Stereoselective cardiovascular toxicity of difenoconazole stereoisomers in zebrafish larvae (Danio rerio) through thyroid hormone disruption by Jiansheng Zhu, Chunlan Liu, Jingyu Wang, Li Zou, Ju Dong, Mingtao Huang

“…Notably, 2 R,4R-DIF displayed the strongest cardiovascular toxicity, followed by 2S,4S-DIF and Rac-DIF. Transcriptome analysis showed that 2 R,4R-DIF and 2S,4S-DIF affected the thyroid hormone signaling pathway, which was validated by altered thyroid hormone levels and hypothalamus-pituitary-thyroid axis-related gene expression. …”
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The phoQ gene of Pseudomonas plecoglossicida influences the immune response in Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂ during infection by Meiqin Mao, Li He, Xiangyang Lin, Jianshao Wu, Zhixia Zhuang, Xiaoru Wang, Huabin Huang, Qingpi Yan

“…The deletion of the phoQ gene significantly affects the pathogenicity of P. plecoglossicida and enhances the host’s immune response, providing a theoretical basis for the potential application of the PhoP/PhoQ system in the immune defense of aquatic animals.…”
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Alcohol Dehydrogenase 4‐Mediated Retinol Metabolism Inhibits Hepatocellular Carcinoma Progression Through Inhibiting the Wnt/β‐Catenin Pathway by Jiaying Li, Mingshu Gao, Yanan Zhang, Dawen Liao, Feng Zhou, Zhaohui Zhang, Lele Ji, Yilin Zhao, Qichao Huang, Qian Bi, Nan Wang

“…In summary, our research elucidates that ADH4‐mediated RA production suppresses HCC growth, providing a theoretical foundation for HCC treatment.…”
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Construction and Influence of Induced Pluripotent Stem Cells on Early Embryo Development in Black Bone Sheep by Daqing Wang, Yiyi Liu, Lu Li, Xin Li, Xin Cheng, Zhihui Guo, Guifang Cao, Yong Zhang

“…The findings demonstrate that black-boned sheep iPSCs possess pluripotency and the potential to differentiate into all three germ layers, revealing the mechanisms by which reprogrammed iPSCs influence early embryonic development and providing a critical foundation for research on sheep pluripotent stem cells.…”
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Reduced apple crop density enhances total polyphenol accumulation via upregulation of anthocyanidin reductase and other phenylpropanoid pathway genes by Shanthanu Krishna Kumar, Kamal Tyagi, Michael Brown, Lailiang Cheng, Zhangjun Fei, Gregory Peck

“…Polyphenols contribute to the quality of hard cider fermented from apple (Malus ×domestica) juice by providing flavor, aroma, color, and microbial stability. …”
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Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche by Chenling Meng, Kevin Lin, Wei Shi, Hongqi Teng, Xinhai Wan, Anna DeBruine, Yin Wang, Xin Liang, Javier Leo, Feiyu Chen, Qianlin Gu, Jie Zhang, Vivien Van, Kiersten L. Maldonado, Boyi Gan, Li Ma, Yue Lu, Di Zhao

“…It establishes ASH1L as an epigenetic driver priming metastasis and macrophage plasticity in the bone niche, providing a bona fide therapeutic target in metastatic malignancies.…”
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Transcriptional landscape of the cell cycle in a model thermoacidophilic archaeon reveals similarities to eukaryotes by Miguel V. Gomez-Raya-Vilanova, Jérôme Teulière, Sofia Medvedeva, Yuping Dai, Eduardo Corel, Philippe Lopez, François-Joseph Lapointe, Debashish Bhattacharya, Louis-Patrick Haraoui, Elodie Turc, Marc Monot, Virginija Cvirkaite-Krupovic, Eric Bapteste, Mart Krupovic

“…To study whether and which other processes are cell cycle-coordinated, we synchronized cultures of S. islandicus and performed an in-depth transcriptomic analysis of samples enriched in cells undergoing the M-G1, S, and G2 phases, providing a holistic view of the S. islandicus cell cycle. …”
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Adaptive phenylpropanoid and flavonoid biosynthesis pathways of Agriophyllum squarrosum on the Qinghai-Xizang Plateau by Chaoju Qian, Xiaoyue Yin, Xia Yan, Xingke Fan, Shanshan Zhou, Tingzhou Fang, Yuxiao Chang, Xiao-Fei Ma

“…To elucidate the molecular mechanism of sandrice adaptation to the QXP, in situ metabolome and transcriptome analyses were conducted between high and mid-altitude ecotypes. …”
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Dual role of TLR4 in bacterial meningitis through regulating endothelial pyroptosis and inflammatory response during extraintestinal pathogenic Escherichia coli infection by Kaixiang Jia, Yangyang Du, Weixian Lin, Xuefeng Cao, Xuefeng Cao, Jialu Zhang, Jialu Zhang, Lianci Peng, Lianci Peng, Zhiwei Li, Zhiwei Li, Rendong Fang, Rendong Fang

“…This study demonstrates for the first time that endothelial pyroptosis is a novel mechanism for ExPEC-induced blood-brain barrier disruption and reveals the crucial role of TLR4 in balancing protective and destructive host responses, providing new insights for therapeutic strategies against bacterial meningitis.…”
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Abnormal α-synuclein binds to synaptotagmin 13, impairing extracellular vesicle release in synucleinopathies by Yasuo Miki, Shuji Shimoyama, Makoto T. Tanaka, Hanae Kushibiki, Asa Nakahara, Xiaopeng Wen, Masanori Hijioka, Tomoya Kon, Megha Murthy, Tomonori Furukawa, Conceição Bettencourt, Fumiaki Mori, Hiroki Mizukami, Shirushi Takahashi, Mari Tada, Yoshihisa Kitamura, Akiyoshi Kakita, Thomas T. Warner, Koichi Wakabayashi

“…Results Based on the transcriptome of the MSA mouse model, we identified 10 vesicular transport proteins, including synaptotagmin 13 (SYT13), that might interact with α-Syn. …”
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RNAPro•SAL: A device for rapid and standardized collection of saliva RNA and proteins by Samantha H. Chiang, Gerald A. Thomas, Wei Liao, Tristan Grogan, Robert L. Buck, Laurel Fuentes, Maha Yakob, Mary J. Laughlin, Chris Schafer, Abu Nazmul-Hossain, Fang Wei, David Elashoff, Paul D. Slowey, David T.W. Wong

“…The stabilization and processing of salivary transcriptome and proteome biomarkers is a critical challenge due to the ubiquitous nature of nucleases and proteases as well as the inherent instability of these biomarkers. …”
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Bioinformatic insights into sugar signaling pathways in sugarcane growth by Lauana Pereira de Oliveira, João Pedro de Jesus Pereira, Bruno Viana Navarro, Marina C. M. Martins, Diego Mauricio Riaño-Pachón, Marcos Silveira Buckeridge

“…We accessed the expression profile of sequences from one sugarcane transcriptome. We found the highest enzymatic activity of HXK in culms in the first month, which, at this stage, provides carbon (sucrose) and nitrogen (amino acids) for initial plant development. …”
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Comparison of sepsis-associated acute kidney injury with different degrees and causes reveals patterns in mitochondrial metabolism and immune infiltration changes by Nan Yuan, Jianwen Chen, Feng Luo, Zhenyu Fang, Mengjie Huang, Jiaona Liu, Xiangmei Chen, Congjuan Luo

“…Transcriptome analysis revealed that SA-AKI induces mitochondrial dysfunction and metabolic disturbances. …”
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SMARCB1 orchestrates cellular plasticity and oncogenic pathways in typical and chondroid chordomas by Weihai Liu, Moksada Regmi, Shikun Liu, Ying Xiong, Yuwei Dai, Yingjie Wang, Jun Yang, Chenlong Yang

“…SMARCB1 knockdown experiments were conducted in chordoma cell lines, followed by comprehensive transcriptome analysis. No exonic SMARCB1 mutations were identified, but heterozygous loss was observed in 3/26 typical chordomas. …”
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Feasibility of Bamboo Sawdust as Sustainable Alternative Substrate for <i>Auricularia heimuer</i> Cultivation by Ya-Hui Wang, Cong-Sheng Yan, Yong-Jin Deng, Zheng-Fu Zhu, Hua-An Sun, Hui-Ping Li, Hong-Yuan Zhao, Guo-Qing Li

“…Nutritional analysis revealed that 20–40% bamboo substitution significantly enhanced the contents of crude protein, polysaccharides, and essential minerals (calcium, iron, and selenium) in fruiting bodies. Transcriptome analysis identified upregulation of glycosyl hydrolase family genes and downregulation of redox-related genes with increasing bamboo proportions. …”
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Elucidating the molecular basis of salt tolerance in potatoes through miRNA expression and phenotypic analysis by Caicai Lin, Shuangshuang Zheng, Kui Liu, Ru Yu, Peiyan Guan, Baigeng Hu, Lingling Jiang, Mengyu Su, Guodong Hu, Qingshuai Chen, Xia Zhang

“…Regression equations established stem thickness, root length, and catalase activity as rapid identification markers for salt tolerance in tetraploid potatoes. Transcriptome analysis of the highly tolerant variety Z1076-1 identified 68 differentially expressed miRNAs (DE miRNAs). qRT-PCR validation for eight randomly selected DE miRNAs confirmed consistent expression trends with transcriptome data. …”
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Identification of gene signatures associated with lactation for predicting prognosis and treatment response in breast cancer patients through machine learning by Jinfeng Zhao, Longpeng Li, Yaxin Wang, Jiayu Huo, Jirui Wang, Huiwen Xue, Yue Cai

“…Single-cell analysis and spatial transcriptome revealed differential expression of the key genes in different cells. …”
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Identification and functional characterization of the RPP13 gene family in potato (Solanum tuberosum L.) for disease resistance by Baoqi Yuan, Chuang Li, Qingfeng Wang, Qi Yao, Xiaowei Guo, Yuhang Zhang, Zhongwei Wang

“…This study provides new insights into the potential functions of the RPP13 gene family in potato disease resistance mechanisms, offering valuable genetic resources and theoretical support for future disease-resistant breeding programs.…”
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Endogenous plasma resuspension of peripheral blood mononuclear cells prevents preparative-associated stress that modifies polyA-enriched RNA responses to subsequent acute stressors by Dongyang Li, Karina Al-Dahleh, Daniel A Murphy, Sonya Georgieva, Nik Matthews, Claire L Shovlin

“…Plasma-resuspended PBMCs demonstrated minor transcriptome changes after 40 μmol/L ferric citrate, whereas consistent and greater magnitude changes were observed for washed/media-resuspended PBMCs. …”
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The Role of <i>Aspergillus niger</i> in Regulating Internal Browning Involves Flavonoid Biosynthesis and the Endophytic Fungal Community of Pineapple by Fei Shen, Guang Wang, Shijiang Zhu

“…This work adds to the understanding of the IB mechanism in postharvest pineapple and provides a new green approach for reducing postharvest losses and controlling physiological diseases.…”
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