Gene expression profiling of patient‐derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine effort... by Benjamin Bian, Martin Bigonnet, Odile Gayet, Celine Loncle, Aurélie Maignan, Marine Gilabert, Vincent Moutardier, Stephane Garcia, Olivier Turrini, Jean‐Robert Delpero, Marc Giovannini, Philippe Grandval, Mohamed Gasmi, Mehdi Ouaissi, Veronique Secq, Flora Poizat, Rémy Nicolle, Yuna Blum, Laetitia Marisa, Marion Rubis, Jean‐Luc Raoul, James E Bradner, Jun Qi, Gwen Lomberk, Raul Urrutia, Andres Saul, Nelson Dusetti, Juan Iovanna

“…Therefore, these results provide new markers and potentially novel therapeutic modalities for distinct subgroups of pancreatic tumors and may find application to the future management of these patients within the setting of individualized medicine clinics.…”
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HebQTLs reveal intra-subgenome regulation inducing unbalanced expression and function among bread wheat homoeologs by Xiaoming Wang, Yuxiu Liu, Peng Zhao, Wenyang Hou, Mingzhu Cheng, Xue Shi, James Simmonds, Philippa Borrill, Xiaojie Wang, Wanquan Ji, Shengbao Xu

“…Results Here we uncover substantial variation in homoeolog expression bias among the root transcriptomes of a natural population of 406 bread wheat (Triticum aestivum ssp. aestivum) accessions collected worldwide. …”
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Dual-omics analysis reveals B vitamin regulation and metabolism in Areca Catechu inflorescence by Wenxiu Jiang, Xiaoxia Liu, Weiying Li, Jing Yang, Panjing Li, Minggeng Xie, Guangzhen Zhou

“…Additionally, integrated transcriptomic and targeted metabolomic analyses revealed hub transcription factors, including AcNAC73, AcMYB61, and AcARF9, that are associated with the regulation of pantothenic acid and thiamine metabolism. …”
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Comparative omics analysis of the impact of Mycoplasma synoviae infection on the immune mechanisms of poultry spleen by Lemiao Zhong, Chunlin Wu, Lvyan Liao, Jian Li, Yijian Wu

“…Building on preliminary findings related to the tissue damage and inflammatory responses in chicken spleens caused by MS infection, this study further utilizes transcriptomic and proteomic technologies to thoroughly investigate the comprehensive effects of MS infection on the chicken spleen. …”
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Genome-wide scanning for candidate lethal genes associated with early embryonic mortality in Holstein dairy cattle by Somaye Rezaei, Abdol Ahad Shadparvar, Hasan Baneh, Shahrokh Ghovvati

“…Transcriptome analysis showed that these genes are steadily expressed in the various embryonic tissues during different stages of embryo development, and therefore were considered as the potential candidate lethal genes. …”
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A novel cancer-associated membrane signature predicts prognosis and therapeutic response for lung adenocarcinoma by Biao Tu, Jun Wu, Wei Zhang, Haitao Tang, Tenghui Dai, Bingfeng Xie

“…We integrated scRNA-seq, spatial transcriptomics, and bulk RNA-seq datasets from multiple LUAD cohorts to identify cancer-specific membrane proteins derived from epithelial subpopulations. …”
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Assessing the Tolerance of Spotted Longbarbel Catfish as a Candidate Species for Aquaculture to Ammonia Nitrogen Exposure by Song Guo, Linwei Yang, Xiaopeng Xu

“…These findings highlight the comprehensive negative impacts of ammonia-N on the health of the spotted longbarbel catfish and provide a theoretical basis for optimizing aquaculture conditions to support the sustainable protection and domestication of the spotted longbarbel catfish.…”
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Linalool exhibit antimicrobial ability against Elizabethkingia miricola by disrupting cellular and metabolic functions by Mingwang He, Weiming Zhong, Rongsi Dai, Su Long, Ying Zhou, Tongping Zhang, Boyang Zhou, Tao Tang, Linlin Yang, Sifan Jiang, Wenbin Xiao, YanJiao Fu, Jiajing Guo, Zhipeng Gao

“…Taken together, these findings provide a theoretical basis for the antibacterial mechanism of linalool and suggest potential applications for preventing E. miricola infections.…”
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Systemic immune response alteration in patients with severe pressure ulcers by Lucía Tejero Peña, Andrea Escolar-Peña, Ricardo Arroyo Solera, Luis Senador Zaldívar Martínez, Osvaldo Graña Castro, Carlos Tarín Cerezo, María M. Escribese, José Barberán López, Tomás Chivato Pérez, Xavier Santos Heredero, Juan Carlos López-Rodríguez, Paloma Fernández Martínez

“…Here, we performed a serum proteomic and transcriptomic profiling of 54 patients with PUs ranging from grade II to grade III-IV. …”
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Molecular mechanisms underlying leaf enlargement in spaceflight-mutated ‘Deqin’alfalfa by Qian Kuang, Rui Ding, Die Huang, Chenggang He, Hua Jiang

“…Results Integrated transcriptomic, targeted phytohormone metabolomic, and microstructural analyses were used to reveal the mechanistic basis of leaf enlargement in the mutant. …”
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Machine learning-based transcriptmics analysis reveals BMX, GRB10, and GADD45A as crucial biomarkers and therapeutic targets in sepsis by Yanwei Cheng, Haoran Peng, Qiao Chen, Lijun Xu, Lijie Qin

“…This study leverages transcriptomics and machine learning (ML) to identify critical biomarkers and therapeutic targets in sepsis. …”
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Analysis of the molecular mechanism endogenous hormone regulating axillary bud development in Pinus yunnanensis by Haihao He, Junfei Xu, Nianhui Cai, Yulan Xu

“…Subsequently, we assessed the phytohormone levels in both axillary and apical buds, and conducted a comprehensive transcriptomic analysis complemented by RT-qPCR validation. …”
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Response mechanism of Saccharomyces cerevisiae under benzoic acid stress in ethanol fermentation by Long Xiu-Feng, Xu Yu-Lei, Zhao Xue-Mei

“…In conclusion, this paper provides important insights into the mechanism underlying the toxicity of benzoic acid to yeast cells and for realizing high-concentration ethanol production by sugarcane molasses fermentation.…”
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Disease-resistant watermelon variety against Fusarium wilt by remodeling rhizosphere soil microenvironment by Bingye Yang, Caipeng Yue, Chunhui Guo, Mingzi Zheng, Xiefeng Yao, Jinhua Xu, Sijie Huang, Mengmeng Yang

“…Results In this study, the transcriptome of different watermelon varieties after continuous planting in pathogen-containing and pathogen-free soils was analyzed. …”
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Advancing omics technologies in acute respiratory distress syndrome: paving the way for personalized medicine by Lou’i Al-Husinat, Mohammad Araydah, Sarah Al Sharie, Saif Azzam, Denise Battaglini, Arqam Alrababah, Rana Haddad, Khaled Al-Asad, Claudia C. Dos Santos, Marcus J. Schultz, Fernanda F. Cruz, Pedro L. Silva, Patricia R. M. Rocco

“…However, recent advances in omics technologies, including genomics, transcriptomics, proteomics, metabolomics, lipidomics, and epigenomics, have provided deeper insights into ARDS mechanisms. …”
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Sex-specific differential gene expression during stolonization in the branching syllid Ramisyllis kingghidorahi (Annelida, Syllidae) by Guillermo Ponz-Segrelles, Thilo Schulze, Kohei Oguchi, Daisuke S. Sato, Mayuko Nakamura, Yoshinobu Hayashi, Christopher J. Glasby, Toru Miura, M. Teresa Aguado

“…Results Transcriptomes were assembled from different body regions (anterior end, midbody, and stolons) of male, female, and non-reproductive individuals. …”
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Identification of progression-related genes and construction of prognostic model for chronic kidney disease by machine learning by Bingkun Zhou, Hu Zhou, Xiaodong Huang, Shijie Liu

“…A high degree of similarity between mouse CKD and human CKD in KEGG enrichment was observed in the mouse unilateral ureteral obstruction model, and the core genes related to the occurrence and progression of human CKD remained diagnostically valuable in mice.ConclusionThis study provides a transcriptomics-based risk prediction model for the occurrence and development of CKD based on machine learning, offering potential target genes for the further experimental research of CKD.…”
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Taurine-mediated metabolic immune crosstalk indicates and promotes immunosuppression with anti-PD-1 resistance in bladder cancer by Zhengfang Liang, Fengwei Nong, Fengwei Nong, Zhenjie Li, Runmin Chen, Haoxu Zhao, Yongping Huang, Yongping Huang

“…Deciphering the molecular mechanisms by which TM reprogramming fosters immunosuppression is imperative for advancing BLCA immunotherapy.MethodsThis study employed an integrative approach combining single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (ST), and bulk transcriptome analyses to unravel taurine metabolic dysregulation in the BLCA TME. …”
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Probiotic efficacy and mechanism of a pigeon derived Ligilactobacillus salivarius strain in promoting growth and intestinal development of pigeons by Puze Zhao, Yumei Li, Yuwei Yang, Qingxing Xiao, Ziyi Zhang, Xiaoqing Hong, Hongyu Ni, Zhuxuan Xia, Kun Zhan, Sibao Yang, Yonghong Zhang

“…Transcriptomic profiling of the ileum revealed 1828 differentially expressed genes (DEGs) between CG and MG. …”
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Toxoplasma gondii-induced host’s high secretion of 25-hydroxycholesterol for immunoprotection by Zi-Han Yang, Wei-Ling Wu, Jia-Jia Zheng, Chi Zhang, Ying-Ying Lu, Hong-Juan Peng

“…These findings highlight the central role of cholesterol metabolism in T. gondii pathogenesis and provide innovative strategies for the diagnosis, prevention, and treatment of toxoplasmosis. …”
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