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Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences
Published 2025-02-01“…When this recombination phenomenon occurs in live vaccine strains, it becomes increasingly difficult to prevent and control PRRSV. Reverse genetic manipulation to engineer a different transcriptional regulatory sequence (TRS) circuit introduces genetic traps into the viral genome that are lethal to recombinant RNA progeny viruses. …”
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143
Neutrophils restricted contribution of CCRL2 genetic variants to COVID-19 severity
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144
Development of a Portable Rapid Detection Method for Porcine Epidemic Diarrhea Virus Using Reverse Transcription-Recombinase-Aided Amplification Technology
Published 2025-01-01“…In this study, a point-of-care rapid detection method for PEDV was successfully established using reverse transcription-recombinase-aided amplification (RT-RAA) technology. …”
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145
Unraveling TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR Transcription Factors in Safflower: A Blueprint for Stress Resilience and Metabolic Regulation
Published 2025-01-01“….), a versatile medicinal and economic crop, harbors untapped genetic resources essential for stress resilience and metabolic regulation. …”
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146
Plasmodium falciparum transcription factor AP2-06B is mutated at high frequency in Southeast Asia but does not associate with drug resistance
Published 2025-01-01“…Members within the Plasmodium transcription factor family AP2 regulate the growth and development of the parasite, and are also thought to be involved in unclear aspects of drug resistance. …”
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147
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
Published 2025-01-01“…HDAC7 could modulate astrocytic uptake and lysosomal degradation of tau proteins through a transcriptional factor EB (TFEB) acetylation-dependent manner. …”
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148
Genetic structure and evolutionary diversity of mating-type (MAT) loci in Hypsizygus marmoreus
Published 2021-12-01“…In this study, we analyzed the genetic structure and diversity of MAT loci in tetrapolar system of H. marmoreus through sequencing of 54 heterokaryon and 8 homokaryon strains. …”
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149
The <i>OsGATA</i> gene family as a promising candidate for applying the CRISPR/Cas genome editing technology to improve the nutritional and yield qualities of rice (<i>Oryza sativa...
Published 2025-01-01“…Living organisms manifest genetically determined responses to environmental factors, including stressors. …”
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Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis
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151
Identification of new genes regulating nodule development in Medicago truncatula: an in-silico approach
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A Local Genetic Algorithm for the Identification of Condition-Specific MicroRNA-Gene Modules
Published 2013-01-01“…Transcription factor and microRNA are two types of key regulators of gene expression. …”
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Differences in Transcriptional Activation by the Two Allelic (L162V Polymorphic) Variants of PPARα after Omega-3 Fatty Acids Treatment
Published 2009-01-01“…Omega-3 fatty acids (FAs) have the potential to regulate gene expression via the peroxisome proliferator-activated receptor α (PPARα); therefore, genetic variations in this gene may impact its transcriptional activity on target genes. …”
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Collaborative Encoding of Text Genesis: A Pedagogical Approach for Teaching Genetic Encoding with the TEI
Published 2020-04-01“…The paper discusses the question of how genetic encoding can be taught in order to introduce encoding strategies of text genesis to less technologically adept scholars. …”
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157
Heterosis: current advances in the search for molecular mechanisms
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158
Molecular Detection and Genetic Characterization of Avian Leukosis Virus From Field Outbreaks in Bangladesh
Published 2024-11-01“…The diagnosis of ALV infection in chickens was confirmed through necropsy, histopathological examinations, reverse transcription‐polymerase chain reaction (RT‐PCR), and sequence analysis. …”
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Genetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism
Published 2025-01-01“…Background: Several studies suggested the genetic association between IL10RA variants and susceptibility to Behcet's disease (BD). …”
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