A comparative genomic study across 396 liver biopsies provides deep insight into FGF21 mode of action as a therapeutic agent in metabolic dysfunction‐associated steatotic liver dis... by Shifang Tang, Jürgen Borlak

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Enhancement of body red coloration in juvenile spotted scat (Scatophagus argus) by dietary supplementation with Lianjiang red orange peels as a natural carotenoid source by Tong Han, Yongguan Liao, Lei Yang, Xinyi Li, Gang Shi, Dong-Neng Jiang, Chunhua Zhu, Chunhua Zhu, Guangli Li, Hongjuan Shi

“…This study enhances body coloration by influencing carotenoid and pteridine pigment deposition, and provides theoretical guidance for aquaculture practices involving spotted scat.…”
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Transcriptome analysis of H2O2-treated wheat seedlings reveals a H2O2-responsive fatty acid desaturase gene participating in powdery mildew resistance. by Aili Li, Rongzhi Zhang, Lei Pan, Lichuan Tang, Guangyao Zhao, Mingzhu Zhu, Jinfang Chu, Xiaohong Sun, Bo Wei, Xiangqi Zhang, Jizeng Jia, Long Mao

“…Together, our data presents the first global picture of the wheat transcriptome under H(2)O(2) stress and uncovers potential links between H(2)O(2) and Bgt responses, hence providing important candidate genes for the PM resistance in wheat.…”
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Integrated analysis of microbiome and transcriptome reveals the mechanisms underlying the chlorogenic acid-mediated attenuation of oxidative stress and systemic inflammatory respon... by Zhaoying Hu, Lianchi Wu, Yujie Lv, Chaoyue Ge, Xinyu Luo, Shenao Zhan, Weichen Huang, Xinyu Shen, Dongyou Yu, Bing Liu

“…The optimal dose of CGA is 400 mg/kg in this experiment. These results provide a sound theoretical basis for the application of CGA as an exogenous animal feed additive for laying hens.…”
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Transcriptomic analysis of laser-capture microdissected tumors reveals RAD51AP1 as a tumor-specific marker associated progression from pancreatic intraepithelial neoplasia to invas... by Fereshteh Rezagholizadeh, Adel Salimi, Ali Sharifi-Zarchi, Farid Azmoudeh-Ardalan, Kazem Mousavizadeh, Fatemeh Tajik, Mahshid Panahi, Hossein Khorramdelazad, Masoud Baghai Wadji, Atefeh Kashanizadeh, Alireza Lotfalizadeh, Seyed Javad Mowla, Mohammad Taghi Joghataei

“…Methods This issue was addressed through a comprehensive in-silico analysis of laser-capture microdissected (LCM) pure tumor epithelial cells from transcriptomic PDAC cohort datasets, with survival outcomes further validated using TCGA. …”
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Transcriptome Analysis of Rice Near-Isogenic Lines Inoculated with Two Strains of <i>Xanthomonas oryzae</i> pv. <i>oryzae</i>, AH28 and PXO99^A by Pingli Chen, Xing Zhang, Xiaogang Li, Bingrui Sun, Hang Yu, Qing Liu, Liqun Jiang, Xingxue Mao, Jing Zhang, Shuwei Lv, Zhilan Fan, Wei Liu, Wenfeng Chen, Chen Li

“…This study performed a transcriptome analysis on the leaves of Fan3 and YHSM following inoculation with <i>Xoo</i> strains AH28 and PXO99^A. …”
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Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research by Zheng Yixian, Wang Hai, Liu Xiuying, Yan Jichun

“…Genome-wide association studies (GWAS), transcriptome-wide association studies (TWAS), and other methods have identified multiple novel susceptibility loci and genes, providing crucial insights into the genetic etiology of MG. …”
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Natural ligand 3,3’-diindolylmethane functions as an AHR agonist to modulate angiogenesis and organ development in chicken embryos by Gee-yea Lim, Hao Chen, Woo-seon Song, Dong-hee Koh, Dong-ha Kim, Hisato Iwata, Eun-Young Kim

“…Further investigations into the effects of DIM were performed through in ovo experiments, transcriptome analysis, and a shell-less incubation system, assessing its impact on chicken embryo development. …”
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Identification of key modules and genes in response to high-temperature stress in Platostoma palustre based on WGCNA by Xiufang Li, Fan Wei, Changqian Quan, Meihua Xu, Danfeng Tang

“…This study investigated the molecular mechanism of heat tolerance in P. palustre at the gene expression level, providing a scientific basis for heat-tolerant breeding of P. palustre.…”
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Beyond Asexual: Genomics-Driven Progress in Unveiling Sexual Reproduction in Cereal Rust Fungi by Shideh Mojerlou, Mareike Moeller, Benjamin Schwessinger, Julian Rodriguez-Algaba

“…Recent advances in genomics technologies have revolutionized our understanding of cereal rust fungi, providing unprecedented insights into the complexities of their sexual life cycle. …”
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Innovative data augmentation strategy for deep learning on biological datasets with limited gene representations focused on chloroplast genomes by Mohammad Ali Abbasi-Vineh, Shirin Rouzbahani, Kaveh Kavousi, Masoumeh Emadpour

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The betA/B genes as a key factor in Cronobacter sakazakii survival under desiccation stress by Y. Yang, W. Wang, X. Meng, B. Niu, J. Yang, Q. Chen

“…To study the relationship between pathways and phenotypes from complex metabolic networks, this study used metabolomics and transcriptomics to analyze the different metabolites and genes of the strong desiccation resistance Cronobacter sakazakii CS 34 before and after drying treatment. …”
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The key metabolic pathway of roots and leaves responses in Arachis hypogaea under Al toxicity stress by Jianning Shi, Yishuang Zhou, Shaoxia Yang, Yingbin Xue, Yanyan Wang, Hanqiao Hu, Ying Liu

“…However, the molecular mechanisms underlying the effects of Al toxicity on peanut plants remain unclear. Transcriptome and metabolome analyses were conducted to investigate the responses of peanut leaves and roots to Al toxicity. …”
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Multi-omics exploration of the factors influencing feather coverage in laying hens by Xin Li, Xiaohui Shen, Xiaoliang Wang, Yao Yan, Wei Liu, Kai Zhan, Daqian He, Changsuo Yang, Huaxiang Yan, Junfeng Yao

“…By integrating multi-omics approaches, we sought to identify key genetic and microbial determinants of feather morphology and their synergistic effects on host physiology.MethodsA retrospective analysis was conducted on 400 laying hens classified into high (H) and low (L) feather coverage groups using a standardized 4-point scoring system. Transcriptomic profiling of cecal tissue was performed via RNA sequencing, while gut microbiota composition was analyzed using 16S rRNA amplicon sequencing. …”
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Multi-omics landscape of childhood simple obesity: novel insights into pathogenesis and biomarkers discovery by Yi Ren, Peng Huang, Lu Zhang, Yufen Tang, Siyi He, HaiDan Li, XiaoYan Huang, Yan Ding, Lingjuan Liu, Liqun Liu, Xiaojie He

“…Methods Transcriptome, untargeted metabolome, and 16 S rDNA sequencing were conducted on subjects to examine transcripts, metabolites in blood, and gut microflora in stool. …”
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Research on the Degradation Efficacy and Mechanism of Zearalenone by Tibetan Yeast Meyerozyma caribbica by Zhiliang XU, Yingbo CHEN, Keliang MENG, Chenxiaoye YANG, Dandan JIANG, Disha JIANG, Yulin WANG, Hao HU

“…【Objective】To isolate and screen a yeast strain capable of degrading zearalenone (ZEN) from Tibetan soil samples and investigate its degradation characteristics and mechanisms under varying conditions, thereby providing a theoretical basis for mycotoxin detoxification.…”
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Advancing precision medicine: the transformative role of artificial intelligence in immunogenomics, radiomics, and pathomics for biomarker discovery and immunotherapy optimization by Luchen Chang, Jiamei Liu, Jialin Zhu, Shuyue Guo, Yao Wang, Zhiwei Zhou, Xi Wei

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Innovative construction of the first reliable catalogue of bovine circular RNAs by Annie Robic, Frieder Hadlich, Gabriel Costa Monteiro Moreira, Emily Louise Clark, Graham Plastow, Carole Charlier, Christa Kühn

“…CircRNA identification is mostly an in-silico process, and the analysis of data from the BovReg project (https://www.bovreg.eu/) provided an opportunity to explore new ways to identify reliable circRNAs. …”
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Use of next-generation sequencing in genomic studies of polyploid crops: cotton as an example by Zhu Qianhao, Danny Llewellyn, Iain Wilson

“…Next-generation sequencing (NGS) technologies provide enormous power and new potential to access the complex polyploid genomes and transcriptomes of major crops, including cotton. …”
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Genomic and Multi-Omics Analysis of <i>Phlebopus portentosus</i>: Effects of Cultivation on Secondary Metabolites by Zujiang Kang, Xiaolong Yuan, Chuanguang Zhang, Yi Wang, Lu Li, Yuan Zheng

“…In this study, the genomics, metabolomics, and transcriptomics were integrated to reveal the biosynthesis mechanism of secondary metabolites in <i>P. portentosus</i> under different cultivation conditions. …”
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