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A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis
Published 2025-01-01“…This novel approach offers several advantages: (1) it eliminates the need for anesthesia in mice during administration and simplifies the instrument manipulation; (2) it is cost-effective by utilizing mice instead of larger animals; (3) it shortens the time from several months to 16 or 17 days for obtaining result; (4) it is non-invasive by directly measuring the live RLUs of mice as a surrogate marker for colony-forming units for in vivo drug activity testing; (5) up to six mice can be administrated daily and simultaneously, even 2–3 times/day; (6) results are relatively objective and reproducible results minimizing human factors. …”
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A sustainable breakthrough in rodent pest control: laboratory validation of novel neem-andrographolide bait with dual toxic and contraceptive effects
Published 2025-02-01“…Results Results revealed good palatability of NSA bait and 54.16% mortality in rats. Remaining live rats revealed significant reduction in the body weight, weight of reproductive organs, duration of estrous cycle, number of both normal and atretic follicles, and level of sex hormones in all the treated groups. …”
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A Novel Power-Driven Grey Model with Whale Optimization Algorithm and Its Application in Forecasting the Residential Energy Consumption in China
Published 2019-01-01“…Along with the improvement of Chinese people’s living standard, the proportion of residential energy consumption in total energy consumption is rapidly increasing in China year by year. …”
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A Novel Telehealth Exercise Program Designed for Rural Survivors of Cancer With Cancer-Related Fatigue: Single-Arm Feasibility Trial
Published 2025-01-01“…ObjectiveThe purpose of this investigation was to assess the feasibility of a novel telehealth exercise program designed specifically for rural survivors of cancer with CRF. …”
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Six new species of zombie-ant fungi from Yunnan in China
Published 2023-05-01“…We have provided a method for obtaining living cultures of Ophiocordyceps unilateralis complex species and their asexual morphs based on the living cultures, which is of significant value for further studies of Ophiocordyceps unilateralis complex species in the future.…”
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Antibody in Lymphocyte Supernatant (ALS) responses after oral vaccination with live Shigella sonnei vaccine candidates WRSs2 and WRSs3 and correlation with serum antibodies, ASCs,...
Published 2021-01-01“…A recently completed trial of two novel S. sonnei live oral vaccine candidates WRSs2 and WRSs3 established that both candidates were safe, well tolerated and immunogenic in a vaccine dose-dependent manner. …”
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Unterzakhn, Dirty Laundry, and the Map of Lost New York: An Interview with Leela Corman
Published 2015-08-01“…Finally, she discusses her desire to tell a story about women’s lives from a female perspective, as well as the ways her characters’ lives are circumscribed by gender roles.…”
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Novel Fast-Setting and Mechanically-Strong Calcium Phosphate Pulp-Capping Cement with Metformin Release to Enhance Dental Pulp Stem Cells
Published 2024-12-01“…These findings suggest that the novel CPCC-Met demonstrates promise as a fast-setting, cost-effective pulp-capping material, offering metformin delivery to enhance dentin repair.…”
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A Novel, Cell-Compatible Hyaluronidase Activity Assay Identifies Dextran Sulfates and Other Sulfated Polymeric Hydrocarbons as Potent Inhibitors for CEMIP
Published 2025-01-01“…To identify novel inhibitors of the CEMIP hyaluronidase activity, we established here a cell-compatible, medium-throughput assay for CEMIP-dependent HA depolymerization. …”
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Bringing Motor Imagery BCI systems outside of the laboratory into daily activities
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Cross-species comparison of AlphaFold-derived G protein-coupled receptor structures reveals novel melatonin-related receptor in Neurospora crassa.
Published 2025-01-01“…Melatonin, a molecule with diverse biological functions, is ubiquitously present in living organisms. There is significant interest in understanding melatonin signal transduction pathways in humans, particularly due to its critical role in regulating the sleep-wake cycle. …”
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