Protective Effects of Extracts from Green Leaves and Rhizomes of <i>Posidonia oceanica</i> (L.) Delile on an In Vitro Model of the Human Blood–Brain Barrier by Giulia Abruscato, Manuela Mauro, Marie-Christine Boucau, Vincenzo Arizza, Mirella Vazzana, Lucie Dehouck, Fabien Gosselet, Claudio Luparello, Pietra Candela

“…These findings suggest that <i>P. oceanica</i>’s extracts may help preserve BBB function and mitigate inflammation-induced damage. …”
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Examining Form and Function of Dendritic Spines by Kevin F. H. Lee, Cary Soares, Jean-Claude Béïque

“…We highlight emerging molecular mechanisms that link structural and functional changes in spines during plasticity, and also consider circumstances that underscore some divergence from a tight structure-function coupling. …”
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Hsa-miR-31-3p targets CLDN8 to compromise skin barrier integrity in psoriasis by Yunhua Tu, Li Wang, Lijun An, Li He

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Effect of Probiotics Complex on Improving Antibiotic-associated Diarrhea in Mice by Liyi LU, Yecheng GAO, Junlong CHEN, Yajuan GUO, Hualin LIU, Chang CHEN, Xinliang MAO

“…Furthermore, the administration of probiotics complex notably up-regulated the mRNA expression levels of intestinal tight junction proteins ZO-1 and occludin (P<0.05). …”
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The Role of Tau in Neuronal Function and Neurodegeneration by Gonzalo Emiliano Aranda-Abreu, Fausto Rojas-Durán, María Elena Hernández-Aguilar, Deissy Herrera-Covarrubias, Luis Isauro García-Hernández, María Rebeca Toledo-Cárdenas, Donají Chi-Castañeda

“…Tau protein plays a pivotal role in maintaining neuronal structure and function through its regulation of microtubule stability and neuronal polarity. …”
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Restoring brain barriers: an innovative approach for treating neurological disorders by Sighild Lemarchant, Britta Engelhardt, Francesca Cicchetti, Gregory J. Bix, Annette Janus, Yann Godfrin, Hélène Blasco, Matthew Campbell, Aurélie de Rus Jacquet

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A fruitful approach to gut health and functionality by Paulo Sérgio Loubet Filho, Vitória Helena de Oliveira Teixeira Reis, Patrícia Berilli, Giovanna Monteiro Rodrigues, Áquila Matheus de Souza Oliveira, Gabriela Torres Silva, Elisvânia Freitas dos Santos, Cinthia Baú Betim Cazarin

“…Their role in gut integrity includes modulating microbiota, enhancing tight junction proteins, and reducing oxidative stress. …”
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Unveiling the metabolic transformation of Astragalus membranaceus through probiotic fermentation and its impact on growth and gut health in common carp (Cyprinus carpio) by Hongtao Shi, Mengfei Ma, Baocai Ma, Xiufen Wang, Jianxun Guo, Xianqian Jiao, Yueying Wang, Heping Li, Kai Zhong, Guoyu Yang, Huanling Wang, Yingqian Han

“…FA supplementation enhanced gut enzyme activities and upregulated genes associated with tight junctions and immune function. FA supplementation enhanced tissue antioxidants, gut function, and microbiota composition in common carp, leading to improved growth.…”
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Lysophosphatidylcholine 14:0 Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Protecting Alveolar Epithelial Barrier by Activation of Nrf2/HO-1 Pathway by Liu X, Su S, Xia L, Lei X, Zou S, Zhou L, Yang R, Li K, Lin P, Li Y

“…Mechanistically, ML385, the Nrf2 inhibitor, inhibited the protective effects of LPC14:0 on barrier function in vitro.Conclusion: This study first demonstrated that LPC14:0 mitigated LPS-induced ALI and the destruction of tight junctions, at least in part through up-regulation of the Nrf2/HO-1 pathway.Keywords: acute lung injury, ALI, alveolar epithelial barrier, lysophosphatidylcholine 14:0, tight junction, Nrf2…”
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Amelioration of gut dysbiosis-induced cognitive deterioration by repeated administration of human clostridium butyricum: targeting intestinal and blood–brain barrier by Dalia Azmy Elberry, Maha Gamal, Zeinab Gawish, Esraa A. Hegazy, Sara Adel Hosny, Laila Ahmed Rashed, Marwa Nagi Mehesen, Asmaa Mohammed ShamsEldeen

“…Conclusion Repeated intake of CB hindered systemic /neuroinflammation, enhanced the tight junction proteins’ expression in the gut/brain barrier, and improved cognitive functions.…”
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Assessment of Digestion and Absorption Properties of 1,3-Dipalmitoyl-2-Oleoyl Glycerol-Rich Lipids Using an In Vitro Gastrointestinal Digestion and Caco-2 Cell-Mediated Coupled Mod... by Hyeon-Jun Chang, A-Young Lee, Jeung-Hee Lee

“…The in vitro-digested POP-rich lipid containing FFA > 2.95 mM caused the disruption of monolayer tight junctions in Caco-2 cells. The major triacylglycerols (TAG) of POP-rich lipids were POP (50.8%), POO (17.8%), POL/OPL/PLO (7.6%), PPO (7.1%), and PLP (6.8%). …”
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Dose-dependent effects of capsaicin on intestinal morphology and microbiota composition in mice: Structural, immunohistochemical, and microbial insights by Kai Li, Jianghai Xu, Siying Chen, Aifei Du, Shaohua Feng, Shibin Yuan, Bangyuan Wu

“…This study aimed to investigate the effects of varying CAP doses on intestinal morphology, tight junction protein expression, goblet cell density, mucosal injury markers, and gut microbiota composition in mice. …”
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Clinical Experience with Gastrocnemius Recession Surgery in Chronic Plantar Fasciitis by Rahul Upadhyay, Jitesh Jain, Divyanshu Goyal

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MCT4 inhibition attenuates inflammatory response to Mycobacterium avium paratuberculosis infection and restores intestinal epithelial integrity in vitro by Ala’ Alhendi, Saleh A. Naser

“…MCT4 is also involved in the negative regulation of intestinal epithelial barrier function.MethodsIn this in vitro study, we examined the role of MCT4 in macrophages and its effect on intestinal epithelial homeostasis during MAP infection. …”
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Exofection by exosomes: A transient functional cargo transfer by Ramkumar Menon, Madhuri Tatiparthy, Jessica Selim, Isidore Mushimiyimana, Brinley Harrington, Awanit Kumar, Lauren Richardson, Emmanuel Amabebe, Ananth Kumar Kammala

“…For instance, mitochondria-containing EVs from brain endothelial cells restore mitochondrial function and tight junction integrity in ischemic brain tissues. …”
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Efficient exploration of electronic and dielectric properties using advanced first-principles analysis grounded in modern theory of polarization: Application to PbTiO3 by Aimad Belboukhari, Souad Ait Saghir, Abderrahim Bakak, Said El-Jallal, Khaled Ait Bentaleb, My Abdelaziz Koumina, Daoud Mezzane, Yaovi Gagou

“…Electronic and dielectric properties are essential for understanding many functional materials, predicting their behavior and optimizing their performance across different shapes, geometries and scales. …”
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The Connectivity of DVcube Networks: A Survey by Ruo-Wei Hung

“…In this survey, we focus on connectivity, tightly super connectivity, and <i>h</i>-extra connectivity within DVcube networks—a compound architecture combining disk-ring and hypercube-like topologies. …”
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Functional Constipation in Children: Chronic Disease or Developmental Problem? by V. N. Panfilova, S. N. Doroshchenko, T. V. Tret’yakova

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Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders by E. Rossignol

“…Furthermore, I review the tightly controlled genetic cascades that determine the fate of cortical interneurons and summarize how the dysfunction of genes important for the generation, specification, maturation, and function of cortical interneurons might contribute to these disorders.…”
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Maturation of small nucleolar RNAs: from production to function by Sarah F. Webster, Homa Ghalei

“…Besides their classic roles in ribosome biogenesis, snoRNAs are also implicated in several other cellular activities including regulation of splicing, transcription, RNA editing, cellular trafficking, and miRNA-like functions. Mature snoRNAs must undergo a series of processing steps tightly regulated by transiently associating factors and coordinated with other cellular processes including transcription and splicing. …”
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