Comparative Analysis of Cardiovascular Development Related Genes in Stem Cells Isolated from Deciduous Pulp and Adipose Tissue by Zhang Xin Loo, Wijenthiran Kunasekaran, Vijayendran Govindasamy, Sabri Musa, Noor Hayaty Abu Kasim

“…Upregulated expression of transcription factor (TF) genes was detected in both sources. …”
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Migration of primordial germline cells is negatively regulated by surrounding somatic cells during early embryogenesis in Drosophila melanogaster by N. V. Dorogova, A. S. Khruscheva, Iu. A. Galimova, D. Yu. Oshchepkov, D. E. Maslov, E. D. Shvedkina, K. A. Akhmetova, S. A. Fedorova

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Proximity‐dependent biotinylation reveals an interaction between ubiquitin‐specific peptidase 46 and centrosome‐related proteins by Kazuma Yoshioka, Reiko Nakagawa, Chi Lieu Kim Nguyen, Hayate Suzuki, Kiyohiro Ishigaki, Seiya Mizuno, Tsukasa Okiyoneda, Shizufumi Ebihara, Kazuya Murata

“…Protein ubiquitination extensively modulates protein functions and controls various biological processes, such as protein degradation, signal transduction, transcription, and DNA repair. …”
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Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential by Kewalin Inthanon, Natthawut Wong-a-nan, Srisulak Dheeranupattana, Andres Garcia Guerra, Neal M. Davies, Chatchai Kesornpun, Sasithorn Sangher, Prasat Kittakoop

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Emergence of Enteric Viruses in Production Chickens Is a Concern for Avian Health by Elena Mettifogo, Luis F. N. Nuñez, Jorge L. Chacón, Silvana H. Santander Parra, Claudete S. Astolfi-Ferreira, José A. Jerez, Richard C. Jones, Antonio J. Piantino Ferreira

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Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids by Margherita Maioli, Valentina Basoli, Sara Santaniello, Sara Cruciani, Alessandro Palmerio Delitala, Roberto Pinna, Egle Milia, Regina Grillari-Voglauer, Vania Fontani, Salvatore Rinaldi, Roberta Muggironi, Gianfranco Pigliaru, Carlo Ventura

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The Genetic Expression Difference of A2058 Cells Treated by Plasma Direct Exposure and Plasma-Treated Medium and the Appropriate Treatment Strategy by Chao-Yu Chen, Chung-Hsien Chou, Yun-Chien Cheng

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Creating burdock polysaccharide-oleanolic acid-ursolic acid nanoparticles to deliver enhanced anti-inflammatory effects: fabrication, structural characterization and property evalu... by Shanshan Zhu, Zhichang Qiu, Xuguang Qiao, Geoffrey I.N. Waterhouse, Wenqing Zhu, Wenting Zhao, Qiuxia He, Zhenjia Zheng

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Mechanism of <italic>Coptis chinensis</italic> in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking by LIU Huiling, TAN Dingying, HUANG Min, CHEN Pingping, ZHANG Wang

“…In addition, molecular docking was conducted between the core targets and the active ingredients of <italic>Coptis chinensis</italic> to verify the binding ability between the active ingredients and the core targets.Results① A total of 14 active ingredients of <italic>Coptis chinensis</italic>, 189 targets for the treatment of type 2 diabetes mellitus were screened out, among which 136 potential targets were identified, including 20 core targets (degree≥12), 137 signaling pathways with significant significance. ② Gene Ontology (GO) functional enrichment analysis showed that, the biological processes (BP) involved in the predicted target of <italic>Coptis chinensis</italic> in the treatment of type 2 diabetes mellitus involved gland development, epithelial cell proliferation, regulation of DNA-binding transcription factor activity, oxidative stress and apoptosis response to lipopolysaccharide, etc. …”
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Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach by Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia

“…The dysfunctional pathways, the potential transcription factor, and microRNA targets were analyzed by bioinformatics methods. …”
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Characterization and Study of Gene Expression Profiles of Human Periodontal Mesenchymal Stem Cells in Spheroid Cultures by Transcriptome Analysis by Takenori Suga, Michihiko Usui, Satoru Onizuka, Kotaro Sano, Tsuyoshi Sato, Kohji Nakazawa, Wataru Ariyoshi, Tatsuji Nishihara, Keisuke Nakashima

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Detection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears by Anastasia A. Artyukh, Mikhail K. Ivanov, Mikhail K. Ivanov, Sergei E. Titov, Sergei E. Titov, Victoria V. Dzyubenko, Sergey E. Krasilnikov, Sergey E. Krasilnikov, Anastasia O. Shumeikina, Anastasia O. Shumeikina, Anastasia O. Shumeikina, Nikita A. Afanasev, Anastasia V. Malek, Sergei A. Glushkov, Eduard F. Agletdinov

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Surface functionalization of titanium implants with controlled-release glutathione conjugate for antioxidant and osteogenesis by Huichuan Xu, Kosuke Nozaki, Ziniu Yu, Nobuyuki Kawashima, Takeshi Ueno, Huaze Wu, Hao Wu, Noriyuki Wakabayashi

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Lipid Isolated from a Leishmania donovani Strain Reduces Escherichia coli Induced Sepsis in Mice through Inhibition of Inflammatory Responses by Subhadip Das, Nabanita Chatterjee, Dipayan Bose, Somenath Banerjee, Prajnamoy Pal, Tarun Jha, Krishna Das Saha

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Transcriptome Analysis Reveals Complex Defensive Mechanisms in Salt-Tolerant and Salt-Sensitive Shrub Willow Genotypes under Salinity Stress by Dezong Sui, Baosong Wang

“…Gene Ontology (GO) and MapMan annotations suggested that many DEGs were involved in various defense-related biological pathways, including cell wall integrity, hormone signaling, antioxidant system, heat shock proteins, and transcription factors. …”
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Targeting MDM2 affects spastin protein levels and functions: implications for HSP treatment by Francesca Sardina, Federica Polverino, Sonia Valentini, Claudia Carsetti, Elisabetta Falvo, Giada Tisci, Silvia Soddu, Fabiola Moretti, Alessandro Paiardini, Cinzia Rinaldo

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Metformin Delays Satellite Cell Activation and Maintains Quiescence by Theodora Pavlidou, Milica Marinkovic, Marco Rosina, Claudia Fuoco, Simone Vumbaca, Cesare Gargioli, Luisa Castagnoli, Gianni Cesareni

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Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus by Rui Zhao, Jun Li, Yingtian Li, Xujuan Pei, Jingyi Di, Zhoujie Xie, Hao Liu, Weixia Gao

“…The molecular weight (MW) of HA is crucial for its biological functions. Streptococcus zooepidemicus, a prominent HA industrial producer, naturally synthetizes HA with high MW. …”
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EGF-R is Expressed and AP-1 and NF-κ:B Are Activated in Stromal Myofibroblasts Surrounding Colon Adenocarcinomas Paralleling Expression of COX-2 and VEGF by Panagiotis A. Konstantinopoulos, Gerasimos P. Vandoros, Michalis V. Karamouzis, Maria Gkermpesi, Georgia Sotiropoulou-Bonikou, Athanasios G. Papavassiliou

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A nociceptor-specific RNAi screen in Drosophila larvae identifies RNA-binding proteins that regulate thermal nociception by Amber Dyson, Gita Gajjar, Katherine C. Hoffman, Dakota Lewis, Sara Palega, Erik Rangel Silva, James Auwn, Andrew Bellemer

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