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Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression
Published 2025-02-01Get full text
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Transcriptional Profiling Reveals Kidney Neutrophil Heterogeneity in Both Healthy People and ccRCC Patients
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RLS-associated MEIS transcription factors control distinct processes in human neural stem cells
Published 2024-11-01“…By separate knockout and overexpression of MEIS1 and MEIS2 in human neural stem cells, we find they control specific sets of target genes, associated with distinct biological processes. Integration of DNA binding sites with differential transcriptomics implicates MEIS1 to co-regulate gene expression by interaction with transcription factors of the SOX and FOX families. …”
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Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways
Published 2025-01-01“…Abstract Understanding how proteins discriminate between preferred and non-preferred ligands (‘selectivity’) is essential for predicting biological function and a central goal of protein engineering efforts, yet the biophysical mechanisms underpinning selectivity remain poorly understood. …”
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Targeting Endothelial Adhesion Molecule Transcription for Treatment of Inflammatory Disease: A Proof-of-Concept Study
Published 2016-01-01“…We explored the concept of targeting endothelial adhesion molecule transcription during inflammation in a human system. …”
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Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology
Published 2009-01-01“…Here we present the exciting as well as the complex role that EPO and FoxOs possess to uncover the benefits as well as the risks of these agents for cell biology and clinical care in processes that range from stem cell development to uncontrolled cellular proliferation.…”
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Multiple Roles of the Y Chromosome in the Biology of Drosophila melanogaster
Published 2010-01-01Get full text
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The BES1/BZR1 transcriptional factor SlBES2 regulates photosynthetic apparatus in tomato fruit
Published 2025-01-01“…Results In this study, we identified a transcriptional factor SlBES2, the closest homolog of BES1 and BZR1 in tomato BES1 family, is highly expressed in fruit at mature green (MG) stage and exhibited transcriptional inhibition activity. …”
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Systems Biology Profiling of AMD on the Basis of Gene Expression
Published 2013-01-01“…Our analysis suggests a more complex transcriptional profile of the phenotypes than expected. …”
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