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Transcription factor KLF2 is associated with the dysfunctional status of NK cells and the prognosis of pediatric B-ALL patients
Published 2025-01-01“…Among them, the C2 cluster, which is present in healthy bone marrow but reduced in B-ALL bone marrow, displays overexpression of a transcription factor KLF2 and a significant downregulation of the “leukocyte proliferation” pathway. …”
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Evidence that a STAT3 Mutation Causing Hyper IgE Syndrome Leads to Repression of Transcriptional Activity
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Harnessing the diversity of a lettuce wild relative to identify anthocyanin-related genes transcriptionally responsive to drought stress
Published 2025-01-01“…These genetic variants could explain the differences in the gene expression patterns between the wild (significantly up/downregulated) and the cultivated (no significant changes) species. …”
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Transgenic plants as genetic models for studying functions of plant genes
Published 2016-09-01“…Gene engineering instruments for the design of transgenic plants with either elevated or suppressed expression of target genes are discussed. Genetic constructs for protein synthesis or antisense RNA/self-complementary double-stranded RNA transcription are described. …”
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Genetic Comparison of Stemness of Human Umbilical Cord and Dental Pulp
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Genetic coupling of enhancer activity and connectivity in gene expression control
Published 2025-01-01“…Jointly, our findings suggest an inherent genetic coupling of enhancer activity and connectivity in gene expression control relevant to human disease and highlight the regulatory role of genetically determined chromatin boundaries.…”
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<i>GLI1</i>-Rearranged Enteric Tumors: Updates on Clinicopathologic and Molecular Genetics Features
Published 2025-01-01“…Modern technological developments in cytogenetics and next-generation sequencing have enabled the analysis of small clinical samples, expanded our understanding of tumor biology, and improved the diagnostic, prognostic, and predictive precision by identifying targeted genetic alterations, confirming the presence of fusion transcripts, and/or revealing the overexpression of specific genes and their targets. …”
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CoTF-reg reveals cooperative transcription factors in oligodendrocyte gene regulation using single-cell multi-omics
Published 2025-02-01“…Abstract Oligodendrocytes are the myelinating cells within the central nervous system, but the mechanisms by which transcription factors (TFs) cooperate for gene regulation in oligodendrocytes remain unclear. …”
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