Methylome and transcriptome analyses reveal HLA-DMB's contribution to periodontitis development. by Bo Zhao, Ronghua Li

“…<h4>Results</h4>After integrating DNA methylation with transcriptome profiles, GRASP, HLA-DMB, HLA-DMA, CAB39, NCOA2 and TLE4 were identified as candidate genes in periodontitis PMNs. …”
Get full text

Macrophage Transcriptomic Alterations Driven by Alphavirus-Based Cancer Immunotherapy Vectors by Ksenija Korotkaja, Darija Lapina, Zhanna Rudevica, Anna Zajakina

“…Reprogramming TAMs by viral immunotherapy vectors represents a promising strategy for cancer therapy. However, the factors driving macrophage reprogramming into a tumour-suppressing M1-like phenotype in response to viral vectors remain unclear. …”
Get full text

Identifying diagnostic biomarkers for glaucoma based on transcriptome combined with Mendelian randomization by Xiuli Lin, Chuanyong Ma, Xiaoxue Zhang, Yuzhe Qiu, Yi Cui, Nuo Xu

Get full text

Unraveling the genetic landscape of high-risk retinoblastoma through transcriptome profiling by Mukesh Kumar, Vikas Shrivastava, Isha Goel, Manoj Phalak, Sanjay kumar Mishra, Pramod Kumar Sharma, Amit Katiyar, Tej P. Singh, Punit Kaur

“…These inhibitors hold promise for inhibiting the growth of RB cells. Our findings underscore PLK1 as a promising therapeutic target, highlighting computational approaches' efficacy in RB research.…”
Get full text

RNA-Seq transcriptome analysis of porcine cloned and in vitro fertilized blastocysts by Wei-hua XU, Zi-cong LI, Zhi-ping OUYANG, Bo YU, Jun-song SHI, De-wu LIU, Zhen-fang WU

Get full text

Deciphering transcriptomic signatures in schizophrenia, bipolar disorder, and major depressive disorder by Priyanka, Rajesh Kumar, Vinod Kumar, Ashwani Kumar, Sandeep Singh Rana

“…In this study, we performed a large-scale transcriptomic analysis by integrating 557 publicly available RNA-seq datasets from post-mortem brain tissues, spanning multiple regions, to better understand the shared and distinct molecular features of these disorders. …”
Get full text

Single-cell transcriptomics for immune profiling of cerebrospinal fluid in neurological diseases by David Ramos-Vicente, Paola Monterosso, Oriol de Fàbregues, Oriol de Fàbregues, Gerard Roch, Miquel Vila, Miquel Vila, Miquel Vila, Miquel Vila, Jordi Bové

“…This review highlights the promising advancements and addresses the current limitations of single-cell transcriptomics in the context of CSF and neurological diseases, setting the stage for future breakthroughs.…”
Get full text

New insights into liver injury and regeneration from single-cell transcriptomics by Cynthia Ju, Yankai Wen

“…The application of single-cell transcriptomics continues to hold promise for identifying novel therapeutic targets, ultimately advancing the development of novel treatment strategies for acute liver diseases.…”
Get full text

Comprehensive bioinformatics analysis identified HMGB3 as a promising immunotherapy target for glioblastoma multiforme by Libin Wang, Peizhi Xu, Xinglong Li, Qinghua Zhang

Get full text

Deoxynucleosides as promising antimicrobial agents against foodborne pathogens and their applications in food and contact material surfaces by Olajide Sunday Faleye, Jin-Hyung Lee, Jintae Lee

“…Notably, they downregulated genes encoding biofilms and quorum sensing (aphA, cpsA, luxS &amp; opaR), outer membrane (tolC), response regulators (toxR, rpoS) and DNA synthesis (dnaE) as revealed by transcriptomic studies. These results demonstrate that nucleosides, especially FdCyd are promising novel compounds for controlling biofilm formation, maintaining hygiene and safety in food industry.…”
Get full text

A bioinformatics analysis and experimental validation of PDGFD as a promising diagnostic biomarker for acute myeloid leukemia by Lulu Yang, Shuangshuang Ren, Lijiang Lou, Jiasu He, Qianlei Huang, Xiaojin Wu, Ranran Zhao

Get full text

Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptations by Yixin Fu, Yong Yi, Yongxiang Shao, Jingcheng Jiang, Qingshan Deng

“…This review integrates recent advancements in single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to elucidate glioblastoma’s cellular heterogeneity and metabolic reprogramming. …”
Get full text

Induced Sputum Transcriptomics Profile and Serum C3 are Associated with Asthma Severity by Du F, Wang H, Chen Z, Xiong W, Wang Q, Li B, Li R, Li L, Shen Y, Zhu T

“…Then, this study aimed to explore asthma severity-associated transcriptomics profile and promising biomarkers for asthma severity prediction.Methods: In discovery cohort, induced sputum cells from 3 non-severe and 3 severe asthma patients were collected and analyzed using RNA-seq. …”
Get full text

Transcriptomic Profiling Reveals Key Genes Underlying Cold Stress Responses in Camphora by Bowen Shi, Linlin Zheng, Yifeng Wang, Qirui Wang

“…This study seeks to elucidate the molecular basis of cold tolerance through comparative transcriptomic analysis complemented by physiological characterization. …”
Get full text

Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease by Qian Yue, Shang Li, Chon Lok Lei, Huaibin Wan, Zaijun Zhang, Maggie Pui Man Hoi

Get full text

A new era in gammaherpesvirus transcriptomics: high-resolution profiling and model development by Kiran Fida, Brent A. Stanfield

“…., mSystems 10:e01678-24, 2025, https://doi.org/10.1128/msystems.01678-24) presents the first high-resolution, long-read transcriptomic atlas of Caviid gammaherpesvirus 1 (CaGHV-1), offering insights into its transcriptional complexity. …”
Get full text

Transcriptomic HEPN1 signatures predict treatment response in low grade glioma by Lei Jiao, Shuhua Fang, Jianbo Zhang

“…Abstract Background Iron-dependent ferroptosis emerges as a promising therapeutic avenue for glioma treatment, with ferroptosis-related genes such as HEPN1 offering potential as critical biomarkers when analyzed at single-cell resolution. …”
Get full text

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome. by Denis A Baird, Jimmy Z Liu, Jimmy Z Liu, Jie Zheng, Solveig K Sieberts, Thanneer Perumal, Benjamin Elsworth, Tom G Richardson, Chia-Yen Chen, Minerva M Carrasquillo, Mariet Allen, Joseph S Reddy, Philip L De Jager, Nilufer Ertekin-Taner, Lara M Mangravite, Ben Logsdon, Karol Estrada, Philip C Haycock, Gibran Hemani, Heiko Runz, George Davey Smith, Tom R Gaunt, AMP-AD eQTL working group

Get full text

Integration of single cell and bulk transcriptomes identifies T cell stress subtypes in LUAD by Shengping Min, Linfeng Pan, Xinyu Zhang, Huili Chen, Lixuan Qiu, Xinyu Wang, Yiluo Xie, Kai Zhang, Qiang Zhang, Chaoqun Lian, Jing Zhang

“…Methods The categorization and validation of cluster types for Tstr signature genes were systematically carried out using transcriptomic data sourced from the TCGA and GEO databases. …”
Get full text

Profiling the full-length transcriptome of plasma cell mastitis via nanopore sequencing by Su Li, Hongyue Chen, Yan Fan, Can Wang, Lijing An, Qifeng Xu, Wenming Cai, Suzhen Zhao, Tian Tian, Baoyong Zhang, Mengmeng Yang, Lulu Zhang

“…Abstract Introduction In this study, we aimed to determine the transcriptomic profile of plasma cell mastitis (PCM) and elucidate its underlying mechanisms using nanopore sequencing technology (ONT). …”
Get full text