Accuracy of Artificial Intelligence Based Chatbots in Analyzing Orthopedic Pathologies: An Experimental Multi-Observer Analysis by Tobias Gehlen, Theresa Joost, Philipp Solbrig, Katharina Stahnke, Robert Zahn, Markus Jahn, Dominik Adl Amini, David Alexander Back

“…However, there is a broad variation in the accuracy between different digital tools. Altogether, this field of AI application shows excellent potential and should be further examined in future studies.…”
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Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis by Lei Xiang, Qingzhou Li, Zhiwei Guan, Guilin Wang, Xiankuo Yu, Xianwen Zhang, Guochen Zhang, Jushan Hu, Xue Yang, Mingrui Li, Xilinqiqige Bao, Yumei Wang, Dong Wang

“…Gene expression profiles (GEPs) were collected from MDA-MB-231 cells treated with ORes at varying concentrations using HTS2. Bioinformatics tools were used to predict the anticancer activity and MOA of ORes. …”
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Multiparametric MRI and artificial intelligence in predicting and monitoring treatment response in bladder cancer by Yuki Arita, Thomas C. Kwee, Oguz Akin, Keisuke Shigeta, Ramesh Paudyal, Christian Roest, Ryo Ueda, Alfonso Lema-Dopico, Sunny Nalavenkata, Lisa Ruby, Noam Nissan, Hiromi Edo, Soichiro Yoshida, Amita Shukla-Dave, Lawrence H. Schwartz

“…Predictive models integrate imaging biomarkers and clinical data using AI tools. Multicenter studies with strict criteria validate radiomics and QIBs clinically. …”
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Community health system capacities and capabilities within an evolving community health policy framework: mixed methods study of stakeholders in central Uganda by Raymond Tweheyo, Diana Atwine, Richard Kabanda, Ronald Miria Ocaatre, Bounggui Kim, Simon Erisa Waiswa, Prichard Denzel Kavuma, Yeni Lee, Loretah Mutoni, Solyi Kim, Yein Park, Monica Okuga

“…Households’ most received CHW services included home visits, treatment for sick under-five children and child immunisation.Conclusions The existing CHW system has governance and reporting strengths but could be enhanced through revitalization, enhanced coordination of stakeholders, providing appropriate training, work tools, supervision and engaging the community for accountability of results.…”
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CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials by Dimitrios Zouraris, Angelos Mavrogiorgis, Andreas Tsoumanis, Laura Aliisa Saarimäki, Giusy del Giudice, Antonio Federico, Angela Serra, Dario Greco, Ian Rouse, Julia Subbotina, Vladimir Lobaskin, Karolina Jagiello, Krzesimir Ciura, Beata Judzinska, Alicja Mikolajczyk, Anita Sosnowska, Tomasz Puzyn, Mary Gulumian, Victor Wepener, Diego S.T. Martinez, Romana Petry, Naouale El Yamani, Elise Rundén-Pran, Sivakumar Murugadoss, Sergey Shaposhnikov, Vasileios Minadakis, Periklis Tsiros, Harry Sarimveis, Eleonora Marta Longhin, Tanima SenGupta, Ann-Karin Hardie Olsen, Viera Skakalova, Peter Hutar, Maria Dusinska, Anastasios G. Papadiamantis, L. Cristiana Gheorghe, Katie Reilly, Emilie Brun, Sami Ullah, Sebastien Cambier, Tommaso Serchi, Kaido Tämm, Candida Lorusso, Francesco Dondero, Evangelos Melagrakis, Muhammad Moazam Fraz, Georgia Melagraki, Iseult Lynch, Antreas Afantitis

“…Despite challenges, such as limited regulatory acceptance of New Approach Methodologies (NAMs) currently, which has implications for predictive nanosafety assessment, CompSafeNano has successfully developed tools and models that are integral to the safety evaluation of NMs, and that enable the extensive datasets on NMs safety to be utilised for the re-design of NMs that are inherently safer, including through prediction of the acquired biomolecule coronas which provide the biological or environmental identities to NMs, promoting their sustainable use in diverse applications. …”
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Balancing environmental impact: A sustainability index analysis of sorghum production for food and feed by A. Prabowo, R.N. Hayati, S. Minarsih, B. Haryanto, D.D. Ludfiani, A. Supriyo, S. Subiharta, E. Nurwahyuni, Y. Hindarwati, M.N. Setiapermas, S. Sudarto, S. Samijan, B. Utomo, E. Winarn, N.D. Suretno, W. Wibawa, S. Agustini, A. Prasetyo, F.R.P. Hantoro, W. Hariyanto, V.E. Aristya

“…Analysis across four dimensions showed that the social dimension had the highest (83.80) sustainability index, followed by the technological (82.28), economical (77.46), and environmental (75.15) dimensions. A total of 12 attributes were found to greatly affect sustainability. …”
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Expression of USP18 and IL2RA Is Increased in Individuals Receiving Latent Tuberculosis Treatment with Isoniazid by Eleane de Oyarzabal, Lourdes García-García, Claudia Rangel-Escareño, Leticia Ferreyra-Reyes, Lorena Orozco, María Teresa Herrera, Claudia Carranza, Eduardo Sada, Esmeralda Juárez, Alfredo Ponce-de-León, José Sifuentes-Osornio, Robert J. Wilkinson, Martha Torres

“…Changes in the profiles of USP18, IL2RA, IFNA, CCL4, and CXCL11 expressions during INH treatment in TST-positive individuals, regardless of IGRA status, are potential tools for monitoring latent tuberculosis treatment.…”
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Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies by Camilla T. Ekanger, Camilla T. Ekanger, Camilla T. Ekanger, Nilima Dinesh Kumar, Rosanne W. Koutstaal, Fan Zhou, Martin Beukema, Joanna Waldock, Simon P. Jochems, Noa Mulder, Cécile A. C. M. van Els, Cécile A. C. M. van Els, Othmar G. Engelhardt, Nathalie Mantel, Kevin P. Buno, Karl Albert Brokstad, Karl Albert Brokstad, Agnete S. T. Engelsen, Agnete S. T. Engelsen, Rebecca J. Cox, Rebecca J. Cox, Barbro N. Melgert, Barbro N. Melgert, Anke L. W. Huckriede, Puck B. van Kasteren

“…IntroductionComplex in vitro respiratory models, including air-liquid interface (ALI) transwell cultures and airway organoids, have emerged as promising tools for studying human respiratory virus infections. …”
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Titanium nanotubes modulate immunophenotyping and cytokine secretion of T cells via IL-17A: a bioinformatic analysis and experimental validation by Jingju Yin, Jingju Yin, Jingju Yin, Jingju Yin, Yunyang Liao, Yunyang Liao, Yunyang Liao, Yunyang Liao, Shaofeng Liu, Shaofeng Liu, Shaofeng Liu, Shaofeng Liu, Bangwei Che, Hanghang Zhu, Hanghang Zhu, Bingbing Yang, Bingbing Yang, Bingbing Yang, Bingbing Yang, Bin Shi, Bin Shi

“…ObjectWe aim to explore the immunomodulatory properties of T cells on different titanium nanotubes and the key immunological factors involved in this process.MethodsTranscriptome data from GEO database of healthy people and healthy implants were used to analyze cell infiltration and factor distribution of adaptive immune using bioinformatics tools. T cells from activated rat were cultured on titanium nanotubes that were prepared by anodization with different diameters (P-0, NT15-30 nm, NT40-100 nm, NT70-200 nm). …”
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Can system dynamics explain long-term hydrological behaviors? The role of endogenous linking structure by X. Zhou, Z. Sheng, K. Manevski, K. Manevski, K. Manevski, R. Zhao, R. Zhao, Q. Zhang, Y. Yang, S. Han, J. Liu, J. Liu, Y. Yang, Y. Yang, Y. Yang

“…<p>Hydrological models with conceptual tipping bucket and process-based evapotranspiration formulations are the most common tools in hydrology. However, these models consistently fail to replicate long-term and slow dynamics of a hydrological system, indicating the need for model augmentation and a shift in formulation approach. …”
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Characterizing executive functioning and associated behaviors in individuals with dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) syndrome by Hannah M. Rea, Sara Jane Webb, Sara Jane Webb, Evangeline C. Kurtz-Nelson, Caitlin M. Hudac, Caitlin M. Hudac, Raphael A. Bernier, Conor Miles, Rachel Earl, Alana Whiting, Curtis Eayrs, Margaret Johansson, Tianyun Wang, Tianyun Wang, Tianyun Wang, Evan E. Eichler, Evan E. Eichler, Emily Neuhaus, Emily Neuhaus

“…We first examined the feasibility and appropriateness of established executive functioning measures among participants with DYRK1A syndrome to inform selection of executive functioning tools in future research. We then characterized executive functioning among the group, including associations with other phenotypic features.ResultsNeurocognitive assessments of executive functioning were deemed infeasible due to cognitive and verbal functioning. …”
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Three-dimensional structure of entire hydrated murine hearts at histological resolution by Jasper Frohn, Frederik Böddeker, Marius Reichardt, Hendrik Bruns, Titus Czajka, Amara Khan, Ludovic Broche, Michael Krisch, Alberto Bravin, Frauke Alves, Jana Zschüntzsch, Tim Salditt

“…Semi-automatic determination of structural metrics is already achieved and the corresponding tools and resulting data are made publically available. …”
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Unveiling the role of ASPP1 in cancer progression: pan-cancer bioinformatics and experimental validation in colorectal cancer by Keyuan Xiao, Xiang Li, Ihsan Ullah, Wenqing Hu, Kaiqiang Wang, Fan Yang, Chengyu Yang, Chunqi Feng, Liang Zong, Xinghua Li

“…Data were extracted from public resources, including The Cancer Genome Atlas (TCGA), GTEx, and the Human Protein Atlas, and analyzed via tools such as cBioPortal, GEPIA, and TIMER2. Statistical and network analyses were performed with R, Cytoscape, and Hiplot. …”
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Genomic epidemiology of third-generation cephalosporin-resistant Escherichia coli from companion animals and human infections in Europe by Adrien Biguenet, Benoit Valot, Farid El Garch, Xavier Bertrand, Didier Hocquet

“…The aim of this study was to compare the genomes of third-generation cephalosporin-resistant (3GC-R) Escherichia coli responsible for human and pet infections in Europe.Whole-genome sequencing data from 3GC-R E. coli isolated from clinical samples of humans, dogs and cats, and published in eight European studies were re-analyzed using bioinformatics tools. The acquired genes responsible for 3GC-R were identified. …”
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Artificial intelligence-enabled non-invasive ubiquitous anemia screening: The HEMO-AI pilot study on pediatric population by Daniel Gordon, Jason Hoffman, Keren Gamrasni, Yotam Barlev, Alex Levine, Tamar Landau, Ronen Shpiegel, Avishai Lahad, Ariel Koren, Carina Levin, Osnat Naor, Hannah Lee, Xin Liu, Shwetak Patel, Gilad Chayen, Michael Brandwein

“…Conclusions This study lays the groundwork for the future evolution of non-invasive, pain-free, and accessible anemia screening tools tailored specifically for pediatric patients. …”
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Analysis of stomatal characteristics of maize hybrids and their parental inbred lines during critical reproductive periods by Changyu Zhang, Changyu Zhang, Yu Jin, Yu Jin, Jinglu Wang, Jinglu Wang, Ying Zhang, Ying Zhang, Yanxin Zhao, Xianju Lu, Xianju Lu, Wei Song, Xinyu Guo, Xinyu Guo

“…The evolving imaging and image processing technologies offer effective tools for precise analysis of stomatal phenotypes. …”
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Early diagnosis and the effect of treatment compliance on the prognosis and progression of glaucomatous optic neuropathy by S.V. Diordiychuk, A.V. Kuroyedov, N.E. Fomin, O.V. Gapon’ko, V.V. Gorodnichiy, I.V. Kondrakova, N.M. Sol’nov

“…The specificity of this case report is a long-term observation period at one hospital and the use of standardized diagnostic tools. Moreover, dynamic monitoring was performed using the same devices to assess structural and functional alterations of the retina and optic nerve. …”
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Whole-genome analysis of a ST45-SCCmec IVa (2B)-t116 methicillin-resistant Staphylococcus aureus strain isolated from the sputum of a 5-year-old child with pneumonia by Lin Huang, Rui Guo, Jingxian Lin, Xiaowei Li, Zhicong Li, Limei Zhang, Wenting Li, Rui Xue, Cheng Zhang, Xiaosan Feng, Xiaobin Li, Xiaobin Li

“…The carriage of antibiotic resistance genes, virulence genes, and mobile genetic elements were identified using bioinformatics tools. The comparative genomic analyses of MRSA strain SA2107 with other MRSA strains worldwide were performed.FindingsThe genome size of ST45-SCCmec IVa (2B)-t116 MRSA strain SA2107 was ~2.9 Mb. …”
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Overexpression of miR-21-5p as a potential pathogenesis marker for ovarian endometriosis by Mohamed Mahmoud, Amr Ahmed WalyEldeen, Mohamed A. Samie, Ahmed M. Sadek, Sayed Elakhras, Mohamed Samir, Osama Ahmed, Rasha Mohamed Samir Sayed, Ahmed Abdelaziz Baiomy, Sherif Abdelaziz Ibrahim, Hebatallah Hassan

“…A significant overexpression of miR-21-5p in ovarian endometrioma was further independently verified by qPCR. Using bioinformatics tools, Gene Ontology Kyoto Encyclopedia of Genes and Genomes pathways, and protein–protein interactions, we identified differentially expressed genes and several pathways regulated by miR-21-5p that may contribute to endometriosis progression. …”
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Expression and delivery of HA1-M2e antigen using an innovative attenuated Salmonella–mediated delivery system confers promising protection against H9N2 avian influenza challenge by Ram Prasad Aganja, In-Shik Kim, Hyun-Jin Tae, John Hwa Lee

“…It demonstrated a safety profile with lower induction of inflammatory cytokines than the wild-type strain. Bioinformatics tools predicted that the HA1 and M2e sequences, which were designed as consensus sequences of South Korean strains (2000–2021), would have high antigenicity and favorable structures. …”
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