Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…Naegleria fowleri is a thermophilic free-living amoeba that can cause a rare and fatal infection of the brain called primary amoebic meningoencephalitis (PAM). …”
Get full text

Analysis and Recommendation of Outdoor Activities for Smart City Users Based on Real-Time Contextual Data by S. R. Mani Sekhar, D. M. Mushtaq Ahmed, G. M. Siddesh

“…Smart cities leverage advanced technologies to enhance urban living through the real-time collection, processing, and analysis of contextual information. …”
Get full text

Assessment of Geriatric Problems and Risk Factors for Delirium in Surgical Medicine: Protocol for Multidisciplinary Prospective Clinical Study by Henriette Louise Möllmann, Eman Alhammadi, Soufian Boulghoudan, Julian Kuhlmann, Anica Mevissen, Philipp Olbrich, Louisa Rahm, Helmut Frohnhofen

“…This collectively raises novel challenges due to higher age heavily impacting treatment. …”
Get full text

A cell-penetrating bispecific antibody suppresses hepatitis B virus replication and secretion by Chongwei Xie, Bing Zhou, Da Yao, Xin Wang, Lihong Zhong, Chuanghua Qiu, Junfang Zhang

“…This cell-penetrating bispecific antibody is a novel approach to suppressing HBV replication and secretion and is a promising anti-HBV therapeutic antibody candidate.…”
Get full text

Autologous Bone Marrow Mononuclear Cells in Ischemic Cerebrovascular Accident Paves Way for Neurorestoration: A Case Report by Alok Sharma, Hemangi Sane, Anjana Nagrajan, Nandini Gokulchandran, Prerna Badhe, Amruta Paranjape, Hema Biju

“…We hypothesize that cell therapy may be safe, novel and appealing treatment for chronic ischemic stroke. …”
Get full text

Hemodynamic disturbance and mTORC1 activation: Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome by Ming-Yuan Liu, Meili Wang, Junjun Liu, An-Qiang Sun, Chang-Shun He, Xin Cong, Wei Kong, Wei Li

“…Thoracic aortic aneurysm (TAA) significantly endangers the lives of individuals with Marfan syndrome (MFS), yet the intricacies of their biomechanical origins remain elusive. …”
Get full text

Malaria exposure remodels the plasma proteome of Ghanaian children by Aisha M. Mohammed, Charles Ochieng’ Olwal, Andrea Fossati, Nancy K. Nyakoe, Jacqueline M. Fabius, Martin Gordon, Benjamin J. Polacco, Danielle L. Swaney, Gordon A. Awandare, Nevan J. Krogan, Mehdi Bouhaddou, Yaw Bediako

“…Results We identified several differentially abundant proteins in children living in high malaria transmission areas relative to children in low transmission areas. …”
Get full text

The burden of group A Streptococcus (GAS) infections: The challenge continues in the twenty-first century by Aswin Thacharodi, Saqib Hassan, Avadh Vithlani, Tawfeeq Ahmed, Sanjana Kavish, Nicole-Mae Geli Blacknell, Ali Alqahtani, Arivalagan Pugazhendhi

“…This review thus provides insights into the most recent research on the pathogenesis, virulence, resistance, and host interaction mechanisms of GAS, as well as novel management options to assist scientific communities in combating GAS infections.…”
Get full text

Designing smartphone-based cognitive assessments for schizophrenia: Perspectives from a multisite study by Aishwarya Raje, Abhijit R. Rozatkar, Urvakhsh Meherwan Mehta, Ritu Shrivastava, Ameya Bondre, Manaal Amir Ahmad, Anshika Malviya, Yogendra Sen, Deepak Tugnawat, Anant Bhan, Tamonud Modak, Nabagata Das, Srilakshmi Nagendra, Erlend Lane, Juan Castillo, John A. Naslund, John Torous, Soumya Choudhary

“…Discussion & conclusion: People living with schizophrenia, from different sites in the US and India, appear interested in using smartphone apps to track their cognition. …”
Get full text

Impact of the external knee flexion moment on patello-femoral loading derived from in vivo loads and kinematics by Adam Trepczynski, Paul Kneifel, Mark Heyland, Marko Leskovar, Philippe Moewis, Philipp Damm, William R. Taylor, Stefan Zachow, Georg N. Duda

“…Our study also demonstrates the relevance of PF contact forces, which reach magnitudes similar to TF forces during activities of daily living.…”
Get full text

Genome evolution following an ecological shift in nectar-dwelling Acinetobacter by Vivianna A. Sanchez, Tanya Renner, Lydia J. Baker, Tory A. Hendry

“…Acinetobacter living in nectar gained genes for degrading pectin, a plant polysaccharide, which may improve access to nutrients in their environment. …”
Get full text

Opening up Corpus FinSL: enriching corpus analysis with linguistic ethnography in a study of constructed action by Puupponen Anna, Hodge Gabrielle, Anible Benjamin, Salonen Juhana, Wainio Tuija, Keränen Jarkko, Hernández Doris, Jantunen Tommi

“…We argue that this kind of approach enables signed language corpus linguistics to “open up” more to signers’ lived experiences, while still “tying down” empirical descriptions of FinSL. …”
Get full text

Scalable Manufacturing Method for Model Protein-Loaded PLGA Nanoparticles: Biocompatibility, Trafficking and Release Properties by Selin Akpinar Adscheid, Marta Rojas-Rodríguez, Salma M. Abdel-Hafez, Francesco S. Pavone, Marc Schneider, Akif E. Türeli, Martino Calamai, Nazende Günday-Türeli

“…We tested the biocompatibility of the NPs in living RPMI 2650 and neuroblastoma cell lines, as well as their trafficking and uptake. …”
Get full text

Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing by Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M. J. Aertker, Fabian Higel

“…Previous reports have shown that mAbs containing high-mannose N-glycans are cleared faster from blood circulation, leading to reduced half-lives. The high-mannose N-glycan content of mAbs can be influenced during the cell culture process by factors such as cell lines, process conditions, and media. …”
Get full text

RETRACTED: Modern Subtype Classification and Outlier Detection Using the Attention Embedder to Transform Ovarian Cancer Diagnosis by S. M. Nuruzzaman Nobel, S M Masfequier Rahman Swapno, Md. Ashraful Hossain, Mejdl Safran, Sultan Alfarhood, Md. Mohsin Kabir, M. F. Mridha

“…This study highlights how machine learning can revolutionize the medical field’s ability to classify ovarian cancer subtypes and identify outliers, giving doctors a valuable tool to lessen the severe effects of the disease. Adopting this novel method is likely to improve the practice of medicine and give people living with ovarian cancer worldwide hope.…”
Get full text

Investigating LiDAR Metrics for Old-Growth Beech- and Spruce-Dominated Forest Identification in Central Europe by Devara P. Adiningrat, Andrew Skidmore, Michael Schlund, Tiejun Wang, Haidi Abdullah, Marco Heurich

“…This study introduces a novel approach for identifying old-growth forests by optimizing a set of selected LiDAR standards and structural metrics. …”
Get full text

The association between dolutegravir-based antiretrovirals and high blood pressure among adults with HIV in southern Ethiopia: a cross-sectional study by Agete Tadewos Hirigo, Daniel Yilma, Ayalew Astatkie, Zelalem Debebe

“…Background: Dolutegravir (DTG), a novel antiretroviral therapy (ART) for HIV, is increasingly adopted across sub-Saharan Africa. …”
Get full text

Addressing cancer care inequities in sub-Saharan Africa: current challenges and proposed solutions by Olabode Omotoso, John Oluwafemi Teibo, Festus Adebayo Atiba, Tolulope Oladimeji, Oluwatomiwa Kehinde Paimo, Farid S. Ataya, Gaber El-Saber Batiha, Athanasios Alexiou

Get full text

Effects of home-based mirror therapy and cognitive therapeutic exercise on the improvement of the upper extremity functions in patients with severe hemiparesis after a stroke: a pr... by Josefa Gonzalez-Santos, Raul Soto-Camara, Paula Rodriguez-Fernández, Maria Jimenez-Barrios, Jeronimo Gonzalez-Bernal, Carla Collazo-Riobo, Maha Jahouh, Yolanda Bravo-Anguiano, Jose M Trejo-Gabriel-Galan

“…These study results will provide relevant and novel information on effective neurorehabilitation strategies and improve the quality of intervention programmes aimed at patients after a stroke.Trial registration number ClinicalTrials.gov (NCT04163666).…”
Get full text

Fusarium oxysporum assisted green synthesis of small-sized silver nanoparticles for high antibacterial, and photocatalytic decolorization performances by Reyad M. El-Sharkawy, Inas A. Ahmed, Taghrid G. Kharboush

“…Abstract Background Novel platforms using nanotechnology-based medicines have exponentially increased in our daily lives. …”
Get full text