Electron-beam FLASH whole brain irradiation induced a unique changes of intestinal flora by Feifei Gao, Wei Cheng, Yanxi Ma, Boyi Yu, Xinle Lang, Xiaodong Jin, Jianxin Wang, Xianhong Liu, Cuixia Di, Hui Wang, Fei Ye, Ting Zhao, Weiqiang Chen, Qiang Li

“…Conclusions In summary, we explored the unique gut microbiota changes induced by eFLASH WBRT for the first time, providing a theoretical basis for exploring the mechanism of action of FLASH.…”
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Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the 5xFAD transgenic mouse model by Mingfeng Li, Xinghan Wu, Lin Jiang, Min Liu, Gong Yanju, Xiaomeng Li, Fan Tian, Fan Ye, Jinlong Wang, Siyuan Wang, Chuan Qin, Ling Zhang

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The intensity of the transcriptional response varies across infection with distinct viral strains in an insect host by Allyson M. Ray, Anja Tehel, Jason L. Rasgon, Robert J. Paxton, Christina M. Grozinger

“…While previous research has characterized general host transcriptomic responses to viral exposure, host responses to different DWV strains have not been fully explored. …”
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Mechanisms of three typical endocrine-disrupting chemicals causing myocardial infarction: Gene-level computational modeling by Jing-Xuan Zhou, Shan-Shan Chen, Zi-Yi Zheng, Wang-Bo Yuan, Xiong-Bo Liu, Hong-Gang Ni

“…Molecular dynamics simulations and DFT further validated the stable binding of EDCs to target proteins and their potential effects on cardiomyocyte function. This study provides a new insight into the molecular mechanism of EDCs in MI, and provides a theoretical basis for the prevention of cardiovascular diseases and environmental toxicology research.…”
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Synchronous bacterial barrier and exudate absorption: A novel dual-function dressing strategy for pin-site infection prevention by Bing Liang, Sha Zhou, Linyuan Xue, Qizun Wang, Qianqian Li, Zihan Zheng, Xinyue Ma, Jiyixuan Li, Li Sun, Kunyue Xing, Xiaobo Wen, Xiaolin Wu, Miao Zhang, Dongming Xing

“…This innovative design provides a versatile platform for infection control and personalized wound care, with broad implications for treating open wounds in orthopedic and other invasive device scenarios.…”
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Progress on omics studies of chronic thromboembolic pulmonary hypertension by DUAN Wenxin, SONG Wanlu, YANG Peiran, WANG Jing

“…In recent years, multi-omics technologies have provided multidimensional insights into CTEPH. Single-cell transcriptomics has identified key pathogenic cell subsets and related mechanisms; Genomics has revealed susceptibility genes associated with coagulation; Proteomics has uncovered differentially expressed proteins closely linked to vascular remodeling; And metabolomics has characterized metabolic reprogramming features and potential sub-typing biomarkers. …”
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Intrinsic Gene Expression Correlates of the Biophysically Modeled Diffusion Magnetic Resonance Imaging Signal by Ajay P. Singh, Michael Fromandi, Daniel Pimentel-Alarcón, Donna M. Werling, Audrey P. Gasch, John-Paul J. Yu

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Carbon dots induce endoplasmic reticulum stress-mediated lipid dysregulation and embryonic developmental toxicity in zebrafish by Xiaoyan Zhong, Liwen Zeng, Yunnuo Cai, Ying Zhu, Qiyao Ma, Ouxi Shen, Xiaoyao Song, Jie Zhang

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Coordinated gene expression and hormonal fluxes dictating ginsenoside Rb3 biosynthesis in floral development of Panax notoginseng by Can Wang, Hongwei Sun, Yuling Yang, Cuixian Peng, Yuan Liu, Yonghong Tao

“…Conclusions These findings provide insights into the complex gene networks and molecular pathways that regulate ginsenoside biosynthesis, thereby promoting the medicinal properties of PN.…”
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The Alleviating Effect of Arginine on Ethanol Stress in <i>Wickerhamomyces anomalus</i> by Yinfeng Li, Yujie Wang, Shuangyan Liu, Guilan Jiang, Mingzheng Huang, Xiaozhu Liu

“…These findings provide intriguing insights into the mechanistic role of arginine in enhancing the tolerance of <i>W. anomalus</i> to ethanol stress, and broaden its application in the fermentation industry for alcoholic beverages.…”
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Modulation of neural activity and gene expression by arecoline by Xiaonan Li, Jie Gao, Xiaomin Liu, Jianfeng Guo, Yifan Liu, Peicai Cui, Dawei Yan, Ting Fei, Ming Chen, Yihan Gao

“…These results provide valuable insights into the addictive potential of arecoline and its underlying neurobiological mechanisms, offering crucial information for understanding its broader impact on CNS function. …”
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Integrated Multi-Omics Analysis of the Developmental Stages of <i>Antheraea pernyi</i> Pupae: Dynamic Changes in Metabolite Profiles and Gene Expression by Shuhui Ma, Yongxin Sun, Yajie Li, Xuejun Li, Zhixin Wen, Rui Mi, Nan Meng, Xingfan Du

“…This study integrated non-targeted metabolomics and transcriptomics to investigate dynamic changes in <i>Antheraea pernyi</i> pupae across five developmental stages. …”
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Identification and Characterization of Three Novel Iflaviruses in the Cabbage Whitefly <i>Aleyrodes proletella</i> by Zhuang-Xin Ye, Guo-Wei Gu, Peng-Peng Ren, Chuan-Xi Zhang, Jun-Min Li, Yan Zhang, Jian-Ping Chen

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The Response Characteristics of One <i>Saccharomyces cerevisiae</i> Strain Under Continuous Passage in Artificial Culture Medium by Tengyu Ma, Hongguang Zhu, Jiajia Yin, Yu Tian, Wenjing Yan, Haixin Sun

“…Subsequently, the changes in intergenerational biological traits after serial subculturing were investigated. Finally, transcriptomic analysis was employed to examine differential gene expression under high-glucose stress during continuous subculturing. …”
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ABA-GA antagonism and modular gene networks cooperatively drive acquisition of desiccation tolerance in perilla seeds by Xiaohuan Yang, Minghao Chen, Mingwang Liu, Mingwang Liu, Bowen Li, Zhichao Sun, Ailian Lu, Sen Zhang, Xinghai Shi, Jun Ren, Xiuzhen Qin, Jinhu Ma

“…Using WGCNA, we correlated these DEGs with physiological traits to identify key modules.ResultsWe identified the D17-D27 stage as the critical window for DT acquisition in perilla seeds. Transcriptome analysis revealed 14,040 DEGs across different developmental stages. …”
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A Knowledge‐Guided Graph Learning Approach Bridging Phenotype‐ and Target‐Based Drug Discovery by Qing Ye, Yundian Zeng, Linlong Jiang, Yu Kang, Peichen Pan, Jiming Chen, Yafeng Deng, Haitao Zhao, Shibo He, Tingjun Hou, Chang‐Yu Hsieh

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Blood from septic patients with necrotising soft tissue infection treated with hyperbaric oxygen reveal different gene expression patterns compared to standard treatment by Julie Vinkel, Alfonso Buil, Ole Hyldegaard

“…Conclusion The global gene expression pattern in blood changed in response to HBO2 treatment in a direction associated with clinical biochemistry improvement, and the study provides potential novel biomarkers and pathways for monitoring HBO2 treatment effects and predicting an HBO2 responsive NSTI-sepsis profile. …”
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Differential Expression Analyses on Human Aortic Tissue Reveal Novel Genes and Pathways Associated With Abdominal Aortic Aneurysm Onset and Progression by Gerard Temprano‐Sagrera, Olga Peypoch, Begoña Soto, Jaume Dilmé, Laura Calsina Juscafresa, David Davtian, Mireia de la Rosa Estadella, Lluís Nieto, Andrew Brown, José Román Escudero, Ana Viñuela, Mercedes Camacho, Maria Sabater‐Lleal

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Integrated analysis of tyrosine-induced MiRNA and mRNA expression profiles in melanocytes reveals the regulatory role of miR-1560-3p in melanin deposition in Xichuan black-bone chi... by Zhiyuan Zhang, Pengwei Zhang, Fumin He, Yingdong Hou, Xiaowen Geng, Ruilong Xu, Ruiting Li, Yadong Tian, Wenting Li, Guirong Sun, Ruirui Jiang, Xiaojun Liu, Ruili Han, Guoxi Li, Xiangtao Kang, Donghua Li

“…The results of this study provide experimental evidence for elucidating the mechanism of tyrosine in melanin deposition in black-bone chickens, and may serve as a reference for future investigations.…”
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Shared transcriptional regulators and network rewiring identify therapeutic targets linking type 2 diabetes mellitus and hypertension by Claudia Desireé Norzagaray-Valenzuela, Claudia Desireé Norzagaray-Valenzuela, Marco Antonio Valdez-Flores, Josue Camberos-Barraza, Josue Camberos-Barraza, Alberto Kousuke De la Herrán-Arita, Juan Fidel Osuna-Ramos, Javier Magaña-Gómez, Carla Angulo-Rojo, Alma Marlene Guadrón-Llanos, Katia Aviña-Padilla, Loranda Calderón-Zamora

“…This study aimed to uncover shared transcriptional programs and disease-specific regulatory networks contributing to cardiometabolic dysfunction.MethodsWe systematically selected transcriptomic datasets and employed an integrative systems biology approach that combined differential gene expression analysis, co-expression network construction, protein-protein interaction mapping, transcription factor activity inference, and network rewiring analysis. …”
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