Association of antihypertensive drug target genes with alzheimer’s disease: a mendelian randomization study by He Zheng, Chaolei Chen, Yingqing Feng

“…A similar direction of association was also observed between ACE expression in prefrontal cortex (OR, 1.19; 95% CI, 1.10–1.28), frontal cortex (OR, 1.19; 95% CI, 1.11–1.27), cerebellum (OR, 1.13; 95% CI, 1.09–1.17), cortex (OR, 1.59; 95% CI, 1.33–1.28) and ACE protein levels in plasma (OR, 1.13; 95% CI, 1.09–1.17) and AD risk. …”
Get full text

Effect of breathing exercises with biofeedback on blood pressure in pre-hypertensive women: a randomised controlled trial by Afaf M. Botla, Reham S. Ebrahim, Soheir M. Elkosery, Ahmed M. Darwesh, Dina M.A. Mohamed

“…They were divided randomly into two equal groups, with ages ranging from 30 to 40: study group (group A) who performed slow abdominal breathing (six cycles/minute) combined with frontal electromyography (EMG) biofeedback training (3 days per week for 10 sessions) and a control group (group B) who performed slow abdominal breathing (six cycles/minute, 3 days per week for 10 sessions). …”
Get full text

Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control by Danyan Chen, Jiaying Lu, Hucheng Zhou, Jiehui Jiang, Ping Wu, Qihao Guo, Jingjie Ge, Huiwei Zhang, Kuangyu Shi, Chuantao Zuo

“…Moreover, four significantly altered regions were observed in the DLB group: Inferior frontal gyrus, opercular part (IFG.R), olfactory cortex (OLF.R), hippocampus (HIP.R), and fusiform gyrus (FFG.L). …”
Get full text

EGFR-Mutated Lung Adenocarcinoma With Li–Fraumeni Syndrome: The Imperative for Germline Testing in Patients With a Family History, a Case Report by Hiroyuki Fujii, MD, Yusuke Okuma, MD, PhD, Makoto Hirata, MD, PhD, Yuki Shinno, MD, PhD, Tatsuya Yoshida, MD, PhD, Yasushi Goto, MD, PhD, Hidehito Horinouchi, MD, PhD, Noboru Yamamoto, MD, PhD, Yuichiro Ohe, MD, PhD

“…After the diagnosis of LFS, she underwent genetic counseling and has been screened for the development of a second cancer based on the Toronto protocol.This case highlights the importance of family history interviews and considering the practice of germline genomic testing for optimal management of lung cancer patients with a hereditary cancer syndrome such as LFS. …”
Get full text

Alterations in the social-conditioned place preference and density of dopaminergic neurons in the ventral tegmental area in Clsnt2-KO mice by I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev, K. E. Uldanova, E. A. Chuyko, V. A. Naprimerov, T. V. Lipina, T. G. Amstislavskaya, S. Ya. Amstislavsky

Get full text

Derivation and Application of a Scaling between Hinode/SP and SDO/HMI Vector Magnetic Fields to Improve Magnetic Field Extrapolations by C. Beck, A. Prasad, Q. Hu, M. S. Yalim, S. Gosain, D. Prasad Choudhary

Get full text

Differential impact of minimum unit pricing on alcohol consumption between Scottish men and women: controlled interrupted time series analysis by Peter Anderson, Eileen F S Kaner, Jakob Manthey, Jürgen Rehm, Amy O'Donnell, Eva Jané Llopis

Get full text

The Interaction Effects of Suicidal Ideation and Childhood Abuse on Brain Structure and Function in Major Depressive Disorder Patients by Wei Wang, Lijun Kang, Nan Zhang, Xin Guo, Peilin Wang, Xiaofen Zong, Lihua Yao, Hanping Bai, Jing Cheng, Ning Tu, Hongyan Feng, Gaohua Wang, Lihong Bu, Fei Wang, Zhongchun Liu

“…Results showed that the changes of GMV in the cuneus, precuneus, paracentric lobule, inferior frontal gyrus, and caudate nucleus and local activity in cuneal and middle temporal gyrus are in relation with SI and childhood abuse. …”
Get full text

Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome by Xin Tao, Katilynne Croom, Adrian Newman-Tancredi, Mark Varney, Khaleel A. Razak

“…Using epidural electrodes, we recorded auditory event related potentials (ERP) and auditory temporal processing with a gap-in-noise auditory steady state response (ASSR) paradigm at two ages, postnatal (P) 21 and 30 days, from both auditory and frontal cortices of awake, freely moving mice, following NLX-101 (at 1.8 mg/kg i.p.) or saline administration. …”
Get full text

Increased Growth Differentiation Factor 15 Levels Are Associated with HIV-Associated Neurocognitive Impairment: A Pilot Study by Ali Boustani, Mary K. Ford, Jacqueline R. Kulbe, Anna E. Laird, Leeann Shu, Matthew Spencer, Bryant Avalos, Kyle C. Walter, Ronald J. Ellis, Jerel Adam Fields

“…GDF15 protein levels were significantly elevated in the frontal cortices of PWH with NCI compared to NUI PWH. …”
Get full text

Profundización del tope de permafrost y tendencias en la dinámica criogénica, a partir de 1989, en el glaciar de escombros compuesto del valle de Morenas Coloradas, Mendoza, Argent... by Darío Trombotto Liaudat

“…Las variaciones descriptas se expresan a través de la profundización del tope de permafrost, formación de termokarst y reactivación de los más antiguos a lo largo del valle, y pérdida de movimiento, o de la criodinámica, en los taludes frontales (“narices”) en la parte inferior y de menor altura de las geoformas investigadas. …”
Get full text

Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury by Sandra Strazzer, Maria A. Rocca, Erika Molteni, Ermelinda De Meo, Monica Recla, Paola Valsasina, Filippo Arrigoni, Susanna Galbiati, Alessandra Bardoni, Massimo Filippi

“…They also experienced a greater activation of frontal regions, which was correlated with worse performance on FIM, WISC, and fMRI CCPT. …”
Get full text

In Vivo Corneal Confocal Microscopy Detects Improvement of Corneal Nerve Parameters following Glycemic Control in Patients with Type 2 Diabetes by Xiaofan Jia, Xiaogang Wang, Xiaoxia Wang, Qi Pan, Tongzhang Xian, Xiaobin Yu, Lixin Guo

“…Thirty-two patients with diabetes complicated by DPN and 12 age-matched control subjects underwent detailed clinical examination and were assessed per the Toronto Clinical Scoring Scale for DPN, nerve conduction studies, and IVCCM at baseline and after approximately one year from the first visit. …”
Get full text

Incidence of alexithymia in worsening symptoms and quality of life of Systemic Lupus Erythematosus patients (SLE) by Fabio Rapisarda, Concetta Mezzatesta, Antonina Butticè, Alessandro Raffa, Stefano Boca

“…The group of patients was recruited within the Connetiviti outpatients’ clinic of the UOC (Complex Oparational Unit) of Rheumatology of the Paolo Giaccone University Polyclinic in Palermo, consisting of healthy subjects and/or with known diagnoses identified within non-clinical contexts, chosen randomly (statistical sense) in order to better represent the general population of the territorial context.Specific psycho-diagnostic measures were administered: Toronto Alexithymia Scale (TAS-20), Response Evaluation Measure (REM-71),Attachment Style Questionnaire (ASQ), Eysenck Personality Inventory (EPI),Symptom Check list (SCL-90), Short Form (SF-36). …”
Get full text

Successful Treatment of Tumor-Induced Osteomalacia by Multidisciplinary Therapy with Radiation to Intracranial Fibromyxoid Tumor by Mariangela Massaccesi, Francesco Miccichè, Mario Rigante, Gianluigi Petrone, Elisabetta Lepre, Maria Antonietta Gambacorta, Vincenzo Valentini

“…After multidisciplinary consultation, in July 2015, postoperative adjuvant radiotherapy was offered to a 52-year-old man with a multiple recurrent ossifying fibromyxoid tumor in the right frontal sinus causing TIO. The patient had a history of multiple bone fractures and pain since more than 20 years. …”
Get full text

Longitudinal Screening Detects Cognitive Stability and Behavioral Deterioration in ALS Patients by Susan Woolley, Ray Goetz, Pam Factor-Litvak, Jennifer Murphy, Jonathan Hupf, Catherine Lomen-Hoerth, Howard Andrews, Daragh Heitzman, Richard Bedlack, Jonathan Katz, Richard Barohn, Eric Sorenson, Bjorn Oskarsson, Americo Fernandes Filho, Edward Kasarskis, Tahseen Mozaffar, Sharon Nations, Andrea Swenson, Agnes Koczon-Jaremko, Georgia Christodoulou, Hiroshi Mitsumoto

“…We found significant worsening of behavior (ALS Cognitive Behavioral Screen (ALS CBS) behavioral scale, p<0.001; Frontal Behavioral Inventory-ALS (FBI-ALS) disinhibition subscale, p=0.044). …”
Get full text

Understanding the exodus: a 15-year retrospective cohort study on the pattern and determinants of migration among Nigerian doctors and dentists by Oghenebrume Wariri, Patience Toyin-Thomas, Itua C.G. Akhirevbulu, Oladapo Oladeinde, Oluchi Omogbai, Philippa Odika, John Osakue, Avwebo Ukueku, Efetobo Orikpete, Chinelo Iwegim, Efe E. Omoyibo, Jermaine Okpere, Uwaila Otakhoigbogie, Ekhosuehi T. Agho, Sunday C. Madubueze, Nnennaya C. Ugoji, Chukwunwike W. Ozegbe, Oti N. Aria, Paul Ikhurionan

Get full text

Trends in the Use of Sphingosine 1 Phosphate in Age-Related Diseases: A Scientometric Research Study (1992-2020) by Qiong He, Gaofeng Ding, Mengyuan Zhang, Peng Nie, Jing Yang, Dong Liang, Jiaqi Bo, Yi Zhang, Yunfeng Liu

“…The USA (n=175), China (n=42), and Germany (n=37) were the three largest contributors to the global publications on S1P and aging, while the Medical University of South Carolina (n=15), University of California, San Francisco (n=13), and University of Toronto (n=13) were the leading institutions in this field. …”
Get full text

Association of individual-based morphological brain network alterations with cognitive impairment in type 2 diabetes mellitus by Die Shen, Xuan Huang, Ziyu Diao, Jiahe Wang, Kun Wang, Weiye Lu, Shijun Qiu, Shijun Qiu

“…Subsequently, partial correlation analyses were performed to explore the relationship between clinical biochemical indices, neuropsychological test scores, and altered cortical morphology and network indices.ResultsBrain regions with reduced gray matter volume and cortical thickness in T2DM patients were mainly concentrated in the frontal lobe, temporal lobe, parietal lobe, anterior cingulate gyrus, insula, lingual gyrus, and cerebellar hemispheres. …”
Get full text

Utilities Associated with the Treatment of Growth Hormone Deficiency (GHD): A Time Trade-off (TTO) Study in the UK and Canada by Kirsch S, Butler G, Jensen LDF, Okkels A, Yssing C, Håkan-Bloch J

“…Susan Kirsch,1 Gary Butler,2 Lasse de Fries Jensen,3 Anna Okkels,4 Cecilie Yssing,4 Jonas Håkan-Bloch3 1Department of Pediatric Endocrinology, Hospital for Sick Children, Toronto and Oak Valley Health Hospital, Markham, Ontario, Canada; 2Department of Paediatric Endocrinology, University College London Hospitals, and UCL Great Ormond Street Institute of Child Health, London, UK; 3Novo Nordisk, Søborg, 2860, Denmark; 4EY Godkendt Revisionspartnerselskab, Frederiksberg, 2000, DenmarkCorrespondence: Lasse de Fries Jensen, Novo Nordisk, Vandtårnsvej 108-110, Søborg, 2860, Denmark, Tel +45 34482020, Email LDFJ@novonordisk.comPurpose: Growth hormone deficiency (GHD) causes decreased growth rate in children, resulting in short stature in childhood and adulthood. …”
Get full text