Exploring the effects of dietary methionine supplementation on European seabass mucosal immune responses against Tenacibaculum maritimum by Inês Carvalho, Inês Carvalho, Diogo Peixoto, Diogo Peixoto, Inês Ferreira, Inês Ferreira, Diego Robledo, Diego Robledo, Lourenço Ramos-Pinto, Rodolfo Miguel Silva, José Fernando Gonçalves, Marina Machado, Carolina Tafalla, Benjamin Costas, Benjamin Costas

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Functional heterogeneity of mesenchymal stem cells and their therapeutic potential in the K18-hACE2 mouse model of SARS-CoV-2 infection by Kátia Nunes da Silva, Fernanda Martins Marim, Gisele Vieira Rocha, Zaquer Suzana Munhoz Costa-Ferro, Luciana Souza de Aragão França, Carolina Kymie Vasques Nonaka, Bruno Diaz Paredes, Erik Aranha Rossi, Erick Correia Loiola, Corynne Stephanie Ahouefa Adanho, Rachel Santana Cunha, Mayck Medeiros Amaral da Silva, Fernanda Ferreira Cruz, Vivian Vasconcelos Costa, Dalila Lucíola Zanette, Clarissa Araújo Gurgel Rocha, Renato Santana Aguiar, Patricia Rieken Macedo Rocco, Bruno Solano de Freitas Souza

“…Variations in MSCs’ secretory and proliferation profiles, and their proteomic and transcriptional characteristics significantly influence their therapeutic potency, highlighting the need for enhanced characterization methods to better predict their efficacy. …”
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Diel changes in the expression of a marker gene and candidate genes for intracellular amorphous CaCO3 biomineralization in Microcystis by Bruley, Apolline, Gaëtan, Juliette, Gugger, Muriel, Pancrace, Claire, Millet, Maxime, Gaschignard, Geoffroy, Dezi, Manuela, Humbert, Jean-François, Leloup, Julie, Skouri-Panet, Fériel, Callebaut, Isabelle, Benzerara, Karim, Duprat, Elodie

“…The ccyA gene shows a clear day/night expression pattern with maximum transcript abundances during the second half of the night. …”
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Development of a recombinant infectious bronchitis virus vaccine expressing infectious laryngotracheitis virus multiple epitopes by Guanming Shao, Jun Fu, Yun Pan, Shiying Gong, Chaoyi Song, Sheng Chen, Keyu Feng, Xinheng Zhang, Qingmei Xie

“…This difference may be related to the presence of more signals affecting virus replication or transcription in larger heterologous genes. In addition, the stability of recombinant IBV varied depending on the genome region being replaced. …”
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Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway by Tingting Zhang, Mengmeng Zhu, Jialing Ma, Zhenghong Liu, Zhidan Zhang, Meijie Chen, Yaping Zhao, Huaxin Li, Shengnan Wang, Xiaoning Wei, Wenwen Zhang, Xiaoxiao Yang, Peter J. Little, Danielle Kamato, Hao Hu, Yajun Duan, Baotong Zhang, Jianbo Xiao, Suowen Xu, Yuanli Chen

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Alu Mobile Elements: From Junk DNA to Genomic Gems by Sami Dridi

“…Indeed, Alu RNAs have been shown to control mRNA processing at several levels, to have complex regulatory functions such as transcriptional repression and modulating alternative splicing and to cause a host of human genetic diseases. …”
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Identification of a Fetal De Novo Splice Variant in ARCN1 Associated With Growth and Skeletal Abnormalities by Wencong He, Zejun Yang, Jianjian Cui, Ruilin Ma, Hui Tao, Yanan Li, Yin Zhao, Yang Pan, Jue Li

“…To report a fetus with ARCN1-related syndrome caused by a novel de novo heterozygous variant, highlighting the importance of early genetic diagnosis in prenatal care. Methods:. The clinical and genetic data of a fetus with a complex combination of clinical signs and a novel de novo heterozygous variant were collected and have been summarized in this study. …”
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Rescue of common and rare exon 2 skipping variants of the GAA gene using modified U1 snRNA by Paolo Peruzzo, Natascha Bergamin, Martina Bon, Sara Cappelli, Alessandra Longo, Elisa Goina, Cristiana Stuani, Emanuele Buratti, Andrea Dardis

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Multi-Omics Insights into Regulatory Mechanisms Underlying Differential Deposition of Intramuscular and Abdominal Fat in Chickens by Yuxin Xing, Chenglin Ma, Hongbo Guan, Jianing Shen, Ying Shen, Guoxi Li, Guirong Sun, Yadong Tian, Xiangtao Kang, Xiaojun Liu, Hong Li, Weihua Tian

“…This review systematically summarizes the regulatory mechanisms underlying intramuscular and abdominal fat traits at chromatin, genomic, transcriptional, post-transcriptional, translational, and epigenetic-modification scales. …”
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Gene function revealed at the moment of stochastic gene silencing by Shreyan Gupta, James J. Cai

“…Abstract Gene expression is a dynamic and stochastic process characterized by transcriptional bursting followed by periods of silence. …”
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Alternative Splicing in Self-Renewal of Embryonic Stem Cells by Clara Y. Cheong, Thomas Lufkin

“…Much of embryonic stem cell biology has focused on transcriptional expression and regulation of genes that could mediate its unique potential in self-renewal or pluripotency. …”
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Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease by Lauren G. Russell, Maria Kolatsi‐Joannou, Laura Wilson, Jennifer C. Chandler, Nuria Perretta Tejedor, Georgie Stagg, Karen L. Price, Christopher J. Rowan, Tessa Crompton, Norman D. Rosenblum, Paul J. D. Winyard, David A. Long

“…Abstract Polycystic kidney diseases (PKD) are genetic disorders which disrupt kidney architecture and function. …”
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A short ncRNA modulates gene expression and affects stress response and parasite differentiation in Leishmania braziliensis by José C. Quilles, Caroline R. Espada, Lissur A. Orsine, Tânia A. Defina, Letícia Almeida, Fabíola Holetz, Angela K. Cruz

“…Apart from its medical relevance, this organism has a genetic organization that is unique among eukaryotes. …”
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The promising role of nanopore sequencing in cancer diagnostics and treatment by Xinming Su, Qingyuan Lin, Bin Liu, Chuntao Zhou, Liuyi Lu, Zihao Lin, Jiahua Si, Yuemin Ding, Shiwei Duan

“…Cancer arises from genetic alterations that impact both the genome and transcriptome. …”
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Genomic Variability among Field Isolates and Laboratory-Adapted Strains of Leptospira borgpetersenii Serovar Hardjo by Alejandro Llanes, Carlos Mario Restrepo, Pablo Riesgo-Ferreiro, Sreekumari Rajeev

“…In contrast, several differences regarding gene content and genetic variants were observed between the two subtypes. …”
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Transcriptome analysis provides insights into the role of TLP16 in Musa acuminata Resistance to Fusarium oxysporum f. sp. cubense wilt by Yi-le Huo, Si-wen Liu, Huo-qing Huang, Zai-yuan Li, Mudassar Ahmad, Meng-xia Zhuo, Wen-juan Chen, Chun-yu Li, Bo Liu, Ya-dong Li

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Identification of deep intronic variants in junctional epidermolysis bullosa using genome sequencing and splicing assays by Fuying Chen, Ruoqu Wei, Yumeng Wang, Qiaoyu Cao, Jianbo Wang, Chenfei Wang, Dingjin Yao, Zhirong Yao, Cheng Ni, Ming Li

“…We enrolled 69 cases of recessive JEB, with 13.0% of these cases remained genetically undiagnosed following an initial exome sequencing. …”
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Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn’s Disease and Ulcerative Colitis by Maria Dobre, Elena Milanesi, Teodora Ecaterina Mănuc, Dorel Eugen Arsene, Cristian George Ţieranu, Carlo Maj, Gabriel Becheanu, Mircea Mănuc

“…Genetic research has shaped the inflammatory bowel disease (IBD) landscape identifying nearly two hundred risk loci. …”
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The emerging roles of aberrant alternative splicing in glioma by Reda Ben Mrid, Sara El Guendouzi, Marco Mineo, Rachid El Fatimy

“…Despite successful advances in understanding glioma, several genetic, epigenetic, and post-transcriptional alterations leave various targeted therapies ineffective, leading to a poor prognosis for high-grade glioma. …”
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In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage by Ian Hare, Marieta Gencheva, Rebecca Evans, James Fortney, Debbie Piktel, Jeffrey A. Vos, David Howell, Laura F. Gibson

“…Nonhomologous end joining (NHEJ) transcripts showed little alteration with VP16 exposure or passage; however, homologous recombination (HR) transcripts were reduced following VP16 exposure with this decrease amplified as MSCs were passaged in vitro. …”
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