Tau seeding activity in the cerebrospinal fluid of Alzheimer disease patients predicts short-term cognitive decline by Ludivine Houzé, Marc Dhenain, Suzanne Lam, Fanny Petit, Stéphane Haïk, François Mouton-Liger, Jacques Hugon, Julie Dam, Claire Paquet, Ralf Jockers, Erika Cecon

“…The advancement of cognitive decline in AD is tightly linked to the spread of pathological tau protein aggregates in the brain, through tau seeding properties. …”
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Lactate in ferroptosis regulation: A new perspective on tumor progression and therapy by Nan Wu, Xiaoqi Wei, Shuang Yu, Lina Yang, Xiaowen Zhang

“…Ferroptosis is a type of regulated cell death induced by iron-dependent lipid peroxidation, which is tightly regulated by metabolism. Lactate is a byproduct of glycolysis that regulates energy, fatty acid metabolism, and redox homeostasis as a fuel or signaling molecule. …”
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Identification of three distinct cell populations for urate excretion in human kidneys by Yoshihiko M. Sakaguchi, Pattama Wiriyasermkul, Masaya Matsubayashi, Masaki Miyasaka, Nau Sakaguchi, Yoshiki Sahara, Minoru Takasato, Kaoru Kinugawa, Kazuma Sugie, Masahiro Eriguchi, Kazuhiko Tsuruya, Hiroki Kuniyasu, Shushi Nagamori, Eiichiro Mori

“…Urate excretion from the human kidney is tightly regulated by reabsorption and secretion. At least eleven genes have been identified as human renal urate transporters. …”
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Chalkophore-mediated respiratory oxidase flexibility controls M. tuberculosis virulence by John A Buglino, Yaprak Ozakman, Chad E Hatch, Anna Benjamin, Derek S Tan, Michael S Glickman

“…Mtb synthesizes diisonitrile lipopeptides that tightly chelate copper, but the role of these chalkophores in host-pathogen interactions is also unknown. …”
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Preconfigured cortico-thalamic neural dynamics constrain movement-associated thalamic activity by Perla González-Pereyra, Oswaldo Sánchez-Lobato, Mario G. Martínez-Montalvo, Diana I. Ortega-Romero, Claudia I. Pérez-Díaz, Hugo Merchant, Luis A. Tellez, Pavel E. Rueda-Orozco

“…However, their existence and function in motor networks have been scarcely studied. …”
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Update on NKCC2 regulation in the thick ascending limb (TAL) by membrane trafficking, phosphorylation, and protein-protein interactions by Dipak Maskey, Dipak Maskey, Jessica Granados Pineda, Jessica Granados Pineda, Pablo A. Ortiz, Pablo A. Ortiz

“…Here, we update the latest molecular mechanisms and players that control NKCC2 function, which gives an increasingly complex picture of NKKC2 regulation in the apical membrane of the TAL.Recent FindingsProtein-protein interactions are required as a regulatory mechanism in many cellular processes. …”
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The Hybrid Model: Prediction-Based Scheduling and Efficient Resource Management in a Serverless Environment by Louai Shiekhani, Hui Wang, Wen Shi, Jiahao Liu, Yuan Qiu, Chunhua Gu, Weichao Ding

“…However, the cold start problem remains a major challenge, not only because of the substantial latency it introduces to function execution time, but also because frequent cold starts lead to poor resource utilization, especially during workload fluctuations. …”
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Multidomain Connectivity as a Marker of HIIT-Induced Adaptation in Elite Youth Soccer Players: A Correlational Mapping Approach by Moses Gnanasigamani, Agnieszka Kaczmarek, Jarosław Nosal, Eugenia Murawska-Ciałowicz, Paweł Chmura

“…HIIT elicited statistically significant improvements in aerobic capacity, buffering efficiency, and perceptual-cognitive function, with a notable emergence of cross-domain associations. …”
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TRABD maintains mitochondrial homeostasis and protects against ischemia reperfusion-induced renal tubular injury by Wenqi Duan, Wenye Wu, Cui Yang, Mei Zhang, Xuemei Li, Wenmin Tian, Yang Chen, Xinjun Zhang, Xinjun Zhang, Xinjun Zhang

“…Mitochondria serve as hubs for many critical cellular processes, and their functions and dynamics are tightly controlled. TRABD is a Tiki/TraB family protein with unknown function. …”
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Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development by Divyesh Joshi, Preeti Jindal, Ronak K Shetty, Maneesha S Inamdar

“…The transforming growth factor β (TGFβ) signaling pathway is critical for survival, proliferation, and cell migration, and is tightly regulated during cardiovascular development. …”
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High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states. by Kevin A Wilkinson, Robert J Gorelick, Suzy M Vasa, Nicolas Guex, Alan Rein, David H Mathews, Morgan C Giddings, Kevin M Weeks

“…Replication and pathogenesis of the human immunodeficiency virus (HIV) is tightly linked to the structure of its RNA genome, but genome structure in infectious virions is poorly understood. …”
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Potassium Clearance in Optic Nerve: A Multidomain Model by Shanfeng Xiao, Huaxiong Huang, Robert Eisenberg, Zilong Song, Shixin Xu

“…Background: Ion and water transport in the central nervous system (CNS) is governed by tightly coupled mechanisms involving electrodiffusion, osmotic pressure, and fluid convection. …”
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Flavonoid compound icariin enhances BMP-2 induced differentiation and signalling by targeting to connective tissue growth factor (CTGF) in SAMP6 osteoblasts. by Bing Xu, Xueqiang Wang, Chengliang Wu, Lihe Zhu, Ou Chen, Xiaofeng Wang

“…<h4>Conclusion</h4>These results suggest that decreased osteoblast development and function potentially contributes to age-associated disease. …”
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Structured exercise program on Foot Biomechanics & Insulin Resistance among people living with type 2 diabetes with and without peripheral neuropathy by Amaravadi Sampath Kumar, Animesh Hazari, Arun G Maiya, Barkur A. Shastry, Shivashankara K Nagiri, Vaishali K

“…These changes could be seen due to musculoskeletal factor like reduction in intrinsic foot muscle strength, tightness of lower limb muscles, postural changes, etc. …”
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Crosstalk between metabolism and epigenetics during macrophage polarization by Kangling Zhang, Chinnaswamy Jagannath

“…While arginine methylation primarily functions in epigenetics by regulating gene expression through protein modifications, the degradation of methylated proteins releases arginine derivatives like asymmetric dimethylarginine (ADMA), which contribute directly to arginine metabolism—a key factor in macrophage polarization. …”
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Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells. by Siem van der Laan, Eleonora Golfetto, Jean-Marc Vanacker, Domenico Maiorano

“…Pluripotency of embryonic stem cells (ESC) is tightly regulated by a network of transcription factors among which the estrogen-related receptor β (Esrrb). …”
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Outcomes of complex decongestive therapy in managing upper limb lymphedema in female breast cancer patients at a palliative care unit of a tertiary care hospital in Bangladesh. by Rifat Jahan, A K M Motiur Rahman Bhuiyan, Afroja Alam, Mostofa Kamal Chowdhury, Romena Hassan, Nisha Mortuja Aktar

“…<h4>Background</h4>Lymphedema is a chronic condition that significantly affects both physical function and quality of life of breast cancer patients. …”
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Integrated Transcriptomics and Metabolomics Unveil Key Regulators of Feed Efficiency in Larimichthys crocea on Fishmeal-Free Diets by Yuhan Jin, Gongsi Wang, Peng Ren, Lining Zhang, Qinghui Ai, Yunzhang Sun, Fang Han, Zhiyong Wang

“…Integrative O2PLS and correlation analyses identified tightly linked gene–metabolite pairs, such as pfkp and peptide fragment, and highlighted mao as a regulatory factor that links energy and protein digestion. …”
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Values, intercultural sensitivity, and uncertainty management: a cross-cultural investigation of motivational profiles by Jungsun Kim, Huai-Rhin Kim

“…IntroductionPersonal values function as core motivational forces shaping cognition and behavior. …”
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Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care by Alina-Georgiana Cristea (Hohotă), Elena-Lăcrămioara Lisă, Simona Iacob (Ciobotaru), Ionut Dragostin, Claudia Simona Ștefan, Iuliu Fulga, Andra Monica Anghel (Ștefan), Maria Dragan, Ionela Daniela Morariu, Oana-Maria Dragostin

“…Wound healing is a complex, tightly regulated process essential for maintaining skin barrier function. …”
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