TelAP2 links TelAP1 to the telomere complex in Trypanosoma brucei by Nadine Weisert, Verena Majewski, Laura Hartleb, Katarina Luko, Liudmyla Lototska, Nils Christian Krapoth, Helle D. Ulrich, Christian J. Janzen, Falk Butter

“…Three functional homologs of mammalian telomere complex proteins have been characterized thus far, and novel telomere-interacting proteins, such as telomere-associated protein 1 (TelAP1), have recently been identified. …”
Get full text

Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability by Alexandra Berroyer, Albino Bacolla, John A. Tainer, Nayun Kim

“…Interestingly, Top1 binds tightly to G4 struc-tures, and its inhibition or depletion can cause elevated instability at these ge-nomic loci. …”
Get full text

Bioinformatics and experimental approach reveal potential prognostic and immunological roles of key mitochondrial metabolism-related genes in cervical cancer by Qing Huang, Yang-feng Xu, Hui-ping Li, Ting Zhang

“…A prognostic risk model comprising five genes (BDH1, MIR210, MSMO1, POLA1, and STARD3NL) was established, showing significant associations with survival outcomes of CC patients. Functional enrichment analysis revealed that DEGs between high- and low-risk groups were tightly associated with the immune system. …”
Get full text

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling by Elise S Bruguera, Jacob P Mahoney, William I Weis

“…Wnt/β-catenin signaling directs animal development and tissue renewal in a tightly controlled, cell- and tissue-specific manner. …”
Get full text

Genome Annotation of Molting-Related Protein-Coding Genes in <i>Propsilocerus akamusi</i> Reveals Transcriptomic Responses to Heavy Metal Contamination by Wenbin Liu, Anmo Zhou, Ziming Shao, Jiaxin Nie, Chuncai Yan, Shaobo Gao, Yiwen Wang

“…Based on previous genome assembly, we conducted a systematic annotation and functional analysis of genes involved in these metabolic pathways in <i>P</i>. …”
Get full text

Development and application of a cGPS 20K liquid-phase SNP microarray in Jiaji ducks by Tieshan Xu, Zixin Xu, Dingping Bai, Fanghu Wu, Yuanyuan Shang, Mao Li, Guang Rong, Lihong Gu

“…In conclusion, this independently designed microarray will be useful for large-scale genotyping and can lay the foundation for future screening of mutation loci and functional genes.…”
Get full text

Cytological, Phytohormone, and Transcriptomic Analyses Reveal the Key Genes and Pathways Involved in Melon Fruit Cracking by Rong Fan, Bin Liu, Xiaoyu Duan, Meihua Li, Yongbing Zhang, Xuejun Zhang, Guozhi Hu, Yong Yang

“…These findings lay a foundation for further studies on the functional roles of crack-resistant genes and the breeding of crack-tolerant varieties.…”
Get full text

Development of a CRISPR/Cas9 genome editing toolbox for Corynebacterium stationis and its application in hypoxanthine biosynthesis by Zhilin Ouyang, Xinyu Zhang, Xinyi Hou, Jiabei Huang, Ying Lin, Suiping Zheng

“…By engineering a tightly regulated Cas9 expression system (Plac promoter with dual LacO∗ operators), we achieved high-efficiency genome editing, with deletion efficiencies of 81.2–98.6 % for 1.7–50 kb fragments and insertion efficiencies of 27.5–65.2 % for 1–5 kb fragments. …”
Get full text

Identification of Antioxidant Peptides and α-Glucosidase Inhibitory Peptides from Milk Pimples and Their Stability Analysis by Ziqi XU, Yuzhu WANG, Guangqiang WEI, Daodian WANG, Shaomei HU, Xinglun LI, Aixiang HUANG

“…Milk pimple peptide had good antioxidant and α-glucosidase inhibitory activities, which would provide a basis for further development of milk pimple functional food.…”
Get full text

Influence mechanisms of dynamic metamorphism on the evolution of micro/nano pore structures in tectonically deformed coals by Hewu LIU, Xiaoxue LYU, Chenliang HOU, Zuopeng XIONG

“…In detail, the aromatic structures in the TDCs experienced chemical changes like rotation, folding, and recombination, forming a more tightly arranged molecular structural configuration. …”
Get full text

Application of multi-layer chitosan-based wound dressings in dentistry by Alexandr S. Gumenyuk, Denis I. Ushmarov, Sergey E. Gumenyuk, Tatyana V. Gaivoronskaya, Alexandr S. Sotnichenko, Karina I. Melkonyan, Yulia A. Belich, Timofey E. Grigoriev

“…This dressing has a dense outer layer, which structure retains frame functions for a long time, thus providing proper drainage of the pathological focus. …”
Get full text

Integrating Ambient In-Home Sensor Data and Electronic Health Record Data for the Prediction of Outcomes in Amyotrophic Lateral Sclerosis: Protocol for an Exploratory Feasibility S... by William E Janes, Noah Marchal, Xing Song, Mihail Popescu, Abu Saleh Mohammad Mosa, Juliana H Earwood, Vovanti Jones, Marjorie Skubic

“… BackgroundAmyotrophic lateral sclerosis (ALS) leads to rapid physiological and functional decline before causing untimely death. Current best-practice approaches to interdisciplinary care are unable to provide adequate monitoring of patients’ health. …”
Get full text

Unraveling the Nectar Secretion Pathway and Floral-Specific Expression of <i>SWEET</i> and <i>CWIV</i> Genes in Five Dandelion Species Through RNA Sequencing by Sivagami-Jean Claude, Sunmi Park, Seong-Jun Park, SeonJoo Park

“…Floral nectar is a key reward that plants use to attract pollinators, and its production is tightly regulated by genes such as <i>SWEET</i> sugar transporters and <i>CELL WALL INVERTASE</i> (<i>CWIN</i>), which govern sugar efflux and hydrolysis. …”
Get full text

COMPOSITION UNIQUENESS OF “KONARMIA” (“CAVALRY ARMY”) BY I. BABEL by Feliks M. Shteinbuk

“…Second, the composition of “Konarmiya” (“Cavalry Army”) is not an arbitrary or random selection of works but a thoroughly built and tightly bound structure, every part of which, becoming a part of the whole, almost loses its “independence” and “autonomy” because it is determined and in its turn determines other parts of the book. …”
Get full text

Hybrid bamboo-banana-cotton sandwich composites for lightweight roofing: Mechanical, thermal and microstructural analyses by Barshan Dev, Md Ashikur Rahman, Shah Ashiquzzaman Nipu, Syeda Umme Habiba, Saifur Rahman, Farhad Ahmed, Md Zillur Rahman

“…SEM micrographs reveal effective fiber–matrix interfaces—with bamboo skins and cotton/banana core fibers tightly embedded, minimal voids, and clearly delineated sandwich layers—while FTIR spectra display the broad O–H band at ∼3400 cm−1, C–H stretches at ∼2900 cm−1, CO vibrations at 1735 cm−1, aromatic CC peaks at 1510 cm−1, and C–O–C/C–O–H bands near 1050 cm−1, confirming the characteristic functional groups and successful integration of the natural fibers within the crosslinked epoxy matrix. …”
Get full text

Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity by Andrew E Worthy, Joanna T Anderson, Alicia R Lane, Laura J Gomez-Perez, Anthony A Wang, Ronald W Griffith, Andre F Rivard, Jay B Bikoff, Francisco J Alvarez

“…Our results validate previously proposed V1 clades as unique functional subtypes that differ in circuit placement, with Foxp2-V1 cells forming the most heterogeneous subgroup. …”
Get full text

RNA binding protein HuR regulated by OIP5-AS1 may be involved in maternal transcript degradation during the human maternal-to-zygotic transition by Yan-na Liu, Ke-Yi Li, Hao Wei, Wen-xiu Li, Yue-hua Zhang, Jia-jun Qiu, Fanyi Zeng, Jing-bin Yan

“…Moreover, RNA immunoprecipitation sequencing in human induced pluripotent stem cells (iPSCs) revealed HuR and OIP5-AS1 are likely to tightly bind together and involved in functions related to the cell cycle and transcriptional regulation. …”
Get full text

Emerging insights into epigenetics and hematopoietic stem cell trafficking in age-related hematological malignancies by Yang Xinyi, Reshetov Igor Vladimirovich, Narasimha M. Beeraka, Allaka Satyavathi, Dinisha Kamble, Vladimir N. Nikolenko, Allaka Naga Lakshmi, Basappa Basappa, Padmanabha Reddy Y, Ruitai Fan, Junqi Liu

“…Abstract Background Hematopoiesis within the bone marrow (BM) is a complex and tightly regulated process predominantly influenced by immune factors. …”
Get full text

Transcriptome remodeling drives acclimation to iron availability in the marine N2-fixing cyanobacterium Trichodesmium erythraeum IMS101 by Xin Zhong, Ran Duan, Shengwei Hou, Meng Chen, Xiaoming Tan, Wolfgang R. Hess, Tuo Shi

“…The expression of genes encoding major Fe-binding metalloproteins is tightly linked to cellular carbon and nitrogen metabolism and appears to be controlled by the ferric uptake regulator FurA, which is involved in regulating Fe uptake and homeostasis. …”
Get full text

Comparative transcriptomics analysis of the Oleidesulfovibrio alaskensis G20 biofilms grown on copper and polycarbonate surfaces by Priya Saxena, Dipayan Samanta, Payal Thakur, Vinoj Gopalakrishnan, Rajesh K. Sani

“…Protein-protein interaction analysis identified tightly regulated clusters associated with ribosomal synthesis, folate metabolism, and quorum sensing, underscoring their role in biofilm resilience. …”
Get full text