Human Adipose Tissue Metabolism in Obesity by Shuhao Lin, Michael D. Jensen

“…Adipose tissue lipid storage and lipolysis are tightly controlled by hormones, such as insulin, in response to the body’s energy needs. …”
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Revealing the mechanisms and therapeutic potential of immune checkpoint proteins across diverse protein families by Ran Liu, Xinyan Jiang, Ruijuan Dong, Yuting Zhang, Cong Gai, Peng Wei

“…Host immune responses to antigens are tightly regulated through the activation and inhibition of synergistic signaling networks that maintain homeostasis. …”
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Protein–Protein Interactions in Base Excision Repair by Govardhan Rathnaiah, Joann B. Sweasy

“…We also briefly discuss the interactions of other proteins that interact with the components of SN-BER based on functional evidence.…”
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MicroRNA Signature in Alcoholic Liver Disease by Shashi Bala, Gyongyi Szabo

“…Increased proinflammatory cytokines, particularly TNF alpha, play a central role in the pathogenesis of ALD. TNF alpha is tightly regulated at transcriptional and posttranscriptional levels. …”
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An arginine switch drives the stepwise activation of β-arrestin by CXCR7. by Jeong Seok Ji, Yaejin Yun, Tomasz Maciej Stepniewski, Hye-Jin Yoon, Kyungjin Min, Ji Young Park, Chiwoon Chung, Miguel Dieguez Eceolaza, Ka Young Chung, Jana Selent, Hyung Ho Lee

“…Depending on the specific interaction pattern with the receptor, βarrs adopt multiple conformational states, each tightly linked to a specific functional outcome of βarr recruitment. …”
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Proteoglycans in normal physiology and carcinogenesis by A. V. Suhovskih, E. V. Grigorieva

“…An important role in this process belongs to the complex protein-carbohydrate molecules – proteoglycans (PG), which are one of the main component of ECM and cell surface of any tissue and are tightly involved in cell-cell and cell-matrix interactions and signaling. …”
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Evolution Characteristics and Regional Roles’ Influencing Factors of Interprovincial Population Mobility Network in China by Wei Fang, Pengli An, Siyao Liu

“…By constructing the interprovincial population mobility network, we examine the provinces’ functions during periods of population mobility through population mobility diversity, population mobility, and population mobility intermediation. …”
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PTPN11 in cartilage development, adult homeostasis, and diseases by Wentian Yang, Véronique Lefebvre

“…Moreover, SHP2 inhibition was found to mitigate osteoarthritis pathogenesis in mice, and abundant but incomplete evidence suggests that SHP2 is crucial for cartilage development and adult homeostasis, during which its expression and activity are tightly regulated transcriptionally and posttranslationally, and by varying sets of functional partners. …”
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The Sec1/Munc18 protein Vps45 regulates cellular levels of its SNARE binding partners Tlg2 and Snc2 in Saccharomyces cerevisiae. by Scott G Shanks, Lindsay N Carpp, Marion S Struthers, Rebecca K McCann, Nia J Bryant

“…Intracellular membrane trafficking pathways must be tightly regulated to ensure proper functioning of all eukaryotic cells. …”
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Ca2+ signaling in vascular smooth muscle and endothelial cells in blood vessel remodeling: a review by Yoshiaki Suzuki, Wayne R. Giles, Gerald W. Zamponi, Rubii Kondo, Yuji Imaizumi, Hisao Yamamura

“…This allows Ca2+ signaling to be tightly controlled in localized areas within the cell, resulting in a balanced vascular tone. …”
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A fungal chromatin remodeler drives transcription by establishing an open chromatin architecture and activated histone environment by Mengting Xu, Qi Zhang, Yuan Li, Wei Zhou, Lingyun Lei, Fucheng Lin, Yanjun Kou, Zeng Tao

“…RSC1 is indispensable for establishing open chromatin architecture, and its activity is tightly correlated with altered nucleosome occupancy. …”
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Transcriptome analysis identifies CCR7 and cell adhesion molecules as mediators of B cell migration to the bursa of Fabricius during chicken embryonic development by Milena Brunner, Catarina L. C. T. Cavaleiro, Tom V. L. Berghof, Theresa von Heyl, Mohanned Naif Alhussien, Christine Wurmser, Daniel Elleder, Benjamin Schusser

“…Abstract The development of functional B lymphocytes during chicken embryogenesis relies on a series of tightly regulated processes. …”
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Time-varying 3D optical torque via a single beam by Yi-Jing Wu, Jing-Han Zhuang, Pan-Pan Yu, Yi-Fan Liu, Zi-Qiang Wang, Yin-Mei Li, Cheng-Wei Qiu, Lei Gong

“…To this end, we construct a theoretical relationship between the 3D SAM vector of a tightly focused field and the local polarization helicity of the incident field. …”
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In-chip critical plasma seeds for laser writing of reconfigurable silicon photonics systems by Andong Wang, Amlan Das, Vladimir Yu Fedorov, Pol Sopeña, Stelios Tzortzakis, David Grojo

“…To achieve highly localized and reliable processing, we create plasma seeds with tightly focused pre-ionizing femtosecond pulses. We show how critical density conditions can be used for extremely confined energy deposition with a synchronized writing irradiation and create ~ 1-µm-sized isotropic modifications inside silicon. …”
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Identification of NIBAN2‐Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis by Sheng Zhang, Zhiqiang Yang, Yuanlong Xie, Yufeng Zhang, Zhe Chen, Xuan Lv, Zhouming Deng, Zan Huang, Lin Cai, Renxiong Wei

“…Through integral analyses of multiple datasets, NIBAN2 is found to be tightly associated with bone formation and osteoporosis. …”
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Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy by Wenjing Bai, Jinxin Xu, Wenbin Gu, Danyang Wang, Ying Cui, Weidong Rong, Xiaoan Du, Xiaoxia Li, Cuicui Xia, Qingqing Gan, Guantao He, Huahui Guo, Jinfeng Deng, Yuqiong Wu, Ray-Whay Chiu Yen, Srinivasan Yegnasubramanian, Scott B. Rothbart, Cheng Luo, Linping Wu, Jinsong Liu, Stephen B. Baylin, Xiangqian Kong

“…Herein, we demonstrate that human STELLA (hSTELLA) is inadequate, while mouse STELLA (mSTELLA) is fully proficient in inhibiting the abnormal DNA methylation and oncogenic functions of UHRF1 in human cancer cells. Structural studies reveal a region of low sequence homology between these STELLA orthologs that allows mSTELLA but not hSTELLA to bind tightly and cooperatively to the essential histone-binding, linked tandem Tudor domain and plant homeodomain (TTD-PHD) of UHRF1, thus mediating ortholog-specific UHRF1 inhibition. …”
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Emerging regulated cell death mechanisms in bone remodeling: decoding ferroptosis, cuproptosis, disulfidptosis, and PANoptosis as therapeutic targets for skeletal disorders by Hai-Ting Hu, Zhen-Yu Zhang, Zi -Xin Luo, Hui-Bo Ti, Jun-Jie Wu, Hao Nie, Zheng-Dong Yuan, Xian Wu, Ke-Yue Zhang, Shu-Wen Shi, Yi-Qing Qian, Xin-Chen Wang, Jing-Jing Wu, Xia Li, Feng-Lai Yuan

“…Abstract The adult skeleton preserves its structural and functional integrity through continuous bone remodeling, a process tightly regulated by osteoblasts, osteoclasts, and osteocytes. …”
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Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate by Peng Zuo, Weize Wang, Zonglin Dai, Jiye Zheng, Shang Yu, Guangxi Wang, Yue Yin, Ling Liang, Yuxin Yin

“…Abstract Inorganic phosphate (Pi) is essential for life, and its intracellular levels must be tightly regulated to avoid toxicity. XPR1, the sole known phosphate exporter, is critical for maintaining this balance. …”
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Engineering a drug-inducible pyroptosis platform enables precise tumor suppression in colorectal cancer by Xiang Yao, Yu Wei, Yuan Gao, Lei Li, Junchi Liu, Wenmin Zhou, Tao Yan, Letian Gong, Yang Zhou, Ganglong Gao

“…Here, we report the design and functional validation of a chemically inducible gene circuit that harnesses Gasdermin E (GSDME) to trigger pyroptotic cell death on demand. …”
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Strongly Bound Frenkel Excitons on TiO2 Nanoparticles: An Evolutionary and DFT Approach by Oscar Olvera-Neria, Raúl García-Cruz, Julio Gonzalez-Torres, Luz María García-Cruz, Jean Luis Castillo-Sánchez, Enrique Poulain

“…More than 61,000 structures were calculated with a semiempirical method and reoptimized using density functional theory. The exciton binding energy of TiO2 nanoparticles was determined through the fundamental and optical band gap. …”
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