Homeostatic Imbalance in Epithelial Ducts and Its Role in Carcinogenesis by Katarzyna A. Rejniak

“…The structural and functional integrity (homeostasis) of such ducts is vital in carrying many life functions (breathing, lactation, production of hormones). …”
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Chapter 8: Biological knowledge assembly and interpretation. by Ju Han Kim

“…Biomedical ontology and pathway-based functional enrichment analysis is widely used to interpret the functional role of tightly correlated or differentially expressed genes. …”
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CCDC66 regulation of cytoskeleton and cilia stability is important for signaling and epithelial organization. by Jovana Deretic, Seyma Cengiz-Emek, Ece Seyrek, Elif Nur Firat-Karalar

“…It dynamically assembles and disassembles in response to intrinsic and extrinsic stimuli while maintaining remarkable structural stability and tightly regulated length. The mechanisms underlying this stability and length control are not well understood. …”
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Preliminary evidences of the presence of extracellular DNA single stranded forms in soil. by Shamina Imran Pathan, Paola Arfaioli, Maria Teresa Ceccherini, Judith Ascher-Jenull, Giacomo Pietramellara

“…The relevance of extracellular DNA (eDNA) in the soil ecosystem is becoming more and more evident to the scientific community by the progressive discovery of functions accompanying to natural gene transformation. …”
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Measuring communities’ efficiencies within the global tourism network by He Zhu

“…Abstract Tourist flows between countries shape the global tourism network, with tightly interconnected nations forming distinct communities. …”
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Determination of Temporal Order among the Components of an Oscillatory System. by Sandra Barragán, Cristina Rueda, Miguel A Fernández, Shyamal D Peddada

“…Oscillatory systems in biology are tightly regulated process where the individual components (e.g. genes) express in an orderly manner by virtue of their functions. …”
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The rhetorical structure of newspaper reports: A synergy between corpus, genre and discourse analysis by Hafizah Hajimia, Nur Rasyidah Mohd Nordin, Manvender Kaur Sarjit Singh, Philip Golingai

“…Additionally, based on the functions of the moves, it was found that the newspaper report is a hybrid genre with various communicative functions. …”
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Endoscopic Debridement, Ostectomy, Release, and Radiofrequency: A Fully Endoscopic Technique for Treating Recalcitrant Plantar Fasciitis by Walter-Soon-Yaw Wong, M.B.Ch.B., M.R.C.S., Dhivakaran Gengatharan, M.B.B.S., Inderjeet Singh Rikhraj, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Keen Wai Chong, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Wen Xian Png, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Eric Wei Liang Cher, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth)

“…This comprehensive approach aims to improve patient satisfaction and functional outcomes.…”
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A Complex Network of Obesity-Risk Genes Revealed by Systematic Bioinformatics and Single-Cell Transcriptomic Analyses by Yuenan Liu, Haolin Yuan, Junhui Hu, Xu Xu, Shankai Yin, Yiming Hu, Feng Liu

“…Our protein–protein interaction (PPI) network analysis revealed that these genes form a tightly connected functional network primarily involved in neurological and metabolic regulatory processes. …”
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SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis by Laura Gebetsberger, Zahra Malekshahi, Aron Teutsch, Gabor Tajti, Frédéric Fontaine, Nara Marella, André Mueller, Lena Prantl, Hannes Stockinger, Heribert Stoiber, Anna Ohradanova-Repic

“…Blockage of the biological functions of virion-associated CD55 and CD59 and competition of FH recruitment with functionally inactive recombinant FH-derived short consensus repeats SCR18-20 restore SARS-CoV-2 complement sensitivity in a synergistic manner. …”
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Regulators and Effectors of Arf GTPases in Neutrophils by Jouda Gamara, François Chouinard, Lynn Davis, Fawzi Aoudjit, Sylvain G. Bourgoin

“…G protein-dependent signalling pathways tightly control PMN functions. In this review, we will focus on the small monomeric GTPases of the Arf family and their guanine exchange factors (GEFs) and GTPase activating proteins (GAPs) as components of signalling cascades regulating PMN responses. …”
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Who needs microtubules? Myogenic reorganization of MTOC, Golgi complex and ER exit sites persists despite lack of normal microtubule tracks. by Kristien J M Zaal, Ericka Reid, Kambiz Mousavi, Tan Zhang, Amisha Mehta, Elisabeth Bugnard, Vittorio Sartorelli, Evelyn Ralston

“…The mechanism of these changes and their functional implications are still poorly understood, in large part because all changes occur seemingly simultaneously. …”
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Intrinsic Disorder and Phase Separation Coordinate Exocytosis, Motility, and Chromatin Remodeling in the Human Acrosomal Proteome by Shivam Shukla, Sean S. Lastorka, Vladimir N. Uversky

“…Protein–protein interaction networks revealed acrosomal proteins as hubs in tightly interconnected systems, emphasizing their functional importance. …”
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Recombinant Expression and Characterization of Human and Murine ACE2: Species-Specific Activation of the Alternative Renin-Angiotensin-System by Marko Poglitsch, Oliver Domenig, Cornelia Schwager, Stefan Stranner, Bernhard Peball, Evelyne Janzek, Bettina Wagner, Helmut Jungwirth, Hans Loibner, Manfred Schuster

“…Its preferred substrate is Angiotensin II, which is tightly involved in the regulation of important physiological functions including fluid homeostasis and blood pressure. …”
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Regulation of the mitochondrial permeability transition pore and its effects on aging by Damiano Pellegrino-Coppola

“…Aging is an evolutionarily conserved process and is tightly connected to mitochondria. To uncover the aging molecular mechanisms related to mitochondria, different organisms have been extensively used as model systems. …”
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pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity by Marie-Anne Deprez, Elja Eskes, Tobias Wilms, Paula Ludovico, Joris Winderickx

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Role of Immune Escape Mechanisms in Hodgkin's Lymphoma Development and Progression: A Whole New World with Therapeutic Implications by Luis de la Cruz-Merino, Marylène Lejeune, Esteban Nogales Fernández, Fernando Henao Carrasco, Ana Grueso López, Ana Illescas Vacas, Mariano Provencio Pulla, Cristina Callau, Tomás Álvaro

“…The recent advances in our understanding of HL biology and immunology show that infiltrated immune cells and cytokines in the tumoral microenvironment may play different functions that seem tightly related with clinical outcomes. …”
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B cell development: transcriptional regulation and immunological mechanisms in homeostasis by Jorge Gómez-Manríquez, Jorge Hernández-Bello, José Francisco Muñoz-Valle, Sonia Sifuentes-Franco, Omar Graciano-Machuca, José Javier Morales-Núñez, José Javier Morales-Núñez

“…B lymphocytes are essential elements of the adaptive immune response, performing critical functions such as antigen presentation, cytokine secretion, and antibody production. …”
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The local microenvironment suppresses the synergy between irradiation and anti-PD1 therapy in breast-to-brain metastasis by Vladimir Wischnewski, Paola Guerrero Aruffo, Matteo Massara, Roeltje R. Maas, Klara Soukup, Johanna A. Joyce

“…Summary: The brain environment is uniquely specialized to protect its neuronal tissue from excessive inflammation by tightly regulating adaptive immunity. However, in the context of brain cancer progression, this regulation can lead to a conflict between T cell activation and suppression. …”
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Glucose deprivation and identification of TXNIP as an immunometabolic modulator of T cell activation in cancer by Agathe Dubuisson, Adèle Mangelinck, Samantha Knockaert, Adrien Zichi, Etienne Becht, Wendy Philippon, Sandra Dromaint-Catesson, Manon Fasquel, Fabien Melchiore, Nicolas Provost, Dawid Walas, Dawid Walas, Hélène Darville, Jean-Pierre Galizzi, Céline Lefebvre, Véronique Blanc, Vincent Lombardi

“…BackgroundThe ability of immune cells to rapidly respond to pathogens or malignant cells is tightly linked to metabolic pathways. In cancer, the tumor microenvironment (TME) represents a complex system with a strong metabolism stress, in part due to glucose shortage, which limits proper T cell activation, differentiation and functions preventing anti-tumor immunity.MethodsIn this study, we evaluated T cell immune reactivity in glucose-restricted mixed lymphocyte reaction (MLR), using a comprehensive profiling of soluble factors, multiparametric flow cytometry and single cell RNA sequencing (scRNA-seq).ResultsWe determined that glucose restriction potentiates anti-PD-1 immune responses and identified thioredoxin-interacting protein (TXNIP), a negative regulator of glucose uptake, as a potential immunometabolic modulator of T cell activation. …”
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