Innovative 3D microfluidic intestinal organoid model for assessing cadmium bioavailability in food: implications for enhanced exposure risk assessment by Yan Li, Wen Sun, Qiao Wang, Wan Shi, Yu Chen, Zhiyong Gong, Xiao Guo, Xin Liu, Yongning Wu

“…Caco-2 cells were cultured on the chip to mimic small intestinal villi’s 3D structure, mucus production, and absorption functions. The model’s physiological relevance was thoroughly characterized, demonstrating the formation of a confluent epithelial monolayer with well-developed tight junctions (ZO-1), high microvilli density (F-actin), and significant mucus secretion (Alcian blue staining), closely resembling the physiological intestinal epithelium. …”
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Sex differences in sleep apnea and Alzheimer’s Disease: role of cerebrovascular dysfunction by Ian M. Greenlund, Jill N. Barnes, Sarah E. Baker, Virend K. Somers, Joshua M. Bock

“…Given that cardiovascular and cerebrovascular diseases are tightly linked, OSA-mediated impacts on cerebrovascular function and Alzheimer’s Disease (AD) risk are also likely more manifest in females. …”
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Effects of kelp phlorotannins on the growth, immunity, intestinal health and disease resistance against Vibrio splendidus of sea cucumber Apostichopus japonicus by Zhikai Zhang, Yan Chi, Yongheng Du, Feng Li, Ning Ma, Song Qin

“…Phlorotannins are natural polyphenols from brown seaweed and their health-promoting functions have been identified in mammals. Although the sources of phlorotannins are widely distributed and inexpensive, they were rarely investigated in aquatic animals. …”
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Glial and immune dysregulation in glaucoma independent of retinal ganglion cell loss: a human post-mortem histopathology study by Akanksha Salkar, Viswanthram Palanivel, Devaraj Basavarajappa, Mehdi Mirzaei, Angela Schulz, Peng Yan, Vivek Gupta, Stuart Graham, Yuyi You

“…Additionally, biochemical evidence of alterations to the BRB integrity, characterized by reduced tight junction protein expression, facilitates immune cell infiltration, as indicated by the minimal and inconsistent presence of CD3/CD4+ T cells. …”
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Comparative study of lysine acetylation in Vesicomyidae clam Archivesica marissinica and the manila clam Ruditapes philippinarum: adaptation mechanisms in cold seep environments by Xue Kong, Wei Wang, Sunan Chen, Manzong Song, Ying Zhi, Yuefeng Cai, Haibin Zhang, Xin Shen

“…The findings present many potential proteins for further exploration of acetylation functions in cold seep clams and other deep-sea mollusks.…”
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β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways by Xinxin Yang, Endian Zheng, Yuxian Lin, Haoyue Sun, Ji Zhang, Yingcong Yu

“…It also reduced the release of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, which were triggered by ethanol exposure, improved energy homeostasis in the ileum, and reversed the downregulation of mRNA and protein expression of key tight junction proteins in the ileum, specifically ZO-1, Claudin-1, and Occludin, thereby restoring their functional integrity. …”
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Quantitative evaluation of IVL: based on the tunica media gypsum calcification model and a prospective animal study by Zongwei Liu, Zongwei Liu, Zongwei Liu, Chuang Xu, Chuang Xu, Bin Zhao, Bin Zhao, Jiayin Guo, Jiayin Guo, Jingzhong Song, Jingzhong Song, Jiaxue Bi, Jiaxue Bi, Yujun Shen, Yujun Shen, Yujun Shen, Xiangchen Dai, Xiangchen Dai

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Isolation and characterization of novel peptides from fermented products of Lactobacillus for ulcerative colitis prevention and treatment by Dong He, Wen Zeng, Yi Wang, Yifan Xing, Kang Xiong, Nan Su, Chong Zhang, Yuan Lu, Xinhui Xing

“…Compared to the current therapeutic drugs, bioactive peptides are more promising and safe substances as functional foods or drugs for the prevention and treatment of UC. …”
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SUN-domain proteins of the malaria parasite Plasmodium falciparum are essential for proper nuclear division and DNA repair by Sofiya Kandelis-Shalev, Manish Goyal, Tal Elam, Shany Assaraf, Noa Dahan, Omer Farchi, Eduard Berenshtein, Ron Dzikowski

“…In addition, the two components have different functions in activating the DNA damage response and in their association with heterochromatin. …”
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Assessment of The Effectiveness of Fiscal Policy in The Context of Socio-Economic Interests by I. A. Karpukhno

“…The functional limitations of these objective functions are substantiated and the logic of justifying the parameters of the Laffer curve is proposed. …”
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SIRT7 deletion inhibits Glaesserella parasuis-mediated inflammatory responses in porcine alveolar macrophages by Hao Zheng, Hao Zheng, Baoxin Wang, Baoxin Wang, Xia Dong, Xia Dong, Junjing Wu, Liangyu Shi, Liangyu Shi, Jing Zhang, Jing Zhang, Hongbo Chen, Hongbo Chen, Ao Zhou, Ao Zhou

“…In addition, RNA-seq analysis showed that differentially expressed genes(DEGs) induced by SIRT7 deficiency were enriched in biological processes such as cell proliferation, actin cytoskeleton formation, lipid synthesis, protein kinase activation regulation, and GTPase activity regulation. Functional enrichment analysis further indicated the involvement of these DEGs in tight junction pathway, PI3K-Akt signaling pathway, actin cytoskeleton regulation, cGMP-PKG signaling pathway, Hippo signaling pathway, and TNF signaling pathway. …”
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Microfluidics-enabled polydopamine-coated selenium nanoparticles in hyaluronic hydrogel microspheres for targeted antioxidant and immunomodulatory therapy of ulcerative colitis by Ying Fang, Hongwei Yu, Xiaochen Feng, Haike Xia, Yunze Xu, Ranjith Kumar Kankala, Aizheng Chen, Chaoping Fu

“…Overall, this microfluidics-enabled, colon-targeted delivery system with integrated antioxidative and immunomodulatory functions offers a promising strategy for the non-invasive treatment of UC and other inflammation-associated gastrointestinal disorders.…”
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Characteristics of Intestinal Microecology during Mesenchymal Stem Cell-Based Therapy for Mouse Acute Liver Injury by Xiaotian Dong, Xudong Feng, Jingqi Liu, Yanping Xu, Qiaoling Pan, Zongxin Ling, Jiong Yu, Jinfeng Yang, Lanjuan Li, Hongcui Cao

“…Lower expression and discontinuous staining of zonula occludens, as well as disrupted tight junctions, were observed in CCl4-treated mice at 48 h compared with MSC-transplanted mice. …”
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Development of a Caco-2-based intestinal mucosal model to study intestinal barrier properties and bacteria–mucus interactions by Evelien Floor, Jinyi Su, Maitrayee Chatterjee, Elise S. Kuipers, Noortje IJssennagger, Faranak Heidari, Laura Giordano, Richard W. Wubbolts, Silvia M. Mihăilă, Daphne A. C. Stapels, Yvonne Vercoulen, Karin Strijbis

“…This novel in vitro intestinal model can facilitate studies into mucus and epithelial barrier functions and in-depth molecular characterization of pathogenic and commensal microbe–mucus interactions.…”
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Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota by Lingyu Ruan, Zhennan Wang, Mengyun Zheng, Qi Zheng, Qing Qing, Hongyan Lin, Yuheng Tao, Liqun Wang, Junsong Wang, Wenhao Ge, Wenhao Ge

“…PMP could lower the levels of inflammatory cytokines, such as TNF-α and IL-1β, and boost tight junction protein both in brain and intestinal tissues. …”
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The Mater Dolorosa: Spanish Diva Lola Flores as Spokesperson for Francoist Oppressive Ideology by Irene Mizrahi

“…While her image has been celebrated as a symbol of Spanish cultural identity, it also functioned as a tool for maintaining patriarchal and nationalist ideologies under the guise of entertainment.…”
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Macrophage Membrane Coated Manganese Dioxide Nanoparticles Loaded with Rapamycin Alleviate Intestinal Ischemia-Reperfusion Injury by Reducing Oxidative Stress and Enhancing Autopha... by Sheng R, Wang W, Zeng W, Li B, Yu H, Li X, Liang Y, Wang Y, Liao Y, Liu D

“…In a mouse I/R model, Ma@(MnO₂+RAPA) significantly reduced Chiu’s score, improved tight conjunction proteins, decreased apoptosis, reduced levels of inflammatory cytokines and oxidative stress. …”
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Respiratory Disorders Related to e-Waste Exposure among Workers in the Informal Sector in a Sub-Saharan African City: An Exposed Nonexposed Study by Ablo Prudence Wachinou, Nonvignon Marius Kêdoté, Geraud Padonou, Serge Adè, Joaquin Darboux, Mirlène Tohi, Arnauld Fiogbé, Julius Fobil, Gildas Agodokpessi

“…Participants underwent lung function test using a portable spirometer (MIR SPIROBANK). …”
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Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation. by Esther Magdalena Marquez-Lona, Ana Lilia Torres-Machorro, Frankie R Gonzales, Lorraine Pillus, Gentry N Patrick

“…The ubiquitin proteasome system (UPS) is a highly conserved and tightly regulated biochemical pathway that degrades the majority of proteins in eukaryotic cells. …”
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The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapy by Xin Zhou, Ning-ning Shan

“…Immune cell activation, proliferation, and function are tightly regulated by metabolism, and metabolic products influence immune responses. …”
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