Role for circadian clock genes in seasonal timing: testing the Bünning hypothesis. by Mirko Pegoraro, Joao S Gesto, Charalambos P Kyriacou, Eran Tauber

“…Our results support an underlying circadian function mediating seasonal daylength measurement and indicate that clock genes are tightly involved in photo- and thermo-periodic measurements.…”
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Anesthesia management using remimazolam for coronary artery bypass grafting and aortic valve replacement in a patient with severe cardiac dysfunction: A case report by Tomoki Sagawa, Yusuke Ishida, Tomomi Sasaki, Maiko Hosokawa, Kiyoko Bito, Katsunori Oe

“…Anesthesia management using remimazolam of a patient with impaired cardiac function and several complications is reported. A man in his 50s with hypertension, diabetes mellitus, and chronic kidney disease (G 5) on dialysis came to our hospital with a chief complaint of exertional dyspnea and chest tightness, and a close examination showed stenoses of three coronary arteries. …”
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Chest Care and Respiratory Therapy in Pediatric SARS-CoV-2 Acute Infection by Chien-Lin Huang, Ke-Yun Chao, Yu-Hsuan Chien, Shu-Chi Mu

“…Respiratory rate-oxygen index is a useful tool to predict patient’s respiratory function whether intubation is needed or not. Besides, chest care with appropriate position change improves respiratory status. …”
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Convergence Rates of Gradient Methods for Convex Optimization in the Space of Measures by Chizat, Lénaïc

“…We also prove the tightness of our analysis with matching lower bounds and confirm the theoretical results with numerical experiments on low dimensional problems. …”
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Fusion of SARS-CoV-2 neutralizing LCB1 peptide with Bacillus amyloliquefaciens RNase improves antiviral efficacy by Nikita N. Kostin, Tatyana V. Bobik, Elena V. Konovalova, Milita V. Kocharovskaya, Maria A. Simonova, Natalia Yu Rushkevich, Yuliana A. Mokrushina, George A. Skryabin, Roman S. Kalinin, Sergey I. Kovalchuk, Rustam H. Ziganshin, Leonid A. Kaluzhskiy, Oksana V. Gnedenko, Evgeniy O. Yablokov, Alexis S. Ivanov, Aleksandr S. Chernov, Vitaly A. Kazakov, Oksana N. Khokhlova, Arkady N. Murashev, Senlian Hong, Elena I. Shramova, Alexey A. Schulga, Ekaterina N. Lyukmanova, Mikhail P. Kirpichnikov, Ivan V. Smirnov, Alexey A. Belogurov, Yuri P. Rubtsov, Alexey V. Stepanov, Hongkai Zhang, Alexander G. Gabibov, Sergey M. Deyev

“…However, limited avidity, lack of effector functions, short circulatory half-life, and restricted administration routes make them inferior compared to neutralizing antibodies. …”
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Amorphization and siliconization of silicon carbide as a first wall material by Aritra De, Jerome Guterl, Zachary Bergstrom, Tyler Abrams, Gregory Sinclair, John David Elder, Dmitry Rudakov

“…Surface evolution is tightly coupled to impurity transport in the plasma and therefore needs to be integrated with impurity transport simulations to effectively predict Si erosion rates and sub-surface concentrations as a function of time. …”
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Pediatric metanephric adenoma with Fanconi–Bickel syndrome: a case report and review of literature by Osama M. Sarhan, Ahmed Al Farhan, Salma Abdallah, Hamzah Al Ghwanmah, Deena Boqari, Helmy Omar, Abdulmohsin Al Faddagh, Hanan Al Kanani, Fouad Al Kawai

“…A nephron-sparing surgery is better for this age group in which the future renal function is considered.…”
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Relationship of cardiac and carotid arteries remodeling in women with arterial hypertension by I. M. Zubko

“…Conclusions: Cardio - vascular remodeling in AH is associated not only with traditional common intima – media thickness but more tightly with separate media thickness and inner vessel diameter of large arteries enlargement. …”
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Effects of antagonistic network-targeted tDCS on brain co-activation patterns depends on the networks’ electric field: a simultaneous tDCS-fMRI study by Hechun Li, Hongru Shi, Sisi Jiang, Changyue Hou, Haonan Pei, Hanxi Wu, María Luisa Bringas Vega, Gang Yao, Dezhong Yao, Cheng Luo

“…Material and method: The current study utilized simultaneous network-targeted transcranial direct current stimulation(tDCS) and functional magnetic resonance imaging (fMRI) to investigate the effects of tDCS targeting antagonistic networks on brain dynamics. …”
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Molecular mechanisms of the anchang group prescription in treating radiation enteritis: network pharmacology analysis and experimental evidence by Wei Liang, Bo Li, Yuehong Sun, Dapeng Jia, Tingting Hu, Rujing Huang, Zhilong Liu, Huan Yang, Baocai Chen, Xiaoming Yin, Xinying He, Yunchuan Sun

“…Cytoscape 3.8.2 along with the STRING database were instrumental in developing a protein-protein interaction (PPI) network for the identification of pivotal targets. Functional enrichment analyses, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, were conducted via the DAVID database. …”
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Research Progress on NK Cell Receptors and Their Signaling Pathways by Yingying Chen, Dan Lu, Alexey Churov, Rong Fu

“…The expression and function of NK cell surface receptors also alter in virus infection, tumor, and autoimmune diseases and influence the occurrence and development of diseases. …”
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Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. by Christine R Collins, Fiona Hackett, Malcolm Strath, Maria Penzo, Chrislaine Withers-Martinez, David A Baker, Michael J Blackman

“…The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). Eventually, in a tightly regulated process called egress, proteins of the PV and intracellular merozoite surface are modified by an essential parasite serine protease called PfSUB1, whilst the enclosing PV and erythrocyte membranes rupture, releasing merozoites to invade fresh erythrocytes. …”
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Wettability of Binary Solid-Supported Films of Zwitterionic/Anionic Phospholipids by Małgorzata Jurak

“…These enabled the possibility to track changes in the wettability of the tightly packed or phase-separated phospholipid films and their surface free energy as a function of the monolayer composition. …”
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Modulation of lipid metabolism by exercise: exploring its potential as a therapeutic target in cancer endocrinology by Haodong Liu, Tong Yang, Seongbeom Choi

“…Cancer progression is tightly linked to metabolic changes, particularly in lipid metabolism, which is crucial for tumor growth and metastasis. …”
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Mouse-derived Synaptosomes Trypsin Cleavage Assay to Characterize Synaptic Protein Sub-localization by Jasmeet Shergill, Domenico Azarnia Tehran

“…The localization, abundance, and function of these proteins are essential for productive neurotransmission and are often affected in neurological and neurodegenerative disorders. …”
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Deciphering 17-β-hydroxysteroid dehydrogenase 4: from molecular insights to cancer therapeutics by Meng-Bin Liao, Andy T. Y. Lau, Yan-Ming Xu

“…Impairment of lipid metabolism represents one of the most critical metabolic alterations in cancer, with lipid metabolic processes tightly linked to tumor cell proliferation, survival, invasion, and metastasis. …”
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Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single‐Cell Transcriptomic Data with MetaTF by Yongfei Hu, Yuanyuan Zhu, Guangjue Tang, Ming Shan, Puwen Tan, Ying Yi, Xiyuan Zhang, Man Liu, Xinyu Li, Le Wu, Jia Chen, Hailong Zheng, Yan Huang, Zhuan Li, Xiaobo Li, Dong Wang

“…Generally, the cell identity and function are orchestrated by the expression of given specific genes tightly regulated by transcription factors (TFs). …”
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Du chapitre à l’épisode : le devenir des chapitres dans les adaptations en franchises multi-médiatiques by Aude Leblond

“…Adapting a chapter into an episode requires a change in rhythm and composition as well: chapters are condensed into short, two minutes sequences, and combined in a montage which makes characters and storylines alternate much more tightly. Chapters and episodes thus differ in rhythm and content, but this distinction is blurred when we examine their function in the overall structure: both provide an incomplete closure, promising some form of sequel. …”
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Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models by Raman Sood, Paul Liu

“…Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors. …”
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Modulation of the central nervous system immune response and neuroinflammation via Wnt signaling in health and neurodegenerative diseases by Kevin Fang

“…Abstract The immune response in the central nervous system (CNS) is a highly specialized and tightly regulated process essential for maintaining neural health and protecting against pathogens and injuries. …”
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