Molecular Characterization of Ferulate 5-Hydroxylase Gene from Kenaf (Hibiscus cannabinus L.) by Jonggeun Kim, Bosung Choi, Young-Hwan Park, Byoung-Kwan Cho, Hyoun-Sub Lim, Savithiry Natarajan, Sang-Un Park, Hanhong Bae

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Exploring biomarkers and molecular mechanisms of Type 2 diabetes mellitus promotes colorectal cancer progression based on transcriptomics by Simin Luo, Yuhong Zhu, Zhanli Guo, Chuan Zheng, Xi Fu, Fengming You, Xueke Li

“…The limma package was used to identify differentially expressed genes in tumor tissue from CRC patients with or without T2DM. The key biological processes were screened by gene ontology and gene set enrichment analysis. …”
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CYP3A5 promotes glioblastoma stemness and chemoresistance through fine-tuning NAD+/NADH ratio by Wentao Hu, Xiaoteng Cui, Hongyu Liu, Ze Li, Xu Chen, Qixue Wang, Guolu Zhang, Er Wen, Jinxin Lan, Junyi Chen, Jialin Liu, Chunsheng Kang, Ling Chen

“…NAD(H) emerges as a crucial factor influencing GSC maintenance through its involvement in diverse biological processes, including mitochondrial fitness and DNA damage repair. …”
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Interactions between NAD+ metabolism and immune cell infiltration in ulcerative colitis: subtype identification and development of novel diagnostic models by Linglin Tian, Huiyang Gao, Tian Yao, Tian Yao, Yuhao Chen, Linna Gao, Jingxiang Han, Lanqi Zhu, He Huang, He Huang, He Huang

“…GSEA and GSVA identified potential biological pathways active within these subtypes, while the CIBERSORT algorithm assessed differential immune cell infiltration. …”
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miR-9-5p/HMMR regulates the tumorigenesis and progression of clear cell renal cell carcinoma through EMT and JAK1/STAT1 signaling pathway by Xinyang Niu, Dingheng Lu, Weitao Zhan, Jiazhu Sun, Yuxiao Li, Yuchen Shi, Kai Yu, Suyuelin Huang, Xueyou Ma, Xiaoyan Liu, Ben Liu

“…Furthermore, overexpression of an upstream transcriptional regulator, miR-9-5p, effectively downregulated HMMR expression and thus impeded ccRCC cells proliferation and migration. …”
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Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events by Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

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The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy by Natalia Simionescu, Radu Zonda, Anca Roxana Petrovici, Adriana Georgescu

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Uncovering the whole genome silencers of human cells via Ss-STARR-seq by Xiusheng Zhu, Lei Huang, Chao Wang, Guoli Li, Biao Deng, Dashuai Kong, Xiaoxiao Wang, Rongrong Chang, Yi Gu, Qiuhan Wen, Siyuan Kong, Yuwen Liu, Yubo Zhang

“…Silencers exhibited a substantial enrichment of transcriptional-inhibitory motifs, including REST, and demonstrated overlap with the binding sites of repressor transcription factors within the endogenous environment. …”
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Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells by Xu Zhou, Wen-Ming Liu, Han-Yong Sun, Yuan Peng, Ren-Jie Huang, Cai-Yang Chen, Hong-Dan Zhang, Shen-Ao Zhou, Hong-Ping Wu, Dan Tang, Wei-Jian Huang, Han Wu, Qi-Gen Li, Bo Zhai, Qiang Xia, Wei-Feng Yu, He-Xin Yan

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MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter by Marius Hyprath, Maximilian Molitor, Ilona Schweighöfer, Rolf Marschalek, Dieter Steinhilber

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A pan-cancer analysis of homeobox family: expression characteristics and latent significance in prognosis and immune microenvironment by Yuanhui Wang, Jie Gao, Ziyi Ren, Ziyi Shen, Wei Gu, Qinyi Miao, Xiaomeng Hu, Xiaomeng Hu, Yan Wu, Yan Wu, Wei Liu, Jia Jia, Jia Jia, Yi Cai, Chunpeng (Craig) Wan, Lei Sun, Tingdong Yan, Tingdong Yan

“…BackgroundThe Homeobox (HOX) gene family are conserved transcription factors that are essential for embryonic development, oncogenesis, and cancer suppression in biological beings. …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…Next, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to elucidate associated biological functions and signaling pathways. Meanwhile, molecular docking between core targets and SSA was performed using Autodock software. …”
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Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…The SCENIC analysis identified three primary transcription factors' clusters (CEBPB, MYC and TAL1). …”
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Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice by Hailyn V. Nielsen, Letitia Yang, James L. Mueller, Alexander J. Ritter, Ryosuke Hiwa, Irina Proekt, Elze Rackaityte, Dominik Aylard, Mansi Gupta, Christopher D. Scharer, Mark S. Anderson, Byron B. Au-Yeung, Julie Zikherman

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Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response by Wazim Mohammed Ismail, Jenna A. Fernandez, Moritz Binder, Terra L. Lasho, Minsuk Kim, Susan M. Geyer, Amelia Mazzone, Christy M. Finke, Abhishek A. Mangaonkar, Jeong-Heon Lee, Liguo Wang, Kwan Hyun Kim, Vernadette A. Simon, Fariborz Rakhshan Rohakthar, Amik Munankarmy, Seul Kee Byeon, Susan M. Schwager, Jonathan J. Harrington, Melissa R. Snyder, Keith D. Robertson, Akhilesh Pandey, Eric D. Wieben, Nicholas Chia, Alexandre Gaspar-Maia, Mrinal M. Patnaik

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Mechanism study of KCMF1 promoting proliferation and NF-κB signaling transduction in colorectal cancer cells by WU Zhibai, XU Guiqin, ZHANG Li, YANG Zhaojuan, LIU Yun, JIAO Kun, CHEN Zehong, XU Chen, ZUO You, ZHENG Ningqian, YE Zhiqian, LIU Yongzhong

“…It binds to target proteins through the RING domain and participates in the regulation of a variety of biological processes in vivo. However, the function of KCMF1 in CRC remains unclear. …”
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Significance of Biogenetic Markers in Giant Cell Tumor Differentiation and Prognosis: A Narrative Review by Muhammad Taqi, Haseeb ul Rasool, Mobeen Zaka Haider, Munjed Al Muderis

“…<b>Aims and Objectives</b>: The purpose of this study was to explore biological and genetic markers which can be used for detection, differentiation, recurrence, and prognosis of GCTB. …”
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The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases by Lei Zhang, Qun Wang, Wen Liu, Fangyan Liu, Ailing Ji, Yanzhang Li

“…Orphan nuclear receptor 4A1 (NR4A1) is a transcriptional factor of the nuclear orphan receptor (NR4A) superfamily that has sparked interest across different research fields in recent years. …”
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Tenidap sodium inhibits secretory non-pancreatic phospholipase A2 synthesis by foetal rat calvarial osteoblasts by W. Pruzanski, B. P. Kennedy, H. van den Bosch, E. Stefanski, M. Wloch, P. Vadas

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Genome Sequencing of a Mung Bean Plant Growth Promoting Strain of P. aeruginosa with Biocontrol Ability by Devaraj Illakkiam, Manoharan Shankar, Paramasivan Ponraj, Jeyaprakash Rajendhran, Paramasamy Gunasekaran

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