Human brain single-cell data reveal shared synaptic dysfunction and immune abnormality in epilepsy and Alzheimer′s disease by YU Xiaolin, ZHANG Erning, SHA Longze

“…The results of research provide a theoretical support for further elucidating their comorbidity mechanisms and developing targeted therapeutic strategy.…”
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Stress-induced premature senescence in high five cell cultures: a principal factor in cell-density effects by Rui Min, Dahe Zhang, Mingzhe He, Jingyuan Chen, Xiaoping Yi, Yingping Zhuang

“…This study aimed to explore the mechanisms of the cell density effect through time-series analysis of transcriptomes and proteomes, with the goal of overcoming or alleviating the decline in productivity caused by increased cell density. …”
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Peptide Toxin Diversity and a Novel Antimicrobial Peptide from the Spider <i>Oxyopes forcipiformis</i> by Kexin Wang, James Mwangi, Kaixun Cao, Yi Wang, Jinai Gao, Min Yang, Brenda B. Michira, Qiumin Lu, Juan Li

“…This study presents a transcriptome analysis of venom glands from an undescribed <i>Oxyopes forcipiformis</i> species, revealing 339 putative protein and peptide toxin sequences categorized into seven functional groups. …”
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Adaptation of Diqing Tibetan pigs to hypoxic and cold environments through extramedullary hematopoiesis and uncoupled thermogenesis in the liver by Xinpeng Li, Xinxing Dong, Shuhong Zhao, Yunlong Ma, Siqi Jin, Chunlu Zhou, Yi Lan, Shuyuan Luo, Bin Ni, Hongjiang Wei, Dawei Yan

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Validation of Senescence of the Role of ATM/P53 Pathway in Myocardial Senescence in Mice with Sepsis by Yan Z, Shi X, Ding R, Xia F, Du Y, Wang X, Peng Q

“…Targeting DDR pathways, as demonstrated by KU60019 treatment, provides novel insights into the role of cellular senescence in severe sepsis and its potential therapeutic implications for improving cardiovascular prognosis in septic patients.Keywords: sepsis-induced myocardial dysfunction, cell senescence, transcriptome, key genes, database, ATM/P53 pathway…”
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Toxicity of Flonicamid to <i>Diaphorina citri</i> (Hemiptera: Liviidae) and Its Identification and Expression of Kir Channel Genes by Jiangyue Zhu, Xinjing Wang, Yunfei Mo, Beibei Wu, Tuyong Yi, Zhongxia Yang

“…The analysis of the transcriptomes revealed 345 differentially expressed genes (DEGs) in <i>D. citri</i> adults subjected to different treatments. …”
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Genetic and molecular insights into tiller development and approaches for crop yield improvement by Zaid Chachar, Xiaoming Xue, Junteng Fang, Ming Chen, Weiwei Chen, Xuhui Li, Nazir Ahmed, Sadaruddin Chachar, Aamir Ali, Zhong liang Chen, Lina Fan, Ruiqiang Lai, Yongwen Qi

“…Additionally, transcriptome analyses have offered a dynamic view of gene expression, shedding light on molecular regulatory mechanisms that govern tillering. …”
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Alterations in neutrophil mRNA profiles in multiple sclerosis and identification of candidate genes for further investigation by Huining Zhang, Huining Zhang, Huining Zhang, Ruoyi Guo, Ruoyi Guo, Ruoyi Guo, Yusen Han, Yusen Han, Yusen Han, Zhichao Yao, Zhichao Yao, Zhichao Yao, Moyuan Quan, Moyuan Quan, Moyuan Quan, Bin Li, Bin Li, Bin Li, Li Guo, Li Guo, Li Guo

“…Protein-level validation using ELISA confirmed elevated levels of LCN2, ELANE, CAMP, and CTSG, consistent with transcriptomic findings, further supporting their role as biomarkers. …”
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Transcriptomic and physiological analyses revealed the effects of exogenous MeJA on the antioxidant system and hormone signaling network in apple roots (Malus baccata L.) in respon... by Ping Dai, Yilu Zhao, Aiguo Wang, Huafeng Li, Deguo Lyu, Huaiyu Ma

“…The purpose of this work was to explore the potential regulating mechanisms of jasmonate signal in M. baccata roots in response to suboptimal low root-zone temperature stress (5 ± 0.5 °C for 2 h) through transcriptome and physiological analysis. Transcriptome bioinformatics analyses demonstrated that 2285 differentially expressed genes (DEGs) were predominantly associated with the jasmonates biosynthesis, hormone signaling pathways, MAPK signaling, and glutathione metabolism. …”
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Multi-Omics Joint Analysis of Molecular Mechanisms of Compound Essential Oils Inhibiting Spoilage Yeast in Paocai by Xinyi Wu, Zhiyan Zhu, Hao Tian, Li Liu, Xuerui Li, Jun Pan, Yifan Hu, Zhirui Niu, Hanmo Wang, Xiuwei Liu

“…The results of this study provided new insights into the mechanism of <i>P. manshurica</i> inhibition by CEOs, and provide a reference basis for the development of food-related bacteriostatic agents by CEOs.…”
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The genetic puzzle of multicopy genes: challenges and troubleshooting by Vania Gabriela Sedano Partida, Henrique Moura Dias, Maria Teresa Portes, Marie-Anne Van Sluys

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Fantastic genes and where to find them expressed in CHO by Markus Riedl, Caterina Ruggeri, Nicolas Marx, Nicole Borth

“…Individual datasets, however, do not provide a comprehensive overview and characterization of the CHO cell's transcriptome, such that the fundamental structure of the transcriptome remains unknown. …”
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Mining of Candidate Genes and Developing Molecular Markers Associated with Pokkah Boeng Resistance in Sugarcane (<i>Saccharum</i> spp.) by Haidong Lin, Zhengjie Jiang, Tuan He, Guomeng Li, Mengyu Zhao, Liangyinan Su, Jihan Zhao, Chengwu Zou, Xiping Yang

“…Breeding sugarcane varieties resistant to PB has become a priority, and the mining of PB resistance genes and the development of molecular markers provide a solid foundation for this purpose. This work comprehensively analyzes the genetic components of sugarcane’s resistance to PB using transcriptome sequencing. …”
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Characterization of Mucosal Immune-Related lncRNAs and mRNAs in a Mouse Model of Allergic Conjunctivitis by Zhang H, Zhang H, Leng Q, Zheng YJ

“…These findings underscore the unique involvement of mucosal immunity in AC and provide potential new targets for immune modulation in ocular allergy treatment.Keywords: allergic conjunctivitis, lncRNA, transcriptomic analysis, immune-related genes…”
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SMORE: spatial motifs reveal patterns in cellular architecture of complex tissues by Zainalabedin Samadi, Kai Hao, Amjad Askary

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Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease by Zachery D. Morrissey, Zachery D. Morrissey, Zachery D. Morrissey, Pavan Kumar, Trongha X. Phan, Mark Maienschein-Cline, Alex Leow, Alex Leow, Orly Lazarov

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Multi-omics profiling of cross-resistance between ceftazidime-avibactam and meropenem identifies common and strain-specific mechanisms in Pseudomonas aeruginosa clinical isolates by Bartosz J. Bartmanski, Anja Bösch, Steven Schmitt, Niranjan R. Ireddy, Qun Ren, Jacqueline Findlay, Adrian Egli, Maria Zimmermann-Kogadeeva, Baharak Babouee Flury

“…Altogether, our study provides insights into the molecular response of P. aeruginosa to CZA and MEM and informs therapeutic interventions, suggesting that CZA could still be effective for patients infected with MEM-resistant pathogens.…”
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Mapping Cell Identity from scRNA-seq: A primer on computational methods by Daniele Traversa, Matteo Chiara

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Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation by Steven J. Kunnen, Giulia Callegaro, Jeffrey J. Sutherland, Panuwat Trairatphisan, Hugo W. van Kessel, Lukas S. Wijaya, Git Chung, Keith Pye, Keith M. Goldstein, Claire R. Teague, Ciaran P. Fisher, Julio Saez-Rodriguez, Colin Brown, Susan A. Elmore, Kathleen M. Heinz-Taheny, James L. Stevens, Bob van de Water

“…Summary: Toxicogenomic data provide key insights into molecular mechanisms underlying drug-induced organ toxicities. …”
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Multi-omics insights into biomarkers of breast cancer associated diabetes: a computational approach by Tamizhini Loganathan, C. George Priya Doss

“…We reanalyzed transcriptomic data by stratifying BC patients with and without diabetes into two cohorts, identifying 3,245 DEGs in AA and 3,208 DEGs in EA, with 786 genes commonly altered between both groups. …”
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