The role of KLF4 in phagocyte activation during infectious diseases by Toni Herta, Toni Herta, Aritra Bhattacharyya, Stefan Hippenstiel, Janine Zahlten

“…Their activation and function are tightly regulated by transcription factors that coordinate immune responses. …”
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Alternate Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation by Nicole Dominado, Rachel Ye, Franca Casagranda, James Heaney, Nicole A. Siddall, Helen E. Abud, Gary R. Hime

“…Ectopic expression of a Grh.N isoform also resulted in ISC differentiation similar to loss of Grh.O function. Grh.O expression must be tightly regulated as high level ectopic expression of a member of this isoform class in enteroblasts, but not ISCs, resulted in cells with confused identity and promoted excess proliferation in the epithelium. …”
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Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice. by Martine Bot, Paul P Van Veldhoven, Saskia C A de Jager, Jason Johnson, Niels Nijstad, Peter J Van Santbrink, Marijke M Westra, Gerd Van Der Hoeven, Marion J Gijbels, Carsten Müller-Tidow, Georg Varga, Uwe J F Tietge, Johan Kuiper, Theo J C Van Berkel, Jerzy-Roch Nofer, Ilze Bot, Erik A L Biessen

“…<h4>Aims</h4>Altered sphingosine 1-phosphate (S1P) homeostasis and signaling is implicated in various inflammatory diseases including atherosclerosis. As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(-/-)) deficiency on leukocyte subsets relevant to atherosclerosis.…”
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Alternative Splicing in Tumorigenesis and Cancer Therapy by Huiping Chen, Jingqun Tang, Juanjuan Xiang

“…Alternative splicing (AS) is a pivotal post-transcriptional mechanism that expands the functional diversity of the proteome by enabling a single gene to generate multiple mRNA and protein isoforms. …”
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Influence of wiring cost on the large-scale architecture of human cortical connectivity. by David Samu, Anil K Seth, Thomas Nowotny

“…Specifically, our results suggest that the cortical network is less tightly integrated than its spatial constraints would allow, but more strongly segregated than its spatial constraints would necessitate. …”
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Static Clathrin Assemblies at the Peripheral Vacuole-Plasma Membrane Interface of the Parasitic Protozoan Giardia lamblia. by Jon Paulin Zumthor, Lenka Cernikova, Samuel Rout, Andres Kaech, Carmen Faso, Adrian B Hehl

“…Trophozoites are non-invasive but associate tightly with the enterocyte surface of the small intestine. …”
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Effectiveness of scapular clock exercises in scapular dyskinesia in post operative cardiac patients: A randomized clinical trial by Izza Ayub, Sana Zahir, Aqsa Shahid, Rohail Amir Babar, Amir Mushtaq

“… Background: Scapular dyskinesia is a frequent complication after cardiac surgery due to thoracic immobility, pectoral tightness, and muscle imbalances, contributing to persistent shoulder pain and functional deficits. …”
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Mutational Analysis of Substrate Recognition in Trypsin-like Protease Cocoonase: Protein Memory Induced by Alterations in Substrate-Binding Site by Nana Sakata, Shigeru Shimamoto, Yuri Murakami, Orika Ashida, Toshiki Takei, Mitsuhiro Miyazawa, Yuji Hidaka

“…This reveals that the structural characteristics of precursor proteins are maintained in the mature proteins, potentially influencing substrate recognition and catalytic function. These findings suggest that the pro-regions of these mutants interact much more tightly with the mature enzyme than in the wild-type CCN. …”
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Reversible ubiquitination conferred by domain shuffling controls paired NLR immune receptor complex homeostasis in plant immunity by Zhiyi Chen, Jianhua Huang, Jianyu Li, Frank L. H. Menke, Jonathan D. G. Jones, Hailong Guo

“…Abstract Plant intracellular NLR immune receptors can function individually or in pairs to detect pathogen effectors and activate immune responses. …”
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Sex-differences in the multidimensional evaluation of dyspnea in respiratory outpatients by Kathryn M. Milne, Kathryn M. Milne, Kathryn M. Milne, Julia Zhang, Owen D. Harris, Jordan A. Guenette, Jordan A. Guenette, Jordan A. Guenette

“…Males and females experienced similar dyspnea impact (mMRC) and were matched for relative impairment in lung function. Females rated higher intensity of breathing muscle work, chest tightness, and mental effort. …”
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Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration by Bolaji Oyetayo, Yurixy Mendoza-Silva, Temitayo Subair, Luisa C Hernández-Kelly, Marie-Paule Felder-Schmittbuhl, Tatiana N. Olivares-Bañuelos, Arturo Ortega

“…An exquisite interplay between glutamate receptor signaling and glutamate transporter expression and function is fundamental for the integrity and proper function of the retina. …”
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A stele‐enriched gene regulatory network in the Arabidopsis root by Siobhan M Brady, Lifang Zhang, Molly Megraw, Natalia J Martinez, Eric Jiang, Charles S Yi, Weilin Liu, Anna Zeng, Mallorie Taylor‐Teeples, Dahae Kim, Sebastian Ahnert, Uwe Ohler, Doreen Ware, Albertha J M Walhout, Philip N Benfey

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Research advances of the role of T lymphocytes in lupus nephritis by Zhang Ling-ge, Liu Xiao-xi, Li Lu

“…T cell differentiation and function are tightly regulated to ensure protection against pathogens and prevent autoimmune attack versus self-antigens. …”
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Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans by Yixuan Jiang, Ying Liang, Fujie Zhao, Zhenguo Lu, Siyu Wang, Yao Meng, Zhanxiang Liu, Jing Zhang, Youbao Zhao

“…Rtf1 is not tightly associated with the Paf1C, and its histone modification domain (HMD) is sufficient to promote H2Bub1 and the expression of genes related to fungal mating and filamentation. …”
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Roles of Zinc Signaling in the Immune System by Shintaro Hojyo, Toshiyuki Fukada

“…In this review, we highlight the emerging functional roles of Zn and Zn transporters in immunity, focusing on how crosstalk between Zn and immune-related signaling guides the normal development and function of immune cells.…”
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Age-related calcium signaling disturbance restricted cAMP metabolism and induced ovarian oxidation stress in laying ducks by Cheng-long Jin, Sheng-lin Wang, Shuang Wang, Ya-nan Zhang, Wei-guang Xia, Chang Zhang, Xue-bing Huang, Kai-chao Li, Chun-tian Zheng, Wei Chen

“…However, whether Ca provided a functional role in follicle development of aged avian, and its further mechanism was still unknown. …”
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A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects. by Thomas Ricketts, Philip McGoldrick, Pietro Fratta, Pietro Fratta, Hugo M de Oliveira, Rosie Kent, Vinaya Phatak, Sebastian Brandner, Gonzalo Blanco, Linda Greensmith, Abraham Acevedo-Arozena, Elizabeth M C Fisher

“…Attempts to model TDP43 dysfunction in mice have used knockouts or transgenic overexpressors, which have revealed the difficulties of manipulating TDP43, whose level is tightly controlled by auto-regulation. In a complementary approach, to create useful mouse models for the dissection of TDP43 function and pathology, we have identified a nonsense mutation in the endogenous mouse Tardbp gene through screening an N-ethyl-N-nitrosourea (ENU) mutant mouse archive. …”
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Traditional Mongolian Medicine Qiqirigan-8 alleviates non-alcoholic fatty liver disease via restoring gut microbiota and metabolism by Dandan Yang, Dandan Yang, Wuyunsiqin, Wuyunsiqin, YanNiu, Hashentuya, Tana, Anna, Mingxing Ma, Wenhui Zhao, Menggenduxi, Minjie Wang, Minjie Wang

“…The expression of intestinal tight junction genes was analyzed by qRT-PCR to observe the protective effect of MMQ-8 against intestinal epithelial mucosal barrier disruption. …”
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Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy by Virginia Gao, Julita Chlebowicz, Karlton Gaskin, Juan A. Briano, Lauren E. Komer, André Pineda, Shrey Jhalani, Saad Ahmad, Eseosa Uwaifo, Luca S. Black, Jillian E. Haller, Serge Przedborski, Diane A. Lane, Sheng Zhang, Manu Sharma, Jacqueline Burré

“…Abstract Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. …”
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Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency by Shao Yang, Yawei Sun, Wei Luo, Xiaofeng Zhou, Xiao Gu, Wenzhe Zhang, Huashan Zhu, Wenjia Wu, Xueying Wu, Mengru Yu, Shan Wang

“…Dominant follicles play a vital role in ovarian endocrine and reproductive function. Zona pellucida glycoprotein 3 (ZP3) is a specific component of the zona pellucida around the oocyte and is tightly associated with the dominant follicle. …”
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