Intra-BLA alteration of interneurons’ modulation of activity in rats, reveals a dissociation between effects on anxiety symptoms and extinction learning by Rinki Saha, Lisa-Sophie Wüstner, Darpan Chakraborty, Rachel Anunu, Silvia Mandel, Joyeeta Dutta Hazra, Martin Kriebel, Hansjuergen Volkmer, Hanoch Kaphzan, Gal Richter-Levin

“…Activity within the BLA is tightly modulated by GABAergic interneurons, and thus inducing lasting alteration of GABAergic modulation of principal neurons may have an impactful metaplastic effect on BLA functioning. …”
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The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation by Felix Knab, Giambattista Guaitoli, Mohamed Ali Jarboui, Felix von Zweydorf, Fatma Busra Isik, Franziska Klose, Anto Praveen Rajkumar, Thomas Gasser, Thomas Gasser, Christian Johannes Gloeckner

“…We provide a list of ten biomarker candidates that are functionally relevant to neurodegeneration and linked to LRRK2-associated pathology, for example, the sonic hedgehog signaling molecule, a protein that has tightly been linked to LRRK2-related disruption of cilia function.ConclusionIn conclusion, we characterized the cellular and extracellular proteome of dopaminergic neurons carrying the LRRK2 G2019S mutation and proposed an experimentally based list of biomarker candidates for future studies.…”
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Effects of Pueraria montana and Melastoma dodecandrum Intercropping on Soil and Tea Plant Growth in Terraced Tea Gardens: A Sustainable Agricultural Practice by Lingshan Shi, Dongliang Li, Shuaibo Shao, Fajie Feng, Qisong Li, Fanfan Zeng, Lingyuan Shi, Jianming Zhang, Yongcong Hong, Pumo Cai

“…However, HWT has a greater impact on functional microorganisms related to C and N cycles, especially N cycling. …”
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Profiling Language Skills in Minimally Verbal Autism: Findings From Greek-Speaking Preschoolers by Eleni Peristeri, Maria Andreou

“…The negative effect of age on language performance underscores the risk of language deterioration over time for the specific population, while the lack of correlation between language performance and PIQ suggests that linguistic ability in MV autistic children is not tightly linked to their general cognitive function. …”
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Cloning, sequence and expression analysis of two SOC1 genes from Anthurium by MA Guangying, ZHU Kaiyuan, SHI Xiaohua, ZOU Qingcheng, LIU Huichun, ZHAN Jing, TIAN Danqing

“…Phylogenetic tree analysis showed that the two SOC1 transcription factors from Anthurium were tightly clustered with each other, and also with other monocotyledons. …”
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Hypomethylation of GCNT2 isoform A correlates with transcriptional expression and is associated with poor survival in acute myeloid leukemia by De-hong Wu, De-hong Wu, Hong-chun Qiu, Jing Xu, Jiang Lin, Jun Qian

“…BackgroundThe function of GCNT2 has been documented to act as an oncogenic driver or tumor suppressor in different types of tumor, but the role of GCNT2 and the epigenetic regulation mechanism in AML, however, has not yet been clarified. …”
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Bi-allelic variants in WDR47 cause a complex neurodevelopmental syndrome by Efil Bayam, Peggy Tilly, Stephan C Collins, José Rivera Alvarez, Meghna Kannan, Lucile Tonneau, Elena Brivio, Bruno Rinaldi, Romain Lecat, Noémie Schwaller, Ludovica Cotellessa, Sateesh Maddirevula, Fabiola Monteiro, Carlos M Guardia, João Paulo Kitajima, Fernando Kok, Mitsuhiro Kato, Ahlam A A Hamed, Mustafa A Salih, Saeed Al Tala, Mais O Hashem, Hiroko Tada, Hirotomo Saitsu, Mariano Stabile, Paolo Giacobini, Sylvie Friant, Zafer Yüksel, Mitsuko Nakashima, Fowzan S Alkuraya, Binnaz Yalcin, Juliette D Godin

“…Abstract Brain development requires the coordinated growth of structures and cues that are essential for forming neural circuits and cognitive functions. The corpus callosum, the largest interhemispheric connection, is formed by the axons of callosal projection neurons through a series of tightly regulated cellular events, including neuronal specification, migration, axon extension and branching. …”
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Robust Symbol Detection in Large-Scale Overloaded NOMA Systems by Hiroki Iimori, Giuseppe Thadeu Freitas De Abreu, Takanori Hara, Koji Ishibashi, Razvan-Andrei Stoica, David Gonzalez G., Osvaldo Gonsa

“…</italic>, 2020), the method is not relaxed into the <inline-formula> <tex-math notation="LaTeX">$\ell _{1}$ </tex-math></inline-formula>-norm, but rather approximated with a continuous and asymptotically exact expression without resorting to parallel interference cancellation (PIC). The objective function of the resulting formulation is thus a sum of concave-over-convex ratios, which is then tightly convexified via the quadratic transform (QT), such that its solution can be obtained via the iteration of a simple closed-form expression that closely resembles that of the classic zero-forcing (ZF) receiver, making the method particularly suitable to large-scale set-ups. …”
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CCR3 deficiency shifts adaptive to innate-driven immunity in asthma by Susanne Krammer, RPh, Zuqin Yang, PhD, Hannah Mitländer, MD, Janina C. Grund, MD, Carol I. Geppert, MD, Ralf J. Rieker, MD, Sabine Zirlik, MD, Susetta Finotto, PhD

“…Background: Because of repeated contact with airborne allergens, patients suffering from allergic asthma experience acute asthma attacks, characterized by shortness of breath, chest tightness, and coughing. The underlying immune response is highly complex and involves various immune cells. …”
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Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression by David P. Baird, Maximilian Reck, Ross Campbell, Marie-Helena Docherty, Piotr P. Janas, Tilly Mason, Zenuida Mortuza, Matthieu Vermeren, Andy Nam, Wei Yang, Nathan Schurman, Claire Williams, Jamie P. Traynor, Patrick B. Mark, Katie J. Mylonas, Jeremy Hughes, Laura Denby, Bryan R. Conway, David A. Ferenbach

“…Urinary biomarker concentrations were quantified by ELISA (n = 322) to assess their ability to predict patient outcomes (end-stage kidney disease or > 40% renal functional loss). Results: P21+Ki67- epithelial senescence correlated with age and inversely with renal function. …”
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Bikaverin as a molecular weapon: enhancing Fusarium oxysporum pathogenicity in bananas via rhizosphere microbiome manipulation by Honglin Lu, Suxia Guo, Yongbao Yang, Zhihao Zhao, Qingbiao Xie, Qiong Wu, Changjun Sun, Hongli Luo, Bang An, Qiannan Wang

“…Notably, bikaverin biosynthesis was found to be tightly regulated by environmental cues, including acidic pH, nitrogen scarcity, and microbial competition. …”
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METTL14-mediated m6A modification enhances USP22-ERα axis to drive breast cancer malignancy by Xuefen Zhuang, Shusha Yin, Ji Cheng, Wenshuang Sun, Zesen Fang, Yujie Xiang, E.-ying Peng, Yu Yao, Yuting Li, Xiaoyue He, Li Lu, Yuanfei Deng, Hongbiao Huang, Gengxi Cai, Yuning Liao

“…The abundance and activity of estrogen receptor alpha (ERα) are tightly regulated by ubiquitin-specific peptidase 22 (USP22) during the progression of breast cancer (BCa). …”
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Effects of Wenfei Guyuan umbilical moxibustion on patients with stable chronic obstructive pulmonary disease: A multicenter randomized controlled trial by Qionghua Xiao, Yuanyuan Meng, Gaoming Wang, Minghang Wang, Yong Meng, Miao Zhou

“…The primary outcome was the frequency of acute exacerbations, and the secondary outcomes were the 6-minute walk distance (6MWD), modified Medical Research Council dyspnea scale (mMRC) score, clinical symptoms and signs scores, and lung function tests. Statistical analysis was performed using SPSS software (version 25.0). …”
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TMEM16F Expressed in Kupffer Cells Regulates Liver Inflammation and Metabolism to Protect Against Listeria Monocytogenes by Jianlong Tang, Hua Song, Shimin Li, Sin Man Lam, Jieming Ping, Mengyun Yang, Na Li, Teding Chang, Ze Yu, Weixiang Liu, Yan Lu, Min Zhu, Zhaohui Tang, Zheng Liu, Yusong R. Guo, Guanghou Shui, André Veillette, Zhutian Zeng, Ning Wu

“…Abstract Infection by bacteria leads to tissue damage and inflammation, which need to be tightly controlled by host mechanisms to avoid deleterious consequences. …”
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Modeling memory in gravel-bed rivers: a flow-history-dependent relation for evolving thresholds of motion by C. C. Masteller, J. P. L. Johnson, D. Rickenmann, J. M. Turowski

“…Calibrated parameters describing strengthening are more tightly distributed than weakening parameters, which suggests that magnitudes of bed weakening may be more variable and difficult to accurately predict as a function of flood characteristics than bed strengthening during lower flows.…”
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Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor by Rebecca Slutsky, Roberto Romero, Yi Xu, Jose Galaz, Derek Miller, Bogdan Done, Adi L. Tarca, Sabrina Gregor, Sonia S. Hassan, Yaozhu Leng, Nardhy Gomez-Lopez

“…Successful pregnancy requires a tightly-regulated equilibrium of immune cell interactions at the maternal-fetal interface (i.e., the decidual tissues), which plays a central role in the inflammatory process of labor. …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…While epilepsy and psychiatric behaviors increase in severity with age, communication abilities and motor function tend to improve. iPSCs, which were differentiated into GABAergic neurons, represent the first in vitro neuronal model of SSADHD and express the neuronal marker microtubule-associated protein 2 (MAP2), as well as GABA. …”
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Ozone pollution may limit the benefits of irrigation to wheat productivity in India by G. Everett, Ø. Hodnebrog, M. Agrawal, D. Singh Yadav, C. O'Neill, C. Jamir, J. Cook, J. Cook, P. Pande, S. Bland, L. Emberson

“…The magnitude and interplay of O<span class="inline-formula">₃</span> and water stress effects are tightly coupled via stomatal conductance and the transpiration pathway. …”
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The Diversity of Cold Worlds: A Blended-light Binary Straddling the T/Y Transition in Brown Dwarfs by Daniella C. Bardalez Gagliuffi, Jacqueline K. Faherty, Genaro Suárez, Sherelyn Alejandro Merchan, Brianna Lacy, Ben Burningham, Klara Matuszewska, Rocio Kiman, Johanna M. Vos, Austin Rothermich, Jonathan Gagné, Caroline Morley, Melanie J. Rowland, Dan Caselden, Aaron Meisner, Adam C. Schneider, Marc J. Kuchner, Charles A. Beichman, Peter R. Eisenhardt, Christopher R. Gelino, Ehsan Gharib-Nezhad, Eileen C. Gonzales, Federico Marocco, Niall Whiteford, J. Davy Kirkpatrick

“…We obtained a moderate resolution ( R  ∼ 2700) G395H spectrum of this unresolved binary with JWST/NIRSpec and we fit it to late T and Y dwarf spectra from JWST/NIRSpec, and model spectra of comparable temperatures, both as individual spectra and pairs mimicking an unresolved binary system. We find that this tightly separated binary is likely composed of two unequal-brightness sources with a magnitude difference of 0.50 ± 0.08 mag in IRAC [4.5] and a secondary 1.01 ± 0.13 mag redder than the primary in [3.6]–[4.5]. …”
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Innovation Ecosystem of Iran's Tourism Industry with Emphasis on Supply Chain by Azizolah Jafari, mahdi alaei kerahrudi

“…Today, countries are achieving significant progress in the field of innovation in a tight competition. Tourism is one of the most important sectors that has been recently noticed in the discussion of innovation. …”
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