Tighter bounds on the Gaussian Q-function based on wild horse optimization algorithm by Reza Etesami, Mohsen Madadi

“…The Gaussian Q-function (GQF) is widely used in various scientific and engineering fields, especially in telecommunications and wireless communication. …”
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Integration of Quality Function Deployment and TRIZ Methodologies to Design a Sanitary Part by Dino Caesaron, Farell Ardani, Vidhea Nurhadi, Yusuf Yekti

“…One industry in Indonesia that has a tight competitive level is the ceramics industry with a growth rate of 10% per year. …”
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Arecoline regulates glycolipid and endoplasmic reticulum metabolisms in adult grass carp (Ctenopharyngodon idella) by Liangqin Wu, Na Yao, Weidan Jiang, Pei Wu, Yang Liu, Yaobin Ma, Hongmei Ren, Xiaowan Jin, Hequn Shi, Xiaoqiu Zhou, Lin Feng

“…Secondly, arecoline protected mitochondrial function by promoting the mitochondrial respiratory chain complex I–V-related protein expression and triggering the mitochondrial unfolded protein response (UPRmt) (P < 0.05). …”
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The role of transcytosis in the blood-retina barrier: from pathophysiological functions to drug delivery by Chun-Lin Zhang, Jing-Jie Ma, Xiang Li, Hai-Qing Yan, Yong-Kun Gui, Zhi-Xin Yan, Ming-Feng You, Ping Zhang

“…This review summarizes the fundamental aspects of transcytosis including its function in the healthy retina, the biochemical properties of transcytosis, and the methodologies used to study this process. …”
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The Influence of the Covid-19 Pandemic on General Trends in the Functioning and Competitiveness of Private Clinics by Stanislav Kotenko, Tatjana Tambovceva

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Dietary supplementation of Galactooligosaccharides improves growth performance and intestinal barrier function of offspring by Jichang Zheng, Haibo Shen, Bi’e Tan, Yulong Yin, Jing Wang

“…Maternal GOS improved the intestinal barrier integrity and function of piglets, which exhibiting with increased ileal ratio of villus to crypt, and higher expressions of secretory immunoglobulin A, tight junction protein and mucin-2 in ileum. …”
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Treatment of Hippophae rhamnoides Polysaccharides on Alcoholic Hepatitis and Intestinal Barrier Function in Mice by Qing LI, Guangli MA, Yiheng ZHAI, Tao MENG

“…Conclusion: HRP has a protective effect on alcoholic hepatitis, improving liver damage and intestinal barrier function in mice, and reducing liver lipid accumulation and inflammatory response.…”
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Effect of Exogenous Alpha-B Crystallin on the Structures and Functions of Trabecular Meshwork Cells by Hui Xu, Li Zhu, Yu Wang, Yongzhen Bao

“…This study, for the first time, focused on the role of CRYAB in undesired changes of the structures and functions in trabecular meshwork (TM) cells. Methods. …”
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Two Functional TP53 Genetic Variants and Predisposition to Keloid Scarring in Caucasians by Andrzej Dmytrzak, Agnieszka Boroń, Beata Łoniewska, Klaudyna Lewandowska, Iwona Gorący, Mariusz Kaczmarczyk, Andrzej Ciechanowicz

“…To investigate the association of rs1042522 (c.215G>C, p.Arg72Pro) and rs17878362 (16-bp insertion/duplication in intron 3) variants, two most frequently analyzed TP53 functional polymorphisms and the risk of keloid in Polish patients. …”
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Simulating Marine Ecosystem Dynamics and Biogeochemical Cycling With Multiple Plankton Functional Types by Jun Yu, Kristen M. Krumhardt, J. Keith Moore, Robert T. Letscher, Shanlin Wang, Nicola A. Wiseman, Matthew C. Long, Keith Lindsay, Michael Levy, Colleen M. Petrik, Adam C. Martiny

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Cosmetically Applicable Soluble Agonists for Toll-like Receptor 2 Produced by Fermentation of Asparagus Extract Supplemented with Skimmed Milk Using <i>Lactobacillus delbrueckii</i... by Yasuhiko Komatsu, Kanako Matsunaga

“…Cosmetically applicable soluble agonists for Toll-like receptor 2 (TLR2), which can strengthen skin barrier function, were produced by fermentation of asparagus (<i>Asparagus officinalis</i> L.) extract supplemented with skimmed milk using <i>Lactobacillus delbrueckii</i> subsp. …”
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Structural and functional insights into the pilotin-secretin complex of the type II secretion system. by Shuang Gu, Saima Rehman, Xiaohui Wang, Vladimir E Shevchik, Richard W Pickersgill

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A convenient research strategy for functional verification of epigenetic regulators during spermatogenesis by Shan Li, Ying Yuan, Ke-Yu Zhang, Yi-Dan Guo, Lu-Tong Wang, Xiao-Yuan Zhang, Shu Zhang, Qi Yan, Rong Zhang, Jie Chen, Feng-Tang Yang, Jing-Rui Li

“…Spermatogenesis is a fundamental process that requires a tightly controlled epigenetic event in spermatogonial stem cells (SSCs). …”
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Research progresses on functional roles and regulation mechanisms of nutrient element transporters in plants by CHEN Di, PAN Weihuai, ZHOU Zaicai, YAN Xu, PAN Jianwei

“…Thus, uptake and transport processes of these nutrients must be tightly regulated at the cellular level. Focused on Arabidopsis thaliana and Oryza sativa, this review briefly summarized the types, physical and chemical properties of nutrient element transporters, and elaborated their biological functions and action mechanisms in higher plants, including N transporter families (NPF, NRT2, CLC, SLAC/SLAH, and AMT), P transporter families (PHT1, PHT2, PHT3, PHT4, and PHT5), K transporter families (KT/HAK/KUP, HKT, CHX, and KEA), and Zn transporter families (ZIP, CDF, and P_1B-type ATPase). …”
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Functional analysis of metabolic channeling and regulation in lignin biosynthesis: a computational approach. by Yun Lee, Luis Escamilla-Treviño, Richard A Dixon, Eberhard O Voit

“…Interestingly, this comparative analysis not only helps distinguish two most parsimonious mechanisms of crosstalk between the two channels by formulating a targeted and readily testable hypothesis, but also suggests that the G lignin-specific channel is more important for proper functioning than the S lignin-specific channel. While the proposed strategy of analysis in this article is tightly focused on lignin synthesis, it is likely to be of similar utility in extracting unbiased information in a variety of situations, where the spatial organization of molecular components is critical for coordinating the flow of cellular information, and where initially various control designs seem equally valid.…”
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Design and Functional Testing of a Multichamber Perfusion Platform for Three-Dimensional Scaffolds by Marco Piola, Monica Soncini, Marco Cantini, Nasser Sadr, Giulio Ferrario, Gianfranco B. Fiore

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Ptprd deficiency promotes tau hyperphosphorylation and impairs cognitive function in aged mice by Analía Foncea, Nayhara Franchini, Isidora Tobar, Sebastián Thienel, Ignacio N. Retamal, Gonzalo I. Cancino, Francisca Cornejo

“…Abstract Background Tau phosphorylation is a tightly regulated process that ensures proper neuronal function. …”
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Differential dynamic functional network connectivity in different motor subtypes of Parkinson's disease by Yu Pan, Hang Qu, Yi Zhao, Zhaoxia Qin, Jiangbing Liu, Wei Wang

“…Results: Eight functional networks were identified, and four connectivity states were clustered. …”
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Probiotics improve intestinal oxidative stress to protect intestinal barrier function in uremic rats by WEI Meng, JIANG Hong-li, SHI Ke-hui, WANG Meng, SUN Ling-shuang, HE Quan

“…Objective To investigate whether oral probiotic Bifidobacterium animalis subsp.Lactis Bi-07 protects the intestinal barrier function of uremic rats,and explore whether it plays its biological effects by improving oxidative stress in tissues.Methods Thirty SD rats were randomly divided into 3 groups(n=10),sham operation group,uremic group,uremia + probiotic group.For the sham operation group only the renal capsule was opened,and for the uremic group 5/6 nephrectomy was conducted.For the uremia + probiotic group 5/6 nephrectomy was performed and then the animals were administered with Bi-07 every day for 4 weeks.The rats were anesthetized and the jejunum,ileum and colon segments were taken out.The ultrastructure of the intestinal epithelial tight junction complex was observed by scanning electron microscopy combined with lanthanum nitrate staining.The intestinal homogenate was prepared,and malondialdehyde(MDA) content was determined by thiobarbituric acid condensation method;and superoxide dismutase(SOD) activity was determined by xanthine oxidase method.Results Compared with the uremic group,supplement of probiotics could restore the tight junction ultrastructure between epithelial cells,with neat microvilli and intact structure.Compared with the uremic group,the intestinal permeability in the uremia + probiotic group was significantly decreased(P<0.05);serum inflammatory factors hs-CRP,IL-6,TNF-α levels were significantly lower(P<0.05);the intestinal SOD level was significantly increased(P<0.05);and the intestinal MDA showed a decreasing trend,but the difference was not statistically significant(P>0.05).Conclusions Bi-07 can improve intestinal barrier function in uremic rats.The mechanism may be realized by inhibiting intestinal oxidative stress so as to reduce intestinal barrier damage in uremic rats.…”
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The influence of the choroid plexus on brain function: beyond its role in cerebrospinal fluid production by Sayako Katada, Kelren S. Rodrigues, Kinichi Nakashima

“…The ChP is composed of tight-junction-bound epithelial cells and the underlying stroma-rich fenestrated capillaries of blood vessels. …”
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