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    Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling by Michael Young, David M. Booth, David Smith, Marco Tigano, Gyӧrgy Hajnόczky, Suresh K. Joseph

    Published 2024-12-01
    “…The activation of IP3 receptor (IP3R) Ca2+ channels generates agonist-mediated Ca2+ signals that are critical for the regulation of a wide range of biological processes. It is therefore surprising that CRISPR induced loss of all three IP3R isoforms (TKO) in HEK293 and HeLa cell lines yields cells that can survive, grow and divide, albeit more slowly than wild-type cells. …”
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    Conserved functional features of natural killer cell subsets in chicken, human, and murine immune systems by Seung Je Woo, Jaeryeong Kim, Hong Jo Lee, Kyung Youn Lee, Kyung Je Park, Jin-Kyoo Kim, Jin Lee Kim, Byung Chul Park, Minseok Seo, Jae Yong Han

    Published 2025-08-01
    “…Summary: Immunological conservation across species is crucial for comparative biology. While Natural killer (NK) cells' functions are conserved in humans and mice at the single-cell level, they remain unexplored in chickens due to technical limitations. …”
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