Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization by Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li

“…Moreover, STAT3 is a direct molecular target of isoquercitrin, which as corroborated by tight and stable noncovalent binding between them. …”
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Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis by Ningning Yue, Hailan Zhao, Peng Hu, Yuan Zhang, Chengmei Tian, Chen Kong, Zhiliang Mai, Longbin Huang, Qianjun Luo, Daoru Wei, Ruiyue Shi, Shaohui Tang, Yuqiang Nie, Yujie Liang, Jun Yao, Lisheng Wang, Defeng Li

“…Second, L. reuteri-CMVs were taken up by intestinal epithelial cells (IECs), elevated the expression of ZO-1, E-cadherin (Cdh1), and Occludin (Ocln), decreased intestinal permeability, and exerted protective effects on epithelial tight junction functionality. RNA sequencing analysis demonstrated that L. reuteri-CMVs repaired intestinal barrier by activating the HIF-1 signaling pathway and upregulating HMOX1 expression. …”
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The Arabidopsis bZIP11 transcription factor links low-energy signalling to auxin-mediated control of primary root growth. by Christoph Weiste, Lorenzo Pedrotti, Jebasingh Selvanayagam, Prathibha Muralidhara, Christian Fröschel, Ondřej Novák, Karin Ljung, Johannes Hanson, Wolfgang Dröge-Laser

“…Plants have to tightly control their energy homeostasis to ensure survival and fitness under constantly changing environmental conditions. …”
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The CXCL12/CXCR4 Signaling Pathway: A New Susceptibility Factor in Human Papillomavirus Pathogenesis. by Floriane Meuris, Laetitia Carthagena, Agnieszka Jaracz-Ros, Françoise Gaudin, Pasquale Cutolo, Claire Deback, Yuezhen Xue, Françoise Thierry, John Doorbar, Françoise Bachelerie

“…The productive human papillomavirus (HPV) life cycle is tightly linked to the differentiation and cycling of keratinocytes. …”
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Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids by Petra Geiser, Maria Letizia Di Martino, Ana C. C. Lopes, Alexandra Bergholtz, Magnus Sundbom, Martin Skogar, Wilhelm Graf, Kajsa Björner, Johan Vessby, Dominic-Luc Webb, Per M. Hellström, Jens Eriksson, Mikael E. Sellin

“…However, Shigella compensates for this ineptness by an intraepithelial expansion module reliant on the tight coupling of OspC3-dependent temporal delay of cell death and IcsA-mediated mobility. …”
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Revealing electron transport connectivity as an important factor influencing stability of organic solar cells by Haixia Hu, Rui Zhang, Dongcheng Jiang, Xinyu Mu, Jicheng Yi, Han Yu, Lik-Kuen Ma, Bin Li, Lingxin Cao, Mengzhen Sha, Jiangkai Sun, Ruohua Gui, Wei Liu, Shijie Liang, Longlong Li, Shufen Huang, Jianyu Yuan, Chengwang Niu, Cunquan Qu, Jun Yuan, Rongkun Zhou, Chen Zhang, Lin Lu, Xiaoyan Du, Kun Gao, Weiwei Li, Shu Kong So, Yingping Zou, Yanming Sun, Xiaotao Hao, Feng Gao, He Yan, Hang Yin

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Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition by Jana Koch, Alessandra Ruggia, Carina Beha, Irina Wipf, Damir Zhakparov, Patrick Westermann, Svenja Schmelzer, Anja Heider, Klemens Fröhlich, Katja Baerenfaller

“…Abstract Background T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function. …”
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Evaluation of cognitive and psychomotor faculties in relation to mood-related symptoms under the conditions of sleep deprivation by Marcin Sochal, Marta Ditmer, Piotr Białasiewicz, Szymon Turkiewicz, Filip Franciszek Karuga, Agata Gabryelska

“…A positive correlation was observed between the difference in PSG morning/DS morning depression severity and vigilance (R = 0.37, p = 0.001, R = 0.33, p = 0.005, for error duration eye-hand coordination test and PVT total average score, respectively).ConclusionRE tend to maintain or improve cognitive function after DS, oppositely to NR. Vigilance in particular might be tightly associated with changes in depression symptoms after DS. …”
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Action and therapeutic targets of folliculin interacting protein 1: a novel signaling mechanism in redox regulation by Qingzhi Ran, Aoshuang Li, Bo Yao, Chunrong Xiang, Chunyi Qu, Yongkang Zhang, Yongkang Zhang, Xuanhui He, Hengwen Chen

“…AMPK directly phosphorylates folliculin interacting protein 1 (FNIP1), leading to the nuclear translocation of transcription factor EB (TFEB) in response to mitochondrial functions. While mitochondrial function is tightly linked to finely-tuned energy-sensing mobility, FNIP1 plays critical roles in glucose transport and sensing, mitochondrial autophagy, cellular stress response, and muscle fiber contraction. …”
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Biogeochemical cycling of sedimentary organic carbon and benthic nutrient fluxes in the semi-enclosed Jinhae Bay, Korea: insights into benthic-pelagic coupling by Sung-Uk An, Sung-Uk An, Kyung-Tae Kim, Sung-Han Kim, Sung-Han Kim, Ju-Wook Baek, Ju-Wook Baek, Hyun-Jeong Jeong, Hyun-Jeong Jeong, Chul-In Sun, Jin Young Choi, Jin Young Choi, Sokjin Hong, Dae In Lee, Jae Seong Lee, Jae Seong Lee

“…The mineralization of organic matter at the sediment plays a crucial role in ecosystem functioning by facilitating the biogeochemical cycling of carbon and nutrients. …”
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Strategic supplementation of sanguinarine in a soybean meal free diet for grass carp (Ctenopharyngodon idella) significantly enhances growth performance by promoting liver and inte... by Yuhua Yue, Yong Shi, Meilin Zhang, Shanshan Shi, Guanping Liu, Hairong Shi, Yi Hu, Lei Zhong

“…In the CM group, intestinal villi and microvilli were disrupted, goblet cell counts declined, and macrophage infiltration alongside widened tight junctions was evident; CMS1 and CMS2 groups markedly restored mucosal architecture to levels comparable with the SM and CPC groups. …”
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Profiling of rhizosphere-associated microbial communities in North Alabama soils infested with varied levels of reniform nematodes by Sowndarya Karapareddy, Varsha C. Anche, Sowjanya R. Tamatamu, Madhusudhana R. Janga, Kathy Lawrence, Leopold M. Nyochembeng, Antonette Todd, Lloyd T. Walker, Venkateswara R. Sripathi

“…Moreover, five abundant fungal genera belonging to Fusarium, Aspergillus, Gibberella, Cladosporium, Lactera were identified. The tight clustering of bacterial nodes in Actinobacteria, Acidobacteria, and Proteobacteria shows they are highly similar and often found together. …”
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Exploring the role of mitochondrial uncoupling protein 4 in brain metabolism: implications for Alzheimer’s disease by Simone M. Crivelli, Aisylu Gaifullina, Jean-Yves Chatton

“…The brain’s high demand for energy necessitates tightly regulated metabolic pathways to sustain physiological activity. …”
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Personal Ornaments and Burial Rites in Prehistory by Selena Vitezović

“…Archaeological finds from burial contexts are very diverse in their nature and function, and may include parts of burial constructions, remains of rituals, objects placed along the deceased and objects placed on the deceased. …”
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HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors. by Weibin Zhang, Natasha Miley, Michael S Zastrow, Amy J MacQueen, Aya Sato, Kentaro Nabeshima, Enrique Martinez-Perez, Susanna Mlynarczyk-Evans, Peter M Carlton, Anne M Villeneuve

“…Moreover, SYP proteins load inappropriately along individual unpaired chromosomes in hal-2 mutants, and markers of PC-dependent movement and function are restored in hal-2; syp double mutants. …”
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Duodenal Organoids From Metabolic Dysfunction-Associated Steatohepatitis Patients Exhibit Absorptive and Barrier Alterations by Alia Hadefi, Morgane Leprovots, Gilles Dinsart, Maryam Marefati, Marjorie Vermeersch, Daniel Monteyne, David Pérez-Morga, Anne Lefort, Frédérick Libert, Laurine Verset, Claire Liefferinckx, Christophe Moreno, Jacques Devière, Eric Trépo, Marie-Isabelle Garcia

“…Biopsies and patient-derived organoid transcriptomes were then analyzed to evaluate if specific intestinal pathways were differentially modulated in MASH subjects. Functional assays were performed to assess the duodenal epithelial absorptive potential and barrier functionality. …”
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Exploiting native forces to capture chromosome conformation in mammalian cell nuclei by Lilija Brant, Theodore Georgomanolis, Milos Nikolic, Chris A Brackley, Petros Kolovos, Wilfred van Ijcken, Frank G Grosveld, Davide Marenduzzo, Argyris Papantonis

“…Abstract Mammalian interphase chromosomes fold into a multitude of loops to fit the confines of cell nuclei, and looping is tightly linked to regulated function. Chromosome conformation capture (3C) technology has significantly advanced our understanding of this structure‐to‐function relationship. …”
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The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation by Weiwei Qi, Yanlan Long, Ziming Li, Zhen Zhao, Jinhui Shi, Wanting Xie, Laijian Wang, Yandan Tan, Ti Zhou, Minting Liang, Ping Jiang, Bin Jiang, Xia Yang, Guoquan Gao

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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres by Tomáš Janovič, Gloria I. Perez, Greta Boelting, Jens C. Schmidt

“…To quantitatively analyze shelterin function, we generated a panel of human cancer cell lines expressing HaloTagged shelterin proteins from their endogenous loci. …”
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The interplay between epidermal barrier distribution, microbiota composition, and immune infiltrate defines and stratifies psoriasis patients and is associated with disease severit... by Elizabeth M. Ortega Rocha, Paul Hernández-Herrera, Sofia V. de los Santos- Carmona, Saraí G De León-Rodríguez, Ángel Juárez-Flores, Vadim Pérez-Koldenkova, Octavio Castro-Escamilla, Samira Muñoz-Cruz, Alicia Lemini-López, Laura C. Bonifaz

“…Here, we aimed to investigate the interplay between epidermal tight junctions, Staphylococcus aureus enterotoxin B (SEB), and CD4 T cell-mediated immune responses. …”
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