Functional Diversity of Fibroblast Growth Factors in Bone Formation by Yuichiro Takei, Tomoko Minamizaki, Yuji Yoshiko

“…The functional significance of fibroblast growth factor (FGF) signaling in bone formation has been demonstrated through genetic loss-of-function and gain-of-function approaches. …”
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Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases by Sudha Sharma

“…Such secondary structures have a range of biological functions but also induce genetic instability. Increasing evidence suggests that genomic instabilities induced by non-B DNA secondary structures result in predisposition to diseases. …”
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<i>Ex Vivo</i> Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study by Arijita Sarkar, Matthew C. Gallo, Jennifer A. Bell, Cory K. Mayfield, Jacob R. Ball, Mina Ayad, Elizabeth Lechtholz-Zey, Stephanie W. Chang, Osamu Sugiyama, Denis Evseenko, Jay R. Lieberman

“…However, the cellular and transcriptional mechanisms regulating the response to these two strategies for BMP-2 mediated bone regeneration are largely unknown. …”
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De Novo Acute Myeloid Leukemia with Combined CBFB-MYH11 and BCR-ABL1 Gene Rearrangements: A Case Report and Review of Literature by Venkata Rakesh Sethapati, Ra’ed Jabr, Leyla Shune, Wissam El Atrouni, Patrick R. Gonzales, Wei Cui, Shivani Golem

“…Additionally, inv(16) can cooperate with other genetic aberrations to further increase cell proliferation. …”
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Periostin as a Biomarker of the Amniotic Membrane by Mariya P. Dobreva, Larissa Lhoest, Paulo N. G. Pereira, Lieve Umans, Susana M. Chuva de Sousa Lopes, An Zwijsen

“…In addition, we identify and propose a combination of markers as transcriptional signature for the different extraembryonic tissues in mouse.…”
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Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events by Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

“…Moreover, we illustrated the pivotal role of the Hippo pathway effector TAZ (encoded by the WWTR1 gene) in mediating BRAF inhibition resistance through transcriptional regulation of receptor tyrosine kinases and through interactions with the E3 ubiquitin ligase NEDD4L.…”
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A Full-Length Reference Floral Transcriptome of Boehmeria tricuspis Provides Insights into Apomeiosis and Polyploidy by Qing Tang, Ying Xu, Canhui Deng, Chaohua Cheng, Zhigang Dai, Zemao Yang, Chan Liu, Jianguang Su

“…Although several apomeiosis-associated genes have been described, the genetic control and molecular mechanisms underlying apomeiosis remain poorly understood. …”
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A functional SNP of the core promoter region within goat CDC25A gene affects litter size by Taiyuan Zhang, Jingxuan Wang, Yangyang Bai, Qian Wang, Ke Wang, Haijing Zhu, Lei Qu, Zhengang Guo, Chuanying Pan, Xianyong Lan

“…In short, our study provides a potential molecular genetic marker for improving reproductive efficiency in goat breeding.…”
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Disease-Associated Dopamine Receptor D2 Variants Exhibit Functional Consequences Depending on Different Heterotrimeric G-Protein Subunit Combinations by Nele Niebrügge, Olga Trovato, Roman Praschberger, Andreas Lieb

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Inotersen to Treat Polyneuropathy Associated with Hereditary Transthyretin (hATTR) Amyloidosis by Christopher Robinson, Cynthia Pham, Alec M. Zamarripa, Chase S. Dugay, Christopher A. Lee, Amnon A. Berger, Avi Landman, Elyse M. Cornett, Hisham Kassem, Alan D. Kaye, Ivan Urits, Omar Viswanath, Latha Ganti

“…By targeting TTR mRNA transcripts, Inotersen decreases protein translation and production, reducing the deposition of misfolded proteins. …”
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Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes by Yihan Wang, Daniel A. Armendariz, Lei Wang, Huan Zhao, Shiqi Xie, Gary C. Hon

“…Abstract Background Genetic studies have associated thousands of enhancers with breast cancer (BC). …”
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How energy determines spatial localisation and copy number of molecules in neurons by Cornelius Bergmann, Kanaan Mousaei, Silvio O. Rizzoli, Tatjana Tchumatchenko

“…Abstract In neurons, the quantities of mRNAs and proteins are traditionally assumed to be determined by functional, electrical or genetic factors. Yet, there may also be global, currently unknown computational rules that are valid across different molecular species inside a cell. …”
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Zearalenone exacerbates lipid metabolism disorders by promoting liver lipid droplet formation and disrupting gut microbiota by Xiao Han, Bingxin Huangfu, Tongxiao Xu, Kunlun Huang, Xiaoyun He

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Systems Biology Profiling of AMD on the Basis of Gene Expression by Mones S. Abu-Asab, Jose Salazar, Jingsheng Tuo, Chi-Chao Chan

“…Our analysis suggests a more complex transcriptional profile of the phenotypes than expected. …”
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Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury by Shataakshi Dube, Tejasvi Matam, Jessica Yen, Henry E. Mang, Pierre C. Dagher, Takashi Hato, Timothy A. Sutton

“…STAT3 is a transcriptional regulator that plays an important role in coordinating inflammation and immunity. …”
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Hindguts of Kyphosus sydneyanus harbor phylogenetically and genomically distinct Alistipes capable of degrading algal polysaccharides and diazotrophy by Cesar T. Facimoto, Kendall D. Clements, W. Lindsey White, Kim M. Handley

“…The fish-derived Alistipes were further delineated by their genetic capacity to fix nitrogen, biosynthesize cobalamin (vitamin B12), and utilize marine polysaccharides (e.g., alginate and carrageenan). …”
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Novel loci for triglyceride/HDL-C ratio longitudinal change among subjects without T2D by Lihua Wang, Siyu Wang, Jason A. Anema, Vaha A. Moghaddam, Yanli Lu, Shiow Lin, E. Warwick Daw, Allison L. Kuipers, Iva Miljkovic, Michael Brent, Gary J. Patti, Bharat Thygarajan, Joseph M. Zmuda, Michael A. Province, Ping An

“…While the former variant was associated with EIF4A2 (p = 7e-5)/ADIPOQ (P = 3.49e-2) transcriptional levels, the latter variant was not associated with TPRG1 (P = 0.23) transcriptional levels. …”
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Challenges Faced by Nurses in Transitioning Pediatric Sickle Cell Disease Patients to Adult Care by Gifty Enyonam Amoaku, Delali Adwoa Wuaku, Vivian Efua Senoo-Dogbey

“…Background Sickle-cell disease is a common genetic red blood cell disorder with global concern. …”
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Adaptability of clams to prolonged heatwaves: Influences on gene expression, antioxidant capacity, and histology of Chinese cyclina Cyclina sinensis by Meimei Liu, Zhichao Wang, Hongwei Ni, Wenqing Zhuo, Gaoyuan Yuan, Zhiguo Dong

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Genomic, transcriptomic and metabolomic analyses of Amorphophallus albus provides insights into the evolution and resistance to southern blight pathogen by Longfei Duan, Longfei Duan, Jianfeng Qin, Gaoxin Zhou, Chuan Shen, Baofu Qin

“…These findings not only advance the understanding of genetic and evolutionary characteristics of A. albus but also provide a foundation for future research on the resistance mechanisms of konjac against southern blight disease.…”
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