Characterization and functional analysis of conserved non-coding sequences among poaceae: insights into gene regulation and phenotypic variation in maize by Yi Luo, Hang Zhai, Xiu Zhong, Bo Yang, Yang Xu, Tianhong Liu, Qi Wang, Yang Zhou, Yan Mao, Yaxi Liu, Qi Tang, Yanli Lu, Yao Wang, Jie Xu

“…A significant enrichment of transcription factor binding sites was found within CNS sequences, including different transcription factors involved in abiotic stress response, such as OBP (OBF-BINDING PROTEIN) family and Adof1 (Encodes dof zinc finger protein). …”
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Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes by Miguel Vasconcelos Almeida, Moritz Blumer, Chengwei Ulrika Yuan, Pío Sierra, Jonathan L. Price, Fu Xiang Quah, Aleksandr Friman, Alexandra Dallaire, Grégoire Vernaz, Audrey L. K. Putman, Alan M. Smith, Domino A. Joyce, Falk Butter, Astrid D. Haase, Richard Durbin, M. Emília Santos, Eric A. Miska

“…Abstract Background East African cichlid fishes have diversified in an explosive fashion, but the (epi)genetic basis of the phenotypic diversity of these fishes remains largely unknown. …”
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Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases by Ana I. Rojo, Brigitta Buttari, Susana Cadenas, Ana Rita Carlos, Antonio Cuadrado, Ana Sofia Falcão, Manuela G. López, Milen I. Georgiev, Anna Grochot-Przeczek, Sentiljana Gumeni, José Jimenez-Villegas, Jarosław Olav Horbanczuk, Ozlen Konu, Isabel Lastres-Becker, Anna-Liisa Levonen, Viktorija Maksimova, Charalambos Michaeloudes, Liliya V. Mihaylova, Michel Edwar Mickael, Irina Milisav, Biljana Miova, Patricia Rada, Marlene Santos, Miguel C. Seabra, Dubravka Svob Strac, Sandra Tenreiro, Ioannis P. Trougakos, Albena T. Dinkova-Kostova

“…Nuclear factor erythroid 2-like 2 (NRF2) is a basic leucine-zipper transcription factor that regulates the cellular redox homeostasis. …”
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Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung Cancer by Vito D’Alessandro, Lucia Anna Muscarella, Massimiliano Copetti, Leopoldo Zelante, Massimo Carella, Gianluigi Vendemiale

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Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations by Paula Climent-Cantó, Marc Subirana-Granés, Mireia Ramos-Rodríguez, Estela Dámaso, Fátima Marín, Covadonga Vara, Beatriz Pérez-González, Helena Raurell, Elisabet Munté, José Luis Soto, Ángel Alonso, GiWon Shin, Hanlee Ji, Megan Hitchins, Gabriel Capellá, Lorenzo Pasquali, Marta Pineda

“…Moreover, the epimutant MLH1 promoter exhibited differential 3D chromatin contacts, including lost and gained interactions with distal regulatory elements. Of note, rare genetic alterations potentially affecting transcription factor binding sites were found in the promoter-contacting region of CME carriers. …”
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Development and validation of highly sensitive multiplex real-time RT-PCR assay for detection of classical swine fever virus genome by A. S. Sadchikova, A. S. Igolkin, R. S. Chernyshev, A. A. Kozlov, I. S. Kolbin, A. V. Sprygin, D. A. Biryuchenkov, I. A. Chvala, A. Mazloum

“…Therefore, areal-time reverse transcription-polymerase chain reaction using an internal control sample has been developed. …”
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Expression of the Autoimmune Regulator Gene and Its Relevance to the Mechanisms of Central and Peripheral Tolerance by Roberto Perniola

“…Dysregulation of thymic AIRE expression in genetically transmitted and acquired diseases other than APS-1 may contribute to further forms of autoimmunity. …”
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Long Non-coding RNA: Characterizing the Locus Features by the Approaches by Mohammadreza Hajjari, Saghar Rahnama

“…There is limited knowledge of genetic and epigenetic elements and their interactions for the gene encoding HOTAIR. …”
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The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP by Zigmunds Orlovskis, Archana Singh, Adi Kliot, Weijie Huang, Saskia A Hogenhout

“…The molecular mechanisms behind these extended phenotypes - where genetic information of one organism is manifested as traits in another - remain largely unclear. …”
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Methylome analysis in long-lived men deciphers DNA methylation modifications associated with male longevity in humans by Fu-Hui Xiao, Hao-Tian Wang, Long Zhao, Tian-Rui Xia, Li-Qin Yang, Si-Yu Ma, Qing-Peng Kong

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3-methyl-4-nitrophenol disturbs the maternal-to-zygotic transition of early embryos by damaging mitochondrial function and histone modification by Fan Chen, An-Feng Luo, Kai-Xin Pan, Hao Gu, Chang-Fan Zhou, Wei Zeng, Song Liu, Adrian Molenaar, Hong-Yan Ren, Li-Jun Huo, Yan-Zhen Bi

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Duckweed: a starch-hyperaccumulating plant under cultivation with a combination of nutrient limitation and elevated CO2 by Ling Guo, Ling Guo, Yang Fang, Songhu Wang, Yao Xiao, Yanqiang Ding, Yanling Jin, Xueping Tian, Anping Du, Zhihua Liao, Kaize He, Shuang Chen, Yonggui Zhao, Li Tan, Zhuolin Yi, Yuqing Che, Lanchai Chen, Jinmeng Li, Leyi Zhao, Peng Zhang, Zhengbiao Gu, Fangyuan Zhang, Yan Hong, Qing Zhang, Hai Zhao

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Avian Paramyxovirus Serotype-1: A Review of Disease Distribution, Clinical Symptoms, and Laboratory Diagnostics by Nichole L. Hines, Cathy L. Miller

“…Classification systems have been designed to group isolates based on their genetic composition. The genetic composition of the fusion gene cleavage site plays an important role in virulence. …”
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The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape by Yasuto Araki, Toshihide Mimura

“…Epigenetic mechanisms regulate chromatin state and gene transcription without any change in DNA sequence, resulting in the alteration of phenotypes in several cell types, especially RASFs. …”
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THERAPEUTIC GENE EDITING FOR HEMOGLOBINOPATHIES by Ugo Testa, Giuseppe Leone, Maria Domenica Cappellini

“…Initial studies of gene therapy for hemoglobinopathies involved the use of lentiviral vectors to add functional copies of the gene encoding b-globin in defective CD34 cells; more recently, gene editing techniques have been used involving either CRISPR-Cas9, transcription activation-like effector protein nuclease, zinc finger nuclease, and base editing to either induce fetal hemoglobin production at therapeutic levels or to genetically repair the underlying molecular defect causing the disease. …”
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Nourishing change in Houston, Texas: exploring grocery shopping behaviours and fruit and vegetable consumption among low-income families in the Brighter Bites program by Victoria Kwentua, Allison Marshall, Ru-Jye Chuang, Jessica Chen, Christine Markham, Mallika Mathur, Mike Pomeroy, Megan Hall, Shreela Sharma

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Understanding Disease Susceptibility through Population Genomics by Seonggyun Han, Junnam Lee, Sangsoo Kim

“…Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. …”
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NMD Microarray Analysis for Rapid Genome-Wide Screen of Mutated Genes in Cancer by Maija Wolf, Henrik Edgren, Aslaug Muggerud, Sami Kilpinen, Pia Huusko, Therese Sørlie, Spyro Mousses, Olli Kallioniemi

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An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice by Xiaojuan Wang, Guohui Zhang, Zhiwei Bian, Vimanda Chow, Marina Grimaldi, Coralie Carivenc, Savannah Sirounian, Hao Li, Lucia Sladekova, Stefano Mott, Yulia Luperi, Yufeng Gong, Cait Costello, Linhao Li, Matthew Jachimowicz, Miao Guo, Shian Hu, Derek Wilson, Patrick Balaguer, William Bourguet, Sridhar Mani, Laura Bonati, Hui Peng, John March, Hongbing Wang, Shengpeng Wang, Henry M. Krause, Jiabao Liu

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Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

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