ATP-Binding Pocket-Targeted Suppression of Src and Syk by Luteolin Contributes to Its Anti-Inflammatory Action by Jeong-Oog Lee, Deok Jeong, Mi-Yeon Kim, Jae Youl Cho

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Genome-wide profiling of tRNA modifications by Induro-tRNAseq reveals coordinated changes by Yuko Nakano, Howard Gamper, Henri McGuigan, Sunita Maharjan, Jiatong Li, Zhiyi Sun, Erbay Yigit, Sebastian Grünberg, Keerthana Krishnan, Nan-Sheng Li, Joseph A. Piccirilli, Ralph Kleiner, Nicole Nichols, Brian D. Gregory, Ya-Ming Hou

“…Abstract While all native tRNAs undergo extensive post-transcriptional modifications as a mechanism to regulate gene expression, mapping these modifications remains challenging. …”
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Emerging technologies of single-cell multi-omics by Yi June Kim, Koichi Takahashi

“…These technologies have uncovered the intricate landscape of genetic clonality and transcriptional heterogeneity in both normal and malignant hematopoietic systems, highlighting their roles in differentiation, disease progression, and therapy resistance. …”
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MicroRNAs in the DNA Damage/Repair Network and Cancer by Alessandra Tessitore, Germana Cicciarelli, Filippo Del Vecchio, Agata Gaggiano, Daniela Verzella, Mariafausta Fischietti, Davide Vecchiotti, Daria Capece, Francesca Zazzeroni, Edoardo Alesse

“…Cancer is a multistep process characterized by various and different genetic lesions which cause the transformation of normal cells into tumor cells. …”
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The role of oxidative stress, glucocorticoid receptor and ARMC5 in lipid metabolism by Yosuke Okuno, Atsunori Fukuhara, Iichiro Shimomura

“…This was partly due to the transcriptional upregulation of ATGL. We identified ARMC5 as a novel ubiquitin E3 ligase of full-length SREBF, a master regulator of lipid metabolism. …”
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Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications by Zhenglin He, Yishuo Ji, Yutong Yuan, Tianfang Liang, Chenglin Liu, Yiping Jiao, Yimeng Chen, Yiming Yang, Liang Han, Liang Han, Yue Hu, Yue Hu, Xianling Cong, Xianling Cong, Xianling Cong

“…By integrating insights from genetic sequencing and molecular biology, we identify key miRNAs that promote or inhibit EC progression and treatment resistance. …”
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Identification of deleterious variants associated with male infertility genes in a cohort of idiopathic hypospermatogenesis patients by Nisha Sharma, Ashutosh Halder, Seema Kaushal, Manoj Kumar, Manish Jain

“…This study justifies the importance of genetic screening of idiopathic hypospermatogenesis patients for the presence of structural variants in known human male infertility genes.…”
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Physiological and transcriptomic analysis of the effect of overexpression of the NTPIP2;4 gene on drought tolerance in tobacco by Xu Luo, Yuanshuai Shi, Jie Tan, Tao Long, Juntao Song, Yang Liu

“…In this study, we investigated the regulatory role of NTPIP2;4 on drought tolerance in tobacco at physiological and transcriptional levels. In this experiment, we constructed an NtPIP2;4 overexpression vector and genetically transformed tobacco variety 'K326' to investigate the mechanism of NtPIP2;4 gene in regulating drought tolerance in tobacco at physiological and transcriptomic levels. …”
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Functional Diversity of Fibroblast Growth Factors in Bone Formation by Yuichiro Takei, Tomoko Minamizaki, Yuji Yoshiko

“…The functional significance of fibroblast growth factor (FGF) signaling in bone formation has been demonstrated through genetic loss-of-function and gain-of-function approaches. …”
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Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease by Sorabh Sharma, Rajeev Taliyan

“…Although the exact underlying mechanisms leading to neural cell death in this disease remains unknown, the genetic causes are often established. Indeed, it is becoming increasingly evident that chromatin acetylation status can be impaired during the neurological disease conditions. …”
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MPO Expression of Background Neutrophils in MPO Negative Acute Promyelocytic Leukemia, An Easy Clue to Corroborate a Challenging Diagnosis: A Case Report and Review of Literature by Kritika Krishnamurthy, Jui Choudhuri, K. H. Ramesh, Yanhua Wang

“…Acute promyelocytic leukemia (APL) is characterized by the pathogenic driver fusion transcript PML-RARA resulting from the t(15;17) translocation. …”
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hnRNPU-mediated pathogenic alternative splicing drives gastric cancer progression by Guoguo Jin, Yanming Song, Shaobo Fang, Mingyang Yan, Zhaojie Yang, Yang Shao, Kexin Zhao, Meng Liu, Zhenwei Wang, Zhiping Guo, Zigang Dong

“…The m6A-modified hnRNPU transcripts are recognized by m6A reader YTHDF3 and subsequently demethylated by FTO. …”
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<i>Ex Vivo</i> Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study by Arijita Sarkar, Matthew C. Gallo, Jennifer A. Bell, Cory K. Mayfield, Jacob R. Ball, Mina Ayad, Elizabeth Lechtholz-Zey, Stephanie W. Chang, Osamu Sugiyama, Denis Evseenko, Jay R. Lieberman

“…However, the cellular and transcriptional mechanisms regulating the response to these two strategies for BMP-2 mediated bone regeneration are largely unknown. …”
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Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases by Sudha Sharma

“…Such secondary structures have a range of biological functions but also induce genetic instability. Increasing evidence suggests that genomic instabilities induced by non-B DNA secondary structures result in predisposition to diseases. …”
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De Novo Acute Myeloid Leukemia with Combined CBFB-MYH11 and BCR-ABL1 Gene Rearrangements: A Case Report and Review of Literature by Venkata Rakesh Sethapati, Ra’ed Jabr, Leyla Shune, Wissam El Atrouni, Patrick R. Gonzales, Wei Cui, Shivani Golem

“…Additionally, inv(16) can cooperate with other genetic aberrations to further increase cell proliferation. …”
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Periostin as a Biomarker of the Amniotic Membrane by Mariya P. Dobreva, Larissa Lhoest, Paulo N. G. Pereira, Lieve Umans, Susana M. Chuva de Sousa Lopes, An Zwijsen

“…In addition, we identify and propose a combination of markers as transcriptional signature for the different extraembryonic tissues in mouse.…”
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Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events by Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

“…Moreover, we illustrated the pivotal role of the Hippo pathway effector TAZ (encoded by the WWTR1 gene) in mediating BRAF inhibition resistance through transcriptional regulation of receptor tyrosine kinases and through interactions with the E3 ubiquitin ligase NEDD4L.…”
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A plasmid-chromosome crosstalk in multidrug resistant enterobacteria by Laura Toribio-Celestino, Alicia Calvo-Villamañán, Cristina Herencias, Aida Alonso-del Valle, Jorge Sastre-Dominguez, Susana Quesada, Didier Mazel, Eduardo P. C. Rocha, Ariadna Fernández-Calvet, Alvaro San Millan

“…Although pOXA-48 produces mostly strain-specific transcriptional alterations, it also leads to the common overexpression of a small chromosomal operon present in Klebsiella spp. and Citrobacter freundii strains. …”
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A Full-Length Reference Floral Transcriptome of Boehmeria tricuspis Provides Insights into Apomeiosis and Polyploidy by Qing Tang, Ying Xu, Canhui Deng, Chaohua Cheng, Zhigang Dai, Zemao Yang, Chan Liu, Jianguang Su

“…Although several apomeiosis-associated genes have been described, the genetic control and molecular mechanisms underlying apomeiosis remain poorly understood. …”
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A functional SNP of the core promoter region within goat CDC25A gene affects litter size by Taiyuan Zhang, Jingxuan Wang, Yangyang Bai, Qian Wang, Ke Wang, Haijing Zhu, Lei Qu, Zhengang Guo, Chuanying Pan, Xianyong Lan

“…In short, our study provides a potential molecular genetic marker for improving reproductive efficiency in goat breeding.…”
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