Human beta defensin-2 protects the epithelial barrier during methicillin-resistant Staphylococcus aureus infection in chronic rhinosinusitis with nasal polyps by Tengfei Tian, Szuyao Hsu, Qin Sun, Yang Shi, Xianyang Hu, Yang Wu, Keqing Zhao, Chunquan Zheng

“…ObjectiveWe investigated the effect of human beta defensin-2 (hBD-2) on nasal epithelial barrier function with methicillin-resistant Staphylococcus aureus (MRSA) infection in chronic rhinosinusitis with nasal polyps (CRSwNP).MethodsThe expression of hBD-2 was measured in nasal polyps (NPs) from CRSwNP. …”
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Impact of viral disease hypophagia on pig jejunal function and integrity. by Emma T Helm, Shelby M Curry, Carson M De Mille, Wesley P Schweer, Eric R Burrough, Nicholas K Gabler

“…The mRNA abundance of the tight junction proteins claudin 2, claudin 3, claudin 4, occludin, and zonula occludens-1 were reduced in PRRS+ pigs compared with Ad pigs; however, neither the total protein abundance nor the cellular compartmentalization of these tight junction proteins differed among treatments. …”
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Therapeutic effects of composite probiotics derived from fermented camel milk on metabolic dysregulation and intestinal barrier integrity in type 2 diabetes rats by Tabusi Manaer, Tabusi Manaer, Tabusi Manaer, Tabusi Manaer, Jialehasibieke Sailike, Xin Sun, Baheban Yeerjiang, Baheban Yeerjiang, Baheban Yeerjiang, Baheban Yeerjiang, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi, Xinhua Nabi

“…Inflammatory markers IL-1β (12.7%, p < 0.01), TNF-α (16.7%, p < 0.05), and IL-6 (17.3%, p < 0.01) were significantly reduced. Tight junction protein expression (ZO-1, occludin, claudin-1) and mucin (MUC2) in colonic tissues increased (p < 0.05). …”
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IgSF11–RAP1 signaling promotes cell migration and invasion of cutaneous melanoma by Yasuyuki Kobayashi, Kotaro Sugimoto, Minaka Ishibashi, Makoto Kobayashi, Shohei Igari, Shigeki Kitamura, Toshiyuki Yamamoto, Yuko Hashimoto, Hideki Chiba

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Performance of label-free biosensors as a function of layer thickness by Tommi Åman, Sanna Auer, Vesa P. Hytönen, Juha A. Määttä

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Improved Performance of RT-PPP During Communication Outages Based on Position Constraints and Stochastic Model Optimization by Xiaosong Liu, Lin Zhao, Fuxin Yang, Jie Zhang, Jinjian Shi, Chuanlei Zheng

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The Functional State of Meibomian Glands and Tear Production in Pregnant Women by V. N. Trubilin, E. G. Poluninа, D. V. Andzhelova, Yu. V. Evstigneeva, K. V. Chinenova

“…It makes temporary changes in the functional state of all  organs and systems, including the organ of vision. …”
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Designing Predictive Tools for Personalized Functionalities in Knitted Performance Wear by Martijn ten Bhömer, Hai-Ning Liang, Difeng Yu, Yuanjin Liu, Yifan Zhang, Eva de Laat, Carola Leegwater

“…Moreover, advanced knitting technology in combination with new materials enables the integration of localized functionalities within a garment on a “stitch by stitch level.” …”
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Genome analysis of Bifidobacterium adolescentis and investigation of its effects on inflammation and intestinal barrier function by Bo Li, Bo Li, Haoyu Wang, Haoyu Wang, Haoyu Wang, Mengmeng Wang, Mengmeng Wang, Hewei Liang, Hewei Liang, Hewei Liang, Tongyuan Hu, Tongyuan Hu, Tongyuan Hu, Jinlong Yang, Jinlong Yang, Jinlong Yang, Shangyong Li, Xinbi You, Xinbi You, Xinbi You, Binbin Xia, Binbin Xia, Binbin Xia, Yue Yuan, Yue Yuan, Yuanqiang Zou, Yuanqiang Zou, Yinglei Miao, Yinglei Miao, Yang Sun, Yang Sun, Yang Sun

“…Based on the bacterial collection constructed in our previous studies, we founded that Bifidobacterium adolescentis AF91-08b2A has the potential beneficial function. We designed cohort studies, genomic studies and animal experiments to further explore the probiotic function of Bifidobacterium adolescentis AF91-08b2A and its therapeutic effect on IBD. …”
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Determining the functional relationship between epigenetic and physical chromatin domains in Drosophila by Sandrine Denaud, Gonzalo Sabarís, Marco Di Stefano, Giorgio-Lucio Papadopoulos, Bernd Schuettengruber, Giacomo Cavalli

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Proteins Involved in the Trafficking and Functional Synaptic Expression of AMPA and KA Receptors by Sarah A. De La Rue, Jeremy M. Henley

“…Both receptor types have been shown to be highly developmentally and activity-dependently regulated and their functional synaptic expression is under tight cellular regulation. …”
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Innate epithelial and functional differences in airway epithelium of children with acute wheeze by Kevin Looi, Kevin Looi, Kevin Looi, Thomas Iosifidis, Thomas Iosifidis, Thomas Iosifidis, Thomas Iosifidis, Saraya Harrison, Saraya Harrison, Stephen M. Stick, Peter LeSouef, Peter LeSouef, Peter LeSouef, Ingrid A. Laing, Ingrid A. Laing, Anthony Kicic, Anthony Kicic, Anthony Kicic, Anthony Kicic

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Expansion of cultures of human tracheal epithelium with maintenance of differentiated structure and function by Jonathan H. Widdicombe, Lorne A. Sachs, Joby L. Morrow, Walter E. Finkbeiner

“…We have developed a technique for expanding primary cultures of human tracheal epithelium while minimizing loss of differentiated structure and function. Cells were seeded at 2 × 104 cells/cm2 into T75 flasks and trypsinized when approximately 80% confluent. …”
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TIMP1 inhibits Rac1-mediated ROS production to ameliorate blood–spinal cord barrier disruption in amyotrophic lateral sclerosis by Jingshu Tang, Yuying Kang, Qiuyu Chen, Baodan Zhang, Nianying Shang, Jiaqi Lan, Lei Wu, Ying Peng

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The D-Property of Finite Unions of t-Metrizable Spaces and Certain Function Spaces by Xin Zhang, Hongfeng Guo

“…The additivity of D-property is studied on t-metrizable spaces and certain function spaces. It is shown that a space of countable tightness is a D-space provided that it is the union of finitely many t-metrizable subspaces, or function spaces Cp(Xi) where each Xi is Lindelöf Σ.…”
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Bridging regional neurovascular unit heterogeneity and cognitive function: a review by Amalia Tsintzou, Roseline Poirier, Rania Harati, Almira Kustubayeva, Clemence Disdier, Rifat Hamoudi, Aloïse Mabondzo

“…Abstract The blood-brain barrier (BBB) is a critical central nervous system interface that tightly regulates the exchange of substances between the blood circulation and the brain parenchyma. …”
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Transcriptional Regulation and Function of Malic Enzyme 1 in Human Macrophage Activation by Anna Santarsiero, Simona Todisco, Paolo Convertini, Chiara De Leonibus, Vittoria Infantino

“…Macrophage activation triggers several signaling pathways and is tightly associated with metabolic changes, which drive different immune subsets. …”
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Expression and function of Connexin 43 and Connexin 37 in the murine zona glomerulosa by Gabriel Stölting, Nicole Hellmig, Hoang An Dinh, Frederike Butz, Ali Kerim Secener, Marina Volkert, Ute I. Scholl

“…The recent discovery of mutations in CADM1 was linked to impaired GJ function in the ZG. Based on published transcriptomics data, we re‐examined the presence and functional impact of GJ in the ZG. …”
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Association between Hamstring Flexibility and Functional Performance of Patients with Knee Osteoarthritis by Sejal Sailor, Amisha Limbani, Dhruva Dhola

“…Active Knee Extension Test (AKET) was used to evaluate the hamstring tightness. Functional performance of participants was assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire. …”
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Effect of Storage Temperature on Key Functions of Cultured Retinal Pigment Epithelial Cells by Lara Pasovic, Jon Roger Eidet, Berit S. Brusletto, Torstein Lyberg, Tor P. Utheim

“…Cultures stored at 37°C displayed regulational changes in a larger subset of genes related to phagocytosis, adherens, and tight junctions. Conclusion. RPE cultures stored at 4°C and 16°C for one week are capable of maintaining the expression levels of genes important for key RPE functions close to control levels.…”
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