Transcriptional regulation of hormone signalling genes in black pepper in response to Phytophthora capsici by Chidambareswaren Mahadevan, K. Mohamed Shafi, B Nagarathnam, Manjula Sakuntala, Ramanathan Sowdhamini

“…Conclusions This comprehensive transcriptome analysis of P. nigrum response to P. capsici attack provides valuable insights into the plant defense mechanisms. …”
Get full text

Deciphering the role of acetylation-related gene NAT10 in colon cancer progression and immune evasion: implications for overcoming drug resistance by Xuancheng Zhou, Xun Sang, Lai Jiang, Shengke Zhang, Chenglu Jiang, Yuheng Gu, Yipin Fu, Guanhu Yang, Jieyin Zhang, Hao Chi, Binbin Wang, Xiaolin Zhong

“…Methods This study applied multi-omics analyses, including single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, and Mendelian randomization. Data were obtained from public datasets like GSE132465, UCSC Xena, and GeneCards. …”
Get full text

Hepatoprotective Effects of <i>Citri reticulatae</i> Pericarpium and <i>Chaenomelese speciosa</i> (Sweet) Nakai Extracts in Alcohol-Related Liver Injury: Modulation of Oxidative St... by Shuangshuang Ma, Lingtao Kang, Zhipeng Gao, Zhaoping Pan, Lvhong Huang, Jiaxu Chen, Yanfang Liao, Jiajing Guo, Fuhua Fu

“…These findings highlight that combinations of multiple fruit extracts exhibit significant potential in alleviating ALI by modulating the gut microbiota, providing valuable insights for the development of functional foods.…”
Get full text

Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression by Daphne Wijnbergen, Mridul Johari, Ozan Ozisik, Peter A.C. ‘t Hoen, Friederike Ehrhart, Anaïs Baudot, Chris T. Evelo, Bjarne Udd, Marco Roos, Eleni Mina

Get full text

Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts by Pamela González-Dávila, Markus Schwalbe, Arpit Danewalia, René Wardenaar, Boushra Dalile, Kristin Verbeke, Sushil K Mahata, Sahar El Aidy

Get full text

What Happens Inside the Germinating Grain After Microbial Decontamination by Pulsed Electric Field? Data-Driven Multi-Omics Helps Find the Answer by Milena Stranska, Adam Behner, Jaroslava Ovesna, Pavel Svoboda, Jana Hajslova

Get full text

Decoding SFRP2 progenitors in sustaining tooth growth at single-cell resolution by Tianyuan Zhao, Qing Zhong, Zewen Sun, Xiaoyi Yu, Tianmeng Sun, Zhengwen An

“…Abstract Background Single-cell transcriptomics has revolutionized tooth biology by uncovering previously unexplored areas. …”
Get full text

Thermal tipping points in mediterranean mussel adhesion: molecular mechanisms and mechanical consequences of heatwave on byssus production in Mytilus galloprovincialis by Antonina De Marco, Vito Antonio Baldassarro, Corinne Quadalti, Valentina Burato, Laura Calzà, Luciana Giardino, Devis Montroni, Giuseppe Falini, Gabriela Graziani, Nicolas Greggio, Francesco Dondi, Maria Giulia Ferrari, Pier Paolo Gatta, Luca Parma, Alessio Bonaldo

Get full text

CD28 is superior to 4-1BB costimulation in generating CAR-NK cells for tumor immunotherapy by Pengchao Zhang, Xuejia Feng, Xiangyun Niu, Zhongming Liu, Minghui Li, Maoxuan Liu, Dehong Yan, Guizhong Zhang, Xiaochun Wan

Get full text

Differential gene expression in neonatal calf muscle tissues from Hanwoo cows overfed during mid to late pregnancy period by Borhan Shokrollahi, Myungsun Park, Youl-Chang Baek, Shil Jin, Gi-Suk Jang, Sung-Jin Moon, Kyung-Hwan Um, Sun-Sik Jang, Hyun-Jeong Lee

Get full text

Genome wide identification and characterization of EPFL genes and its potential association with male sterility in Brassica rapa by Kang Wang, Yongkang Wang, Xiaoyan Tang, Na Liao, Danni Yang, Wenjie Wang, Lingyun Yuan, Jinfeng Hou, Jianqiang Wu, Chenggang Wang, Guohu Chen

Get full text

Thallium-induced neurocardiotoxicity in zebrafish: Protective role of adaptive UPR and DNA repair by Yung Chang, Chia-Hsien Wu, Jia-Huang Chen, Tsuyoshi Inoue, Chih-Kang Chiang

“…Our results show that Tl exposure increases mortality, reduces hatching rates, impairs swim bladder development, and causes pericardial edema and brain abnormalities. Transcriptomic and qPCR analyses confirm that Tl induces endoplasmic reticulum (ER) stress and activates the unfolded protein response (UPR), key pathways involved in cellular toxicity. …”
Get full text

Host cellular transcriptional response to respiratory syncytial virus infection in HEp-2 cells: insights from cDNA microarray and quantitative PCR analyses by Manoj K. Pastey, Christopher Lupfer

“…The proinflammatory cytokine interleukin-6 was elevated ~7-fold, underscoring the inflammatory response to RSV. These findings provide a global snapshot of the host transcriptomic response to RSV infection and yield insights into how RSV modulates host cellular machinery to favor viral replication and spread. …”
Get full text

Spatial relationships and interactions of immune cell niches are linked to the pathologic response of muscle-invasive bladder cancer to neoadjuvant therapy by Wasilijiang Wahafu, Quan Zhou, Xihua Yang, Yongming Yang, Yuanyuan Zhao, Zhu Wang, Xiangpeng Kang, Xiongjun Ye, Nianzeng Xing

“…Methods We performed spatial transcriptomic profiling on six MIBC specimens obtained from a registered clinical trial (ChiCTR2000032359), generating whole-transcriptome spatial atlases to map the TME architecture. …”
Get full text

A Non-Specific Phytohormone Regulatory Network in <i>Saccharina japonica</i> Coordinates Growth and Environmental Adaptation by Jiexin Cui, Jinli Zhu, Yinru Dai, Jincheng Yuan, Wen Lin, Tao Liu

“…We also identified 12 phytohormones, such as gibberellin A1, methyl jasmonate, and trans-zeatin for the first time in <i>S. japonica</i>. Transcriptomic profiling revealed the tissue-specific expression of phytohormone biosynthesis genes, such as <i>CYP735A</i> (CTK synthesis), in the rhizoids and <i>LOX/NCED</i> (JA/ABA synthesis) in the tips. …”
Get full text

Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain by Michaela Berankova, Jiri Holoubek, Vaclav Hönig, Zuzana Matusova, Martin Palus, Jiri Salat, Imtissal Krayem, Jarmila Vojtiskova, Pavel Svoboda, Veronika Pranclova, Lukas Valihrach, Peter Demant, Marie Lipoldova, Daniel Ruzek

“…In addition, brains from these TBEV-infected mouse strains underwent in-depth transcriptomic analysis. Results Virus production in BALB/c and CcS-11 macrophages exhibited similar kinetics 24 and 48 h post-infection (hpi), but CcS-11 macrophages yielded significantly higher titers 72 hpi. …”
Get full text

Amniotic fluid-derived mesenchymal stem cells as a therapeutic tool against cytokine storm: a comparison with umbilical cord counterparts by Salvatore Vaiasicca, David W. James, Gianmarco Melone, Omar Saeed, Lewis W. Francis, Bruna Corradetti

“…Mesenchymal stem cells (MSCs) from different sources have been considered for their potential to attenuate the cytokine storm associated to COVID-19 and the consequent multi-organ failure, providing evidence for safe and efficacious treatments. …”
Get full text

Subtype-specific analysis of gene co-expression networks and immune cell profiling reveals high grade serous ovarian cancer subtype linkage to variable immune microenvironment by Kaylin M. Carey, Corey D. Young, Alexis J. Clark, Eric B. Dammer, Rajesh Singh, James W. Lillard

“…Additionally, we utilized TIMER 2.0 to assess immune cell infiltration across different HGSOC subtypes, providing insights into the interplay between tumor immune microenvironment (TIME). …”
Get full text

An integrated approach for analyzing spatially resolved multi-omics datasets from the same tissue section by Thao Tran, Felicia Wee, Craig Ryan Joseph, Wanqiu Zhang, Jeffrey Chun Tatt Lim, Zhen Wei Neo, Li Yen Chong, Francis Hong Xin Yap, Nathan Heath Patterson, Marc Claesen, Alice Ly, Joe Yeong, Joe Yeong, Joe Yeong

“…Recent advances in spatial transcriptomics (ST) and spatial proteomics (SP) technologies have enabled high-dimensional molecular profiling at single-cell resolution, providing deeper insights into the tumour-immune microenvironment. …”
Get full text

Predicting Treatment Outcomes in Patients with Low Back Pain Using Gene Signature-Based Machine Learning Models by Youzhi Lian, Yinyu Shi, Haibin Shang, Hongsheng Zhan

“…Methods The transcriptomic data of patients with LBP from peripheral immune cells were retrieved from the GEO database. …”
Get full text