Trafficking and localization of Golgi-resident N-glycan processing enzymes in plants by Kai Dünser, Jennifer Schoberer

“…Therefore, the precise localization of these enzymes is crucial for the optimal functioning of the glycosylation process and the secretory pathway and hence must be tightly regulated to maintain protein function, cellular health, and overall organismal development. …”
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Potential of the mortgage housing lending market by N. I. Parusimova, D. A. Dobrin

“…The scientific novelty of the study is expressed in the following results: the analysis and systematization of the diverse characteristics of the mortgage housing lending market; the identification of terminological inconsistencies in definitions that reflect the essence of the mortgage market; the refinement of the market concept based on an essentialist approach; the formulation of the market’s functional objectives from the perspective of participants; the establishment of causal relationships, functions, and specific features of the market; as well as the empirical analysis of its practical functioning. …”
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Integrated biomimetic bioprinting of perichondrium with cartilage for auricle reconstruction by Litao Jia, Siyu Liu, Luosha Gu, Xiaomin Liu, Kexin Sun, Feiyang Chu, Jinshi Zeng, Wenshuai Liu, Haiyue Jiang, Xia Liu

“…Simulating the anatomical structure of the native auricle designs a sandwich construction model containing bilateral perichondrium and intermediate cartilage, employing a photocrosslinkable acellular cartilage matrix and gelatin bionics matrix microenvironment, applying co-cultured auricular chondrocytes and adipose-derived stem cells creates functional cell populations, designing hatch patterns imitates microscopic arrangement structures, utilizing sacrificial materials forms interlaminar network traffic to enhance the tight connection between layers, and finally, assessing the regenerative quality of the constructs explores their feasibility and stability. …”
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Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling by Sofie Burgmer, Fenja L. Meyer zu Altenschildesche, Akos Gyenis, Hyun Ju Lee, David Vilchez, Patrick Giavalisco, Arnaud Fichant, Mirka Uhlirova, Gilles Storelli

“…Summary: Animals coexist with bacteria and need to keep these microorganisms under tight control. To achieve such control, pattern recognition receptors (PRRs) sense bacterial cues and induce the production of antimicrobials. …”
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From Spinal Central Pattern Generators to Cortical Network: Integrated BCI for Walking Rehabilitation by G. Cheron, M. Duvinage, C. De Saedeleer, T. Castermans, A. Bengoetxea, M. Petieau, K. Seetharaman, T. Hoellinger, B. Dan, T. Dutoit, F. Sylos Labini, F. Lacquaniti, Y. Ivanenko

“…Although a wealth of research has demonstrated that locomotion is largely controlled by spinal mechanisms, the brain is of utmost importance in monitoring locomotor patterns and therefore contains information regarding central pattern generation functioning. In addition, there is also a tight coordination between the upper and lower limbs, which can also be useful in controlling locomotion. …”
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Using a brain-like endothelial cell differentiation to characterize the CS79iBRCA-n2 BRCA1 mutated patient derived stem cell line by Natalie G. Alexander, Kylie A. Buchanan, Alexandra E. Meyer, Lauren M. Mitterway, Caroline O. Vanderburgh, Shreyas S. Rao, Shreyas S. Rao, Shreyas S. Rao, Brandon J. Kim, Brandon J. Kim, Brandon J. Kim, Brandon J. Kim, Brandon J. Kim

“…This patient-derived hiPSC line can be utilized to study BBB properties as after differentiation into brain-like endothelial cells (BECs), BECs derived from this line express BBB markers such as tight junction proteins, and functional efflux transporters. …”
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Optimisation of the performance and structure of soluble ball seat metal sealing rings based on response surface by CHEN Zhen, RAN Qingjie, CHEN Nengpeng, WANG Qiaomu

“…Horizontal well fracturing technology, as a core tool for efficient development of tight oil and gas reservoirs, is of strategic significance for enhancing the recovery rate of unconventional oil and gas resources. …”
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Fracture Behavior of a 2D Imine‐Based Polymer by Bowen Zhang, Xiaohui Liu, David Bodesheim, Wei Li, André Clausner, Jinxin Liu, Birgit Jost, Arezoo Dianat, Renhao Dong, Xinliang Feng, Gianaurelio Cuniberti, Zhongquan Liao, Ehrenfried Zschech

“…A preferred cleavage orientation in transgranular fracture is attributed to the difference in directional flexibility along distinct orientations, which is substantiated by density functional‐based tight binding (DFTB) calculations. …”
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Gastrointestinal distribution and in vitro-microbial biotransformation of chlorogenic acid by Yunhui Zhang, Bowei Zhang, Xiaoxia Liu, Xiang Li, Fan Wei, Lingda Zhao, Huan Lv, Xudong Wang, Jin Wang, Jing Wu, Yan Zhang, Shuo Wang

“…Chlorogenic acid (CGA), as a polyphenol abundant in daily diet, exerted various intestinal functions. However, the material basis of its intestinal bioactivities was still unclear. …”
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In silico evaluation of missense SNPs in cancer-associated Cystatin A protein and their potential to disrupt Cathepsin B interaction by Shafaat Hossain, Omar Hamza Bin Manjur, Mst Sharmin Sultana Shimu, Tamanna Sultana, Mustafizur Rahman Naim, Shahariar Siddique, Abdullah Al Mamun, Md Miftaur Rahman, Md Abu Saleh, Md Rakibul Hasan, Tania Rahman

“…Cystatin A (CSTA) functions as a cysteine protease inhibitor by forming tight complexes with the cathepsins. …”
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Tetramethylpyrazine Analogue T-006 Protects Neuronal and Endothelial Cells Against Oxidative Stress via PI3K/AKT/mTOR and Nrf2 Signaling by Guiliang Zhang, Zirong Liang, Yuqiang Wang, Zaijun Zhang, Pui-Man Hoi

“…T-006 has been shown to improve neurological and behavioral functions in animal models of ischemic stroke and neurodegenerative diseases. …”
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Two novel Patescibacteria: Phycocordibacter aenigmaticus gen. nov. sp. nov. and Minusculum obligatum gen. nov. sp. nov., both associated with microalgae optimized for carbon dioxid... by Lauren Jonas, Yi-Ying Lee, Tsvetan Bachvaroff, Russell T. Hill, Yantao Li

“…ABSTRACT The functional roles of bacterial symbionts associated with microalgae remain understudied despite the importance of microalgae in biotechnology and environmental microbiology. 16S rRNA gene sequencing was conducted to analyze bacterial communities associated with two microalgae optimized for growth with flue gas containing 5%–10% CO2. …”
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Uncovering the mechanisms underlying the efficacy of probiotic strains in mitigating food allergies: an emphasis on gut microbiota and indoleacrylic acid by Zhangming Pei, Zhangming Pei, Li Qian, Li Qian, Taolin Miao, Hongchao Wang, Hongchao Wang, Wenwei Lu, Wenwei Lu, Wenwei Lu, Yuqing Chen, Qianger Zhuang

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Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis by Lili Zhao, Zihan Wei, Yibin Wang, Wanrong Chen, Wenjing Zhang, Mengfei Xie, Hong Chen, Yiping Zhang, Haiyan Gao, Xiaobing Jiang, Xiaobing Jiang

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Proximity Proteomics Reveals USP44 Forms a Complex with BRCA2 in Neuroblastoma Cells and Is Required to Prevent Chromosome Breakage by Asma Ali, Sajjad Hussain, Tibor Bedekovics, Raymond H. Jeon, Danielle G. May, Kyle J. Roux, Paul J. Galardy

“…We found that high <i>BRCA2</i> transcript was correlated with poor survival in neuroblastoma, likely due to its tight association with proliferation in these tumors. …”
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Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods by Marina Ramal-Sanchez, Chiara Bravo-Trippetta, Veronica D’Antonio, Elena Corvaglia, Angela A. M. Kämpfer, Roel P. F. Schins, Mauro Serafini, Donato Angelino

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Surface protonation amplifies carbon nitride nanosheet-induced phospholipid extraction: Mechanistic insights into enhanced cytotoxicity by Yiping Feng, Jiayong Lao, Jingchuan Xue

“…Molecular docking simulations identified that the interactions between p-C3N4 and phospholipid molecules are governed by electrostatic and hydrophobic forces, as well as hydrogen bonding with oxygen-containing functional groups. Molecular dynamics simulations further revealed that larger oxygen-bearing macropores on p-C3N4 allow for tight and specific binding with phospholipid headgroups, facilitating efficient lipid extraction and intensifying membrane disruption. …”
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Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice by Chaoyu Zhou, Haiyan Wu, Lei Zhang, Xiao Xiao, Xiaodan Wang, Mingju Li, Runqiu Cai, Jia You, Qi Chen, Yifei Yang, Xinyuan Tian, Qianyu Bai, Yinzhu Chen, Huihui Bao, Tianlong Liu

“…The results show that PS-NP exposure during lactation and juvenile periods caused delayed weight gain and impaired organ development, particularly in the liver and kidneys, without causing functional abnormalities or toxic injuries. The primary toxicity of PS-NPs was observed in the intestinal tract, including shortened villi, disrupted tight junctions, inhibited epithelial cell proliferation, and oxidative stress responses. …”
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Proline-2&#x2032;-deoxymugineic acid, a phytosiderophore analog, drives beneficial rhizobacterial community formation to promote peanut micronutrition by Tianqi WANG, Nanqi WANG, Kunguang WANG, Qiaofang LU, Zhechao DOU, Zhiguang CHI, Dongming CUI, Motofumi SUZUKI, Yuanmei ZUO

“…Functional prediction revealed that PDMA fosters microbial communication in the rhizosphere. …”
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Hirsutella sinensis polysaccharides and Parabacteroides goldsteinii reduce lupus severity in imiquimod-treated mice by Shih-Hsin Chang, Yun-Fei Ko, Jian-Ching Liau, Cheng-Yeu Wu, Tsong-Long Hwang, David M. Ojcius, John D. Young, Jan Martel

“…Moreover, the polysaccharides and P. goldsteinii improved markers of kidney and liver functions such as creatinine, blood urea nitrogen, glomerulus damage and fibrosis, and serum liver enzymes. …”
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