Targeting gut microbiota as a therapeutic target in T2DM: A review of multi-target interactions of probiotics, prebiotics, postbiotics, and synbiotics with the intestinal barrier by Keyu Chen, Han Wang, Xiaofei Yang, Cheng Tang, Guojie Hu, Zezheng Gao

“…These mechanisms include the restoration of gut microbiota structure, upregulation of intestinal epithelial cell proliferation and differentiation, enhancement of tight junction protein expression, promotion of mucin secretion by goblet cells, and the immunosuppressive functions of regulatory T cells (Treg) and M2 macrophages. …”
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Archidendron clypearia extract: Modulating intestinal inflammation and enhancing disease resistance in aquacultured American bullfrogs (Aquarana catesbeiana) by Kesong Chen, Han Lin, Jingyang Sun, Hua Li, Jie Ma, Zhendong Qin, Biao Jiang, Wei Li, Qing Wang, Youlu Su, Li Lin, Chun Liu

“…The results suggest the AE positively impacted growth performance and disease resistance, making it a potentially useful functional feed additive in bullfrog breeding. The results suggest that adding 1.0 g/kg AE to the diet positively impacted growth performance and disease resistance, making it a potentially useful functional feed additive in bullfrog breeding.…”
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Natural compounds targeting inflammation and oxidative stress in intestinal ischemia-reperfusion injury: a comprehensive review by Balaji Venkataraman, Aya A. Touny, Shamanth Neralagundi Harihar gowdru, Bhoomendra A. Bhongade, Rajesh B. Patil, Shreesh Ojha, Mauro Pessia, Sandeep B. Subramanya

“…This pathological process induces oxidative stress, inflammation, and cellular damage, which collectively impair intestinal function. Recent studies have explored natural therapeutic approaches, including the use of plants, herbal formulations, and phytochemicals, to mitigate the detrimental effects of intestinal I/R injury. …”
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Prevalence, correlative and statistical relationships of renal dysfunction in patients with chronic ischemic heart failure by D. A. Lashkul

“…According multicenter studies conducted during recent years, coronary heart disease was the leading cause of heart failure and has been on average 64% of patients with chronic heart failure. The tight functional relationship of cardiovascular and urinary system causes a lot of interest to the functional state of kidneys in various cardiovascular diseases. …”
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Nonmuscle Myosin-2B Regulates Apical Cortical Mechanics, ZO-1 Dynamics and Cell Size in MDCK Epithelial Cells by Marine Maupérin, Niklas Klatt, Thomas Glandorf, Thomas Di Mattia, Isabelle Méan, Andreas Janshoff, Sandra Citi

“…In epithelial cells, nonmuscle myosin-2B (NM2B) shows a cortical localization and is tethered to tight junctions (TJs) and adherens junctions (AJs) by the junctional adaptor proteins cingulin and paracingulin. …”
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Development of a highly efficient p-coumaric acid-responsive biosensor in Saccharomyces cerevisiae by Xueqing Pang, Jingyuan Zhu, Yuqing Li, Jing Xiao, Xinyu Zhang, Depeng Ren, Pingping Zhou

“…Notably, the PBS1-CCW12 hybrid promoter exhibited tight regulation by BsPadR and enhanced activity in response to p-coumaric acid. …”
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IRF2BP2 binds to a conserved RxSVI motif of protein partners and regulates megakaryocytic differentiation by Guanchao Wang, Tiantian Lu, Lei Zhang, Jianping Ding

“…These findings elucidate the molecular basis for how IRF2BP2 can engage with different protein partners, thereby exerting diverse regulatory functions in many cellular processes.…”
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Cholecystomegaly: A Case Report and Review of the Literature by Mohammad Bagher Jahantab, Vahid Salehi, Saadat Mehrabi, Lotfolah Abedini, Mohammad Javad Yavari Barhaghtalab

“…Chronic cholecystitis or symptomatic gallbladder is a prolonged mechanical or functional disorder of abnormal gallbladder emptying. …”
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Models of early stages of design of trunk-route passenger airplanes with taking families into account by P. V. Zhuravlev, V. N. Zhuravlev

“…There is a tight connection between the Pre-Design (development of requirements for the designed airplane) and Conceptual Design stages while creating a new aircraft. …”
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Strategy 2020: New Outlines of Russian Innovation Policy by Leonid Gokhberg, Tatiana Kuznetsova

“…It focuses on output-oriented decision making and balancing thematic and functional priorities to reduce failures in the innovation cycle. …”
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Graph-theoretical model of global human interactome reveals enhanced long-range communicability in cancer networks. by Evgeny Gladilin

“…Our ontological analysis shows that these genes are associated with enhanced cell division, DNA replication, stress response, and other cellular functions and processes typically upregulated in cancer. …”
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The Interplay of Iron and Lipid Homeostasis in Non-Alcoholic Fatty Liver Disease by Clinton J. Kidman, Cyril D.S. Mamotte, Keea R. Inder-Smith, Mark J. Tobin, Mark J. Hackett, Ross M. Graham

“… The liver is essential for numerous metabolic functions and is the primary site of iron storage and regulation in addition to maintaining critical functions in lipid metabolism. …”
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Understanding the synergistic interaction between a 1,3,4-thiadiazole derivative and amphotericin B using spectroscopic and theoretical studies by Lidia Ślusarczyk, Klaudia Rząd, Grzegorz Niedzielski, Mikołaj Gurba, Jose Chavez, Luca Ceresa, Joe Kimball, Ignacy Gryczyński, Zygmunt Gryczyński, Mariusz Gagoś, James Hooper, Arkadiusz Matwijczuk

“…Analyses based on the density functional tight-binding and time-dependent density functional theory confirmed that molecular interactions between “small” molecules and AmB lead to a significant increase in the clinical efficacy of the antibiotic.…”
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The protective effect of Gentiana lutea flower against mycotoxin toxicity in a gastrointestinal barrier in vitro model by Giacomo Di Matteo, Giacomo Di Matteo, Giacomo Di Matteo, Massimo Frangiamone, Pilar Vila-Donat, Valter Di Cecco, Luciano Di Martino, Lara Manyes, Luisa Mannina, Luisa Mannina, Luisa Mannina

“…The digested Gentiana samples reduced the expression of pro-apoptotic genes (BAX, CASP3), preserved intestinal barrier integrity by modulating tight junction-related genes (CL-2, ZO-1), and promoted antioxidant responses through SRXN1 regulation.ConclusionThese findings highlight the potential of Gentiana lutea flowers as a source of functional phytocompounds for intestinal barrier protection against mycotoxins.…”
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Extracellular matrix protein anosmin-1 regulates Schwann cell-astrocyte interaction for regenerative axon targeting in dorsal root crush injury model by Xichen Xuan, Xuechun Chu, Ruiliang Wang, Lu Liu, Daqing Li, Pierre Marc Bouloux, Ying Li, Youli Hu

“…After treated with anosmin-1, p75+ immature SCs and P0+ mature SCs mingled well with ASs at the peripheral/central glial interface, reforming the glial barrier from a tight to loose structure. Furthermore, regenerated axons traced by BDA staining revealed proper axonal targeting to the dorsal horn of the spinal cord. …”
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Duplex γ/α-phase evolution of biocompatible high-nitrogen stainless steel in additive manufacturing by Yufeng Tao, Liansheng Lin, Xudong Ren, Xuejiao Wang, Xia Cao, Yunxia Ye, Erjin Zhang, Heng Gu, Zijie Dai

“…Artificial tunability of microstructured high-nitrogen γ/α duplex-phase at tight topological control promises transformative opportunities not possessed by individual ferrite or austenitic phase, allowing pre-programming mechanics (density, strength, hardness, and tensile properties) for next-generation industrial or implantable biomedical uses requiring complex geometries and multi-functions.…”
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Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice by Bingyong Mao, Weiling Guo, Shumao Cui, Qiuxiang Zhang, Jianxin Zhao, Xin Tang, Hao Zhang

“…These results are conducive to accelerate the development of B. producta D4 as a functional probiotic for colitis.…”
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An In Vitro Gut–Liver–Adipose Axis Model to Evaluate the Anti-Obesity Potential of a Novel Probiotic–Polycosanol Combination by Simone Mulè, Rebecca Galla, Francesca Parini, Mattia Botta, Sara Ferrari, Francesca Uberti

“…These findings underline a possible biological relevance of probiotics and polycosanols in modulating metabolic pathways, improving gut barrier integrity, and reducing inflammation, supporting their role as functional ingredients for metabolic health.…”
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In Silico Study of Combined Docking and Molecular Dynamics Simulation for Hops (<i>Humulus lupulus</i>) Active Compounds in Inhibiting Duffy-Binding Protein (DBP) as Anti-<i>Plasmo... by Gusnia Meilin Gholam, Riyan Alifbi Putera Irsal, Maheswari Alfira Dwicesaria, Muhammad Marsha Azzami Hasibuan

“…We conclude that 6-prenylnaringenin has a tight and stable bond with the targeted DBP protein. …”
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Cuproptosis-related gene ACAD8 inhibits the metastatic ability of colorectal cancer by inducing cuproptosis by HuiE Zhuang, Yizhen Chen, Yizhen Chen, Sifu Huang

“…Pathway enrichment analysis suggested that ACAD8 might inhibit the metastasis of CRC by regulating pathways such as response to metal ions and tight junction organization. Finally, experiments confirmed a positive correlation between copper levels and ACAD8 mRNA expression, with CuCl2 upregulating ACAD8 expression. …”
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