitney Neufeld-Kaiser, Mercy Laurino, Siobán Keel, Marshall S. Horwitz, Yajuan J. Liu

“…Conclusion: Combining cytogenetic and genomic methods provided comprehensive characterization and defined the breakpoints at high resolution in both proband and mother. …”
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Morphological, Physiological, and Molecular Bases of Salt Tolerance in Crape Myrtle (<i>Lagerstroemia indica</i>) by Chunmei Yu, Zuorong Ding, Tianyi Yuan, Cannan Yu, Jin Qin, Di Lu, Hui Wei, Fei Zhong, Guoyuan Liu, Yanhong Chen, Jian Zhang

“…Morphological anatomy and transcriptome analyses clarified that the xylem of the ST variety possessed a high number of vessels with a small lumen. …”
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Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma by Yixuan Huo, Wei Zhang, Fan Yang, Wenhua Shao, Guozheng Cong, Shoukai Zhang, Shoukai Zhang

“…The results of this study provide an experimental basis for NK4 as a potential therapeutic target for laryngeal squamous cell carcinoma highlighting its translational medical value.…”
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Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma by Jianwei Cui, Fanyi Zeng, Ming Tang, Ming Tang, Shiwu Yin, Shiwu Yin

“…Additionally, MARCKSL1 is linked to tumour resistance to multiple anticancer drugs.DiscussionThis study sheds light on the molecular characteristics and functional heterogeneity of MVI-associated malignant cell subpopulations. The single-cell transcriptome and bioinformatics analyses provided insights into the mechanisms driving MVI, potentially aiding the development of targeted diagnostic and therapeutic strategies. …”
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Dynamic gene regulatory networks drive seed dormancy and germination of Pinus tabuliformis by Yanjun Li, Duxian Lu, Xinxiu Zuo, Yanyan Zhang, Yufen Bu, Shihui Niu, Jinxing Lin, Yaning Cui

“…We obtained high-quality transcriptome data from seeds at three developmental stages using the Illumina sequencing platform and conducted time-series trend analysis. …”
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Multi-omics analysis reveals Lactobacillus and Indolelactic acid involved in small intestinal adaptation of piglet with short bowel syndrome by Weipeng Wang, Ying Lu, Bo Wu, Shicheng Peng, Wei Cai, Yongtao Xiao

“…Ileal mucosa and serum were collected for untargeted liquid chromatography-mass spectrometry. Transcriptomic analysis on ileal mucosa was performed. …”
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Multi-omics investigation of Porphyromonas gingivalis exacerbating acute kidney injury through the gut-kidney axis by Ling Dong, Zhaoxin Ji, Jing Sun, Jiangqi Hu, Qingsong Jiang, Wei Wei

“…Comprehensive analyses were conducted, including 16S rRNA sequencing, liquid chromatography-mass spectrometry (LC-MS) metabolomics, and transcriptome sequencing. In vitro, the identified metabolite was used to stimulate mouse neutrophils. …”
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Landscape analysis of matrix metalloproteinases reveals key prognostic markers for prostate cancer by Wei Li, Xi Wei, Ying Yu, Yuan Tian, Qi Yu, Jun Qiao, Yuewei Tao, Yanfeng Li, Tao Li

“…Subsequently, single-cell transcriptome and spatial-transcriptome data was analyzed to explore the regulatory effect of MMP11 on microenvironment.ResultMost MMPs exhibit differential expression between tumor and normal tissues, with specific MMPs correlating with pathological features of PCa. …”
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The Efficacy of Pattern Separation Training in Antidepressant Treatment and the Exploration of Its Drug-Target Alternatives by Liu Jia

“…Through this approach, we hope to provide more diverse treatment options for patients with depression, while reducing dependence on drug therapy.…”
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Unraveling the molecular landscape of congenital pseudoarthrosis of the tibia: insights from a comprehensive analysis of 159 probands by Rui Wang, Yu Zheng, Ge Yang, Zhenchao Xu, Yaoxi Liu, Weihua Zhao, Hua Wang, Haibo Mei, Guanghui Zhu

“…Conclusions These findings shed light on novel genetic mutations and osteocyte transcriptome-related molecular pathways involved in CPT, providing a new framework for understanding the genetic regulation of CPT pathology and suggesting potential directions to further elucidate its pathogenesis.…”
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Lnc-MEG8 regulates yak myoblast differentiation via the miR-22-3p/RTL1 axis by Xiaoming Ma, Yongfu La, Tong Wang, Chun Huang, Fen Feng, Xian Guo, Pengjia Bao, Xiaoyun Wu, Min Chu, Chunnian Liang, Ping Yan

“…In this study, we performed transcriptome profiling of yak longissimus dorsi muscle at different growth stages, identifying a key long non-coding RNA, LncRNA-XR_314844 (Lnc-MEG8), with a potential role in muscle development. …”
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Inhibition of the invasive plant Ambrosia trifida by Sigesbeckia glabrescens extracts by Lijuan Yin, Guangzhong Zhang, Haoyu Zhao, Yuxin Zhang, Jiaozi Wangchen, Fanghao Wan, Bo Liu, Wanqiang Qian

“…The phenotypes and transcriptome profiles of the seedlings treated with these chemicals were the same as those of the seedlings treated with the S. glabrescens extracts. …”
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Identification of <i>AP2/ERF</i> Transcription Factors and Characterization of <i>AP2/ERF</i> Genes Related to Low-Temperature Stress Response and Fruit Development in Luffa by Jianting Liu, Haifeng Zhong, Chengjuan Cao, Yuqian Wang, Qianrong Zhang, Qingfang Wen, Haisheng Zhu, Zuliang Li

“…Our findings will help clarify the evolution of the luffa <i>AP2/ERF</i> family, while also providing valuable insights for future studies on AP2/ERF functions.…”
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Identification and validation of integrated stress-response-related genes as biomarkers for age-related macular degeneration by Jingyi Niu, Ling Jin, Yijun Hu, Yiting Wang, Xiaoning Hao, Wenwen Geng, Ruirui Ma

“…Therefore, this study aimed to identify potential biomarkers for AMD through bioinformatics analysis based on the transcriptome database and integrated stress response related genes (ISR-RGs).MethodsTranscriptomic data GSE76237, GSE247168, and ISR-RGs were sourced from public databases and related literature. …”
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Acute hypoxia stress mediates HIF-1α-Yki-Cactus axis to facilitate the infection of Vibrio parahaemolyticus in Litopenaeus vannamei by Honghui He, Honghui He, Honghui He, Honghui He, Shaoqing Huang, Ningze Geng, Ningze Geng, Shaoping Weng, Shaoping Weng, Shaoping Weng, Shaoping Weng, Jianguo He, Jianguo He, Jianguo He, Jianguo He, Chaozheng Li, Chaozheng Li, Chaozheng Li, Chaozheng Li

“…The mechanism of HIF-1α-Yki-Cautus axis provided an explanation for this phenomenon.DiscussionThis study offered new insights into interactions among environmental hypoxia stress, host immunity and pathogens, thereby providing practical guidelines for optimizing shrimp culture practices.…”
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Integrating Drosophila and Vibrio fischeri models for toxicity evaluation: uncovering detoxification trends in psoralea Fructus-TCM formulations by Cheng Zhang, Yina Li, Fangyang Li, Wanyun Dang, Zhuo Shi, Chunqi Yang, Chengrong Xiao, Xianglin Tang, Yuguang Wang, Yuguang Wang, Yuguang Wang, Yue Gao, Yue Gao, Yue Gao, Yue Gao

“…Finally, molecular docking and molecular dynamics simulations explored the mechanisms of action of these toxic components on Vibrio fischeri, providing a comprehensive understanding at the molecular level.ResultsIn Drosophila experiments, ESP and SSP groups showed longer survival times, with male flies being more sensitive, making them more suitable for toxicity studies. …”
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A novel gene signature for predicting outcome in colorectal cancer patients based on tumor cell-endothelial cell interaction via single-cell sequencing and machine learning by Lina Pang, Qingxia Sun, Wenyue Wang, Mingjie Song, Ying Wu, Xin Shi, Xiaonan Shi

“…Methods: We conducted an in silico study integrating single-cell RNA sequencing and bulk transcriptome data to characterize the cellular heterogeneity of CRC. …”
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