Bioinformatics analysis combined with experimental validation reveals the biological role of the ILK gene in prostate cancer by Xiao-xiang Yu, Yi Liu, Rong-jiang Luo, Zi-xuan Song, Wen-kai Chen, Zeng-mi Mo, Feng-jing Wang

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Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives by Shiheng Jia, Xue Yu, Na Deng, Chen Zheng, Mingguang Ju, Fanglin Wang, Yixiao Zhang, Ziming Gao, Yanshu Li, Heng Zhou, Kai Li

“…Abstract RNA pseudouridylation, a dynamic and reversible post‐transcriptional modification found in diverse RNA species, is crucial for various biological processes, including tRNA homeostasis, tRNA transport, translation initiation regulation, pre‐mRNA splicing, enhancement of mRNA translation, and translational fidelity. …”
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Protocol for in vivo chromatin immunoprecipitation on purified chromatin isolated from mouse liver nuclei by Lei Li, May G. Akl, Scott B. Widenmaier

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Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma by Annika L. Gustafson, Annika L. Gustafson, Annika L. Gustafson, Adam D. Durbin, Kristin B. Artinger, Heide L. Ford, Heide L. Ford, Heide L. Ford

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Impact of trace metal supplementation on anaerobic biological methanation under hydrogen and carbon dioxide starvation by G. Ghiotto, N. De Bernardini, E. Orellana, G. Fiorito, L. Cenci, P. G. Kougias, S. Campanaro, L. Treu

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Identification of proteins that can participate in the recruitment of Ttk69 to genomic sites of Drosophila melanogaster by I. S. Osadchiy, T. N. Fedorova, P. G. Georgiev, O. G. Maksimenko

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Mitochondrial Gene Expression of Three Different Dragonflies Under the Stress of Chlorpyrifos by Yuxin Chen, Ziwen Yang, Zhiqiang Guo, Lemei Zhan, Kenneth B. Storey, Danna Yu, Jiayong Zhang

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Altered AKT1 and MAPK1 Gene Expression on Peripheral Blood Mononuclear Cells and Correlation with T-Helper-Transcription Factors in Systemic Lupus Erythematosus Patients by Sonia Garcia-Rodriguez, Jose-Luis Callejas-Rubio, Norberto Ortego-Centeno, Esther Zumaquero, Raquel Ríos-Fernandez, Salvador Arias-Santiago, Pilar Navarro, Jaime Sancho, Mercedes Zubiaur

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Protocol to denoise spatially resolved transcriptomics data utilizing optimal transport-based gene filtering algorithm by Lin Du, Jingmin Kang, Jie Li, Hua Qin, Yong Hou, Hai-Xi Sun

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Aβ-Induced Repressor Element 1-Silencing Transcription Factor (REST) Gene Delivery Suppresses Activation of Microglia-Like BV-2 Cells by Tongya Yu, Hui Quan, Yuzhen Xu, Yunxiao Dou, Feihong Wang, Yingying Lin, Xue Qi, Yanxin Zhao, Xueyuan Liu

“…Compelling evidence from basic molecular biology has demonstrated the crucial role of microglia in the pathogenesis of Alzheimer’s disease (AD). …”
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To be or not to be phosphorylated: understanding the role of Ebola virus nucleoprotein in the dynamic interplay with the transcriptional activator VP30 and the host phosphatase PP2... by Lennart Kämper, Ida Kuhl, Melina Vallbracht, Thomas Hoenen, Uwe Linne, Axel Weber, Petr Chlanda, Michael Kracht, Nadine Biedenkopf

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Viral Transcript and Tumor Immune Microenvironment-Based Transcriptomic Profiling of HPV-Associated Head and Neck Squamous Cell Carcinoma Identifies Subtypes Associated with Progno... by Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden

“…Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HPV-positive HNSCC) has distinct biological characteristics from HPV-negative HNSCC. …”
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Identification of the Transcriptional Networks and the Involvement in Angiotensin II-Induced Injury after CRISPR/Cas9-Mediated Knockdown of Cyr61 in HEK293T Cells by Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yan Jiang, Rentong Hu, Yanwu You

“…Background. The transcriptional networks of Cyr61 and its function in cell injury are poorly understood. …”
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An Immunological and Molecular Study of Regulatory T-cell Activity in Iraqi Patients with Psoriasis Treated by Topical and Biological Therapy by Shawq Raafat Alnaqqash, Zainab Thamer Showait AL-Asady, Mohammed Mahdi Jawad

“…Materials and Methods: In this study 22 blood samples of psoriasis patients and 24 healthy samples as a control group were analyzed to measure the level of TGF-β1 by enzyme-linked immunosorbent assay and the gene expression level of the LRRC32 (GARP gene) by quantitative reverse transcription polymerase chain reaction technique. Results: The results showed a significant decrease (p=0.004) in the level of TGF-β1 in the serum of patients with psoriasis treated with topical therapy and others treated with biological therapy compared to the control group. …”
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Evaluation of ovarian stiffness and its biological mechanism using shear wave elastography in polycystic ovary syndrome by Yifang He, Shuangping Deng, Yanli Wang, Xiali Wang, Qingqing Huang, Jing Cheng, Dandan Wang, Guorong Lyu

“…A rat model of PCOS was established to further investigate the biological basis of increased ovarian stiffness. Histological analysis, enzyme-linked immunosorbent assay, quantitative reverse transcription-polymerase chain reaction, western blotting, transcriptomics, and proteomics were performed to assess alterations in fibrosis and basement membrane (BM) gene expression. …”
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Impact of R-loops on oncogene-induced replication stress in cancer cells by Heuzé, Jonathan, Lin, Yea-Lih, Lengronne, Armelle, Poli, Jérôme, Pasero, Philippe

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Integrated metabolomics and transcriptomics reveal the role of calcium sugar alcohol in the regulation of phenolic acid biosynthesis in Torreya grandis nuts by Qiandan Xie, Zhengchu Jiang, Chenliang Yu, Qi Wang, Wensheng Dai, Jiasheng Wu, Weiwu Yu

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A scATAC-seq atlas of stasis zone in rat skin burn injury wound process by Ruikang Li, Jiashan Li, Shuai Liu, Xinya Guo, Jianyu Lu, Tao Wang, Tao Wang, Junjie Chen, Yue Zheng, Yue Yuan, Jiaxin Du, Jiaxin Du, Bolin Zhu, Bolin Zhu, Xiaoyu Wei, Pengcheng Guo, Longqi Liu, Longqi Liu, Xun Xu, Xi Dai, Runzhi Huang, Xin Liu, Xin Liu, Xiaoyan Hu, Shiwei Wang, Shizhao Ji

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SMYD3 drives cell cycle and epithelial-mesenchymal transition pathways through dual gene transcriptional repression and activation in HPV-negative head and neck cancer by Madhavi Murali, Abbas Saeed, Sohyoung Kim, Kyunghee Burkitt, Hui Cheng, Arfa Moshiri, Jawad Akhtar, Daniel Tsai, Marie Luff, Baktiar Karim, Vassiliki Saloura

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Transcriptomic dynamics and cell-to-cell communication during the transition of prospermatogonia to spermatogonia revealed at single-cell resolution by Zhen He, Rong-Ge Yan, Qin-Bang Shang, Qi-En Yang

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